BR112019023909A8 - Uso de um imunoconjugado que se liga a folr1, e, uso de um imunoconjugado que se liga a folr1 e pembrolizumab - Google Patents

Uso de um imunoconjugado que se liga a folr1, e, uso de um imunoconjugado que se liga a folr1 e pembrolizumab

Info

Publication number
BR112019023909A8
BR112019023909A8 BR112019023909A BR112019023909A BR112019023909A8 BR 112019023909 A8 BR112019023909 A8 BR 112019023909A8 BR 112019023909 A BR112019023909 A BR 112019023909A BR 112019023909 A BR112019023909 A BR 112019023909A BR 112019023909 A8 BR112019023909 A8 BR 112019023909A8
Authority
BR
Brazil
Prior art keywords
immunoconjugate
pembrolizumab
binds folr1
folr1
binds
Prior art date
Application number
BR112019023909A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112019023909A2 (pt
Inventor
R Ruiz Soto Rodrigo
Original Assignee
Immunogen Inc
Merck Sharp & Dohme
Merck Sharp & Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc, Merck Sharp & Dohme, Merck Sharp & Dohme Llc filed Critical Immunogen Inc
Publication of BR112019023909A2 publication Critical patent/BR112019023909A2/pt
Publication of BR112019023909A8 publication Critical patent/BR112019023909A8/pt

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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
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  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112019023909A 2017-05-16 2018-05-15 Uso de um imunoconjugado que se liga a folr1, e, uso de um imunoconjugado que se liga a folr1 e pembrolizumab BR112019023909A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762506940P 2017-05-16 2017-05-16
US201762560462P 2017-09-19 2017-09-19
US201862647008P 2018-03-23 2018-03-23
PCT/US2018/032692 WO2018213260A1 (en) 2017-05-16 2018-05-15 Anti-folr1 immunoconjugates and anti-pd-1 antibody combinations

Publications (2)

Publication Number Publication Date
BR112019023909A2 BR112019023909A2 (pt) 2020-06-09
BR112019023909A8 true BR112019023909A8 (pt) 2023-04-11

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BR112019023909A BR112019023909A8 (pt) 2017-05-16 2018-05-15 Uso de um imunoconjugado que se liga a folr1, e, uso de um imunoconjugado que se liga a folr1 e pembrolizumab

Country Status (13)

Country Link
US (3) US20180333503A1 (enExample)
EP (1) EP3625262A4 (enExample)
JP (2) JP2020519675A (enExample)
KR (1) KR20200006546A (enExample)
CN (2) CN118078987A (enExample)
AU (1) AU2018269173A1 (enExample)
BR (1) BR112019023909A8 (enExample)
CA (1) CA3063893A1 (enExample)
IL (1) IL314823A (enExample)
MX (1) MX2019013753A (enExample)
RU (1) RU2019141270A (enExample)
TW (3) TW202440170A (enExample)
WO (1) WO2018213260A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2535354B1 (en) 2007-06-18 2017-01-11 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
UA125636C2 (uk) 2011-04-01 2022-05-11 Іммуноджен, Інк. Способи ідентифікації раку, який може реагувати на анти-folr1 антитіло або анти-folr1 імунокон'югат
KR102808710B1 (ko) 2018-03-13 2025-05-15 페인스 테라퓨틱스 인코포레이티드 항-폴레이트 수용체 1 항체 및 이의 용도
WO2020060944A1 (en) * 2018-09-17 2020-03-26 Sutro Biopharma, Inc. Combination therapies with anti-folate receptor antibody conjugates
US20220073626A1 (en) * 2019-01-03 2022-03-10 Institut National De La Santé Et De La Recheche Médicale (Inserm) Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer
CA3215850A1 (en) 2021-04-23 2022-10-27 James Spicer Composition comprising an ige antibody
TW202409080A (zh) * 2022-07-26 2024-03-01 美商沙塔克實驗室股份有限公司 用於治療卵巢癌之組合療法
CN115960269A (zh) * 2023-01-30 2023-04-14 上海甲贝医药科技有限公司 一种重组长效人cxcr4&pd-1双靶点抗体融合蛋白及其制备方法
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