JP2020526926A - 回折光学素子を用いたレーザ発生器 - Google Patents
回折光学素子を用いたレーザ発生器 Download PDFInfo
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Abstract
Description
[0067] 図5のアブレーションシステム400を使用し、斯かるシステムへのコヒーレンス混合ファイバ475の組み込みにより達成されるコヒーレンス混合方法の使用を含んで、20Hzで150mJ/mm2のフルエンスに対応する42mJまでのエネルギ出力が、600μmコア径ファイバを介して一貫して達成された。レーザ出力から600μm光ファイバへの結合効率は、約30%であった。これらの結果で報告されるファイバの150mJ/mm2出力は、140mJレーザ出力により制限された。この伝送試験は、各回当たり5分の持続時間で5回繰り返され、ゼロのファイバ故障の結果となった。即ち、当該ファイバは、ファイバが構築される石英ガラス材料の損傷閾値を光が超過することにより壊れることも又は損傷されることもなかった。
[0077] 355nmレーザにより上述したパルス伸張送出方法を用い、単一の600μmファイバを介して20Hzで56mJまでのエネルギ出力が達成された。この出力エネルギは、200mJ/mm2のフルエンスに対応する。レーザ出力から600μm光ファイバへの結合効率は、40%程度であった。達成されるファイバ出力エネルギは、140mJのレーザ出力エネルギに制限された。この伝送試験は各回当たり5分の持続時間で5回繰り返され、ファイバの故障はゼロであった。
[0079] 355nmレーザにより上述したパルス伸張送出方法を用い、2.0mm(97x100μmコア径ファイバ)マルチファイバカテーテルが大気中で55mJ/mm2のフルエンスに対応する43.5mJのエネルギで試験された。レーザ出力から該マルチファイバカテーテルへの結合効率は、約31%であった。達成されるファイバ出力エネルギは、この送出方法を用いて利用可能な全エネルギにより制限された。当該カテーテルのカプラ、先端又は中間シャフトのファイバ損傷は観測されなかった。この伝送試験は各回当たり5分の持続時間で5回繰り返され、ファイバの故障はゼロであった。段落3.2では観察され、この送出方法を用いて存在しないファイバ損傷がないことは、ファイバ結合レンズの前のDOEの配置により達成される均質化された入射ビームプロファイルによるものと考えられる。
[0081] 308nm光に対する355nmレーザ光の組織アブレーション比較を実行するために、新鮮な豚大動脈組織が使用された。該組織は収穫日の翌日配達で送られた。該組織は、塩水の袋に入れられ、使用するまで15℃で保管された。全ての組織が、試験前の組織劣化を制限するために収穫から5日以内に試験された。比較結果が示される場合、サンプルは同一の組織から取り出され、試験は同じ日に実行された。
Claims (14)
- 光ビームを生成するレーザ源と、
前記レーザ源の下流側の、前記光ビームを受光する光学アセンブリと、
を有するレーザ発生器であって、
前記光学アセンブリが、
前記光ビームを受光する波長板と、
前記波長板の下流側の、前記光ビームを受光して該光ビームの第1部分を反射すると共に該光ビームの第2部分を通過させる薄膜偏光子と、
前記光ビームの前記第1部分を受光するビーム廃棄部と、
前記波長板の下流側の、前記光ビームの前記第2部分を受光するビーム拡大器と、
前記ビーム拡大器の下流側の、前記光ビームの前記第2部分を受光する拡散器と、
前記拡散器の下流側の、前記光ビームの前記第2部分を受光すると共に該光ビームの該第2部分を放出する混合ファイバと、
を有する、レーザ発生器。 - 前記レーザ源が約355ナノメートルを有する光ビームを生成する、請求項1に記載のレーザ発生器。
- 前記レーザ源が約10ナノメートルと約5000ナノメートルとの間の光ビームを生成する、請求項1に記載のレーザ発生器。
- 前記拡散器が回折光学素子である、請求項1に記載のレーザ発生器。
- パルス幅を持つ複数のパルスを有する光ビームを生成するレーザ源と、
前記レーザ源の下流側の、前記光ビームを受光する光学アセンブリと、
を有するレーザ発生器であって、
前記光学アセンブリが、
前記光ビームを受光する波長板と、
前記波長板の下流側の、前記光ビームを受光して該光ビームの第1部分を反射すると共に該光ビームの前記パルス幅を持つ第2部分を通過させる薄膜偏光子と、
前記光ビームの前記第1部分を受光するビーム廃棄部と、
前記光ビームの前記第2部分における前記複数のパルスの少なくとも1つのパルス幅を伸張する手段と、
前記パルス幅を伸張する手段の下流側の、第2ビームの他の部分を受光及び放出する拡散器と、
を有する、レーザ発生器。 - 前記複数のパルスの少なくとも1つのパルス幅を伸張する手段が、ビームスプリッタ及びビーム経路を形成する複数のミラーを有する、請求項5に記載のレーザ発生器。
- 前記ミラーの少なくとも1つが平行移動可能である、請求項6に記載のレーザ発生器。
- 前記複数のパルスの少なくとも1つのパルス幅を伸張する手段がビームスプリッタを有する、請求項5に記載のレーザ発生器。
- 前記ビームスプリッタが前記光ビームの前記第2部分を第1ビーム及び第2ビームに分割する、請求項8に記載のレーザ発生器。
- 前記ビームスプリッタは、前記第2ビームが時間遅延ループを通過した後に該第2ビームを前記第1ビームと結合する、請求項9に記載のレーザ発生器。
- 前記時間遅延ループが複数のミラーを有する、請求項10に記載のレーザ発生器。
- 前記時間遅延ループが混合ファイバを有する、請求項10に記載のレーザ発生器。
- 前記混合ファイバがコヒーレンス混合ファイバである、請求項12に記載のレーザ発生器。
- 請求項5に記載のレーザ発生器を使用する方法であって、前記レーザ発生器を複数の光ファイバを有するカテーテルに結合するステップと、前記カテーテルを患者の血管系に挿入するステップと、前記患者の血管系に対する閉塞の少なくとも一部を除去するステップとを有する、方法。
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US201762532286P | 2017-07-13 | 2017-07-13 | |
US62/532,286 | 2017-07-13 | ||
US201862614234P | 2018-01-05 | 2018-01-05 | |
US62/614,234 | 2018-01-05 | ||
PCT/US2018/042165 WO2019014638A1 (en) | 2017-07-13 | 2018-07-13 | LASER GENERATOR USING DIFFRACTIVE OPTICAL ELEMENTS |
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US (1) | US10820943B2 (ja) |
EP (1) | EP3651676B1 (ja) |
JP (1) | JP7258842B2 (ja) |
CN (1) | CN110868952B (ja) |
WO (1) | WO2019014638A1 (ja) |
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WO2012114333A1 (en) | 2011-02-24 | 2012-08-30 | Ilan Ben Oren | Hybrid catheter for vascular intervention |
EP3145430B1 (en) | 2014-05-18 | 2019-07-03 | Eximo Medical Ltd. | System for tissue ablation using pulsed laser |
US11684420B2 (en) | 2016-05-05 | 2023-06-27 | Eximo Medical Ltd. | Apparatus and methods for resecting and/or ablating an undesired tissue |
AU2020208182B2 (en) | 2019-01-15 | 2023-03-09 | Boston Scientific Scimed, Inc. | Alignment method and tools |
CN112842522A (zh) * | 2021-01-27 | 2021-05-28 | 北京航空航天大学 | 一种血管内光学相干断层成像激光消融导管 |
CN113116516A (zh) * | 2021-04-01 | 2021-07-16 | 广州迪光医学科技有限公司 | 激光耦合装置 |
CN114469336B (zh) * | 2021-07-05 | 2024-02-20 | 深圳市中科融光医疗科技有限公司 | 一种激光输出装置和激光消融系统 |
CN113900190B (zh) * | 2021-09-24 | 2023-04-18 | 微创投资控股有限公司 | 光纤集束固定装置及其激光导管及其光纤耦合系统 |
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EP3651676B1 (en) | 2021-06-16 |
US20190015157A1 (en) | 2019-01-17 |
US10820943B2 (en) | 2020-11-03 |
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