JP2020534829A - ウイルスワクチンなどの生体分子の製造システムおよび製造方法 - Google Patents

ウイルスワクチンなどの生体分子の製造システムおよび製造方法 Download PDF

Info

Publication number
JP2020534829A
JP2020534829A JP2020516454A JP2020516454A JP2020534829A JP 2020534829 A JP2020534829 A JP 2020534829A JP 2020516454 A JP2020516454 A JP 2020516454A JP 2020516454 A JP2020516454 A JP 2020516454A JP 2020534829 A JP2020534829 A JP 2020534829A
Authority
JP
Japan
Prior art keywords
bioreactor
concentrator
liquid
compartment
biomolecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020516454A
Other languages
English (en)
Japanese (ja)
Inventor
カスティーリョ，ジョゼ
メレス，バスティアン
ヴィロン，レティシア ド
ヴィロン，レティシア ド
ドラグマンド，ジーン−クリストフ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Univercells SA
Original Assignee
Univercells SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univercells SA filed Critical Univercells SA
Publication of JP2020534829A publication Critical patent/JP2020534829A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M43/00—Combinations of bioreactors or fermenters with other apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020516454A 2017-09-27 2018-09-27 ウイルスワクチンなどの生体分子の製造システムおよび製造方法 Pending JP2020534829A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201762563978P 2017-09-27 2017-09-27
US62/563,978 2017-09-27
US201762564436P 2017-09-28 2017-09-28
US62/564,436 2017-09-28
US201862623812P 2018-01-30 2018-01-30
US62/623,812 2018-01-30
US201862711070P 2018-07-27 2018-07-27
US62/711,070 2018-07-27
US201862725545P 2018-08-31 2018-08-31
US62/725,545 2018-08-31
PCT/EP2018/076354 WO2019072584A1 (en) 2017-09-27 2018-09-27 SYSTEM AND METHOD FOR THE PRODUCTION OF BIOMOLECULES SUCH AS VIRAL VACCINES

Publications (1)

Publication Number Publication Date
JP2020534829A true JP2020534829A (ja) 2020-12-03

Family

ID=66100439

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020516454A Pending JP2020534829A (ja) 2017-09-27 2018-09-27 ウイルスワクチンなどの生体分子の製造システムおよび製造方法

Country Status (9)

Country Link
US (1) US20200318060A1 (de)
EP (1) EP3688134A1 (de)
JP (1) JP2020534829A (de)
KR (1) KR20200058433A (de)
CN (1) CN111770986A (de)
AU (1) AU2018348962A1 (de)
CA (1) CA3075810A1 (de)
RU (1) RU2020114891A (de)
WO (1) WO2019072584A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3613841B1 (de) 2014-03-25 2022-04-20 Terumo BCT, Inc. Passives ersetzen von medien
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
GB201911686D0 (en) * 2019-08-15 2019-10-02 Fujifilm Diosynth Biotechnologies Uk Ltd Process for purifying target substances
EP3895799A1 (de) 2020-04-17 2021-10-20 Sartorius Stedim Biotech GmbH Fluidverarbeitungssystem
KR20230018437A (ko) * 2020-05-29 2023-02-07 유니버셀스 테크놀로지스 에스.에이. 생체분자 생산 시스템 및 방법
EP4208286A1 (de) * 2020-09-01 2023-07-12 CureVac RNA Printer GmbH Herstellungsvorrichtung für ein pharmazeutisches produkt
CA3199735A1 (en) * 2020-11-23 2022-05-27 Chris Klopp Filtration systems,components and methods
CN115261223A (zh) 2021-04-29 2022-11-01 尤尼沃尔塞尔斯技术股份公司 用于连续生产和纯化生物制剂的系统和方法
WO2024003154A1 (en) 2022-06-28 2024-01-04 Univercells Technologies Sa Biomolecule production system comprising pressure sensors for volume measurement
WO2024006893A1 (en) * 2022-06-30 2024-01-04 Genentech, Inc. Systems, apparatus, and methods for cell culture

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512594A (ja) * 1999-02-22 2003-04-02 コフ，ヘンリー 生体物質の精製
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
JP2015526094A (ja) * 2012-08-20 2015-09-10 テルモ ビーシーティー、インコーポレーテッド 細胞成長チャンバーを循環する流体の成分を濃縮する方法
WO2016130940A1 (en) * 2015-02-13 2016-08-18 Takeda Vaccines, Inc. Methods for producing virus for vaccine production

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5503750A (en) * 1993-10-04 1996-04-02 Russo, Jr.; Lawrence J. Membrane-based process for the recovery of lactic acid by fermentation of carbohydrate substrates containing sugars
EP0995483A1 (de) * 1998-10-23 2000-04-26 The Procter & Gamble Company Querstromfiltrationsvorrichtung
DE10335130A1 (de) * 2003-07-31 2005-02-24 Blue Membranes Gmbh Immobilisierung von Katalysatoren auf porösen Körpern auf Kohlenstoffbasis
US20090130704A1 (en) * 2003-11-13 2009-05-21 Gyure Dale C Novel bioreactor
CA2554941A1 (en) * 2004-02-03 2005-08-18 Xcellerex, Llc System and method for manufacturing
DE102004032318B4 (de) * 2004-07-02 2015-08-20 Technische Hochschule Mittelhessen Herstellung einer konzentrierten Lösung aus biologischen Substanzen
FR2940145B1 (fr) * 2008-12-24 2011-03-25 Millipore Corp Chariot et installation de traitement d'un liquide biologique
EP2644259A1 (de) * 2012-03-29 2013-10-02 Roche Diagniostics GmbH Mikroflussfiltrationssystem und Flussfiltrationsverfahren
EP2900804B1 (de) * 2012-09-27 2019-09-18 GE Healthcare Bio-Sciences AB Tangentialfluss-perfusionssystem
US10711238B2 (en) * 2012-10-02 2020-07-14 Repligen Corporation Method for proliferation of cells within a bioreactor using a disposable pumphead and filter assembly
BE1022439B1 (fr) * 2014-02-10 2016-03-30 Univercells Sa Systeme appareil et procede pour production de biomolecules
CN104826101B (zh) * 2015-05-12 2015-12-09 长春长生生物科技股份有限公司 冻干人用狂犬病疫苗及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512594A (ja) * 1999-02-22 2003-04-02 コフ，ヘンリー 生体物質の精製
US20130115588A1 (en) * 2010-04-15 2013-05-09 G & G Technologies, Inc. Integrated bioreactor and separation system and methods of use therof
JP2015526094A (ja) * 2012-08-20 2015-09-10 テルモ ビーシーティー、インコーポレーテッド 細胞成長チャンバーを循環する流体の成分を濃縮する方法
WO2016130940A1 (en) * 2015-02-13 2016-08-18 Takeda Vaccines, Inc. Methods for producing virus for vaccine production

Also Published As

Publication number Publication date
EP3688134A1 (de) 2020-08-05
US20200318060A1 (en) 2020-10-08
CA3075810A1 (en) 2019-04-18
CN111770986A (zh) 2020-10-13
WO2019072584A1 (en) 2019-04-18
RU2020114891A (ru) 2021-10-27
AU2018348962A1 (en) 2020-04-30
KR20200058433A (ko) 2020-05-27

Similar Documents

Publication Publication Date Title
JP2020534829A (ja) ウイルスワクチンなどの生体分子の製造システムおよび製造方法
JP6936937B2 (ja) 細胞および／または細胞生成物の製造システム、製造装置および製造方法
US10494421B2 (en) System, apparatus and method for biomolecules production
CN107995924B (zh) 用于连续且微生物减少地生产和/或处理产品的模块化设备和方法
AU2016259745B2 (en) Method for the continuous elution of a product from chromatography columns
US20210155892A1 (en) System and method for the production of biomolecules
US20130115588A1 (en) Integrated bioreactor and separation system and methods of use therof
US20210355428A1 (en) Method for decontaminating a biomolecule production system and a system suitable for decontamination
US11912741B2 (en) Continuous production of recombinant proteins
WO2015118149A1 (en) System, apparatus and method for anti-rsv antibodies and formulations
RU2755065C2 (ru) Способ отбора образцов из потока текучей среды для отслеживания загрязняющей примеси в непрерывном режиме
WO2024003154A1 (en) Biomolecule production system comprising pressure sensors for volume measurement

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20210706

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210927

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220727

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220809

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230307