JP2020519675A - 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ - Google Patents
抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ Download PDFInfo
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- JP2020519675A JP2020519675A JP2019563246A JP2019563246A JP2020519675A JP 2020519675 A JP2020519675 A JP 2020519675A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2020519675 A JP2020519675 A JP 2020519675A
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- A61P35/04—Antineoplastic agents specific for metastasis
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- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023096307A JP2023113921A (ja) | 2017-05-16 | 2023-06-12 | 抗folr1イムノコンジュゲートと抗pd-1抗体の組み合わせ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506940P | 2017-05-16 | 2017-05-16 | |
| US62/506,940 | 2017-05-16 | ||
| US201762560462P | 2017-09-19 | 2017-09-19 | |
| US62/560,462 | 2017-09-19 | ||
| US201862647008P | 2018-03-23 | 2018-03-23 | |
| US62/647,008 | 2018-03-23 | ||
| PCT/US2018/032692 WO2018213260A1 (en) | 2017-05-16 | 2018-05-15 | Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023096307A Division JP2023113921A (ja) | 2017-05-16 | 2023-06-12 | 抗folr1イムノコンジュゲートと抗pd-1抗体の組み合わせ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020519675A true JP2020519675A (ja) | 2020-07-02 |
| JP2020519675A5 JP2020519675A5 (enExample) | 2021-06-17 |
| JPWO2018213260A5 JPWO2018213260A5 (enExample) | 2022-05-18 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563246A Pending JP2020519675A (ja) | 2017-05-16 | 2018-05-15 | 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ |
| JP2023096307A Pending JP2023113921A (ja) | 2017-05-16 | 2023-06-12 | 抗folr1イムノコンジュゲートと抗pd-1抗体の組み合わせ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023096307A Pending JP2023113921A (ja) | 2017-05-16 | 2023-06-12 | 抗folr1イムノコンジュゲートと抗pd-1抗体の組み合わせ |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20180333503A1 (enExample) |
| EP (1) | EP3625262A4 (enExample) |
| JP (2) | JP2020519675A (enExample) |
| KR (1) | KR20200006546A (enExample) |
| CN (2) | CN110799535A (enExample) |
| AU (1) | AU2018269173A1 (enExample) |
| BR (1) | BR112019023909A8 (enExample) |
| CA (1) | CA3063893A1 (enExample) |
| IL (1) | IL314823A (enExample) |
| MX (1) | MX2019013753A (enExample) |
| RU (1) | RU2019141270A (enExample) |
| TW (3) | TW201900221A (enExample) |
| WO (1) | WO2018213260A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600758A (en) | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| SI2694106T1 (en) | 2011-04-01 | 2018-04-30 | Immunogen, Inc. | Methods for increasing the effectiveness of treatment with FOLR1 receptor cancer |
| CN115925952A (zh) | 2018-03-13 | 2023-04-07 | 东莞凡恩世生物医药有限公司 | 抗叶酸受体1抗体及其用途 |
| US20220047716A1 (en) * | 2018-09-17 | 2022-02-17 | Sutro Biopharma, Inc. | Combination therapies with anti-folate receptor antibody conjugates |
| KR20220008253A (ko) * | 2019-01-03 | 2022-01-20 | 엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) | 암을 앓는 대상에서 cd8+ t 세포 의존성 면역 반응을 향상시키기 위한 방법 및 약학적 조성물 |
| US20240190955A1 (en) | 2021-04-23 | 2024-06-13 | King's College London | Composition comprising an ige antibody |
| TW202409080A (zh) * | 2022-07-26 | 2024-03-01 | 美商沙塔克實驗室股份有限公司 | 用於治療卵巢癌之組合療法 |
| CN115960269A (zh) * | 2023-01-30 | 2023-04-14 | 上海甲贝医药科技有限公司 | 一种重组长效人cxcr4&pd-1双靶点抗体融合蛋白及其制备方法 |
| CN120919340A (zh) * | 2024-05-09 | 2025-11-11 | 百奥泰生物制药股份有限公司 | 抗FRα抗体药物偶联物和PD-1拮抗剂在治疗肿瘤中的应用 |
| CN118684782A (zh) * | 2024-07-17 | 2024-09-24 | 武汉科技大学 | 一种muc16和folr1双靶点嵌合抗原受体dcar-16-r1及应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ600758A (en) * | 2007-06-18 | 2013-09-27 | Merck Sharp & Dohme | Antibodies to human programmed death receptor pd-1 |
| SG10201501342UA (en) * | 2010-02-24 | 2015-04-29 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| AU2013327116C1 (en) * | 2012-10-02 | 2018-08-30 | Bristol-Myers Squibb Company | Combination of anti-KIR antibodies and anti-PD-1 antibodies to treat cancer |
| PT3055332T (pt) * | 2013-10-08 | 2019-12-09 | Immunogen Inc | Regimes de dosagem de imunoconjugados anti-folr1 |
| US20150297744A1 (en) * | 2014-03-28 | 2015-10-22 | Immunogen, Inc. | Anti-FOLR1 Immunoconjugate Dosing Regimens |
| LT3789402T (lt) * | 2014-11-20 | 2022-09-26 | F. Hoffmann-La Roche Ag | Kompleksinė terapija, naudojant t ląsteles aktyvinančias bispecifines antigeną surišančias molekules ir pd-1 ašį surišančius antagonistus |
| WO2016100882A1 (en) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
| CN116440279A (zh) * | 2015-09-17 | 2023-07-18 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
-
2018
- 2018-05-15 JP JP2019563246A patent/JP2020519675A/ja active Pending
- 2018-05-15 RU RU2019141270A patent/RU2019141270A/ru unknown
- 2018-05-15 CN CN201880032356.XA patent/CN110799535A/zh active Pending
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- 2018-05-15 MX MX2019013753A patent/MX2019013753A/es unknown
- 2018-05-15 KR KR1020197034686A patent/KR20200006546A/ko not_active Ceased
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- 2018-05-16 TW TW107116641A patent/TW201900221A/zh unknown
- 2018-05-16 TW TW111134010A patent/TW202322853A/zh unknown
- 2018-05-16 TW TW113100663A patent/TW202440170A/zh unknown
-
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- 2021-07-21 US US17/382,286 patent/US20220160889A1/en not_active Abandoned
-
2023
- 2023-06-12 JP JP2023096307A patent/JP2023113921A/ja active Pending
- 2023-10-18 US US18/489,292 patent/US20240299571A1/en active Pending
Non-Patent Citations (5)
| Title |
|---|
| "Combination Regimens of Mirvetuximab Soravtansine, A Folate Receptor Alpha-Targeting Antibody-Drug C", HEALTH CARE: CURRENT REVIEWS, vol. 5, no. 2, JPN7022002573, April 2017 (2017-04-01), pages 1 - 2, ISSN: 0004792948 * |
| "History of Changes for Study: NCT02606305", CLINICAL TRIALS.GOV ARCHIVE [ONLINE], JPN6022022495, 7 April 2017 (2017-04-07), ISSN: 0004988503 * |
| "New therapies for advanced, recurrent, and metastatic endometrial cancers", GYNECOLOGIC ONCOLOGY RESEARCH AND PRACTICE, vol. 4, JPN7022002572, December 2017 (2017-12-01), pages 1 - 12, ISSN: 0004792949 * |
| "P303 Treatment of tumor cells with mirvetuximab soravtansine, a FRalpha-targeting antibody-drug conj", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol.4(Suppl 1):73, JPN7022002571, 2016, pages 1 - 163, ISSN: 0004792950 * |
| ONCOTARGET, vol. 8, no. 52, JPN7022002574, August 2017 (2017-08-01), pages 90532 - 90544, ISSN: 0004792951 * |
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| CN118078987A (zh) | 2024-05-28 |
| TW201900221A (zh) | 2019-01-01 |
| RU2019141270A (ru) | 2021-06-16 |
| US20180333503A1 (en) | 2018-11-22 |
| JP2023113921A (ja) | 2023-08-16 |
| RU2019141270A3 (enExample) | 2021-09-28 |
| CA3063893A1 (en) | 2018-11-22 |
| CN110799535A (zh) | 2020-02-14 |
| TW202322853A (zh) | 2023-06-16 |
| IL314823A (en) | 2024-10-01 |
| WO2018213260A1 (en) | 2018-11-22 |
| BR112019023909A2 (pt) | 2020-06-09 |
| EP3625262A1 (en) | 2020-03-25 |
| TW202440170A (zh) | 2024-10-16 |
| EP3625262A4 (en) | 2021-03-03 |
| MX2019013753A (es) | 2020-07-20 |
| BR112019023909A8 (pt) | 2023-04-11 |
| AU2018269173A1 (en) | 2019-11-28 |
| KR20200006546A (ko) | 2020-01-20 |
| US20240299571A1 (en) | 2024-09-12 |
| US20220160889A1 (en) | 2022-05-26 |
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