JP2020519675A - 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ - Google Patents

抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ Download PDF

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JP2020519675A
JP2020519675A JP2019563246A JP2019563246A JP2020519675A JP 2020519675 A JP2020519675 A JP 2020519675A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2019563246 A JP2019563246 A JP 2019563246A JP 2020519675 A JP2020519675 A JP 2020519675A
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antibody
immunoconjugate
folr1
cancer
antigen
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JP2020519675A5 (enExample
JPWO2018213260A5 (enExample
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ルイス・ソト,ロドリーゴ・アール
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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JP2019563246A 2017-05-16 2018-05-15 抗folr1イムノコンジュゲートと抗pd−1抗体の組み合わせ Pending JP2020519675A (ja)

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JP2023096307A JP2023113921A (ja) 2017-05-16 2023-06-12 抗folr1イムノコンジュゲートと抗pd-1抗体の組み合わせ

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US201762506940P 2017-05-16 2017-05-16
US62/506,940 2017-05-16
US201762560462P 2017-09-19 2017-09-19
US62/560,462 2017-09-19
US201862647008P 2018-03-23 2018-03-23
US62/647,008 2018-03-23
PCT/US2018/032692 WO2018213260A1 (en) 2017-05-16 2018-05-15 Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations

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US (3) US20180333503A1 (enExample)
EP (1) EP3625262A4 (enExample)
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BR (1) BR112019023909A8 (enExample)
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Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
NZ600758A (en) 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
SI2694106T1 (en) 2011-04-01 2018-04-30 Immunogen, Inc. Methods for increasing the effectiveness of treatment with FOLR1 receptor cancer
CN115925952A (zh) 2018-03-13 2023-04-07 东莞凡恩世生物医药有限公司 抗叶酸受体1抗体及其用途
US20220047716A1 (en) * 2018-09-17 2022-02-17 Sutro Biopharma, Inc. Combination therapies with anti-folate receptor antibody conjugates
KR20220008253A (ko) * 2019-01-03 2022-01-20 엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔 (인쎄름) 암을 앓는 대상에서 cd8+ t 세포 의존성 면역 반응을 향상시키기 위한 방법 및 약학적 조성물
US20240190955A1 (en) 2021-04-23 2024-06-13 King's College London Composition comprising an ige antibody
TW202409080A (zh) * 2022-07-26 2024-03-01 美商沙塔克實驗室股份有限公司 用於治療卵巢癌之組合療法
CN115960269A (zh) * 2023-01-30 2023-04-14 上海甲贝医药科技有限公司 一种重组长效人cxcr4&pd-1双靶点抗体融合蛋白及其制备方法
CN120919340A (zh) * 2024-05-09 2025-11-11 百奥泰生物制药股份有限公司 抗FRα抗体药物偶联物和PD-1拮抗剂在治疗肿瘤中的应用
CN118684782A (zh) * 2024-07-17 2024-09-24 武汉科技大学 一种muc16和folr1双靶点嵌合抗原受体dcar-16-r1及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ600758A (en) * 2007-06-18 2013-09-27 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
SG10201501342UA (en) * 2010-02-24 2015-04-29 Immunogen Inc Folate receptor 1 antibodies and immunoconjugates and uses thereof
AU2013327116C1 (en) * 2012-10-02 2018-08-30 Bristol-Myers Squibb Company Combination of anti-KIR antibodies and anti-PD-1 antibodies to treat cancer
PT3055332T (pt) * 2013-10-08 2019-12-09 Immunogen Inc Regimes de dosagem de imunoconjugados anti-folr1
US20150297744A1 (en) * 2014-03-28 2015-10-22 Immunogen, Inc. Anti-FOLR1 Immunoconjugate Dosing Regimens
LT3789402T (lt) * 2014-11-20 2022-09-26 F. Hoffmann-La Roche Ag Kompleksinė terapija, naudojant t ląsteles aktyvinančias bispecifines antigeną surišančias molekules ir pd-1 ašį surišančius antagonistus
WO2016100882A1 (en) * 2014-12-19 2016-06-23 Novartis Ag Combination therapies
CN116440279A (zh) * 2015-09-17 2023-07-18 伊缪诺金公司 包含抗folr1免疫缀合物的治疗组合

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"Combination Regimens of Mirvetuximab Soravtansine, A Folate Receptor Alpha-Targeting Antibody-Drug C", HEALTH CARE: CURRENT REVIEWS, vol. 5, no. 2, JPN7022002573, April 2017 (2017-04-01), pages 1 - 2, ISSN: 0004792948 *
"History of Changes for Study: NCT02606305", CLINICAL TRIALS.GOV ARCHIVE [ONLINE], JPN6022022495, 7 April 2017 (2017-04-07), ISSN: 0004988503 *
"New therapies for advanced, recurrent, and metastatic endometrial cancers", GYNECOLOGIC ONCOLOGY RESEARCH AND PRACTICE, vol. 4, JPN7022002572, December 2017 (2017-12-01), pages 1 - 12, ISSN: 0004792949 *
"P303 Treatment of tumor cells with mirvetuximab soravtansine, a FRalpha-targeting antibody-drug conj", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. Vol.4(Suppl 1):73, JPN7022002571, 2016, pages 1 - 163, ISSN: 0004792950 *
ONCOTARGET, vol. 8, no. 52, JPN7022002574, August 2017 (2017-08-01), pages 90532 - 90544, ISSN: 0004792951 *

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