JP2020514407A - アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療 - Google Patents
アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療 Download PDFInfo
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- ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N verteporfin Chemical compound C=1C([C@@]2([C@H](C(=O)OC)C(=CC=C22)C(=O)OC)C)=NC2=CC(C(=C2C=C)C)=NC2=CC(C(=C2CCC(O)=O)C)=NC2=CC2=NC=1C(C)=C2CCC(=O)OC ZQFGRJWRSLZCSQ-ZSFNYQMMSA-N 0.000 description 1
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- 229960004026 vilanterol Drugs 0.000 description 1
- 229960001254 vildagliptin Drugs 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229930182877 withaferin Natural products 0.000 description 1
- YCGBUPXEBUFYFV-UHFFFAOYSA-N withaferin A Natural products CC(C1CC(=C(CO)C(=O)O1)C)C2CCC3C4CC5OC56C(O)C=CC(O)C6(C)C4CCC23C YCGBUPXEBUFYFV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
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Application Number | Priority Date | Filing Date | Title |
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PCT/US2017/014754 WO2018139991A1 (en) | 2017-01-24 | 2017-01-24 | Treatment of age-related degeneration and other eye diseases with apolipoprotein mimetics |
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JP (1) | JP2020514407A (ko) |
KR (1) | KR20190124704A (ko) |
CN (1) | CN110545836A (ko) |
WO (1) | WO2018139991A1 (ko) |
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US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CN108712911A (zh) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | 抗体及其缀合物 |
PE20211202A1 (es) | 2017-08-24 | 2021-07-05 | Novo Nordisk As | Composiciones de glp-1 y sus usos |
EP3843721A4 (en) * | 2018-08-29 | 2022-10-12 | Ocugen, Inc. | OPHTHALMIC COMPOSITIONS AND METHODS OF USE |
AU2019378845A1 (en) * | 2018-11-16 | 2021-06-03 | Cymabay Therapeutics, Inc. | Combination treatment of NAFLD and NASH |
AU2019419468A1 (en) * | 2019-01-04 | 2021-07-15 | The Regents Of The University Of California | Compositions and methods for promoting angiogenesis in the eye |
US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
WO2021144476A1 (en) | 2020-02-18 | 2021-07-22 | Novo Nordisk A/S | Pharmaceutical formulations |
CN111494354B (zh) * | 2020-04-21 | 2021-06-22 | 复旦大学附属眼耳鼻喉科医院 | Abca1激动剂在制备治疗眼部疾病的药物中的用途 |
CN113842385A (zh) * | 2021-10-26 | 2021-12-28 | 南京北极光生物科技有限公司 | 一种降低视网膜黄斑变性的方法 |
WO2023194797A1 (en) * | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
WO2024114641A1 (en) * | 2022-11-28 | 2024-06-06 | Shenzhen Oculgen Biomedical Technology Co., Ltd | C5/vegf bispecific binding molecules |
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WO2009100348A2 (en) * | 2008-02-07 | 2009-08-13 | Uab Research Foundation | Peptides and peptide mimetics to treat pathologies associated with eye disease |
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US6046166A (en) * | 1997-09-29 | 2000-04-04 | Jean-Louis Dasseux | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders |
CN1292721C (zh) | 1999-10-21 | 2007-01-03 | 爱尔康公司 | 药物释放装置 |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
US7470659B2 (en) * | 2001-12-07 | 2008-12-30 | The Regents Of The University Of California | Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM) |
US20070254832A1 (en) * | 2006-02-17 | 2007-11-01 | Pressler Milton L | Methods for the treatment of macular degeneration and related eye conditions |
KR102512178B1 (ko) | 2011-05-18 | 2023-03-20 | 메더리스 다이어비티즈, 엘엘씨 | 개선된 펩티드 제약 |
CN117903257A (zh) | 2012-11-20 | 2024-04-19 | 梅德瑞斯糖尿病有限责任公司 | 用于胰岛素抗性的改良的肽药物 |
WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
BR112017001860A2 (pt) * | 2014-07-31 | 2018-02-27 | Uab Research Foundation | peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal |
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2017
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- 2017-01-24 CN CN201780087274.0A patent/CN110545836A/zh active Pending
- 2017-01-24 EP EP17703587.0A patent/EP3554531A1/en not_active Withdrawn
- 2017-01-24 JP JP2019560039A patent/JP2020514407A/ja active Pending
- 2017-01-24 KR KR1020197021355A patent/KR20190124704A/ko unknown
Patent Citations (1)
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---|---|---|---|---|
WO2009100348A2 (en) * | 2008-02-07 | 2009-08-13 | Uab Research Foundation | Peptides and peptide mimetics to treat pathologies associated with eye disease |
Non-Patent Citations (2)
Title |
---|
RUDOLF, M. ET AL.: "ApoA-I mimetic peptide L-4F reduces significantly lipid deposits in Bruch's membrane and complement", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 56, no. 7, JPN6020046839, June 2015 (2015-06-01), pages 1279, ISSN: 0004577479 * |
WHITE, C.R. ET AL.: "Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a review", JOURNAL OF LIPID RESEARCH, vol. 55, no. 10, JPN6020046840, 2014, pages 2007 - 2021, XP055225410, ISSN: 0004577480, DOI: 10.1194/jlr.R051367 * |
Also Published As
Publication number | Publication date |
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EP3554531A1 (en) | 2019-10-23 |
CN110545836A (zh) | 2019-12-06 |
WO2018139991A1 (en) | 2018-08-02 |
KR20190124704A (ko) | 2019-11-05 |
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