JP2020527551A5 - - Google Patents
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- Publication number
- JP2020527551A5 JP2020527551A5 JP2020500791A JP2020500791A JP2020527551A5 JP 2020527551 A5 JP2020527551 A5 JP 2020527551A5 JP 2020500791 A JP2020500791 A JP 2020500791A JP 2020500791 A JP2020500791 A JP 2020500791A JP 2020527551 A5 JP2020527551 A5 JP 2020527551A5
- Authority
- JP
- Japan
- Prior art keywords
- serum albumin
- lysin
- composition
- polypeptide
- gram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 37
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 27
- 102000007562 Serum Albumin Human genes 0.000 claims 25
- 108010071390 Serum Albumin Proteins 0.000 claims 25
- 229920001184 polypeptide Polymers 0.000 claims 22
- 102000004196 processed proteins & peptides Human genes 0.000 claims 22
- 230000027455 binding Effects 0.000 claims 16
- 102000008100 Human Serum Albumin Human genes 0.000 claims 14
- 108091006905 Human Serum Albumin Proteins 0.000 claims 14
- 238000000034 method Methods 0.000 claims 11
- 241000192125 Firmicutes Species 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 10
- 108010014251 Muramidase Proteins 0.000 claims 8
- 102000016943 Muramidase Human genes 0.000 claims 8
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 8
- 239000004325 lysozyme Substances 0.000 claims 7
- 229960000274 lysozyme Drugs 0.000 claims 7
- 235000010335 lysozyme Nutrition 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 6
- 241000283690 Bos taurus Species 0.000 claims 6
- 101001018100 Homo sapiens Lysozyme C Proteins 0.000 claims 6
- 239000012911 assay medium Substances 0.000 claims 6
- 241000194017 Streptococcus Species 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 241000282465 Canis Species 0.000 claims 4
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 4
- 241000191940 Staphylococcus Species 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 230000002101 lytic effect Effects 0.000 claims 4
- 108090000988 Lysostaphin Proteins 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 3
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 239000012503 blood component Substances 0.000 claims 3
- 244000309466 calf Species 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 2
- 206010041925 Staphylococcal infections Diseases 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 230000029586 bacterial cell surface binding Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000006166 lysate Substances 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 102000007079 Peptide Fragments Human genes 0.000 claims 1
- 108010033276 Peptide Fragments Proteins 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 230000000941 anti-staphylcoccal effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000013066 combination product Substances 0.000 claims 1
- 229940127555 combination product Drugs 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 229940049964 oleate Drugs 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 150000002942 palmitic acid derivatives Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023077982A JP2023103347A (ja) | 2017-07-10 | 2023-05-10 | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762530632P | 2017-07-10 | 2017-07-10 | |
| US62/530,632 | 2017-07-10 | ||
| PCT/US2018/041498 WO2019014260A2 (en) | 2017-07-10 | 2018-07-10 | BLOOD COMPONENT POTENTIATION OF ANTIBACTERIAL ACTIVITY OF THE LYTIC PROTEIN AND METHODS AND USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023077982A Division JP2023103347A (ja) | 2017-07-10 | 2023-05-10 | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020527551A JP2020527551A (ja) | 2020-09-10 |
| JP2020527551A5 true JP2020527551A5 (https=) | 2021-08-05 |
Family
ID=65001502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500791A Pending JP2020527551A (ja) | 2017-07-10 | 2018-07-10 | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
| JP2023077982A Pending JP2023103347A (ja) | 2017-07-10 | 2023-05-10 | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023077982A Pending JP2023103347A (ja) | 2017-07-10 | 2023-05-10 | 血液成分による溶菌タンパク質の抗菌活性の強化、並びにその方法及び使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220023399A1 (https=) |
| EP (1) | EP3651739A4 (https=) |
| JP (2) | JP2020527551A (https=) |
| KR (1) | KR20200045468A (https=) |
| CN (2) | CN111295183A (https=) |
| AU (1) | AU2018300062A1 (https=) |
| BR (1) | BR112020000430A2 (https=) |
| CA (1) | CA3069679A1 (https=) |
| IL (1) | IL271913A (https=) |
| MX (1) | MX2020000018A (https=) |
| RU (1) | RU2020104587A (https=) |
| WO (1) | WO2019014260A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3134154A1 (en) * | 2019-03-22 | 2020-10-01 | Contrafect Corporation | Method of treating infective endocarditis |
| CN114681685B (zh) * | 2022-04-08 | 2023-05-19 | 东莞市人民医院 | 杂化蛋白涂层的制备方法、杂化蛋白涂层材料及应用 |
| CN114736894B (zh) * | 2022-05-26 | 2023-10-31 | 华中农业大学 | 一种降解葡萄球菌生物被膜的嵌合酶ClyQ及其制备方法和应用 |
| CN116042585B (zh) * | 2022-07-11 | 2023-10-03 | 无锡佰翱得生物科学股份有限公司 | SortaseA酶作为蛋白水解酶在蛋白纯化领域中的应用 |
| CN120513297A (zh) * | 2023-01-09 | 2025-08-19 | 华中农业大学 | 细菌裂解酶及其应用 |
| CN115970056B (zh) * | 2023-01-31 | 2024-07-19 | 陕西师范大学 | 一种用于骨修复的3d打印材料、骨修复材料及其制备方法和应用 |
| CN116410969B (zh) * | 2023-04-24 | 2024-05-07 | 深圳北辰生物科技有限公司 | 一种噬菌体、噬菌体裂解酶及其用途 |
| CN117965592B (zh) * | 2024-01-29 | 2025-03-28 | 南京农业大学 | 一种猪链球菌菌蜕及其制备方法和应用 |
| CN120187849A (zh) * | 2024-05-21 | 2025-06-20 | 香港瑞星生物科技有限公司 | 一种噬菌体裂解酶或其突变体及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6752988B1 (en) * | 2000-04-28 | 2004-06-22 | New Horizons Diagnostic Corp | Method of treating upper resiratory illnesses |
| CA2404356A1 (en) * | 2002-09-18 | 2004-03-18 | Canadian Inovatech Inc. | Gram-positive antibacterial composition and method for use |
| MXPA05005338A (es) * | 2002-11-18 | 2005-12-14 | Vicuron Pharm Inc | Metodos para administrar dalbavancin para el tratamiento de infecciones bacterianas. |
| US20120077206A1 (en) * | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
| US20080031868A1 (en) * | 2005-06-09 | 2008-02-07 | Mi An | Human lysozyme medicine, its manufacturing method and application thereof |
| EP2157100A1 (en) * | 2008-08-19 | 2010-02-24 | Profos AG | Artificial peptidoglycan lysing enzymes and peptidoglycan binding proteins |
| CN102947464A (zh) * | 2010-05-06 | 2013-02-27 | 约翰内斯堡威特沃特斯兰德大学 | 一种鉴定样品中细菌的方法 |
| CA2833409A1 (en) * | 2011-04-21 | 2012-10-26 | The Rockefeller University | Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria |
| EP2699689A4 (en) * | 2011-04-21 | 2014-12-17 | Univ Utrecht Holding Bv | STREPTOCOCCUS BACTERIOPHAGEN LYSINE FOR THE TREATMENT OF GRAM-POSITIVE BACTERIA IN PETS AND UTILITIES |
| KR20210121313A (ko) * | 2012-05-09 | 2021-10-07 | 콘트라펙트 코포레이션 | 그람 양성 박테리아에 대한 박테리오파지 리신과 항생제의 병용물 |
| WO2014078373A1 (en) * | 2012-11-13 | 2014-05-22 | Iogenetics, Llc | Antimicrobial compositions |
| DK3085770T3 (en) * | 2013-12-18 | 2019-01-07 | Asahi Chemical Ind | Method for detecting staphylococci in milk |
-
2018
- 2018-07-10 CA CA3069679A patent/CA3069679A1/en active Pending
- 2018-07-10 RU RU2020104587A patent/RU2020104587A/ru unknown
- 2018-07-10 AU AU2018300062A patent/AU2018300062A1/en not_active Abandoned
- 2018-07-10 MX MX2020000018A patent/MX2020000018A/es unknown
- 2018-07-10 CN CN201880058639.1A patent/CN111295183A/zh active Pending
- 2018-07-10 BR BR112020000430-8A patent/BR112020000430A2/pt not_active IP Right Cessation
- 2018-07-10 WO PCT/US2018/041498 patent/WO2019014260A2/en not_active Ceased
- 2018-07-10 JP JP2020500791A patent/JP2020527551A/ja active Pending
- 2018-07-10 KR KR1020207003950A patent/KR20200045468A/ko not_active Ceased
- 2018-07-10 US US16/629,916 patent/US20220023399A1/en not_active Abandoned
- 2018-07-10 EP EP18831622.8A patent/EP3651739A4/en active Pending
- 2018-07-10 CN CN202310302877.5A patent/CN116603056A/zh active Pending
-
2020
- 2020-01-08 IL IL271913A patent/IL271913A/en unknown
-
2023
- 2023-05-10 JP JP2023077982A patent/JP2023103347A/ja active Pending
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