JP2020526493A - 化学的に修飾された主鎖を有するバイオコンジュゲート - Google Patents

化学的に修飾された主鎖を有するバイオコンジュゲート Download PDF

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Publication number
JP2020526493A
JP2020526493A JP2019572023A JP2019572023A JP2020526493A JP 2020526493 A JP2020526493 A JP 2020526493A JP 2019572023 A JP2019572023 A JP 2019572023A JP 2019572023 A JP2019572023 A JP 2019572023A JP 2020526493 A JP2020526493 A JP 2020526493A
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JP
Japan
Prior art keywords
peptide
bioconjugate
chemically sulfated
fibrosis
collagen
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Pending
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JP2019572023A
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English (en)
Japanese (ja)
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JP2020526493A5 (enExample
Inventor
ジョン エリック パデリ，
ジョン エリック パデリ，
グレン プレストウィッチ，
グレン プレストウィッチ，
キャサリン アリソン スチュアート，
キャサリン アリソン スチュアート，
ハルシャ カブラ，
ハルシャ カブラ，
エルヴィス イクワ，
エルヴィス イクワ，
Original Assignee
サイミック アイピー， エルエルシー
サイミック アイピー， エルエルシー
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Application filed by サイミック アイピー， エルエルシー, サイミック アイピー， エルエルシー filed Critical サイミック アイピー， エルエルシー
Publication of JP2020526493A publication Critical patent/JP2020526493A/ja
Publication of JP2020526493A5 publication Critical patent/JP2020526493A5/ja
Priority to JP2023032277A priority Critical patent/JP2023065600A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2019572023A 2017-07-07 2018-07-09 化学的に修飾された主鎖を有するバイオコンジュゲート Pending JP2020526493A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023032277A JP2023065600A (ja) 2017-07-07 2023-03-02 化学的に修飾された主鎖を有するバイオコンジュゲート

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762530066P 2017-07-07 2017-07-07
US62/530,066 2017-07-07
PCT/US2018/041280 WO2019010490A1 (en) 2017-07-07 2018-07-09 BIOCONJUGATES WITH CHEMICALLY MODIFIED SKELETONS

Related Child Applications (1)

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JP2023032277A Division JP2023065600A (ja) 2017-07-07 2023-03-02 化学的に修飾された主鎖を有するバイオコンジュゲート

Publications (2)

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JP2020526493A true JP2020526493A (ja) 2020-08-31
JP2020526493A5 JP2020526493A5 (enExample) 2021-08-19

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JP2019572023A Pending JP2020526493A (ja) 2017-07-07 2018-07-09 化学的に修飾された主鎖を有するバイオコンジュゲート
JP2023032277A Pending JP2023065600A (ja) 2017-07-07 2023-03-02 化学的に修飾された主鎖を有するバイオコンジュゲート

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Country Status (7)

Country Link
US (1) US11896642B2 (enExample)
EP (1) EP3648775A4 (enExample)
JP (2) JP2020526493A (enExample)
KR (1) KR20200026918A (enExample)
CN (1) CN111050778B (enExample)
AU (1) AU2018298226B2 (enExample)
WO (1) WO2019010490A1 (enExample)

Cited By (1)

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WO2025023312A1 (ja) * 2023-07-26 2025-01-30 株式会社高研 コラーゲン結合型膜透過性ペプチド、並びに、該ペプチド及びコラーゲン若しくはコラーゲン誘導体を含む運搬体

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EP3142684A4 (en) 2014-05-12 2018-05-23 Purdue Research Foundation Selectin and icam/vcam peptide ligand conjugates
AU2018298224B2 (en) 2017-07-07 2024-08-15 Symic Ip, Llc Synthetic bioconjugates
WO2022227225A1 (zh) * 2021-04-27 2022-11-03 北京博辉瑞进生物科技有限公司 一种嵌合肽修饰的sis膜、其制备方法及应用
CN113754795B (zh) * 2021-10-19 2023-03-10 澳门大学 磺酸化透明质酸类化合物、其制备方法及其应用
CN115040535B (zh) * 2022-08-15 2022-12-16 华南理工大学 硫酸化透明质酸在制备预防角膜纤维化、角膜瘢痕滴眼液中的应用

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JP2016516065A (ja) * 2013-03-15 2016-06-02 サイミック バイオメディカル， インコーポレイテッド 細胞外マトリックス結合性合成ペプチドグリカン
WO2016168743A1 (en) * 2015-04-17 2016-10-20 Symic Ip, Llc Bioconjugates and uses thereof
WO2017066349A1 (en) * 2015-10-13 2017-04-20 Symic Ip, Llc Ve-cadherin binding bioconjugate

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US10772931B2 (en) 2014-04-25 2020-09-15 Purdue Research Foundation Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
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WO2016111651A1 (en) * 2015-01-09 2016-07-14 Agency For Science, Technology And Research Pdgf-b /pdgf-bb binding variants of heparan sulphates
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WO2025023312A1 (ja) * 2023-07-26 2025-01-30 株式会社高研 コラーゲン結合型膜透過性ペプチド、並びに、該ペプチド及びコラーゲン若しくはコラーゲン誘導体を含む運搬体
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JP7725041B2 (ja) 2023-07-26 2025-08-19 株式会社高研 コラーゲン結合型膜透過性ペプチド、並びに、該ペプチド及びコラーゲン若しくはコラーゲン誘導体を含む運搬体

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US11896642B2 (en) 2024-02-13
EP3648775A1 (en) 2020-05-13
WO2019010490A1 (en) 2019-01-10
AU2018298226A1 (en) 2020-01-23
AU2018298226B2 (en) 2024-06-06
CN111050778A (zh) 2020-04-21
KR20200026918A (ko) 2020-03-11
JP2023065600A (ja) 2023-05-12
CN111050778B (zh) 2024-09-10
US20210290726A1 (en) 2021-09-23
EP3648775A4 (en) 2021-04-21

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