JP2020529477A - がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 - Google Patents

がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 Download PDF

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JP2020529477A
JP2020529477A JP2020529104A JP2020529104A JP2020529477A JP 2020529477 A JP2020529477 A JP 2020529477A JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529477 A JP2020529477 A JP 2020529477A
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マーバン，エデュアルド
グリゴリアン，リリアン
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シーダーズ—シナイ メディカル センター
シーダーズ―シナイ メディカル センター
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0031—Serum-free culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Developmental Biology & Embryology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
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  • Virology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020529104A 2017-08-04 2018-08-02 がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 Pending JP2020529477A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762541584P 2017-08-04 2017-08-04
US62/541,584 2017-08-04
PCT/US2018/044956 WO2019028223A1 (en) 2017-08-04 2018-08-02 CARDIOSPHERE-DERIVED CELLS AND THEIR EXTRACELLULAR VESICLES FOR THE TREATMENT AND PREVENTION OF CANCER

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JP2020529477A true JP2020529477A (ja) 2020-10-08
JP2020529477A5 JP2020529477A5 (https=) 2021-09-09

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JP2020529104A Pending JP2020529477A (ja) 2017-08-04 2018-08-02 がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞

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US (2) US20210085724A1 (https=)
EP (2) EP4218775A1 (https=)
JP (1) JP2020529477A (https=)
WO (1) WO2019028223A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532396A (ja) * 2019-05-14 2022-07-14 ステムメディケア・カンパニー・リミテッド 乳酸脱水素酵素Ｂおよびペルオキシソーム増殖因子－活性化受容体γ活性化因子１－αが含有された免疫寛容化された細胞外小胞の製造方法およびこれを利用した抗癌用組成物

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US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US11286463B2 (en) 2012-03-08 2022-03-29 Advanced ReGen Medical Technologies, LLC Reprogramming of aged adult stem cells
AU2013302799B2 (en) 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US10772911B2 (en) 2013-12-20 2020-09-15 Advanced ReGen Medical Technologies, LLC Cell free compositions for cellular restoration and methods of making and using same
CR20160307A (es) 2013-12-20 2016-11-08 Advanced Regen Medical Tech Llc Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
EP3436081A4 (en) 2016-04-29 2019-07-24 Advanced Regen Medical Technologies, LLC Microrna compositions and methods of making and using same
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP4699658A2 (en) 2017-04-19 2026-02-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
US10717981B2 (en) 2018-01-18 2020-07-21 Advanced ReGen Medical Technologies, LLC Therapeutic compositions and methods of making and using the same
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
EP4271396A4 (en) * 2021-01-04 2025-02-05 Biocardia, Inc. Cardiac stromal cell derived exosomes for ischemic heart repair
US20250011780A1 (en) * 2021-11-12 2025-01-09 University Of Ottawa Heart Institute Compositions of human heart derived extracellular vesicles and uses thereof
CN117384822B (zh) * 2022-12-12 2024-03-29 北京大学口腔医学院 一种大鼠牙龈组织来源的凋亡囊泡的制备方法及其应用
US20250099391A1 (en) * 2023-09-08 2025-03-27 Wisconsin Alumni Research Foundation Compositions and Methods for Treating Cancer
WO2025083256A1 (en) * 2023-10-18 2025-04-24 Universite De Liege Modified exosomes or extracellular vesicles for cancer therapeutics

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WO2015022545A2 (en) * 2013-08-14 2015-02-19 Reneuron Limited Stem cell microparticles and mirna
JP2015524844A (ja) * 2012-08-13 2015-08-27 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
WO2016057560A1 (en) * 2014-10-06 2016-04-14 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
WO2016152786A1 (ja) * 2015-03-20 2016-09-29 国立大学法人三重大学 細胞傷害性ｔ細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬

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WO2006052925A2 (en) 2004-11-08 2006-05-18 The Johns Hopkins University Cardiac stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CN102014934B (zh) * 2008-02-22 2014-08-20 新加坡科技研究局 间充质干细胞颗粒
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EP3102191A1 (en) 2014-02-05 2016-12-14 Stc.Unm Exosomes as a therapeutic for cancer
CA2962444C (en) * 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016054569A1 (en) * 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension
WO2017173034A1 (en) * 2016-03-30 2017-10-05 The University Of North Carolina At Chapel Hill Biological agent-exosome compositions and uses thereof

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JP2015524844A (ja) * 2012-08-13 2015-08-27 シーダーズ−サイナイ・メディカル・センターＣｅｄａｒｓ−Ｓｉｎａｉ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ 組織再生のためのエキソソームおよびマイクロリボ核酸
WO2015022545A2 (en) * 2013-08-14 2015-02-19 Reneuron Limited Stem cell microparticles and mirna
WO2016057560A1 (en) * 2014-10-06 2016-04-14 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
WO2016152786A1 (ja) * 2015-03-20 2016-09-29 国立大学法人三重大学 細胞傷害性ｔ細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022532396A (ja) * 2019-05-14 2022-07-14 ステムメディケア・カンパニー・リミテッド 乳酸脱水素酵素Ｂおよびペルオキシソーム増殖因子－活性化受容体γ活性化因子１－αが含有された免疫寛容化された細胞外小胞の製造方法およびこれを利用した抗癌用組成物
JP7261510B2 (ja) 2019-05-14 2023-04-20 ステムメディケア・カンパニー・リミテッド 乳酸脱水素酵素Ｂおよびペルオキシソーム増殖因子－活性化受容体γ活性化因子１－αが含有された免疫寛容化された細胞外小胞の製造方法およびこれを利用した抗癌用組成物

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WO2019028223A1 (en) 2019-02-07
EP4218775A1 (en) 2023-08-02
EP3661526A4 (en) 2021-05-05
US20210085724A1 (en) 2021-03-25
EP3661526A1 (en) 2020-06-10
US20240342221A1 (en) 2024-10-17
EP3661526B1 (en) 2023-07-12

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