JP7247106B2 - 内臓痛の治療のための化合物および方法 - Google Patents

内臓痛の治療のための化合物および方法 Download PDF

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JP7247106B2
JP7247106B2 JP2019561224A JP2019561224A JP7247106B2 JP 7247106 B2 JP7247106 B2 JP 7247106B2 JP 2019561224 A JP2019561224 A JP 2019561224A JP 2019561224 A JP2019561224 A JP 2019561224A JP 7247106 B2 JP7247106 B2 JP 7247106B2
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tetrahydro
diaza
compound
cyclopropa
pentalene
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JP2020518649A5 (OSRAM
JP2020518649A (ja
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シェリル ジェラルディーン ラッセン,
マルセロ ファビアン ピッチリーロ,
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アリーナ ファーマシューティカルズ, インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2019561224A 2017-05-08 2018-05-08 内臓痛の治療のための化合物および方法 Active JP7247106B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762503280P 2017-05-08 2017-05-08
US62/503,280 2017-05-08
PCT/US2018/031688 WO2018208848A1 (en) 2017-05-08 2018-05-08 Compounds and methods for treatment of visceral pain

Publications (3)

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JP2020518649A JP2020518649A (ja) 2020-06-25
JP2020518649A5 JP2020518649A5 (OSRAM) 2021-07-26
JP7247106B2 true JP7247106B2 (ja) 2023-03-28

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US (2) US20200078358A1 (OSRAM)
EP (1) EP3621619B1 (OSRAM)
JP (1) JP7247106B2 (OSRAM)
KR (1) KR20200005614A (OSRAM)
CN (1) CN110709085A (OSRAM)
AU (1) AU2018266145A1 (OSRAM)
BR (1) BR112019023214A2 (OSRAM)
CA (1) CA3062824A1 (OSRAM)
EA (1) EA201992638A1 (OSRAM)
ES (1) ES2956059T3 (OSRAM)
MA (1) MA48625A (OSRAM)
MX (2) MX2019013311A (OSRAM)
WO (1) WO2018208848A1 (OSRAM)

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KR20200005614A (ko) 2017-05-08 2020-01-15 아레나 파마슈티칼스, 인크. 내장 통증의 치료를 위한 화합물 및 방법
CA3212135A1 (en) * 2021-03-02 2022-09-09 Arena Pharmaceuticals, Inc. Methods of treatment with selective cb2 receptor agonists
WO2023059610A1 (en) * 2021-10-05 2023-04-13 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of cannabinoid receptor modulators
WO2023150648A2 (en) * 2022-02-02 2023-08-10 Makscientific, Llc Pharmaceutical compositions, and preparation and methods of use thereof

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CA3062824A1 (en) 2018-11-15
BR112019023214A2 (pt) 2020-05-26
AU2018266145A1 (en) 2019-11-28
MA48625A (fr) 2020-03-18
JP2020518649A (ja) 2020-06-25
US12201633B2 (en) 2025-01-21
KR20200005614A (ko) 2020-01-15
US20230033510A1 (en) 2023-02-02
EP3621619B1 (en) 2023-06-28
EP3621619A1 (en) 2020-03-18
CN110709085A (zh) 2020-01-17
MX2019013311A (es) 2020-08-03
ES2956059T3 (es) 2023-12-12
US20200078358A1 (en) 2020-03-12
MX2022008265A (es) 2022-08-04
WO2018208848A1 (en) 2018-11-15
EA201992638A1 (ru) 2020-03-18
EP3621619C0 (en) 2023-06-28

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