JP2020529477A5 - - Google Patents
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- JP2020529477A5 JP2020529477A5 JP2020529104A JP2020529104A JP2020529477A5 JP 2020529477 A5 JP2020529477 A5 JP 2020529477A5 JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529477 A5 JP2020529477 A5 JP 2020529477A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cdc
- subject
- cancer
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 7
- 238000013194 cardioversion Methods 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000001808 exosome Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007928 intraperitoneal injection Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010064390 Tumour invasion Diseases 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 239000013585 weight reducing agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541584P | 2017-08-04 | 2017-08-04 | |
| US62/541,584 | 2017-08-04 | ||
| PCT/US2018/044956 WO2019028223A1 (en) | 2017-08-04 | 2018-08-02 | CARDIOSPHERE-DERIVED CELLS AND THEIR EXTRACELLULAR VESICLES FOR THE TREATMENT AND PREVENTION OF CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529477A JP2020529477A (ja) | 2020-10-08 |
| JP2020529477A5 true JP2020529477A5 (https=) | 2021-09-09 |
Family
ID=65234147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529104A Pending JP2020529477A (ja) | 2017-08-04 | 2018-08-02 | がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20210085724A1 (https=) |
| EP (2) | EP4218775A1 (https=) |
| JP (1) | JP2020529477A (https=) |
| WO (1) | WO2019028223A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| CR20160307A (es) | 2013-12-20 | 2016-11-08 | Advanced Regen Medical Tech Llc | Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| EP3436081A4 (en) | 2016-04-29 | 2019-07-24 | Advanced Regen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| EP4699658A2 (en) | 2017-04-19 | 2026-02-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| KR102049505B1 (ko) * | 2019-05-14 | 2019-11-29 | 이장호 | 젖산탈수소효소 b 및 페록시좀 증식인자-활성화 수용체 감마 활성화인자 1-알파가 함유된 면역관용화된 세포외소포의 제조방법 및 이를 이용한 항암용 조성물 |
| EP4271396A4 (en) * | 2021-01-04 | 2025-02-05 | Biocardia, Inc. | Cardiac stromal cell derived exosomes for ischemic heart repair |
| US20250011780A1 (en) * | 2021-11-12 | 2025-01-09 | University Of Ottawa Heart Institute | Compositions of human heart derived extracellular vesicles and uses thereof |
| CN117384822B (zh) * | 2022-12-12 | 2024-03-29 | 北京大学口腔医学院 | 一种大鼠牙龈组织来源的凋亡囊泡的制备方法及其应用 |
| US20250099391A1 (en) * | 2023-09-08 | 2025-03-27 | Wisconsin Alumni Research Foundation | Compositions and Methods for Treating Cancer |
| WO2025083256A1 (en) * | 2023-10-18 | 2025-04-24 | Universite De Liege | Modified exosomes or extracellular vesicles for cancer therapeutics |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| CA2586276A1 (en) | 2004-11-08 | 2006-05-18 | The Johns Hopkins University | Bioptome |
| WO2006052925A2 (en) | 2004-11-08 | 2006-05-18 | The Johns Hopkins University | Cardiac stem cells |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| CN102014934B (zh) * | 2008-02-22 | 2014-08-20 | 新加坡科技研究局 | 间充质干细胞颗粒 |
| WO2010118059A1 (en) | 2009-04-06 | 2010-10-14 | Capricor, Inc. | Systems and methods for cardiac tissue repair |
| US20120093885A1 (en) | 2010-10-18 | 2012-04-19 | Northwestern University | Therapeutic vesicles |
| WO2012087241A1 (en) | 2010-12-20 | 2012-06-28 | Agency For Science, Technology And Research | Method of purifying exosomes |
| AU2013302799B2 (en) * | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| EP3033418B1 (en) * | 2013-08-14 | 2019-12-11 | Reneuron Limited | Stem cell microparticles and mirna |
| JP2017501694A (ja) * | 2013-12-04 | 2017-01-19 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 診断および療法のためのエキソソーム中のゲノムｄｎａ、ｒｎａおよびタンパク質の分析 |
| EP3102191A1 (en) | 2014-02-05 | 2016-12-14 | Stc.Unm | Exosomes as a therapeutic for cancer |
| CA2962444C (en) * | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016054569A1 (en) * | 2014-10-03 | 2016-04-07 | Cedars-Sinai Medical Center | Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension |
| EP3204117A4 (en) | 2014-10-06 | 2018-05-09 | Cedars-Sinai Medical Center | Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells |
| US11083744B2 (en) * | 2015-03-20 | 2021-08-10 | Mie University | Therapeutic agent associated with suppression of proliferation and metastasis of tumor, which comprises exosomes released from cytotoxic T cells and targets cancer stromal/mesenchymal cells |
| WO2017173034A1 (en) * | 2016-03-30 | 2017-10-05 | The University Of North Carolina At Chapel Hill | Biological agent-exosome compositions and uses thereof |
-
2018
- 2018-08-02 JP JP2020529104A patent/JP2020529477A/ja active Pending
- 2018-08-02 EP EP23177120.5A patent/EP4218775A1/en not_active Withdrawn
- 2018-08-02 WO PCT/US2018/044956 patent/WO2019028223A1/en not_active Ceased
- 2018-08-02 US US16/635,142 patent/US20210085724A1/en not_active Abandoned
- 2018-08-02 EP EP18842075.6A patent/EP3661526B1/en active Active
-
2024
- 2024-03-11 US US18/601,773 patent/US20240342221A1/en active Pending
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