JP2020514407A - アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療 - Google Patents

アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療 Download PDF

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Publication number
JP2020514407A
JP2020514407A JP2019560039A JP2019560039A JP2020514407A JP 2020514407 A JP2020514407 A JP 2020514407A JP 2019560039 A JP2019560039 A JP 2019560039A JP 2019560039 A JP2019560039 A JP 2019560039A JP 2020514407 A JP2020514407 A JP 2020514407A
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Japan
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administered
apomimetic
apo
amd
dose
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JP2019560039A
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English (en)
Japanese (ja)
Inventor
ルドルフ,マーティン
ロイズマン,キース
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Macregen inc
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Macregen inc
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Publication of JP2020514407A publication Critical patent/JP2020514407A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
JP2019560039A 2017-01-24 2017-01-24 アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療 Pending JP2020514407A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/014754 WO2018139991A1 (en) 2017-01-24 2017-01-24 Treatment of age-related degeneration and other eye diseases with apolipoprotein mimetics

Publications (1)

Publication Number Publication Date
JP2020514407A true JP2020514407A (ja) 2020-05-21

Family

ID=57966185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019560039A Pending JP2020514407A (ja) 2017-01-24 2017-01-24 アポリポプロテイン模倣物を用いる加齢黄斑変性と他の眼疾患の治療

Country Status (5)

Country Link
EP (1) EP3554531A1 (ko)
JP (1) JP2020514407A (ko)
KR (1) KR20190124704A (ko)
CN (1) CN110545836A (ko)
WO (1) WO2018139991A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
CN108712911A (zh) 2015-12-30 2018-10-26 科达制药股份有限公司 抗体及其缀合物
PE20211202A1 (es) 2017-08-24 2021-07-05 Novo Nordisk As Composiciones de glp-1 y sus usos
EP3843721A4 (en) * 2018-08-29 2022-10-12 Ocugen, Inc. OPHTHALMIC COMPOSITIONS AND METHODS OF USE
AU2019378845A1 (en) * 2018-11-16 2021-06-03 Cymabay Therapeutics, Inc. Combination treatment of NAFLD and NASH
AU2019419468A1 (en) * 2019-01-04 2021-07-15 The Regents Of The University Of California Compositions and methods for promoting angiogenesis in the eye
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2021144476A1 (en) 2020-02-18 2021-07-22 Novo Nordisk A/S Pharmaceutical formulations
CN111494354B (zh) * 2020-04-21 2021-06-22 复旦大学附属眼耳鼻喉科医院 Abca1激动剂在制备治疗眼部疾病的药物中的用途
CN113842385A (zh) * 2021-10-26 2021-12-28 南京北极光生物科技有限公司 一种降低视网膜黄斑变性的方法
WO2023194797A1 (en) * 2022-04-06 2023-10-12 Abionyx Pharma Sa Methods for treating eye diseases using lipid binding protein-based complexes
WO2024114641A1 (en) * 2022-11-28 2024-06-06 Shenzhen Oculgen Biomedical Technology Co., Ltd C5/vegf bispecific binding molecules

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100348A2 (en) * 2008-02-07 2009-08-13 Uab Research Foundation Peptides and peptide mimetics to treat pathologies associated with eye disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
CN1292721C (zh) 1999-10-21 2007-01-03 爱尔康公司 药物释放装置
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US7470659B2 (en) * 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20070254832A1 (en) * 2006-02-17 2007-11-01 Pressler Milton L Methods for the treatment of macular degeneration and related eye conditions
KR102512178B1 (ko) 2011-05-18 2023-03-20 메더리스 다이어비티즈, 엘엘씨 개선된 펩티드 제약
CN117903257A (zh) 2012-11-20 2024-04-19 梅德瑞斯糖尿病有限责任公司 用于胰岛素抗性的改良的肽药物
WO2014159813A1 (en) 2013-03-13 2014-10-02 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
BR112017001860A2 (pt) * 2014-07-31 2018-02-27 Uab Research Foundation peptídeo sintético, composição farmacêutica, métodos, regime de dosagem, e, anticorpo monoclonal

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009100348A2 (en) * 2008-02-07 2009-08-13 Uab Research Foundation Peptides and peptide mimetics to treat pathologies associated with eye disease

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RUDOLF, M. ET AL.: "ApoA-I mimetic peptide L-4F reduces significantly lipid deposits in Bruch's membrane and complement", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 56, no. 7, JPN6020046839, June 2015 (2015-06-01), pages 1279, ISSN: 0004577479 *
WHITE, C.R. ET AL.: "Anti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a review", JOURNAL OF LIPID RESEARCH, vol. 55, no. 10, JPN6020046840, 2014, pages 2007 - 2021, XP055225410, ISSN: 0004577480, DOI: 10.1194/jlr.R051367 *

Also Published As

Publication number Publication date
EP3554531A1 (en) 2019-10-23
CN110545836A (zh) 2019-12-06
WO2018139991A1 (en) 2018-08-02
KR20190124704A (ko) 2019-11-05

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