JP2020524996A5 - - Google Patents

Info

Publication number

JP2020524996A5

JP2020524996A5 JP2019569226A JP2019569226A JP2020524996A5 JP 2020524996 A5 JP2020524996 A5 JP 2020524996A5 JP 2019569226 A JP2019569226 A JP 2019569226A JP 2019569226 A JP2019569226 A JP 2019569226A JP 2020524996 A5 JP2020524996 A5 JP 2020524996A5

Authority

JP

Japan

Prior art keywords

chemokine

composition

encoded

viral vector

seq

Prior art date

2018-06-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000013603 viral vector Substances 0.000 claims description 40
• 210000004027 cell Anatomy 0.000 claims description 34
• 102100039291 Geranylgeranyl pyrophosphate synthase Human genes 0.000 claims description 32
• 238000000034 method Methods 0.000 claims description 28
• 239000002245 particle Substances 0.000 claims description 27
• 102000004190 Enzymes Human genes 0.000 claims description 22
• 108090000790 Enzymes Proteins 0.000 claims description 22
• 102000019034 Chemokines Human genes 0.000 claims description 20
• 108010012236 Chemokines Proteins 0.000 claims description 20
• 108091032955 Bacterial small RNA Proteins 0.000 claims description 18
• KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims description 18
• 230000037361 pathway Effects 0.000 claims description 18
• 108010007508 Farnesyltranstransferase Proteins 0.000 claims description 16
• 102000007317 Farnesyltranstransferase Human genes 0.000 claims description 16
• 108010026318 Geranyltranstransferase Proteins 0.000 claims description 16
• 101000888406 Homo sapiens Geranylgeranyl pyrophosphate synthase Proteins 0.000 claims description 16
• 102100027665 Isopentenyl-diphosphate Delta-isomerase 1 Human genes 0.000 claims description 16
• 206010028980 Neoplasm Diseases 0.000 claims description 14
• 201000011510 cancer Diseases 0.000 claims description 14
• 239000013598 vector Substances 0.000 claims description 14
• 102000004127 Cytokines Human genes 0.000 claims description 12
• 108090000695 Cytokines Proteins 0.000 claims description 12
• 210000001744 T-lymphocyte Anatomy 0.000 claims description 12
• 229940079593 drug Drugs 0.000 claims description 11
• 239000003814 drug Substances 0.000 claims description 11
• 102000001902 CC Chemokines Human genes 0.000 claims description 8
• 108010040471 CC Chemokines Proteins 0.000 claims description 8
• 101710153681 Isopentenyl-diphosphate Delta-isomerase 1 Proteins 0.000 claims description 8
• 239000013612 plasmid Substances 0.000 claims description 8
• -1 IL-1β Proteins 0.000 claims description 7
• 108700011259 MicroRNAs Proteins 0.000 claims description 6
• 239000002679 microRNA Substances 0.000 claims description 6
• 102100027154 Butyrophilin subfamily 3 member A3 Human genes 0.000 claims description 5
• 101000984916 Homo sapiens Butyrophilin subfamily 3 member A3 Proteins 0.000 claims description 5
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 4
• OINNEUNVOZHBOX-QIRCYJPOSA-K 2-trans,6-trans,10-trans-geranylgeranyl diphosphate(3-) Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP([O-])(=O)OP([O-])([O-])=O OINNEUNVOZHBOX-QIRCYJPOSA-K 0.000 claims description 4
• 108050005711 C Chemokine Proteins 0.000 claims description 4
• 102000017483 C chemokine Human genes 0.000 claims description 4
• 108050006947 CXC Chemokine Proteins 0.000 claims description 4
• 102000019388 CXC chemokine Human genes 0.000 claims description 4
• 102000001327 Chemokine CCL5 Human genes 0.000 claims description 4
• 108010055166 Chemokine CCL5 Proteins 0.000 claims description 4
• OINNEUNVOZHBOX-XBQSVVNOSA-N Geranylgeranyl diphosphate Natural products [P@](=O)(OP(=O)(O)O)(OC/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)O OINNEUNVOZHBOX-XBQSVVNOSA-N 0.000 claims description 4
• 108010002352 Interleukin-1 Proteins 0.000 claims description 4
• 102000000589 Interleukin-1 Human genes 0.000 claims description 4
• 108010002350 Interleukin-2 Proteins 0.000 claims description 4
• 108090000978 Interleukin-4 Proteins 0.000 claims description 4
• 108010002586 Interleukin-7 Proteins 0.000 claims description 4
• 108091027967 Small hairpin RNA Proteins 0.000 claims description 4
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 4
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 4
• 241000700605 Viruses Species 0.000 claims description 4
• 230000002401 inhibitory effect Effects 0.000 claims description 4
• NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims description 4
• 238000004806 packaging method and process Methods 0.000 claims description 4
• 239000004055 small Interfering RNA Substances 0.000 claims description 4
• XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims description 4
• 229960004276 zoledronic acid Drugs 0.000 claims description 4
• 101710091045 Envelope protein Proteins 0.000 claims description 3
• 101710188315 Protein X Proteins 0.000 claims description 3
• 102100021696 Syncytin-1 Human genes 0.000 claims description 3
• 102100027138 Butyrophilin subfamily 3 member A1 Human genes 0.000 claims description 2
• 102100027155 Butyrophilin subfamily 3 member A2 Human genes 0.000 claims description 2
• 101000984934 Homo sapiens Butyrophilin subfamily 3 member A1 Proteins 0.000 claims description 2
• 101000984917 Homo sapiens Butyrophilin subfamily 3 member A2 Proteins 0.000 claims description 2
• 230000003213 activating effect Effects 0.000 claims description 2
• 108700004026 gag Genes Proteins 0.000 claims description 2
• 108700004029 pol Genes Proteins 0.000 claims description 2
• 108700004030 rev Genes Proteins 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 29
• KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 claims 6
• 229940122361 Bisphosphonate Drugs 0.000 claims 3
• 230000003612 virological effect Effects 0.000 claims 1
• 230000002068 genetic effect Effects 0.000 description 14
• KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 description 12
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
• 241000713666 Lentivirus Species 0.000 description 2
• 108090000623 proteins and genes Proteins 0.000 description 1
• 102000004169 proteins and genes Human genes 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1