JP2020529477A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020529477A5 JP2020529477A5 JP2020529104A JP2020529104A JP2020529477A5 JP 2020529477 A5 JP2020529477 A5 JP 2020529477A5 JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529104 A JP2020529104 A JP 2020529104A JP 2020529477 A5 JP2020529477 A5 JP 2020529477A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cdc
- subject
- cancer
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 14
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 7
- 238000013194 cardioversion Methods 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 210000001808 exosome Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007928 intraperitoneal injection Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010064390 Tumour invasion Diseases 0.000 claims 1
- 230000009400 cancer invasion Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
- 230000005747 tumor angiogenesis Effects 0.000 claims 1
- 239000013585 weight reducing agent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541584P | 2017-08-04 | 2017-08-04 | |
| US62/541,584 | 2017-08-04 | ||
| PCT/US2018/044956 WO2019028223A1 (en) | 2017-08-04 | 2018-08-02 | CARDIOSPHERE-DERIVED CELLS AND THEIR EXTRACELLULAR VESICLES FOR THE TREATMENT AND PREVENTION OF CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020529477A JP2020529477A (ja) | 2020-10-08 |
| JP2020529477A5 true JP2020529477A5 (https=) | 2021-09-09 |
Family
ID=65234147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020529104A Pending JP2020529477A (ja) | 2017-08-04 | 2018-08-02 | がんの治療及び防止のためのカルディオスフィア由来細胞及びその細胞外小胞 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20210085724A1 (https=) |
| EP (2) | EP4218775A1 (https=) |
| JP (1) | JP2020529477A (https=) |
| WO (1) | WO2019028223A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| EP3563859B1 (en) | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| US20150174166A1 (en) | 2013-12-20 | 2015-06-25 | Advanced ReGen Medical Technologies, LLC | Compositions for Cellular Restoration and Methods of Making and Using Same |
| EP4494699A3 (en) | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2017123662A1 (en) | 2016-01-11 | 2017-07-20 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| US11203754B2 (en) | 2016-04-29 | 2021-12-21 | Advanced ReGen Medical Technologies, LLC | Microrna compositions and methods of making and using same |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| JP7336769B2 (ja) | 2017-04-19 | 2023-09-01 | シーダーズ―シナイ メディカル センター | 骨格筋ジストロフィーを治療する方法及び組成物 |
| WO2019126068A1 (en) | 2017-12-20 | 2019-06-27 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| EP3740576A4 (en) | 2018-01-18 | 2021-10-20 | Advanced Regen Medical Technologies, LLC | THERAPEUTIC COMPOSITIONS AND THEIR PREPARATION AND USE METHODS |
| EP3749344A4 (en) | 2018-02-05 | 2022-01-26 | Cedars-Sinai Medical Center | METHODS OF THERAPEUTIC USE OF EXOSOMES AND Y-RNAS |
| KR102049505B1 (ko) * | 2019-05-14 | 2019-11-29 | 이장호 | 젖산탈수소효소 b 및 페록시좀 증식인자-활성화 수용체 감마 활성화인자 1-알파가 함유된 면역관용화된 세포외소포의 제조방법 및 이를 이용한 항암용 조성물 |
| EP4271396A4 (en) * | 2021-01-04 | 2025-02-05 | Biocardia, Inc. | Cardiac stromal cell derived exosomes for ischemic heart repair |
| JP2024543456A (ja) * | 2021-11-12 | 2024-11-21 | ユニバーシティ オブ オタワ ハート インスティテュート | ヒト心臓由来細胞外小胞の組成物及びその用途 |
| CN117384822B (zh) * | 2022-12-12 | 2024-03-29 | 北京大学口腔医学院 | 一种大鼠牙龈组织来源的凋亡囊泡的制备方法及其应用 |
| US20250099391A1 (en) * | 2023-09-08 | 2025-03-27 | Wisconsin Alumni Research Foundation | Compositions and Methods for Treating Cancer |
| WO2025083256A1 (en) * | 2023-10-18 | 2025-04-24 | Universite De Liege | Modified exosomes or extracellular vesicles for cancer therapeutics |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| CN101087563A (zh) | 2004-11-08 | 2007-12-12 | 约翰霍普金斯大学 | 活检钳 |
| WO2006052927A2 (en) | 2004-11-08 | 2006-05-18 | The Johns Hopkins University | Bioptome |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| EP2254586B1 (en) * | 2008-02-22 | 2015-04-08 | Agency For Science, Technology And Research (A*star) | Mesenchymal stem cell particles |
| WO2010118059A1 (en) | 2009-04-06 | 2010-10-14 | Capricor, Inc. | Systems and methods for cardiac tissue repair |
| US20120093885A1 (en) | 2010-10-18 | 2012-04-19 | Northwestern University | Therapeutic vesicles |
| WO2012087241A1 (en) | 2010-12-20 | 2012-06-28 | Agency For Science, Technology And Research | Method of purifying exosomes |
| EP3563859B1 (en) * | 2012-08-13 | 2021-10-13 | Cedars-Sinai Medical Center | Cardiosphere-derived exosomes for tissue regeneration |
| US20160193252A1 (en) * | 2013-08-14 | 2016-07-07 | Reneuron Limited | STEM CELL MICROPARTICLES AND miRNA |
| US9921223B2 (en) * | 2013-12-04 | 2018-03-20 | Board Of Regents, The University Of Texas System | Analysis of genomic DNA, RNA, and proteins in exosomes for diagnosis and theranosis |
| US20160346334A1 (en) | 2014-02-05 | 2016-12-01 | Stc.Unm | Exosomes as a therapeutic for cancer |
| WO2016054569A1 (en) * | 2014-10-03 | 2016-04-07 | Cedars-Sinai Medical Center | Cardiosphere-derived cells (cdcs) as therapeutic agents for pulmonary hypertension |
| EP4494699A3 (en) * | 2014-10-03 | 2025-04-30 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| US20170304368A1 (en) | 2014-10-06 | 2017-10-26 | Cedars-Sinai Medical Center | Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells |
| WO2016152786A1 (ja) * | 2015-03-20 | 2016-09-29 | 国立大学法人三重大学 | 細胞傷害性ｔ細胞放出エキソソームによる癌間質間葉系細胞を標的とした腫瘍増殖及び転移抑制に係る治療薬 |
| US11458097B2 (en) * | 2016-03-30 | 2022-10-04 | The University Of North Carolina At Chapel Hill | Biological agent-exosome compositions and uses thereof |
-
2018
- 2018-08-02 EP EP23177120.5A patent/EP4218775A1/en not_active Withdrawn
- 2018-08-02 JP JP2020529104A patent/JP2020529477A/ja active Pending
- 2018-08-02 WO PCT/US2018/044956 patent/WO2019028223A1/en not_active Ceased
- 2018-08-02 US US16/635,142 patent/US20210085724A1/en not_active Abandoned
- 2018-08-02 EP EP18842075.6A patent/EP3661526B1/en active Active
-
2024
- 2024-03-11 US US18/601,773 patent/US20240342221A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020529477A5 (https=) | ||
| Mohamed et al. | PEGylated liposomes: immunological responses | |
| EP3985002B1 (en) | Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders | |
| US10000516B2 (en) | Phosphonate compounds for treatment of medical disorders | |
| US20210122733A1 (en) | Amino compounds for treatment of immune and inflammatory disorders | |
| EP3448389B1 (en) | Quinazoline and indole compounds to treat medical disorders | |
| Chen et al. | Recent Treatment Advances and the Role of Nanotechnology, Combination Products, and Immunotherapy in Changing the Therapeutic Landscape of Acute Myeloid Leukemia: Chen, Gilabert-Oriol, Bally and Leung | |
| JP2015523355A5 (https=) | ||
| WO2017035348A1 (en) | Alkyne compounds for treatment of medical disorders | |
| WO2017035411A1 (en) | Ether compounds for treatment of immune and inflammatory disorders | |
| WO2017035351A1 (en) | Amino compounds for treatment of medical disorders | |
| WO2017035413A2 (en) | Carbamate, ester, and ketone compounds for treatment of immune and inflammatory disorders | |
| WO2017035361A1 (en) | Disubstituted compounds for the treatment of medical disorders | |
| WO2017035415A1 (en) | Alkyne compounds for treatment of immune and inflammatory disorders | |
| WO2017035417A1 (en) | Phosphonate compounds for treatment of immune and inflammatory disorders | |
| US10632081B2 (en) | Intralymphatic delivery of hyaluronan nanoparticle for cancer metastasis | |
| Liu et al. | Strategies and opportunities of micro/nano delivery systems for targeted therapy of ulcerative colitis: Focus on underlying mechanisms and future perspectives | |
| JP2018516936A5 (https=) | ||
| Zhu et al. | A controllable self-amplifying oxidative stress strategy for boosting noninvasive sonodynamic therapy and synergistic immunotherapy | |
| Ng et al. | Extracellular vesicles as delivery vehicles and therapeutic agents for glioblastoma treatment: a systematic review of in vitro and in vivo preclinical studies | |
| Wang et al. | Absorbable microspheres sustaining epirubicin and TLR7 agonist release for transarterial chemo-immuno-embolization in liver tumor | |
| JP2018516964A5 (https=) | ||
| Zhao et al. | Metabolic nanoblockers for synergistic cancer treatment through glutaminase inhibition and sonodynamic therapy | |
| Iaffaioli | Second-line intra-arterial chemotherapy in advanced pancreatic adenocarcinoma Emiddio Barletta, Francesco Fiore 2, Bruno Daniele, Alessandro Ottaiano 3, Roberto D’Angelo 2, 4, Ettore Ferrari 4, Roberta Formato 4, Anna Tortoriello 5, Giacinto Turitto 6, Giovanni Salvatore Bruni 4, Sandro Pignata 4, and Rosario | |
| Tanino et al. | Therapeutic efficacy of zinc oxide nanoparticles against small cell lung cancer in an Orthotopic Xenograft Model |