JP2020536580A5 - - Google Patents
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- JP2020536580A5 JP2020536580A5 JP2020537300A JP2020537300A JP2020536580A5 JP 2020536580 A5 JP2020536580 A5 JP 2020536580A5 JP 2020537300 A JP2020537300 A JP 2020537300A JP 2020537300 A JP2020537300 A JP 2020537300A JP 2020536580 A5 JP2020536580 A5 JP 2020536580A5
- Authority
- JP
- Japan
- Prior art keywords
- bird
- nucleic acid
- acid sequence
- chromosome
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 16
- 210000000349 chromosome Anatomy 0.000 claims 13
- 231100000518 lethal Toxicity 0.000 claims 13
- 230000001665 lethal effect Effects 0.000 claims 13
- 238000010442 DNA editing Methods 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 235000013601 eggs Nutrition 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 102000018120 Recombinases Human genes 0.000 claims 7
- 108010091086 Recombinases Proteins 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 7
- 108020004414 DNA Proteins 0.000 claims 5
- 108010042407 Endonucleases Proteins 0.000 claims 5
- 102000004533 Endonucleases Human genes 0.000 claims 5
- 239000000411 inducer Substances 0.000 claims 5
- 241000287828 Gallus gallus Species 0.000 claims 4
- 210000001161 mammalian embryo Anatomy 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 3
- 230000013011 mating Effects 0.000 claims 3
- 230000001603 reducing effect Effects 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 241000271566 Aves Species 0.000 claims 2
- 108700039887 Essential Genes Proteins 0.000 claims 2
- 241000286209 Phasianidae Species 0.000 claims 2
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 235000015220 hamburgers Nutrition 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 241000272517 Anseriformes Species 0.000 claims 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 claims 1
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 claims 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 102100025423 Bone morphogenetic protein receptor type-1A Human genes 0.000 claims 1
- 102000004039 Caspase-9 Human genes 0.000 claims 1
- 108090000566 Caspase-9 Proteins 0.000 claims 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 claims 1
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims 1
- 101000934638 Homo sapiens Bone morphogenetic protein receptor type-1A Proteins 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 230000004156 Wnt signaling pathway Effects 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000003837 chick embryo Anatomy 0.000 claims 1
- 235000013330 chicken meat Nutrition 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 210000002149 gonad Anatomy 0.000 claims 1
- 230000012447 hatching Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 230000000384 rearing effect Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 108091006106 transcriptional activators Proteins 0.000 claims 1
- 230000009261 transgenic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762560218P | 2017-09-19 | 2017-09-19 | |
| US62/560,218 | 2017-09-19 | ||
| PCT/IL2018/051056 WO2019058376A1 (en) | 2017-09-19 | 2018-09-17 | BIRDS WITH GENOME EDITION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020536580A JP2020536580A (ja) | 2020-12-17 |
| JP2020536580A5 true JP2020536580A5 (https=) | 2021-10-28 |
Family
ID=65811120
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020537300A Pending JP2020536580A (ja) | 2017-09-19 | 2018-09-17 | ゲノム編集された鳥 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20200214273A1 (https=) |
| EP (1) | EP3684172A4 (https=) |
| JP (1) | JP2020536580A (https=) |
| KR (1) | KR20200088805A (https=) |
| CN (2) | CN111315212B (https=) |
| AU (1) | AU2018336161A1 (https=) |
| BR (1) | BR112020005272A2 (https=) |
| CA (1) | CA3075956A1 (https=) |
| EA (1) | EA202090585A1 (https=) |
| IL (1) | IL273190A (https=) |
| MX (1) | MX2020003123A (https=) |
| WO (1) | WO2019058376A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL286011B2 (en) * | 2019-03-05 | 2024-06-01 | The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo | Genome-edited birds |
| CN112522315B (zh) * | 2020-12-08 | 2023-04-11 | 广东省农业科学院动物科学研究所 | 一种鸡原始生殖细胞转染方法 |
| TW202241259A (zh) * | 2020-12-31 | 2022-11-01 | 以色列國家農業部、農村發展農業研究組織（沃爾卡尼研究所） | 不育禽類胚胎、其產生及用途 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US5944710A (en) | 1996-06-24 | 1999-08-31 | Genetronics, Inc. | Electroporation-mediated intravascular delivery |
| US6774279B2 (en) | 1997-05-30 | 2004-08-10 | Carnegie Institution Of Washington | Use of FLP recombinase in mice |
| AU736087B2 (en) | 1997-08-04 | 2001-07-26 | University Of Massachusetts | Avian primordial germ cell (PGC) cell line and a method for long term culturing thereof |
| GB2355459B (en) * | 1999-11-29 | 2001-09-26 | Isis Innovation | A dominant conditional lethal genetic system |
| FR2810048A1 (fr) * | 2000-06-07 | 2001-12-14 | Centre Nat Rech Scient | Construction d'acide nucleique utile pour l'expression de transgenes notamment dans les cellules souches embryonnaires |
| EP1438401B1 (en) * | 2001-09-18 | 2011-06-15 | Synageva BioPharma Corp. | Production of a transgenic avian by cytoplasmic injection |
| AU2002341795A1 (en) * | 2001-09-21 | 2003-04-01 | Avigenics, Inc. | Production of transgenic avians using sperm-mediated transfection |
| CN1141391C (zh) * | 2001-11-02 | 2004-03-10 | 浙江省农业科学院 | 家蚕性连锁平衡致死系性别控制基因的导入方法 |
| US20030232410A1 (en) | 2002-03-21 | 2003-12-18 | Monika Liljedahl | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| DE10248361A1 (de) * | 2002-06-30 | 2004-01-22 | Beisswanger, Roland, Dr. | Unterdrückung eines Geschlechtes durch die Veränderung von Geschlechtschromosomen |
| EP2806025B1 (en) | 2002-09-05 | 2019-04-03 | California Institute of Technology | Use of zinc finger nucleases to stimulate gene targeting |
| ES2310279T3 (es) | 2003-01-16 | 2009-01-01 | North Carolina State University | Disminucion de celulas germinales primordiales en especies aviares. |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| CA2891996A1 (en) | 2005-10-18 | 2007-04-26 | Duke University | Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity |
| WO2009023800A1 (en) * | 2007-08-14 | 2009-02-19 | Origen Therapeutics | Transgenic chickens with an inactivated endogenous gene locus |
| EP2067402A1 (en) | 2007-12-07 | 2009-06-10 | Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch; | Transponson-mediated mutagenesis in spermatogonial stem cells |
| US20120227119A1 (en) * | 2008-12-17 | 2012-09-06 | Australian Poultry Crc Pty Ltd | Methods of Modulating the Sex of Avians |
| WO2010088742A1 (en) * | 2009-02-08 | 2010-08-12 | The University Of Melbourne | Sex-determination and methods of specifying same |
| JP6208580B2 (ja) | 2010-05-17 | 2017-10-04 | サンガモ セラピューティクス， インコーポレイテッド | 新規のｄｎａ結合タンパク質及びその使用 |
| KR102530118B1 (ko) | 2012-07-25 | 2023-05-08 | 더 브로드 인스티튜트, 인코퍼레이티드 | 유도 ｄｎａ 결합 단백질 및 게놈 교란 도구 및 이의 적용 |
| SG11201504038XA (en) | 2012-11-27 | 2015-06-29 | Childrens Medical Center | Targeting bcl11a distal regulatory elements for fetal hemoglobin reinduction |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| WO2015199225A1 (ja) * | 2014-06-27 | 2015-12-30 | 国立研究開発法人産業技術総合研究所 | 家禽始原生殖細胞の遺伝子改変方法、遺伝子改変された家禽始原生殖細胞、遺伝子改変家禽の生産方法及び家禽卵 |
| CN108474034A (zh) * | 2015-12-03 | 2018-08-31 | 艾吉伊特有限公司 | 对未孵化卵中的禽类胚胎进行性别确定的方法及其用具 |
| CN106359073A (zh) * | 2016-08-23 | 2017-02-01 | 吉林省农业科学院 | 孤雄诱导基因表达盒和孤雄诱导表达载体及其应用 |
| IL286011B2 (en) * | 2019-03-05 | 2024-06-01 | The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization Aro Vo | Genome-edited birds |
-
2018
- 2018-09-17 WO PCT/IL2018/051056 patent/WO2019058376A1/en not_active Ceased
- 2018-09-17 US US16/647,474 patent/US20200214273A1/en active Pending
- 2018-09-17 EA EA202090585A patent/EA202090585A1/ru unknown
- 2018-09-17 BR BR112020005272-8A patent/BR112020005272A2/pt not_active IP Right Cessation
- 2018-09-17 JP JP2020537300A patent/JP2020536580A/ja active Pending
- 2018-09-17 MX MX2020003123A patent/MX2020003123A/es unknown
- 2018-09-17 AU AU2018336161A patent/AU2018336161A1/en not_active Abandoned
- 2018-09-17 KR KR1020207011278A patent/KR20200088805A/ko not_active Ceased
- 2018-09-17 CN CN201880064933.3A patent/CN111315212B/zh active Active
- 2018-09-17 EP EP18859163.0A patent/EP3684172A4/en active Pending
- 2018-09-17 CA CA3075956A patent/CA3075956A1/en active Pending
- 2018-09-17 CN CN202210600684.3A patent/CN114958913A/zh active Pending
-
2020
- 2020-03-09 IL IL273190A patent/IL273190A/en unknown
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