JP2020518649A5 - - Google Patents

Download PDF

Info

Publication number
JP2020518649A5
JP2020518649A5 JP2019561224A JP2019561224A JP2020518649A5 JP 2020518649 A5 JP2020518649 A5 JP 2020518649A5 JP 2019561224 A JP2019561224 A JP 2019561224A JP 2019561224 A JP2019561224 A JP 2019561224A JP 2020518649 A5 JP2020518649 A5 JP 2020518649A5
Authority
JP
Japan
Prior art keywords
tetrahydro
cyclopropa
pentalene
diaza
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019561224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020518649A (ja
JP7247106B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/031688 external-priority patent/WO2018208848A1/en
Publication of JP2020518649A publication Critical patent/JP2020518649A/ja
Publication of JP2020518649A5 publication Critical patent/JP2020518649A5/ja
Application granted granted Critical
Publication of JP7247106B2 publication Critical patent/JP7247106B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019561224A 2017-05-08 2018-05-08 内臓痛の治療のための化合物および方法 Active JP7247106B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762503280P 2017-05-08 2017-05-08
US62/503,280 2017-05-08
PCT/US2018/031688 WO2018208848A1 (en) 2017-05-08 2018-05-08 Compounds and methods for treatment of visceral pain

Publications (3)

Publication Number Publication Date
JP2020518649A JP2020518649A (ja) 2020-06-25
JP2020518649A5 true JP2020518649A5 (OSRAM) 2021-07-26
JP7247106B2 JP7247106B2 (ja) 2023-03-28

Family

ID=62245468

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019561224A Active JP7247106B2 (ja) 2017-05-08 2018-05-08 内臓痛の治療のための化合物および方法

Country Status (13)

Country Link
US (2) US20200078358A1 (OSRAM)
EP (1) EP3621619B1 (OSRAM)
JP (1) JP7247106B2 (OSRAM)
KR (1) KR20200005614A (OSRAM)
CN (1) CN110709085A (OSRAM)
AU (1) AU2018266145A1 (OSRAM)
BR (1) BR112019023214A2 (OSRAM)
CA (1) CA3062824A1 (OSRAM)
EA (1) EA201992638A1 (OSRAM)
ES (1) ES2956059T3 (OSRAM)
MA (1) MA48625A (OSRAM)
MX (2) MX2019013311A (OSRAM)
WO (1) WO2018208848A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200005614A (ko) 2017-05-08 2020-01-15 아레나 파마슈티칼스, 인크. 내장 통증의 치료를 위한 화합물 및 방법
CA3212135A1 (en) * 2021-03-02 2022-09-09 Arena Pharmaceuticals, Inc. Methods of treatment with selective cb2 receptor agonists
WO2023059610A1 (en) * 2021-10-05 2023-04-13 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of cannabinoid receptor modulators
WO2023150648A2 (en) * 2022-02-02 2023-08-10 Makscientific, Llc Pharmaceutical compositions, and preparation and methods of use thereof

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605906A (en) 1995-03-24 1997-02-25 Merck Frosst Canada, Inc. Cannabinoid receptor agonists
JP3964478B2 (ja) 1995-06-30 2007-08-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
US5971080A (en) 1997-11-26 1999-10-26 Central Sprinkler Corporation Quick response dry pipe sprinkler system
US7308894B2 (en) 1998-06-03 2007-12-18 Scott Laboratories, Inc. Apparatuses and methods for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures according to appropriate clinical heuristics
IL145922A0 (en) 1999-04-28 2002-07-25 Aventis Pharma Gmbh Di-aryl acid derivatives as ppar receptor ligands
IL150302A (en) 2002-01-31 2008-07-08 Naim Menashe Bicyclic cb2 cannabinoid receptor ligands
SE0300010D0 (sv) 2003-01-07 2003-01-07 Astrazeneca Ab Novel Compounds
ITMI20041033A1 (it) 2004-05-24 2004-08-24 Neuroscienze S C A R L Composti farmaceutici
WO2005123677A1 (en) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd 4-carbonyl substituted 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa'a!pentalene derivatives as agonists for the g-protein-coupled receptor s1p1/edg1 and immunosuppressive agents
WO2006025069A2 (en) 2004-07-12 2006-03-09 Cadila Healthcare Limited Tricyclic pyrazole derivatives as cannabinoid receptor modulators
WO2006010379A1 (en) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
FR2875230A1 (fr) 2004-09-13 2006-03-17 Sanofi Aventis Sa Derives de pyrazole condense, leur preparation et leur application en therapeutique
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
PE20060949A1 (es) 2004-12-23 2006-10-11 Arena Pharm Inc Derivados fusionados de pirazol como agonistas del receptor de niacina
EP1902034B1 (en) 2005-06-02 2011-03-30 Glenmark Pharmaceuticals S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
US7597910B2 (en) 2005-08-20 2009-10-06 Slgm Medical Research Institute Compositions and methods for treating prostate disorders
US7790718B2 (en) 2005-09-23 2010-09-07 Janssen Pharmaceutica Nv Tetrahydro-cyclopentyl pyrazole cannabinoid modulators
EA200970080A1 (ru) 2006-07-04 2009-06-30 Янссен Фармацевтика Нв Бензимидазольные агонисты каннабиноидов, содержащие замещенную гетероциклическую группу
JP5030114B2 (ja) 2006-09-25 2012-09-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Cb2受容体をモジュレートする化合物
US8481574B2 (en) 2006-10-12 2013-07-09 Abbott Laboratories Compounds as cannabinoid receptor ligands
US7928103B2 (en) 2006-10-17 2011-04-19 Boehringer Ingelheim International Gmbh Compounds which modulate the CB2 receptor
CA2668491A1 (en) 2006-11-03 2008-05-08 Glenmark Pharmaceuticals S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation
WO2008064054A2 (en) 2006-11-21 2008-05-29 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
US9763894B2 (en) 2006-12-05 2017-09-19 Virginia Commonwealth University Inflammation therapy
WO2008085302A1 (en) 2006-12-20 2008-07-17 Merck & Co., Inc. Imidazopyridine analogs as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases
WO2008079316A1 (en) 2006-12-20 2008-07-03 Cara Therapeutics, Inc. Tetrahydroquinolinones, tetrahydronaphthyridones and derivatives thereof
US20080214537A1 (en) 2007-03-02 2008-09-04 Cara Therapeutics, Inc. Bridged phenanthridines
ES2548764T3 (es) 2007-03-30 2015-10-20 Janssen Pharmaceutica N.V. Agonistas de cannabinoides de bencimidazol
US20090209536A1 (en) 2007-06-17 2009-08-20 Kalypsys, Inc. Aminoquinazoline cannabinoid receptor modulators for treatment of disease
BRPI0812504B8 (pt) 2007-06-21 2021-05-25 Cara Therapeutics Inc composto para profilaxia ou tratamento de doença ou condição associada a receptor de canabinoides em sujeito mamífero
US8338623B2 (en) 2007-07-09 2012-12-25 Abbvie Inc. Compounds as cannabinoid receptor ligands
US7943658B2 (en) 2007-07-23 2011-05-17 Bristol-Myers Squibb Company Indole indane amide compounds useful as CB2 agonists and method
WO2009025785A2 (en) 2007-08-21 2009-02-26 Merck & Co., Inc. Cb2 receptor ligands for the treatment of pain
UA104010C2 (en) 2008-12-18 2013-12-25 Эли Лилли Энд Компани Purine compounds
WO2010088050A2 (en) 2009-01-28 2010-08-05 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
US7741350B1 (en) 2009-01-28 2010-06-22 Cara Therapeutics, Inc. Bicyclic pyrazolo-heterocycles
NZ598288A (en) * 2009-08-28 2014-02-28 Arena Pharm Inc Cannabinoid receptor modulators
WO2012116278A1 (en) 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
US9597340B2 (en) * 2011-02-25 2017-03-21 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
CA2827057C (en) 2011-02-25 2022-06-07 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of condensed azacycles (cannabinoid receptor modulators)
ES2929977T3 (es) 2011-02-25 2022-12-05 Arena Pharm Inc Moduladores del receptor cannabinoide
WO2016085941A1 (en) 2014-11-25 2016-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of cannabinoid receptor modulators
US20180252736A1 (en) 2015-09-01 2018-09-06 Arena Pharmaceuticals, Inc. Cb2 receptor internalization
UA124626C2 (uk) 2016-04-10 2021-10-20 Арена Фармасьютікалз, Інк. СПОСОБИ ЛІКУВАННЯ СЕЛЕКТИВНИМИ АГОНІСТАМИ РЕЦЕПТОРА СВ<sub>2</sub>
WO2018208847A1 (en) * 2017-05-08 2018-11-15 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of pain from inflammatory bowel disease
KR20200005614A (ko) 2017-05-08 2020-01-15 아레나 파마슈티칼스, 인크. 내장 통증의 치료를 위한 화합물 및 방법
EP3684353A4 (en) * 2017-09-22 2021-06-23 Inmed Pharmaceuticals Inc. TOPICAL FORMULATIONS OF CANNABINOIDS AND THEIR USES FOR PAIN TREATMENT
CA3212135A1 (en) * 2021-03-02 2022-09-09 Arena Pharmaceuticals, Inc. Methods of treatment with selective cb2 receptor agonists
WO2023059610A1 (en) * 2021-10-05 2023-04-13 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of cannabinoid receptor modulators

Similar Documents

Publication Publication Date Title
ES2391382T3 (es) Compuestos de aril-urea en combinación con otros agentes citostáticos o citotóxicos para tratamiento de cánceres humanos
AU2012255935B2 (en) Compounds for use in treatment of mucositis
JP2020532529A (ja) 抗癌剤としての環状ジヌクレオチド
JP2018520352A (ja) アルギナーゼ活性を阻害するための組成物および方法
JP7028765B2 (ja) ベンズアミドおよび活性化合物組成物および使用方法
KR20200080254A (ko) 혈액학적 장애를 치료하기 위한 화합물 및 조성물
BR112013001553A2 (pt) Métodos e compostos para tratar infecções por vírus paramyxoviridae
KR20110013411A (ko) (f-19)-표지된 l-글루탐산 및 l-글루타민 유도체 (ⅲ), 그의 용도 및 그의 수득 방법
JP2020532539A (ja) 抗癌剤としての環状ジヌクレオチド
US20200000810A1 (en) Brk inhibitory compound
WO2017101791A1 (zh) 化合物及其在制备药物中的用途
JP2025511852A (ja) Pd-1阻害剤及びsik3阻害剤に基づく併用療法
US20240390399A1 (en) Materials and methods for suppressing and/or treating bone related diseases and symptoms
ES2945062T3 (es) Derivados de ácido barbitúrico novedosos, su preparación y uso de los mismos como inhibidores de la transmigración de leucocitos y para el tratamiento de enfermedades inflamatorias, enfermedades autoinmunitarias y cáncer
US20160229857A1 (en) Substituted pyrrolo[2,3-d]dipyrimidines for selectively targeting tumor cells with fr-alpha and fr-beta type receptors
US11254662B2 (en) 2′-halogenated-4′-thio-2′-deoxy-5-azacytidine analogs and use thereof
KR20090025247A (ko) 방사선 치료 증강제
JP7247106B2 (ja) 内臓痛の治療のための化合物および方法
JP2017137323A (ja) 新規抗がん剤
WO1992011247A1 (fr) Composition anticancereuse et compose
JP2014515026A (ja) アカデシン誘導体、それを含有する製剤および組成物、その治療目的での使用、ならびにその合成法
CN115103673A (zh) 组合
JP2003238414A (ja) 医薬組成物
JP7816164B2 (ja) Ep4拮抗薬と免疫チェックポイント阻害物質との併用によるがん治療
WO2019233366A1 (zh) 选择性a 2a受体拮抗剂