JP2020516659A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020516659A5 JP2020516659A5 JP2019555961A JP2019555961A JP2020516659A5 JP 2020516659 A5 JP2020516659 A5 JP 2020516659A5 JP 2019555961 A JP2019555961 A JP 2019555961A JP 2019555961 A JP2019555961 A JP 2019555961A JP 2020516659 A5 JP2020516659 A5 JP 2020516659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- independently
- pharmaceutically acceptable
- case
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *[n]1ncc(Nc2nc(-c3cc(CN(*)CC[C@]4NC(C5=CC=CC=CC=CC=CC5)=O)c4cc3)ccn2)c1 Chemical compound *[n]1ncc(Nc2nc(-c3cc(CN(*)CC[C@]4NC(C5=CC=CC=CC=CC=CC5)=O)c4cc3)ccn2)c1 0.000 description 3
- BRFXPABSZCKBGA-LWUPDDLQSA-N CC(C)(C)N(/C=C(/C(N[C@H](CCN(C1)C2COC2)c(cc2)c1cc2-c1ccnc(Nc2c[n](C)nc2)n1)=O)\N)N Chemical compound CC(C)(C)N(/C=C(/C(N[C@H](CCN(C1)C2COC2)c(cc2)c1cc2-c1ccnc(Nc2c[n](C)nc2)n1)=O)\N)N BRFXPABSZCKBGA-LWUPDDLQSA-N 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022148866A JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762485745P | 2017-04-14 | 2017-04-14 | |
| US62/485,745 | 2017-04-14 | ||
| PCT/US2018/027415 WO2018191577A1 (en) | 2017-04-14 | 2018-04-13 | Benzoazepine analogs as inhibiting agents for bruton's tyrosine kinase |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022148866A Division JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020516659A JP2020516659A (ja) | 2020-06-11 |
| JP2020516659A5 true JP2020516659A5 (enExample) | 2021-05-27 |
| JP7145874B2 JP7145874B2 (ja) | 2022-10-03 |
Family
ID=62092333
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019555961A Active JP7145874B2 (ja) | 2017-04-14 | 2018-04-13 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2022148866A Active JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A Active JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022148866A Active JP7581294B2 (ja) | 2017-04-14 | 2022-09-20 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
| JP2024190472A Active JP7778206B2 (ja) | 2017-04-14 | 2024-10-30 | ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体 |
Country Status (38)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3080103T1 (sl) | 2013-12-11 | 2018-11-30 | Biogen Ma Inc. | Biarilne spojine, ki so uporabne za zdravljenje človeških bolezni na področju onkologije, nevrologije in imunologije |
| JOP20190233A1 (ar) | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
| JP7476214B2 (ja) * | 2018-10-15 | 2024-04-30 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼ阻害剤の結晶多形 |
| JP7747523B2 (ja) * | 2019-05-15 | 2025-10-01 | バイオジェン・エムエイ・インコーポレイテッド | ブルトン型チロシンキナーゼの阻害剤 |
| WO2022140246A1 (en) | 2020-12-21 | 2022-06-30 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
| WO2022212893A1 (en) | 2021-04-02 | 2022-10-06 | Biogen Ma Inc. | Combination treatment methods of multiple sclerosis |
| JP2024544529A (ja) | 2021-11-10 | 2024-12-03 | バイオジェン・エムエイ・インコーポレイテッド | Ｂｔｋ阻害剤 |
| JP2023140319A (ja) | 2022-03-22 | 2023-10-04 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
| WO2024245577A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a reversible btk inhibitor |
| WO2024245578A1 (en) | 2023-06-02 | 2024-12-05 | Netherlands Translational Research Center Holding B.V. | Therapeutic combinations of an irreversible btk inhibitor and a macrocyclic reversible btk inhibitor |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US8188272B2 (en) | 2007-03-21 | 2012-05-29 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US8247410B2 (en) | 2007-10-05 | 2012-08-21 | Verastem | Pyrimidine substituted purine derivatives |
| US20110009421A1 (en) | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
| US8450335B2 (en) | 2008-06-27 | 2013-05-28 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| EP3461824B1 (en) * | 2009-09-04 | 2021-08-25 | Biogen MA Inc. | Bruton's tyrosine kinase inhibitors |
| US8334292B1 (en) | 2010-06-14 | 2012-12-18 | Cystic Fibrosis Foundation Therapeutics, Inc. | Pyrimidine compounds and methods of making and using same |
| SG10201605913VA (en) | 2011-07-19 | 2016-09-29 | Merck Sharp & Dohme | 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides as btk-inhibitors |
| TWI638815B (zh) * | 2013-02-15 | 2018-10-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類（一） |
| WO2014130856A2 (en) | 2013-02-21 | 2014-08-28 | Wayne Rothbaum | Treatment of skeletal-related disorders |
| EP3060550B1 (en) | 2013-10-21 | 2019-05-15 | Merck Patent GmbH | Heteroaryl compounds as btk inhibitors and uses thereof |
| SI3080103T1 (sl) * | 2013-12-11 | 2018-11-30 | Biogen Ma Inc. | Biarilne spojine, ki so uporabne za zdravljenje človeških bolezni na področju onkologije, nevrologije in imunologije |
| AU2015328285B2 (en) * | 2014-10-06 | 2019-07-18 | Merck Patent Gmbh | Heteroaryl compounds as BTK inhibitors and uses thereof |
| JOP20190233A1 (ar) | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
-
2017
- 2017-06-16 JO JOP/2019/0233A patent/JOP20190233A1/ar unknown
-
2018
- 2018-04-13 MD MDE20200193T patent/MD3609886T2/ro unknown
- 2018-04-13 IL IL316713A patent/IL316713A/en unknown
- 2018-04-13 CA CA3058774A patent/CA3058774A1/en active Pending
- 2018-04-13 PE PE2019002016A patent/PE20200740A1/es unknown
- 2018-04-13 AU AU2018253209A patent/AU2018253209B2/en active Active
- 2018-04-13 PL PL18721632.0T patent/PL3609886T3/pl unknown
- 2018-04-13 EP EP23187919.8A patent/EP4249071A3/en active Pending
- 2018-04-13 CN CN201880031744.6A patent/CN110621670B/zh active Active
- 2018-04-13 HU HUE18721632A patent/HUE066253T2/hu unknown
- 2018-04-13 IL IL269933A patent/IL269933B/en unknown
- 2018-04-13 KR KR1020237040706A patent/KR102862996B1/ko active Active
- 2018-04-13 NZ NZ757929A patent/NZ757929A/en unknown
- 2018-04-13 JP JP2019555961A patent/JP7145874B2/ja active Active
- 2018-04-13 HR HRP20240361TT patent/HRP20240361T1/hr unknown
- 2018-04-13 US US15/952,505 patent/US10227341B2/en active Active
- 2018-04-13 LT LTEPPCT/US2018/027415T patent/LT3609886T/lt unknown
- 2018-04-13 IL IL294175A patent/IL294175B2/en unknown
- 2018-04-13 SG SG11201909224Q patent/SG11201909224QA/en unknown
- 2018-04-13 EA EA201992354A patent/EA201992354A1/ru unknown
- 2018-04-13 ES ES18721632T patent/ES2975769T3/es active Active
- 2018-04-13 RS RS20240419A patent/RS65386B1/sr unknown
- 2018-04-13 CR CR20190517A patent/CR20190517A/es unknown
- 2018-04-13 KR KR1020197032715A patent/KR102607900B1/ko active Active
- 2018-04-13 PT PT187216320T patent/PT3609886T/pt unknown
- 2018-04-13 BR BR112019021399-6A patent/BR112019021399A2/pt active Search and Examination
- 2018-04-13 KR KR1020257031163A patent/KR20250140646A/ko active Pending
- 2018-04-13 SI SI201831083T patent/SI3609886T1/sl unknown
- 2018-04-13 DK DK18721632.0T patent/DK3609886T3/da active
- 2018-04-13 TW TW111149550A patent/TWI846229B/zh active
- 2018-04-13 FI FIEP18721632.0T patent/FI3609886T3/fi active
- 2018-04-13 MA MA50013A patent/MA50013B1/fr unknown
- 2018-04-13 SM SM20240166T patent/SMT202400166T1/it unknown
- 2018-04-13 CN CN202311088635.7A patent/CN117567453A/zh active Pending
- 2018-04-13 AR ARP180100935A patent/AR111594A1/es not_active Application Discontinuation
- 2018-04-13 UA UAA201911128A patent/UA127347C2/uk unknown
- 2018-04-13 EP EP18721632.0A patent/EP3609886B1/en active Active
- 2018-04-13 TW TW107112785A patent/TWI790227B/zh active
- 2018-04-13 PE PE2024000228A patent/PE20240930A1/es unknown
- 2018-04-13 WO PCT/US2018/027415 patent/WO2018191577A1/en not_active Ceased
- 2018-08-27 US US16/113,455 patent/US10189829B2/en active Active
-
2019
- 2019-04-13 CR CR20230539A patent/CR20230539A/es unknown
- 2019-08-07 US US16/534,540 patent/US10961237B2/en active Active
- 2019-10-10 SA SA519410292A patent/SA519410292B1/ar unknown
- 2019-10-11 CL CL2019002900A patent/CL2019002900A1/es unknown
- 2019-10-11 MX MX2023000812A patent/MX2023000812A/es unknown
- 2019-10-14 PH PH12019502334A patent/PH12019502334A1/en unknown
- 2019-11-12 CO CONC2019/0012571A patent/CO2019012571A2/es unknown
-
2021
- 2021-02-24 US US17/183,702 patent/US11427577B2/en active Active
-
2022
- 2022-07-22 US US17/871,157 patent/US11858926B2/en active Active
- 2022-08-18 AU AU2022218560A patent/AU2022218560B2/en active Active
- 2022-09-20 JP JP2022148866A patent/JP7581294B2/ja active Active
-
2023
- 2023-06-12 ZA ZA2023/06172A patent/ZA202306172B/en unknown
- 2023-06-15 AR ARP230101541A patent/AR129632A2/es unknown
-
2024
- 2024-06-20 AU AU2024204241A patent/AU2024204241A1/en active Pending
- 2024-10-30 JP JP2024190472A patent/JP7778206B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020516659A5 (enExample) | ||
| ES2536191T3 (es) | Derivados de sulfonamida | |
| CN100430052C (zh) | 组织蛋白酶半胱氨酸蛋白酶抑制剂 | |
| JP6154052B2 (ja) | シクロアルカン誘導体の製造方法 | |
| CN108047115B (zh) | 经乙醛酰胺取代的吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 | |
| JP2018527336A5 (enExample) | ||
| JP2018511587A5 (enExample) | ||
| JP2019508407A5 (enExample) | ||
| RU2455288C2 (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| US8822510B2 (en) | Substituted 3-phenyl-1,2,4-Oxadiazole compounds | |
| RU2011151611A (ru) | Композиции для модуляции киназного каскада и способы их применения | |
| JP2003525872A5 (enExample) | ||
| JP2014532640A5 (enExample) | ||
| HRP20240361T1 (hr) | Analozi benzoazepina kao sredstva za inhibiciju brutonove tirozin kinaze | |
| RU2006101541A (ru) | Производные пиперазина и способ их применения | |
| JP2019536810A5 (enExample) | ||
| JP2018503661A5 (enExample) | ||
| HRP20200606T1 (hr) | Derivati fenila kao agonisti kanabinoidnog receptora 2 | |
| JP2014501232A5 (enExample) | ||
| JP2004525183A5 (enExample) | ||
| HRP20150450T1 (hr) | Spojevi aril triazola sa antitumorskom aktivnošä†u | |
| AU2008297817A1 (en) | 6-pyrimidinyl-pyrimid-4-one derivative | |
| RU2015151742A (ru) | Новые производные тетразолона | |
| RU2019103883A (ru) | Гетероароматические модуляторы ретинол-связанного орфанного рецептора гамма | |
| JP2019521137A5 (enExample) |