JP2020512409A - Colloidal silver combined with botanical extracts used for the treatment of wounds and other skin conditions - Google Patents

Abstract

In one aspect, a composition for topical application is provided. The composition comprises a base. Dispersed in the base material are elemental silver as a colloidal suspension and a plant extract derived from at least 6 types of plants. The plants are Echinacea purpurea, Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis (Calendula). ), Equisetum arvense, Symphytum officinale, Panax ginseng, Rumex crispus, Arctium lappa, Trifolium pratense. , Chelidonium majus, Thuja occidentalis, Urtica dioica, Mahonia aquifolium, and gallium apa It is selected from the group consisting of line (Galium aparine). [Selected figure] Figure 1 [Other] On the same date, we have submitted the applicant's name change notification.

Description

  The present invention relates to a composition for topical application. In particular, the present invention relates to a composition for topical application containing colloidal silver and a combination of plant extracts for use as a cosmetic and / or a medicament.

  There are many skin diseases and superficial skin conditions that can be distressing to humans or animals. The distress may be due to a sensation of pain, itching, or burning. Alternatively, or additionally, the pain may be due to the unsightly appearance associated with the condition, such as redness of the skin, dry skin, or pigmentation of the skin.

  Patients who present with such symptoms often desire to relieve their distress with some form of treatment for the condition. Prescription or over-the-counter medications may be used as one of the options to address these conditions. However, there is a consumer demand for natural remedies, ie drug-free therapies.

  If these conditions can affect only a portion of the patient's body surface, there is consumer demand for topical rather than systemic approaches to address skin disorders or superficial skin conditions. One such suitable approach may be the topical application of treatments that may alleviate or reduce skin disorders or superficial skin conditions.

  Accordingly, a composition suitable for topical application to skin diseases and / or superficial skin conditions, which may optionally at least partially reduce pain, itching, burning, skin redness, dry skin, or skin pigmentation. Is needed.

According to a first aspect of the present invention there is provided a composition for topical application comprising a base, elemental silver as a colloidal suspension dispersed in the base, and Echinacea purpurea, Stellaria.・ Stellaria media, Aloe vera, Matricaria recutita, Hypericum perforatum, Calendula officinalis, Equisetum arvense Symphytum officinale, Panax ginseng, Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Chelidonium majus (Thuja occid entalis), Urtica dioica, Mahonia aquifolium, and a plant extract derived from at least six species of plants selected from the group consisting of Gallium aparine (Galium aparine),
There is provided a composition for topical application comprising:

According to a further aspect, the following is provided.
2) The composition comprises 80% to 99.9% of the composition by volume of the base,
1 × 10 ⁻⁵ % to 1 × 10 ⁻² % by weight of the composition of elemental silver is included,
Comprising 0.1% to 10% by weight of the composition of a plant extract,
The composition according to 1).

  3) The composition according to 1) or 2), wherein the composition is an aqueous suspension, a cream, an ointment, a spray liquid, a gel or an aerosol.

  4) The composition according to 3), wherein the composition is an aqueous suspension and the base is water.

5) The composition is essentially
1 × 10 ⁻⁵ % to 1 × 10 ⁻² % by weight of the composition of silver element;
0.1% to 10% by weight of the composition of the plant extract,
Up to 100% water as the balance of the composition,
The composition according to 4), which comprises

6) The plant extract is an extract in an extractant selected from C _{1 to} C ₄ alkanols, acetic acid, glycerin, propylene glycol, honey, water, and mixtures thereof, any of 1) to 5). The composition according to claim 1.

  7) The composition according to 6), wherein the extractant comprises aqueous ethanol.

  8) The composition according to 6) or 7), wherein the plant extract is an extract of plant material in which the weight / volume ratio of the plant material and the extractant is 1: 1 to 1:12.

  9) The composition according to any one of 1) to 5), wherein the extract is an extract containing no extractant.

  10) The plant extracts are Exetum arbense, Rumex crispas, Arctium trumpet, Trifolium platense, Keridonium majus, Tuya occidentalis, Ultica dioica, Sinfitum officinale, Mahonia aquifolium, Echinacea purpurea, The composition according to any one of 1) to 9), which is derived from Stellaria media, gallium aparine, aloe vera, Matricaria rectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng.

  11) The plant extract is derived from Exetam albense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe Vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Panax ginseng 1) To 9).

  12) The plant extract is derived from Symphytum officinale, Echinacea purpurea, Aloe vera, Matricaria rectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng, according to any one of 1) to 9). Composition.

  13) The composition according to any one of 1) to 9), wherein the plant extract is derived from gallium aparine, aloe vera, Matricaria lectina, Hypericum perforatum, calendula officinalis, and Panax ginseng.

  14) The plant extract is derived from Keridonium majus, Tuya occipientaris, Echinacea purpurea, gallium aparine, Matricaria rectita, Hypericum perforatum, and Calendula officinalis, and described in any one of 1) to 9). Composition.

  15) The plant extract is derived from Exetum albense, Symphytum officinale, Mahonia aquifolium, Matricaria rectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng, and any of 1) to 9). The composition according to.

  16) The composition according to any one of 1) to 9), wherein the plant extract is derived from Arctium trumpet, Echinacea purpurea, Stellaria media, Matricaria rectita, Hypericum perforatum, and Calendula officinalis.

  17) The composition according to any one of 1) to 9), wherein the plant extract is derived from Keridonium majus, Tuya occidentalis, Mahonia aquifolium, Aloe vera, Matricaria rechita, and Calendula officinalis. object.

  18) The plant extract is derived from Arctium trumpet, Ultica dioica, Echinacea purpurea, Stellaria media, Matricaria rechita, Hypericum perforatum, and Calendula officinalis, and described in any one of 1) to 9). Composition.

  19) The plant extract is derived from Ultica dioica, Sinfitum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria rechita, and Calendula officinalis, and described in any one of 1) to 9). Composition.

  20) The plant extracts are Ultica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Aloe Vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The composition according to any one of 1) to 9), which is derived.

  21) The plant extract is derived from Rumex crispas, Arctium trumpet, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng. 1 ) To 9).

  22) The plant extract is derived from Ultica dioica, Sinfitum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria rectita, and Calendula officinalis, and is described in any one of 1) to 9). Composition.

  23) The plant extract is derived from Rumex crispas, Arctium rappa, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Matricaria rechita, and Calendula officinalis 1) -9). The composition according to any one of 1.

  24) The composition according to any one of 1) to 23), which is a cosmetic composition.

  25) The composition according to any one of 1) to 23) used as a drug.

  26) The composition according to any one of 1) to 10), which is used for treating dermatitis.

  27) The composition according to any of 1) to 9) or 11), which is used for treating cut skin.

  28) The composition according to any one of 1) to 9) or 12), which is used for treating burns.

  29) The composition according to any one of 1) to 9) or 13), which is used for treatment of sunburn.

  30) The composition according to any one of 1) to 9) or 14) used for treating tinea pedis.

  31) The composition according to any one of 1) to 9) or 15), which is used for treating blisters.

  32) The composition according to any one of 1) to 9) or 18) used for treating insect bites.

  33) The composition according to any one of 1) to 9) or 19) used for treating inflammatory diaper dermatitis.

  34) The composition according to any one of 1) to 9) or 20) used for treating contact dermatitis associated with incontinence.

35) A method for producing a composition for topical application, the method comprising:
Exetam Albense, Rumex Crispas, Arctium Rappa, Trifolium platense, Keridonium majus, Tuya Occidentalis, Ultica Dioica, Symfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Gallium Providing a plant extract derived from at least 6 plants selected from the group consisting of: Aloe vera, Matricaria lectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng,
A colloidal suspension of elemental silver suspended in a base, wherein the content of the elemental silver in the colloidal suspension is from 1 × 10 ⁻⁵ % to 1 × 10 ⁻² % of the base by weight / volume ratio. Is to prepare a colloidal suspension of elemental silver,
Mixing the plant extract with a colloidal suspension of elemental silver to provide a composition for topical application;
Including the method.

  36) The method according to 35), wherein the base is water.

  37) The plant extract and the colloidal suspension of elemental silver are mixed at a weight-volume ratio of 1:20 to 1: 4, and the mixture of the plant extract and the colloidal suspension of elemental silver is mixed 35) or 36). The method described.

  38) A dressing containing the composition according to any one of 1) to 34).

  39) A porous sheet impregnated with the composition according to any one of 1) to 34).

40) A method of treating an affected area of a skin disease, the method comprising:
Providing the composition according to any one of 1) to 34);
Topically applying the composition to the affected area of the skin disorder,
Including the method.

41) A non-therapeutic beauty method,
Providing the composition according to any one of 1) to 34);
Selecting the body part to which the composition is to be applied,
Topically applying the composition to a selected site,
Including beauty methods.

  Further features and advantages of the invention will become apparent from the following description of a preferred embodiment of the invention, which is merely an example and with reference to the accompanying drawings.

It is a figure which shows the test subject who presents an open wound. It is a figure which shows the time-dependent change of the external appearance of the wound of FIG. 1 after applying the composition of this invention to an affected part. It is a figure which shows the time-dependent change of the external appearance of the wound of FIG. 1 after applying the composition of this invention to an affected part. It is a figure which shows the time-dependent change of the external appearance of the wound of FIG. 1 after applying the composition of this invention to an affected part. It is a figure which shows the time-dependent change of the appearance of a bruise after applying the composition of this invention to an affected part. It is a figure which shows the time-dependent change of the appearance of a bruise after applying the composition of this invention to an affected part. It is a figure which shows the test subject who has two insect bites on the skin. It is a figure which shows the time-dependent change of the appearance of the insect bite of FIG. 7 after applying the composition of this invention to an affected part. It is a figure which shows the time-dependent change of the appearance of the insect bite of FIG. 7 after applying the composition of this invention to an affected part. It is a figure which shows the test subject who presents an open wound. FIG. 11 is a diagram showing changes over time in the appearance of the wound of FIG. 10 after applying the composition of the present invention to the affected area. FIG. 11 is a diagram showing changes over time in the appearance of the wound of FIG. 10 after applying the composition of the present invention to the affected area.

  In the present specification and claims, the volume ratio or volume percentage may be represented by “(v / v)”. The weight volume ratio or the weight volume percentage may be represented by "(w / v)". The weight ratio or weight percentage may be represented by "(w / w)". Unless otherwise specified, ratios or percentages are, where appropriate, given to the total weight or volume of the composition.

The unit "ppm" refers to "parts per million" and is sometimes used herein to describe the concentration of a substance in a fluid phase. Unless otherwise specified, all values given in ppm are given as weight volume (w / v) percentages. Therefore, 1 ppm is equal to 1 × 10 ⁻⁴ % (w / v).

  The composition of the present invention is suitable for topical application. That is, the composition may be applied to a body surface such as skin or mucous membranes.

Base The composition comprises a base, ie a carrier. The base is used as an excipient for the other components of the composition. For the avoidance of doubt, the term “base” used herein does not mean a Bronsted-Lowry base or a Lewis base.

Preferably, the base is a pharmaceutically acceptable base. The nature of the base can influence the formulation of the composition. For example, suitable bases, water may include (particularly, distillation, ion exchange, reverse osmosis, or other water purified by suitable methods), or a mixture of water and C ₁ -C ₄ alkanol. Compositions containing such bases may suitably provide topical applicable aqueous suspension formulations. Depending on the ratio of water to C ₁ -C ₄ alkanol, the topically applicable aqueous suspension is more suitable for spray application (ie the suspension is applied to the skin as droplets in an aerosol). In some cases, it may be more suitable for manual application (ie, the user applies the suspension to the skin or mucous membranes using a cloth, pad, or body part such as the hand).

  In another example, a suitable base can be an oil or an oil-water emulsion. In some embodiments, the base can be an ointment base.

  Any suitable ointment base may be used. Suitable ointment bases may include oily bases. Typically, oily bases may include solid paraffin, soft paraffin (also known as petroleum jelly, petrolatum, white petrolatum, or multiple hydrocarbons), microcrystalline wax, or ceresin. Typically, such bases are anhydrous or have a low water content. These bases may additionally contain film-forming agents, which give rise to a protective film after application to the skin. Suitable film forming agents include polyvinylpyrrolidone, polyvinyl alcohol, and cellulose derivatives.

  Another suitable ointment base may include a water-absorbent base (also known as an emulsion base). Typically, the water-absorptive base comprises any of the above-mentioned oily base and water-in-oil type surfactant, or hydrophilic oil-based base, and a water-in-oil type emulsion upon addition of water. Allows liquid to form. Such bases may include any of the oily bases described above and / or components selected from lanolin, beeswax, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, and sodium lauryl ether sulfate. Suitable water-absorbing bases include hydrophilic petrolatum, anhydrous lanolin, Aquabase (R), Aquaphor (R), and Polysorb (R).

  Another suitable ointment base may include a water-in-oil emulsion base. Typically, a water-in-oil emulsion base comprises water and any of the ointment base components described above. In particular, water-in-oil emulsion bases typically include a water-in-oil surfactant. Suitable water-in-oil emulsion bases include, for example, cold cream, hydrous lanolin, rose perfume ointment, aqueous creams, Hydrocream®, Eucerin®, and Nivea®. Nivea) (registered trademark) and the like.

  Another suitable ointment base may include an oil-in-water emulsion base. Typically, the oil-in-water emulsion base comprises more water than the water in the water-in-oil emulsion base and any of the ointment base components described above. In particular, oil-in-water emulsion bases typically include an oil-in-water surfactant. Suitable oil-in-water emulsion bases include, for example, hydrophilic ointments, Dermabase (R), Velvachol (R), and Unibase (R). To be

  Another suitable ointment base may include a water miscible ointment base. Typically, the water miscible ointment base comprises a combination of low and high molecular weight polyethylene glycols. Examples of the water-miscible ointment base include PEG ointment and Polybase (registered trademark).

  By using the composition containing such an ointment base as described above, a topically applicable ointment preparation or a topically applicable cream preparation can be appropriately provided.

In another example, the suitable base can be a gel. As used herein, the term "gel" refers to any dispersion liquid in which inorganic or organic molecules are dispersed in a liquid system, in which at least cross-linking or association exists between the inorganic or organic molecules. It refers to liquid. The gel is prepared by using water or a liquid such as an aqueous C ₁ -C ₄ alkanol, carbomer, carboxymethyl cellulose, ethyl cellulose, gelatin, hydroxyethyl cellulose, hydroxypropyl cellulose, magnesium aluminum silicate, methyl cellulose, poloxamer, polyvinyl alcohol, sodium alginate, tragacanth. , And a suitable gelling agent such as xanthan gum. Compositions containing such bases may suitably provide gel formulations for topical application.

In another example, suitable bases may include water and / or C ₁ -C ₄ alkanol, and a propellant. Suitable propellants may include hydrocarbons, hydrofluorocarbons, and compressed gases. Compositions containing such bases may suitably be used to provide a topically applicable aerosol formulation.

  The base can be present in the composition in any suitable amount. Preferably, the base comprises the majority of the components of the composition. For example, the base is present in the composition in an amount of 80-99.9% (v / v), 85-99.5% (v / v), or 90-99% (v / v). May be. The base is 99.9% (v / v) or less, 99.5% (v / v) or less, 99% (v / v) or less, 98% (v / v) or less, 97% (v / v). ) Or less, 96% (v / v) or less, 95% (v / v) or less, or 90% (v / v) or less in an amount. The base is 80% (v / v) or higher, 85% (v / v) or higher, 90% or higher, 95% (v / v) or higher, 96% (v / v) or higher, 97% (v / v). ) Or more, 98% (v / v) or more, 99% (v / v) or more, 99.5% (v / v) or more, or 99.9% (v / v) or more in the composition. May exist in.

  In a preferred embodiment, the base comprises water. In certain embodiments, the base consists essentially of water.

The silver composition also contains elemental silver as colloidal silver. That is, it contains a particulate silver element dispersed in a base material as a colloidal suspension. Silver, any suitable amount, for example, 0.1ppm~100ppm, 0.5ppm~50ppm, 1ppm~10ppm or in an amount of 5Ppm～10ppm,, ^{i.e., 1 × 10 -5 ~1 × 10} -2% ( w / v), 5 × 10 ^{−5 to} 5 × 10 ⁻³ % (w / v), 1 × 10 ⁻⁴ to 1 × 10 ⁻³ % (w / v), or 5 × 10 ⁻⁴ to 1 ×. It may be present in the composition in an amount of 10 ⁻³ % (w / v). Silver is in an amount of 100 ppm or less, 50 ppm or less, or 10 ppm or less, that is, 1 × 10 ⁻² % (w / v) or less, 5 × 10 ⁻³ % (w / v) or less, or 1 × 10 ^−3. It may be present in the composition in an amount up to% (w / v). Silver is in an amount of 0.1 ppm or more, 0.5 ppm or more, or 1 ppm or more, that is, 1 × 10 ⁻⁵ % (w / v) or more, 5 × 10 ⁻⁵ % (w / v) or more, or 1 It may be present in the composition in an amount of ^{x10 -4} % (w / v) or higher. Suitably, silver may be present in the composition in an amount of approximately 5 ppm, ie 5 × 10 ⁻⁴ % (w / v).

Plant Extract The composition according to the present invention comprises a plant extract. The plant extract refers to a substance extracted from plant material. A plant extract may be prepared by treating any plant material with an extractant and extracting at least some components of the plant material from the plant material into the extractant. The extractant can be a solvent. The resulting extractant containing at least some components extracted from the plant material is referred to herein as "plant extract". In other words, the “plant extract” may be a component extracted from the plant material by treating the plant material with an extractant.

  The plant material that has been treated with an extractant to provide the plant extract may be or be derived from any part of the plant, such as, for example, plant leaves, bark, roots, seeds or fruits. It may be one that does. In preparing the plant extract, the plant constituents extracted from the plant material are at least partially soluble or suspendable in the extractant. After treating the plant material with the extractant, the insoluble plant material may remain in the extractant or the insoluble plant material may be separated from the extractant. Insoluble plant material may be separated from the extractant by any suitable method such as, for example, decantation, filtration, or centrifugation. In a preferred embodiment of the invention the insoluble plant material is separated from the extractant. That is, the plant extract does not contain insoluble components. In a particularly preferred embodiment, the plant extract is prepared by cold osmosis extraction. Cold osmosis extraction involves charging a plant material into a perforated flask or vessel and treating the plant material with a cryogenic extractant. The resulting plant extract passes through the pores, leaving insoluble and / or non-suspended plant material in the flask or vessel.

Suitable extractants for plant extracts include any extractant that can be used to extract components from plant material, i.e. any capable of dissolving or suspending at least some of the components of plant material. The extractant of. In one embodiment, the extractant _may comprise a C 1 -C ₄ alkanol. Suitable _C 1 -C ₄ alkanols, methanol, ethanol, n- propanol, isopropanol, n- butanol, isobutanol, sec- butanol, and tert- butanol. In one embodiment, the extractant may include methanol and / or ethanol. In certain embodiments, the extractant can include ethanol.

  In another embodiment, the extractant may include acetic acid, glycerin (particularly vegetable glycerin), propylene glycol, honey, or water. The plant extract may be prepared with hot water or cold water.

The extractant may include a combination of extractants. For example, the extractant may include a combination of any of the above extractants. In certain embodiments, the extractant may comprise water _and a C 1 -C ₄ alkanol. Such combination may be referred to as an aqueous _C 1 -C ₄ alkanol. In a preferred embodiment, the extractant comprises water and ethanol. Such a combination is sometimes called aqueous ethanol.

In a further embodiment, the extractant may consist essentially of any one of the above extractants, or a combination thereof. In certain embodiments, the extraction agent, and water may be composed of a C ₁ -C ₄ alkanol. In a preferred embodiment, the extractant consists of water and ethanol.

  The ethanol content of the aqueous ethanol can be any suitable content. For example, the ethanol content of aqueous ethanol is 5 to 95% (v / v), 10 to 90% (v / v), 20 to 80% (v / v), 30 to 70% (v / v), Alternatively, it may be 40 to 60% (v / v). The ethanol content of aqueous ethanol is 5% (v / v) or higher, 10% (v / v) or higher, 20% (v / v) or higher, 30% (v / v) or higher, 40% (v / v). ) Or more, 50% (v / v) or more, 60% (v / v) or more, 70% (v / v) or more, 80% (v / v) or more, 90% (v / v) or more, or 95 % (V / v) or higher. The ethanol content of aqueous ethanol is 95% (v / v) or less, 90% (v / v) or less, 80% (v / v) or less, 70% (v / v) or less, 60% (v / v). ) Or less, 50% (v / v) or less, 40% (v / v) or less, 30% (v / v) or less, 20% (v / v) or less, 10% (v / v) or less, or 5 It may be less than or equal to% (v / v).

  A plant extract suitable for use in the present invention may be prepared by treating the plant material with an extractant in any suitable ratio. For example, the plant extract used in the present invention may have a plant material to extractant ratio of 2: 1 to 1:20 (w / v), or a plant material to extractant ratio of 1: 1 to 1 : 10 (w / v) or a ratio of plant material to extractant of 1: 2 to 1: 9 (w / v) may be prepared by treating the plant material with an extractant.

  The plant extracts suitable for use in the present invention may be referred to by various names. Suitable plant extracts for use in the present invention include, in particular, extracts (typically aqueous plant material solutions carried out with a ratio of plant material to extractant of approximately 1: 1 (w / v)). Ethanol extraction), tincture (typically aqueous ethanol extraction of plant material performed with a ratio of plant material to extractant of approximately 1: 3 to 1: 5 (w / v)), mother tincture (typically Is an aqueous ethanol extraction of plant material carried out with a ratio of plant material to extractant of approximately 1: 9 (w / v), a Tizan liquid such as a leachate (typically hot water extraction of plant material), Commercially referred to as decoction (typically water extraction of plant material carried out in boiling water for an extended period of time) and dip (typically extraction of finely chopped plant material in cold water). Products that may be.

  Suitable plant extracts for use in the present invention may be purchased from the supplier G Baldwin & Co.

  In some embodiments, the plant extract is an extract without an extractant. That is, the plant extract is prepared by the method described above, after which the extractant is removed leaving the dry matter. Dry matter may correspond only to plant constituents extracted from plant material, or derivatives thereof.

  The composition of the present invention comprises an exetam albense (also known as common horsetail, or field horsetail), lumex crispus (also known as curly dock, or yellow dock), arctium trumpet (burdock). (Also known as burdock, or greater burdock), Trifolium platense (also known as red clover), Keridonium majus (also known as greater celandine, tetterwort, nipplewort, or swallowwort) , Tuya occidentalis (also known as northern white-cedar or eastern arborvitae), Ultica dioika (also known as nettle), Symfitum officinale (comfrey), especially the common comfrey (Also known as common comfrey), Honia aquifolium (also known as Oregon grape), Echinacea purpurea, Stellaria media (also known as chickweed), Gallium aparine (also known as cleavers), aloe -Bella (also known as Aloe barbadensis), Matricaria lectita (also known as chamomile), Hypericum perforatum (also known as St John's wort), Calendula officinalis (also known as St John's wort). Calendula (also known as common marigold), and plant extracts derived from plants selected from Panax ginseng.

  In some embodiments, the composition may contain other botanical extracts in addition to the botanical extracts described above. In other embodiments, the composition may contain only the plant extracts described above and no other plant extracts.

  The composition comprises a combination of extracts derived from at least 6 plants selected from the above group. In some embodiments, the composition comprises at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, selected from the group above. It includes a combination of extracts from at least 15, at least 16, or at least 17 plants.

  Without being bound by theory, the combination of the plant extract and colloidal silver described herein differs from those corresponding to the cumulative effect of using the plant extract or colloidal silver individually. It is considered that the effect or better effect can be obtained.

  If a plant extract in the compositions described herein is always an extract derived from a combination of plants, it may be referred to as a "combination of plant extracts".

  The plant extract derived from the combination of plants can be provided as a single extract derived from the combination of plants, or can be provided as the combination of the extracts derived from individual plants. Preferably, the plant extract derived from the combination of plants is provided as a combination of the extracts derived from the individual plants. In embodiments that include a combination of extracts from individual plants, the extracts from individual plants may be referred to as the components of the combination of plant extracts.

  The composition may include the plant extract in any suitable amount. For example, the composition contains a plant extract of 0.1% to 10% (w / v), 0.25% to 5% (w / v) 0.5% to 2.5% (w / v). , Or 0.75% to 2% (w / v). The plant extract is 10% (w / v) or less, 5% (w / v) or less, 2.5% (w / v) or less, 2% (w / v) or less, or 1.5% (w / V) or less, and may be present in the composition. The plant extract is 0.1% (w / v) or more, 0.25% (w / v) or more, 0.5% (w / v) or more, 0.75% (w / v) or more, or It may be present in the composition in an amount of 1% (w / v) or higher.

  In embodiments where the plant extract is provided as a combination of extracts derived from individual plants, each component of the plant extract may be present in the composition in any suitable amount. For example, each component of the plant extract is 0.05% to 10% (w / v), 0.1% to 5% (w / v), 0.25% to 2.5% (w / v). , 0.5% to 2% (w / v), or 0.6% (w / v) to 1% (w / v), may be present in the composition. Each component of the plant extract is 10% (w / v) or less, 5% (w / v) or less, 2.5% (w / v) or less, 2% (w / v) or less, 1.5% It may be present in the composition in an amount of (w / v) or less, or 1% (w / v) or less. Each component of the plant extract is 0.05% (w / v) or more, 0.1% (w / v) or more, 0.25% (w / v) or more, 0.5% (w / v) As above, it may be present in the composition in an amount of 0.6% (w / v) or more, or 0.75% (w / v) or more.

  In an embodiment where the plant extract is provided as an extractant-free plant extract, each component of the extractant-free plant extract is 0.01% to 1% (w / v), 0.025. % -0.5% (w / v), 0.05% -0.25% (w / v), or 0.075% -0.2% (w / v) in the composition. It may exist. The plant extract contains 1% (w / v) or less, 0.5% (w / v) or less, 0.25% (w / v) or less, 0.2% (w / v) or less, or 0. It may be present in the composition in an amount up to 15% (w / v). The plant extract is 0.01% (w / v) or more, 0.025% (w / v) or more, 0.05% (w / v) or more, 0.075% (w / v) or more, or It may be present in the composition in an amount of 0.1% (w / v) or higher.

  Plant extracts derived from individual plants can be combined in any ratio with respect to each other to provide a combination of plant extracts. In some embodiments, the ratio of the maximum amount of components in the plant extract combination to the minimum amount of components in the plant extract combination may be less than 10: 1 (w / w), 8 It may be smaller than: 1 (w / w), smaller than 6: 1 (w / w), or smaller than 4: 1 (w / w).

Use of Compositions The compositions of the present invention may be suitable for human use. For example, the composition may be suitable for application to the skin and / or mucous membranes of the human body. In other embodiments, the composition may be suitable for use in non-human animals. For example, the composition may be suitable for application to the skin, mucous membranes, body hair, and / or the coat of an animal. The composition may be suitable for application to the skin, mucous membranes, hair, and / or coats of non-human animals such as fish, amphibians, reptiles, birds, and non-human mammals. In particular, the composition may be suitable for application to the skin, mucous membranes, body hair and / or the coat of domestic pets such as cats, dogs, rabbits, lizards, snakes, parrots, budgerigars. Alternatively, or additionally, the composition may be particularly suitable for application to the skin, mucous membranes, body hair, and / or coat of livestock such as cattle, pigs, sheep, horses, goats, donkeys.

  The composition of the present invention can be used as a medicine. The composition can be used as an agent for a wide range of indications such as dermatitis, psoriasis, wounds, tinea pedis (also known as athlete's foot), blisters, insect bites, and inflammation. In some cases, one combination of plant extracts may not be optimal for all treatments for a given indication. Rather, a combination of certain plant extracts may be particularly suitable for use as a drug for certain indications.

  Specific combinations and indications that these combinations are particularly suitable are described herein.

  Dermatitis is sometimes called eczema. Dermatitis includes atopic dermatitis, contact dermatitis, dry dermatitis, and seborrheic dermatitis. The compositions of the invention may be used in particular as agents against contact dermatitis, such as inflammatory diaper dermatitis (also known as diaper rash) and contact dermatitis associated with incontinence.

  Wounds include open wounds such as incisions, lacerations, abrasions, dehiscences, and punctures. Open wounds are sometimes referred to as cut skin, or cuts. Wounds also include closed wounds such as hematomas. Hematomas include contusions (also known as bruises), petechiae, purpura, and hemorrhagic spots. The composition of the present invention may be used in particular as an agent against open wounds and / or contusions. Some embodiments may improve the healing rate of such wounds.

  Burns include burns, chemical burns, and radiation burns. The compositions of the invention may be used especially as a medicament against radiation burns such as sunburn. Alternatively, or additionally, the compositions of the present invention may be used as an agent, especially against burns such as oil burns, iron burns, oven burns, and steam burns. Some embodiments may improve the healing rate of such wounds.

  The present invention also relates to methods of treating skin disorders. The method comprises providing a composition as described herein and applying the composition to the affected area. For example, the method can include providing a composition to be used as a medicament against dermatitis and applying the composition to the site of skin presenting with dermatitis. Alternatively, the method can include providing a composition to be used as a medicament against psoriasis and applying the composition to the site of skin exhibiting psoriasis. Alternatively, the method can include providing a composition to be used as a medicament for a wound and applying the composition to the wound. Alternatively, the method may include providing a composition to be used as a drug for tinea pedis and applying the composition to a site of skin presenting with tinea pedis. Alternatively, the method can include providing a composition to be used as an agent against blisters, and applying the composition to at least a portion of the surface of the blisters. Alternatively, the method may include providing a composition to be used as a medicament against insect bites and applying the composition to insect bites. Alternatively, the method may include providing a composition to be used as an agent against inflammation and applying the composition to a site of inflamed skin.

  Alternatively, or additionally, the composition of the invention may be a cosmetic composition. For example, the composition may be applied to the skin to reduce the size and / or pigmentation of bruises (also known as moles), chloasma, hyperpigmentation, skin redness, and rashes.

  The present invention also relates to non-therapeutic cosmetic methods. The method comprises providing a composition as described herein, selecting a body site to which the composition is to be applied, and topically applying the composition to the selected site. For example, the method can include providing a composition, selecting a bruise, and applying the composition to at least a portion of the surface of the bruise. Alternatively, the method may include providing a composition, selecting a melasma, and applying the composition to at least a portion of the surface of the melasma. Alternatively, the method may include providing a composition, selecting the overdye, and applying the composition to at least a portion of the surface of the overdye. Alternatively, the method may include providing a composition, selecting a skin redness area, and applying the composition to at least a portion of the surface of the skin redness. Alternatively, the method may include providing a composition, selecting a rash, and applying the composition to at least a portion of the surface of the rash.

  The composition may also be used to provide the user with a sensation in the skin and / or mucous membranes. For example, by applying the composition to the skin and / or mucous membranes, the user may perceive a cold and / or analgesic sensation.

  Alternatively, or additionally, the compositions of the invention may be used on the skin and / or hair of domestic pets such as cats, dogs.

  The composition of the present invention may be provided to the user in any form. For example, the compositions may be provided alone or in combination depending on the application. For example, in one embodiment, a dressing is provided that includes a composition described herein. In another embodiment, a perforated sheet impregnated with the compositions described herein is provided. Such an impregnated porous sheet is sometimes called a "wet tissue".

Specific Combinations of Components In certain embodiments, the composition comprises water in an amount of 80-99.9% (v / v). Further, the composition, in an amount of 0.1Ppm～100ppm ^{(i.e., 1 × 10 -5 ~1 × 10} -2% (w / v)), the silver-containing as a colloidal suspension. In addition, the composition is Exetam arbense, Rumex crispas, Arctium rappa, Trifolium platense, Keridonium majus, Tuya occhidentalis, Ultica dioica, Symfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stella. • Includes plant extracts derived from at least 6 plants selected from the group consisting of Media, Gallium aparine, Aloe Vera, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The plant extract is present in the composition in an amount of 0.1% to 10% (w / v).

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and 0.1% to 10% (w / v) plant extract. The balance consists of up to 100% water.

  In one embodiment, the plant extract comprises extracts derived from Exetam arbense, Symphytum officinale, Mahonia aquifolium, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. Or may consist of such an extract. This embodiment may be particularly suitably used as an agent against blisters.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Exetam arbense, Symfitum officinale, Mahonia aquifolium, Matricaria rectita, Hypericum. -0.1% -10% (w / v) plant extract comprising or consisting of extracts derived from perforatum, Calendula officinalis, and Panax ginseng, and composition The balance may be up to 100% water.

  In one embodiment, the botanical extract may include extracts from Arctium trumpet, Echinacea purpurea, Stellaria media, Matricaria rectita, Hypericum perforatum, and Calendula officinalis, and so on. It may consist of an extract. This embodiment may be particularly suitably used as a cosmetic composition applied to skin spots.

In a further embodiment, the composition comprises from 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver with Arctium trumpet, Echinacea purpurea, Stellaria media, Matricaria lectina, Hypericum perforatum. , And 0.1% to 10% (w / v) plant extract comprising or consisting of an extract derived from Calendula officinalis, and up to 100% as the balance of the composition. It may be composed of water.

  In one embodiment, the plant extract may include extracts derived from Symphytum officinale, Echinacea purpurea, Aloe Vera, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng. However, it may consist of such an extract. This embodiment may be particularly suitable for use as a drug against burns.

In a further embodiment, the composition comprises from 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver with Synfitum officinale, Echinacea purpurea, Aloe vera, Matricaria lectina, Hypericum perforatum. 0.1% to 10% (w / v) plant extract comprising, or consisting of, extracts derived from Calendula officinalis, and Panax ginseng, and the balance of the composition May consist of up to 100% water.

  In one embodiment, the botanical extracts may include extracts derived from gallium aparine, aloe vera, matricaria lectita, hypericum perforatum, calendula officinalis, and panax ginseng, and so on. It may consist of an extract. This embodiment may be particularly suitable for use as an agent against sunburn.

In a further embodiment, the composition comprises from 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and gallium aparine, aloe vera, Matricaria rechita, Hypericum perforatum, Calendula officis. 0.1% to 10% (w / v) plant extract comprising or consisting of extracts derived from Naris and Panax ginseng, and up to 100% as the balance of the composition It may be composed of water.

  In one embodiment, the botanical extract is Exetum arbense, Rumex crispas, Arctium trumpet, Trifolium platense, Keridonium majus, Tuya occidentalis, Ultica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea. • It may include extracts derived from purpurea, stellaria media, gallium aparine, aloe vera, matricaria lectina, hypericum perforatum, calendula officinalis, and panax ginseng. This embodiment may be particularly suitably used as a drug against eczema.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Exetam albense, Rumex crispas, Arctium trumpet, Trifolium platense, Keridonium. Majus, Tuya Occidentalis, Ultica Dioika, Symfitum officinale, Mahonia Aquifolium, Echinacea purpurea, Stellaria Media, Galleria Aprine, Aloe Vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Calendula officinalis. 0.1% to 10% (w / v) plant extract comprising or consisting of an extract derived from Panax ginseng, with the balance of the composition being up to 100% water. Consists of It may be.

  In one embodiment, the botanical extract is derived from Exetam arbense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe Vera, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng. It may contain an extract or may consist of such an extract. This embodiment may be particularly suitably used as a drug for open wounds.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Exetam arbense, Symfitum officinale, Echinacea purpurea, Stellaria media, Aloe vera. %, 10% (w / v) plants comprising or consisting of extracts derived from S. mori, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng. It may consist of the extract and up to 100% water as the balance of the composition.

  In one embodiment, the plant extract may include extracts derived from Keridonium majus, Tuya occipientaris, Echinacea purpurea, gallium aparine, Matricaria lectina, Hypericum perforatum, and Calendula officinalis. However, it may consist of such an extract. This embodiment may be particularly suitably used as a drug against tinea pedis.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Kelidonium majus, Tuya occipientalis, Echinacea purpurea, Gallium aparine, Matricaria lectita. 0.1% to 10% (w / v) plant extract comprising, or consisting of, an extract derived from, Hypericum perforatum, and Calendula officinalis, and the balance of the composition May consist of up to 100% water.

  In one embodiment, the botanical extract may include extracts from Keridonium majus, Tuya occidentalis, Mahonia aquifolium, aloe vera, Matricaria recutita, and Calendula officinalis, It may consist of such an extract. This embodiment may be particularly suitably used as a cosmetic composition applied to bruises.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Kelidonium majus, Tuya occidentalis, Mahonia aquifolium, Aloe vera, Matricaria. Rectita, and 0.1% to 10% (w / v) plant extract comprising or consisting of an extract derived from Calendula officinalis and 100 as the balance of the composition. % Of water.

  In one embodiment, the botanical extract may include extracts from Arctium trumpet, Ultica dioica, Echinacea purpurea, Stellaria media, Matricaria recutita, Hypericum perforatum, and Calendula officinalis. However, it may consist of such an extract. This embodiment may be particularly suitably used as a drug against insect bites.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Arctium rappa, Ultica dioica, Echinacea purpurea, Stellaria media, Matricaria lectita. 0.1% to 10% (w / v) plant extract comprising, or consisting of, an extract derived from, Hypericum perforatum, and Calendula officinalis, and the balance of the composition May consist of up to 100% water.

  In one embodiment, the plant extract may include extracts derived from Ultica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria lectina, and Calendula officinalis. However, it may consist of such an extract. This embodiment may be particularly suitably used as a drug against inflammatory diaper dermatitis.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Ultica dioica, Symfitum officinale, Echinacea purpurea, Stellaria media, Aloe vera. %, 10% (w / v) plant extract comprising, or consisting of, extracts derived from S., Matricaria lectitia, and Calendula officinalis, and the balance of the composition May consist of up to 100% water.

  In one embodiment, the botanical extract is Ultica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Aloe Vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and It may contain an extract derived from Panax ginseng, or may consist of such an extract. This embodiment may be particularly suitably used as an agent against contact dermatitis resulting from incontinence.

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Ultica dioica, Synfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria. 0.1% -10% containing or consisting of extracts derived from Media, Aloe Vera, Matricaria lectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng ( w / v) plant extract and the balance of the composition up to 100% water.

  In one embodiment, the botanical extract is derived from Rumex crispas, Arctium rappa, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The extract may be included or may be composed of such an extract. This embodiment may be particularly suitably applied to the skin and hair of domestic pets.

In a further embodiment, the composition comprises from 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Rumex crispas, Arctium trumpet, Trifolium platense, Symfitum officinale, Echinacea. 0.1% to 10% (w / v) containing or consisting of extracts derived from Purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng. It may consist of a plant extract and up to 100% water as the balance of the composition.

  In one embodiment, the plant extract may include extracts derived from Ultica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria lectina, and Calendula officinalis. However, it may consist of such an extract. This embodiment may be particularly suitably included in a perforated sheet (also known as wet tissue).

In a further embodiment, the composition comprises 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Ultica dioica, Symfitum officinale, Echinacea purpurea, Stellaria media, Aloe vera. %, 10% (w / v) plant extract comprising, or consisting of, extracts derived from S., Matricaria lectitia, and Calendula officinalis, and the balance of the composition May consist of up to 100% water.

  In one embodiment, the plant extract is an extract derived from Lumex crispas, Arctium rappa, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Matricaria rechita, and Calendula officinalis. It may be contained or may consist of such an extract. This embodiment may be particularly suitably included in a perforated sheet (also known as wet tissue) for application to the skin and hair of domestic pets.

In a further embodiment, the composition comprises from 1 × 10 ⁻⁵ to 1 × 10 ⁻² % (w / v) elemental silver and Rumex crispas, Arctium trumpet, Trifolium platense, Symfitum officinale, Echinacea. 0.1% to 10% (w / v) plant extract comprising or consisting of extracts derived from Purpurea, Stellaria media, Matricaria lectina, and Calendula officinalis. , The balance of the composition being up to 100% water.

Method of Preparing the Composition The composition according to the present invention may be manufactured by any suitable method. One suitable method is Exetam arbense, Rumex crispas, Arctium trumpet, Trifolium platense, Keridonium majus, Tuya occidentalis, Ultica dioica, Symfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stella. -A plant extract derived from at least 6 plants selected from the group consisting of Media, Gallium aparine, Aloe Vera, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng is provided. . The method further comprises providing a colloidal suspension of silver suspended in the base, wherein the colloidal suspension has a silver content of 0.1 ppm to 100 ppm (ie 1 × 10 ^{− of the} base). ⁵ % to 1 × 10 ⁻² % (w / v)). The plant extract and colloidal suspension are then mixed to provide a composition for topical application.

  The base can be any of the bases described herein. In one embodiment, the base is water.

  The botanical extract and the colloidal suspension of silver can be mixed in any suitable ratio. In one embodiment, they have a ratio of plant extract to colloidal silver suspension of 1:20 to 1: 4 (w / v), 1:15 to 1: 6, or 1:12 to 1 :. 8, mixed. In one embodiment, they are mixed in a ratio of plant extract to colloidal silver suspension of about 1: 9 (w / v).

In Examples 1 to 14, compositions for topical application containing a plant extract prepared by extracting the plant material with aqueous ethanol, with the weight ratio of the plant material to aqueous ethanol being 1: 1. Things are offered. The ratio of ethanol to water in the aqueous ethanol (that is, the ethanol content) in each extract is as follows.

Example 1
This is an example of a composition applied to blisters.

  Exetam arbense (0.20 mL), Symfitum officinale (0.40 mL), Mahonia aquifolium (0.20 mL), Matricaria rectita (0.20 mL), Hypericum perforatum (0.12 mL), Calendula offici Naris (0.20 mL) and an aqueous extract of Panax ginseng (0.20 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 2
This is an example of a composition applied to skin spots.

  Arctium trumpet (0.20 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.20 mL), Matricaria rectita (0.20 mL), Hypericum perforatum (0.12 mL), and Calendula officinalis. The (0.12 mL) aqueous extract was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 3
This is an example of a composition applied to skin burns.

  Symphytum officinale (0.28 mL), Echinacea purpurea (0.12 mL), Aloe Vera (0.20 mL), Matricaria rectita (0.20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis ( 0.20 mL) and an aqueous extract of Panax ginseng (0.28 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 4
This is an example of a composition applied to eczema.

  Exetam arbense (0.20 mL), Lumex crispas (0.20 mL), Arctium trumpet (0.08 mL), Trifolium platense (0.28 mL), Keridonium majus (0.08 mL), Tuya occidentalis ( 0.08mL), Ultica Dioca (0.12mL), Symfitum officinale (0.20mL), Mahonia aquifolium (0.20mL), Echinacea purpurea (0.20mL), Stellaria media (0.28mL) ), Gallium aparine (0.28 mL), aloe vera (0.20 mL), Matricaria rectita (0.20 mL), Hypericum perforatum (0.12 mL), calendula officinalis (0.12 mL), and Panak An aqueous extract of Sujin (0.20 mL) was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 5
This is an example of a composition applied to cuts.

  Exetam arbense (0.20 mL), Symfitum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.12 mL), Aloe vera (0.20 mL), Matricaria recutita (0) 0.12 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.28 mL) aqueous extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 6
This is an example of a composition applied to tinea pedis (athletes).

  Keridonium majus (0.04mL), Tuya occipientaris (0.20mL), Echinacea purpurea (0.12mL), gallium aparine (0.40mL), Matricaria rectita (0.40mL), Hypericum perforatum (0) .12 mL) and an aqueous extract of Calendula officinalis (0.28 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 7
This is an example of a composition applied to tans.

  Gallium aparine (0.20 mL), Aloe Vera (0.28 mL), Matricaria lectita (0.20 mL), Hypericum perforatum (0.28 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.20 mL) of aqueous extract was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 8
This is an example of a composition applied to moles.

  Keridonium majus (0.12 mL), Tuya occipientaris (0.28 mL), Mahonia aquifolium (0.20 mL), Aloe Vera (0.30 mL), Matricaria lectita (0.20 mL), and calendula. The aqueous extract of Officinalis (0.28 mL) was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 9
This is an example of a composition applied to insect bites.

  Arctium Rappa (0.20 mL), Ultica Dioca (0.28 mL), Echinacea purpurea (0.28 mL), Stellaria Media (0.20 mL), Matricaria Rectita (0.12 mL), Hypericum perforatum (0) .20 mL) and an aqueous extract of Calendula officinalis (0.28 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 10
This is an example of a composition applied to inflammatory diaper dermatitis.

  Ultica Dioca (0.20 mL), Symfitum officinale (0.28 mL), Echinacea purpurea (0.28 mL), Stellaria media (0.20 mL), Aloe Vera (0.28 mL), Matricaria lectita (0) 0.28 mL) and an aqueous extract of Calendula officinalis (0.28 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 11
This is an example of a composition used in the treatment of contact dermatitis associated with incontinence.

  Ultica Dioca (0.20 mL), Symfitum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Mahonia aquifolium (0.12 mL), Stellaria media (0.20 mL), Aloe Vera (0.28 mL), Matricaria rectita (0.28 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.28 mL), and Panax ginseng (0.28 mL) aqueous extracts in containers. Mixed in. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 12
This is an example of a composition applied to the skin of domestic pets.

  Lumex Crispas (0.20 mL), Arctium Rappa (0.20 mL), Trifolium platense (0.20 mL), Symfitum officinale (0.12 mL), Echinacea purpurea (0.20 mL), Stellaria media ( 0.12 mL), Hypericum perforatum (0.12 mL), Calendula officinalis (0.12 mL), and Panax ginseng (0.12 mL) aqueous extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 13
This is an example of a composition suitable to be provided in combination depending on the application, for example, by impregnating a porous sheet with the composition.

  Ultica Dioca (0.20 mL), Symfitum officinale (0.28 mL), Echinacea purpurea (0.20 mL), Stellaria media (0.20 mL), Aloe Vera (0.28 mL), Matricaria rechita (0 0.28 mL) and an aqueous extract of Calendula officinalis (0.28 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

Example 14
This is an example of a composition suitable for being provided in combination depending on the application, for example, by impregnating a porous sheet with a composition suitable for use in household pets.

  Lumex Crispas (0.20 mL), Arctium Rappa (0.20 mL), Trifolium platense (0.20 mL), Symfitum officinale (0.12 mL), Echinacea purpurea (0.20 mL), Stellaria media ( 0.12 mL), Matricaria lectina (0.12 mL), and an aqueous extract of Calendula officinalis (0.12 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

In Examples 15 to 28, a topically applicable composition containing a mother tincture prepared by extracting plant material with aqueous ethanol was used, in which the weight-volume ratio of plant material to aqueous ethanol was 1: 9. Provided. The ratio of ethanol to water in the aqueous ethanol (that is, the ethanol content) in each extract is as follows.

Example 15
This is an example of a composition applied to blisters.

  Exetam arbense (0.32 mL), Symphytum officinale (0.40 mL), Mahonia aquifolium (0.32 mL), Matricaria rectita (0.32 mL), Hypericum perforatum (0.20 mL), Calendula offici Naris (0.32 mL) and Panax ginseng (0.20 mL) aqueous ethanol extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 16
This is an example of a composition applied to skin spots.

  Arctium trumpet (0.32 mL), Echinacea purpurea (0.40 mL), Stellaria media (0.32 mL), Matricaria rectita (0.32 mL), Hypericum perforatum (0.20 mL), and Calendula officinalis. (0.20 mL) aqueous ethanol extract was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 17
This is an example of a composition applied to skin burns.

  Symphytum officinale (0.40 mL), Echinacea purpurea (0.20 mL), Aloe Vera (0.32 mL), Matricaria rectita (0.32 mL), Hypericum perforatum (0.32 mL), Calendula officinalis ( 0.32 mL), and Panax ginseng (0.40 mL) aqueous ethanol extract were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 18
This is an example of a composition applied to eczema.

  Exetam Albense (0.32 mL), Lumex Crispas (0.32 mL), Arctium Rappa (0.08 mL), Trifolium Platense (0.40 mL), Keridonium Majus (0.08 mL), Tuya Occidentalis ( 0.08mL), Ultica Dioca (0.20mL), Symfitum officinale (0.32mL), Mahonia aquifolium (0.32mL), Echinacea purpurea (0.20mL), Stellaria media (0.40mL) ), Gallium aparine (0.40 mL), aloe vera (0.32 mL), Matricaria rectita (0.32 mL), Hypericum perforatum (0.20 mL), calendula officinalis (0.20 mL), and Panak Aqueous ethanolic extract of S. ginseng (0.32 mL) was mixed in the container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 19
This is an example of a composition applied to cuts.

  Exetam Albense (0.32 mL), Symfitum officinale (0.40 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.20 mL), Aloe Vera (0.32 mL), Matricaria recutita (0) .20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.40 mL) aqueous ethanol extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 20
This is an example of a composition applied to tinea pedis (athletes).

  Keridonium majus (0.12mL), Tuya occipientaris (0.32mL), Echinacea purpurea (0.20mL), gallium aparine (0.40mL), Matricaria lectita (0.40mL), Hypericum perforatum (0) .20 mL) and an aqueous ethanol extract of Calendula officinalis (0.40 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 21
This is an example of a composition applied to tans.

  Gallium aparine (0.32 mL), Aloe Vera (0.40 mL), Matricaria lectita (0.32 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.32 mL) aqueous ethanol extract was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 22
This is an example of a composition applied to moles.

  Keridonium majus (0.20 mL), Tuya okdendentalis (0.40 mL), Mahonia aquifolium (0.20 mL), Aloe Vera (0.20 mL), Matricaria lectita (0.20 mL), and calendula. The aqueous ethanolic extract of Officinalis (0.40 mL) was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 23
This is an example of a composition applied to insect bites.

  Arctium Rappa (0.32 mL), Ultica Dioca (0.40 mL), Echinacea purpurea (0.40 mL), Stellaria Media (0.32 mL), Matricaria Rectita (0.20 mL), Hypericum perforatum (0) .32 mL) and an aqueous ethanol extract of Calendula officinalis (0.40 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 24
This is an example of a composition applied to inflammatory diaper dermatitis.

  Ultica Dioca (0.32mL), Symfitum officinale (0.40mL), Echinacea purpurea (0.32mL), Stellaria media (0.32mL), Aloe Vera (0.40mL), Matricaria lectita (0) .40 mL) and an aqueous ethanol extract of Calendula officinalis (0.40 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 25
This is an example of a composition used in the treatment of contact dermatitis associated with incontinence.

  Ultica dioica (0.32mL), Symfitum officinale (0.40mL), Mahonia aquifolium (0.20mL), Echinacea purpurea (0.40mL), Stellaria media (0.32mL), Aloe vera (0.32 mL), Matricaria rectita (0.40 mL), Hypericum perforatum (0.32 mL), Calendula officinalis (0.32 mL), and Panax ginseng (0.40 mL) aqueous ethanol extracts in containers Mixed in. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 26
This is an example of a composition applied to the skin of domestic pets.

  Lumex crispas (0.32mL), Arctium trumpet (0.32mL), Trifolium platense (0.32mL), Symfitum officinale (0.20mL), Echinacea purpurea (0.32mL), Stellaria media (0.32mL) 0.20 mL), Hypericum perforatum (0.20 mL), Calendula officinalis (0.20 mL), and Panax ginseng (0.20 mL) aqueous ethanol extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 27
This is an example of a composition suitable to be provided in combination depending on the application, for example, by impregnating a porous sheet with the composition.

  Ultica Dioca (0.20 mL), Symfitum officinale (0.40 mL), Echinacea purpurea (0.32 mL), Stellaria media (0.32 mL), Aloe Vera (0.40 mL), Matricaria recutita (0) .40 mL) and an aqueous ethanol extract of Calendula officinalis (0.40 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

Example 28
This is an example of a composition suitable for being provided in combination depending on the application, for example, by impregnating a porous sheet with a composition suitable for use in household pets.

  Lumex crispas (0.32mL), Arctium trumpet (0.32mL), Trifolium platense (0.32mL), Symfitum officinale (0.20mL), Echinacea purpurea (0.32mL), Stellaria media (0.32mL) 0.20 mL), Matricaria lectina (0.20 mL), and Calendula officinalis (0.20 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

  In Examples 29 to 42, topically applicable compositions comprising a plant tincture prepared by extracting the plant material with aqueous ethanol, with a weight-volume ratio of the plant material to aqueous ethanol of 1: 3. Will be provided. The ratio of ethanol to water in the aqueous ethanol (that is, the ethanol content) in each extract is as shown in Table 1 above.

Example 29
This is an example of a composition applied to blisters.

  Exetam arbense (0.60 mL), Symfitum officinale (0.40 mL), Mahonia aquifolium (0.60 mL), Matricaria rectita (0.60 mL), Hypericum perforatum (0.40 mL), Calendula offici Naris (0.60 mL) and an aqueous extract of Panax ginseng (0.20 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 30
This is an example of a composition applied to skin spots.

  Arctium Rappa (0.60 mL), Echinacea purpurea (0.40 mL), Stellaria Media (0.60 mL), Matricaria rechita (0.60 mL), Hypericum perforatum (0.40 mL), and Calendula officinalis. The aqueous extract (0.40 mL) was mixed in the vessel. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 31
This is an example of a composition applied to skin burns.

  Symfitum officinale (0.80 mL), Echinacea purpurea (0.40 mL), Aloe Vera (0.60 mL), Matricaria rectita (0.60 mL), Hypericum perforatum (0.60 mL), Calendula officinalis ( 0.60 mL) and an aqueous extract of Panax ginseng (0.80 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 32
This is an example of a composition applied to eczema.

  Exetam arbense (0.60 mL), Lumex crispas (0.60 mL), Arctium trumpet (0.04 mL), Trifolium platense (0.80 mL), Keridonium majus (0.04 mL), Tuya okdendentalis ( 0.04mL), Ultica Dioca (0.40mL), Symfitum officinale (0.60mL), Mahonia aquifolium (0.60mL), Echinacea purpurea (0.20mL), Stellaria media (0.80mL) ), Gallium aparine (0.80 mL), aloe vera (0.60 mL), Matricaria rectita (0.60 mL), Hypericum perforatum (0.40 mL), calendula officinalis (0.40 mL), and Panak An aqueous extract of Sujin (0.60 mL) was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 33
This is an example of a composition applied to cuts.

  Exetam Albense (0.60 mL), Symfitum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.40 mL), Aloe Vera (0.60 mL), Matricaria recutita (0) .40 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.80 mL), and Panax ginseng (0.80 mL) aqueous extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 34
This is an example of a composition applied to tinea pedis (athletes).

  Kelidonium majus (0.20 mL), Tuya occipientaris (0.60 mL), Echinacea purpurea (0.40 mL), gallium aparine (0.40 mL), Matricaria rectita (0.40 mL), Hypericum perforatum (0) .40 mL) and an aqueous extract of Calendula officinalis (0.80 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 35
This is an example of a composition applied to tans.

  Gallium aparine (0.60 mL) Aloe Vera (0.80 mL), Matricaria lectita (0.60 mL), Hypericum perforatum (0.80 mL), Calendula officinalis (0.80 mL), and Panax ginseng (0.80 mL) 0.60 mL) of the aqueous extract was mixed in the vessel. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 36
This is an example of a composition applied to moles.

  Keridonium majus (0.40 mL), Tuya okdendentalis (0.80 mL), Mahonia aquifolium (0.20 mL), Aloe Vera (0.20 mL), Matricaria lectita (0.20 mL), and calendula. The aqueous extract of Officinalis (0.80 mL) was mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 37
This is an example of a composition applied to insect bites.

  Arctium Rappa (0.60 mL), Ultica Dioika (0.80 mL), Echinacea purpurea (0.80 mL), Stellaria Media (0.60 mL), Matricaria Rectita (0.40 mL), Hypericum perforatum (0) .60 mL) and an aqueous extract of Calendula officinalis (0.60 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 38
This is an example of a composition applied to inflammatory diaper dermatitis.

  Ultica dioica (0.60 mL), Symfitum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.60 mL), Aloe Vera (0.80 mL), Matricaria rechita (0) .80 mL) and an aqueous extract of Calendula officinalis (0.80 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 39
This is an example of a composition used in the treatment of contact dermatitis associated with incontinence.

  Ultica Dioca (0.60 mL), Symphytum Officinale (0.80 mL), Mahonia Aquifolium (0.40 mL), Echinacea purpurea (0.80 mL), Stellaria Media (0.60 mL), Aloe Vera (0.60 mL), Matricaria rectita (0.80 mL), Hypericum perforatum (0.60 mL), Calendula officinalis (0.60 mL), and Panax ginseng (0.80 mL) aqueous extract in a container. Mixed in. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 40
This is an example of a composition applied to the skin of domestic pets.

  Lumex Crispas (0.60 mL), Arctium Rappa (0.60 mL), Trifolium platense (0.60 mL), Symfitum officinale (0.40 mL), Echinacea purpurea (0.60 mL), Stellaria media ( 0.40 mL), Hypericum perforatum (0.40 mL), Calendula officinalis (0.40 mL), and Panax ginseng (0.40 mL) aqueous extracts were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was applied topically.

Example 41
This is an example of a composition suitable to be provided in combination depending on the application, for example, by impregnating a porous sheet with the composition.

  Ultica dioica (0.60 mL), Symfitum officinale (0.80 mL), Echinacea purpurea (0.60 mL), Stellaria media (0.60 mL), Aloe Vera (0.80 mL), Matricaria rechita (0) .80 mL) and an aqueous extract of Calendula officinalis (0.80 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

Example 42
This is an example of a composition suitable for being provided in combination depending on the application, for example, by impregnating a porous sheet with a composition suitable for use in household pets.

  Lumex Crispas (0.60 mL), Arctium Rappa (0.60 mL), Trifolium platense (0.60 mL), Symfitum officinale (0.40 mL), Echinacea purpurea (0.60 mL), Stellaria media ( 0.40 mL), Matricaria lectina (0.40 mL), and an aqueous extract of Calendula officinalis (0.40 mL) were mixed in a container. Then, 5 ppm of aqueous colloidal silver was added to the combination of extracts to make 100 mL, and the composition was obtained. A porous sheet was treated with the obtained composition to obtain a porous sheet (“wet tissue”) impregnated with the composition.

Description of Embodiments with Reference to the Drawings FIG. 1 shows a subject 100 having an intact skin area 110. The localized area 120 of skin exhibits an open wound 122. A photograph of this subject 100 was taken at 15:00 on day 0 of the study period prior to application of the compositions described herein.

  Exetam arbense, symfitum officinale, echinacea purpurea, stellaria media, aloe contained in 5 ppm of aqueous colloidal silver in a ratio of 3: 4: 3: 2: 3: 2: 2: 4: 4 (w / w). A composition was prepared consisting of an aqueous extract of Bella, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng (corresponding to Example 33). A skin area 120 containing the wound was selected and the composition was topically applied to the selected area. The composition was applied to area 120 regularly throughout the 8 day test period.

  FIG. 2 is a photograph of the subject 100 taken at 10:22 on the third day of the test period. The open wound 102 in the region 120 has a scab formed to form a scab wound 124.

  FIG. 3 is a photograph of subject 100, taken at 16:26 on the sixth day of the study period, showing that scabbed wound 124 in area 120 has shrunk into scabbed wound 126.

  FIG. 4 is a photograph of the subject 100 showing the appearance of the subject 100 on the 8th day of the test period. The scab wound in region 120 has completely healed to new skin 128. The new skin 128 in the skin area 120 at day 8 is similar to the intact skin 110. Therefore, Figures 1-4 demonstrate that regular application of the compositions of the present invention to open wounds can improve the rate of wound healing.

  In another example, subject 200 had a bruise on a local area 220 of the skin. The shape of the bruise was roughly circular, and it was more pigmented and darker than the surrounding normal skin color, and protruded from the surface of the skin. Keridonium majus, Tuya occidentalis, Mahonia aquifolium, aloe vera, Matricaria lectita, and 5 ppm hydrocolloid silver in a ratio of 2: 4: 1: 1: 1: 4 (w / w), and A composition consisting of an aqueous extract of Calendula officinalis was prepared (corresponding to Example 36). A skin area 220 containing the bruise was selected and the composition was topically applied to the selected area. The composition was applied periodically to selected areas throughout the 95 day test period.

  FIG. 5 is a photograph of subject 200 taken on day 80 of the test period. The subject has an area of normal skin color 210. The localized area 220 of the skin exhibits more intense pigmentation 222 than the normal skin color 210. In addition, the darker pigmentation 222 protrudes from the surrounding normal skin 210. Bruise size, area 220 pigmentation, and bruise protrusion from the skin are reduced compared to the appearance of the bruise prior to application of the composition. In particular, here the local area of skin 220 contains a normal skin color 212, which was part of the bruise on day 0.

  FIG. 6 is a photograph showing the appearance of the subject 200 on the 95th day of the test period. Skin pigmentation 222 is substantially reduced. Here, skin pigmentation 222 of body region 220 is similar to normal skin color 210, and skin region 220 now includes only normal skin color 214. Moreover, there is no protrusion from the body here. Thus, Figures 5 and 6 demonstrate that regular application of the composition of the invention to bruises can reduce pigmentation and physical protrusion of the bruises.

  FIG. 7 shows a subject 300 with a normal skin color 310. Localized areas of skin 320 and 330 are red bulging skin 322 and 332 after being bitten by a newly formed mosquito. This picture of subject 300 was taken prior to topical application of the compositions described herein.

  Arctium rappa, Ultica dioica, Echinacea purpurea, Stellaria media, Matricaria rechita, Hypericum contained in 5 ppm of aqueous colloidal silver in a ratio of 3: 4: 4: 3: 2: 3: 3 (w / w). A composition was prepared consisting of perforatum and an aqueous extract of Calendula officinalis (corresponding to Example 37). Skin areas 320 and 330 exhibiting insect bites were selected and the composition was topically applied to the selected areas. The composition was applied to regions 320 and 330 regularly (three times a day) throughout the 24 hour test period.

  FIG. 8 is a photograph of subject 300 taken at 6 hours of the test period. The red-bulging skins 324 and 334 are smaller than the red-bulging skins 322 and 332. The skin color of the red swelling skins 324 and 334 is more similar to the normal skin color 310 than the red swelling skins 322 and 332.

  FIG. 9 is a photograph of the subject 300 taken at 24 hours of the test period. Red puffy skin 326 and 336 is even smaller than red puffy skin 324 and 334. The skin color of the red swelling skins 326 and 336 is more similar to the normal skin color 310 than the red swelling skins 324 and 334. Subject 300 also reported that after applying the composition, he noticed a reduced itch sensation after being bitten by a mosquito.

  Therefore, FIG. 7 to FIG. 9 show that the composition of the present invention can be applied regularly after insect bites, especially mosquito bites, to reduce the size of insect bites, redness, and itching. Has demonstrated.

  FIG. 10 shows a subject 400 having intact skin 410. The localized area of skin 420 includes a newly created open wound. The localized area of skin 420 includes two smaller areas 430 and 440. Area 430 includes a portion of open wound 432 and area 440 includes a portion of scab wound 442. This photograph of subject 400 was taken at 9:30 on day 0 of the study period prior to topical application of the compositions described herein.

  Exetam arbense, symfitum officinale, echinacea purpurea, stellaria media, aloe contained in 5 ppm of aqueous colloidal silver in a ratio of 3: 4: 3: 2: 3: 2: 2: 4: 4 (w / w). A composition was prepared consisting of an aqueous extract of Bella, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng (corresponding to Example 33). A skin area 420 containing a wound was selected and the composition was topically applied to the selected area. The composition was periodically applied to area 420 for the first 5 days of the 10 day test period.

  FIG. 11 is a photograph of the subject 400 taken at 10:12 on the third day of the test period. A portion of the open wound 432 of region 430 is scabbed and becomes part of the scab wound 434 of region 430. A portion of scabbed wound 442 in region 440 has become smaller and is now part of scabbed wound 444 in region 440. Inflammation around a portion of wounds 434 and 444 in region 420 is reduced compared to that shown in FIG.

  FIG. 12 is a photograph showing the appearance of the subject 400 at 11:17 on the 10th day of the test period. A portion of the scab wound 434 in area 430 has healed to become new skin 436 in area 430. A portion of the scab wound 444 in area 440 has healed to become new skin 446 in area 440. Wounds of this size inflicted on subject 400 would typically not be expected to heal within 10 days. Thus, Figures 10-12 demonstrate that regular application of a composition of the present invention to a wound can improve the rate of wound healing.

  It should be understood that the above embodiments are illustrative of the present invention. Further embodiments of the invention are envisioned. Any feature described in connection with any one embodiment may be used alone or in combination with the other features described. It may be used in combination with one or more features of other embodiments, or may be used in combination with one or more features of any combination of other embodiments. Furthermore, equivalents and modifications not described above may be employed without departing from the scope of the present invention as defined by the appended claims.

Claims (41)

A composition for topical application, comprising a base, elemental silver as a colloidal suspension dispersed in said base, Echinacea purpurea, Stellaria media, Aloe vera (Aloe vera), Matricaria recutita, Hypericum perforatum, Calendula officinalis, Equisetum arvense, Symfitum officinalis, Sale Panax ginseng), Rumex crispus, Arctium lappa, Trifolium pratense, Chelidonium majus, Thuja occidentalis, Ultica de Oika (Urtica dioica), and Mahonia-acquisitor Folie um (Mahonia aquifolium), and gallium Aparine plant extract from at least six plant selected from the group consisting of (Galium aparine),
A composition for topical application, comprising: The composition comprises 80% to 99.9% by volume of the base of the composition,
1 × 10 ⁻⁵ % to 1 × 10 ⁻² % by weight of the composition of elemental silver, and
Comprising 0.1% to 10% by weight of the composition of a plant extract,
The composition of claim 1.   The composition according to claim 1 or 2, wherein the composition is an aqueous suspension, a cream, an ointment, a spray, a gel, or an aerosol.   4. The composition of claim 3, wherein the composition is an aqueous suspension and the base is water. The composition is essentially
1 × 10 ⁻⁵ % to 1 × 10 ⁻² % by weight of the composition of silver element, and
0.1% to 10% by weight of the composition of a plant extract,
Up to 100% water as the balance of the composition,
A composition according to claim 4 consisting of: The plant extracts, C ₁ -C ₄ alkanol, acetic acid, glycerol, propylene glycol, honey, water, and an extract containing the extracting agent mixtures thereof, in any of the preceding claims The composition as described.   The composition according to claim 6, wherein the extractant comprises aqueous ethanol.   The composition according to claim 6 or 7, wherein the plant extract is an extract of plant material in which a weight volume ratio of the plant material and the extractant is 1: 1 to 1:12.   The composition according to any one of claims 1 to 5, wherein the extract is an extract containing no extractant.   The plant extracts are Exetam arbense, Lumex crispas, Arctium trumpet, Trifolium platense, Keridonium majus, Tuya occidentalis, Ultica dioica, Symfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stella. The composition according to any one of claims 1 to 9, which is derived from Media, Gallium aparine, Aloe Vera, Matricaria lectina, Hypericum perforatum, Calendula officinalis, and Panax ginseng.   2. The plant extract is derived from Exetam albense, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe Vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. ~ The composition according to claim 9.   The plant extract is derived from Symphytum officinale, Echinacea purpurea, Aloe vera, Matricaria rectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng, according to any one of claims 1 to 9. The composition as described.   The composition according to any one of claims 1 to 9, wherein the plant extract is derived from gallium aparine, aloe vera, Matricaria lectina, Hypericum perforatum, calendula officinalis, and Panax ginseng. .   10. The plant extract is derived from Keridonium majus, Tuya okdendentalis, Echinacea purpurea, gallium aparine, Matricaria rectita, Hypericum perforatum, and Calendula officinalis, according to any one of claims 1 to 9. The composition as described.   10. The plant extract is derived from Exetum albense, Symphytum officinale, Mahonia aquifolium, Matricaria rectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng, any of claims 1 to 9. The composition according to claim 1.   The composition according to any one of claims 1 to 9, wherein the plant extract is derived from Arctium trumpet, Echinacea purpurea, Stellaria media, Matricaria rectita, Hypericum perforatum, and Calendula officinalis. .   10. The plant extract according to any one of claims 1 to 9, wherein the plant extract is derived from Keridonium majus, Tuya occipientalis, Mahonia aquifolium, aloe vera, Matricaria rechita, and Calendula officinalis. Composition.   10. The plant extract according to any one of claims 1 to 9, wherein the plant extract is derived from Arctium trumpet, Ultica dioica, Echinacea purpurea, Stellaria media, Matricaria rechita, Hypericum perforatum, and Calendula officinalis. The composition as described.   10. The plant extract according to any one of claims 1 to 9, which is derived from Ultica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria rechita, and Calendula officinalis. The composition as described.   The plant extract is derived from Ultica dioica, Symphytum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria rechita, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The composition according to any one of claims 1 to 9, which is:   The plant extract is derived from Rumex crispas, Arctium trumpet, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Hypericum perforatum, Calendula officinalis, and Panax ginseng. The composition according to any one of claims 1 to 9.   10. The plant extract according to any one of claims 1 to 9, which is derived from Ultica dioica, Symphytum officinale, Echinacea purpurea, Stellaria media, Aloe vera, Matricaria rechita, and Calendula officinalis. The composition as described.   The plant extract is derived from Rumex crispas, Arctium trumpet, Trifolium platense, Symfitum officinale, Echinacea purpurea, Stellaria media, Matricaria rechita, and Calendula officinalis. 10. The composition according to any of 9.   Composition according to any of the preceding claims, which is a cosmetic composition.   The composition according to any one of claims 1 to 23, which is used as a drug.   The composition according to any one of claims 1 to 10, which is used for treating dermatitis.   The composition according to any one of claims 1 to 9 or claim 11, which is used for treating cut skin.   The composition according to any one of claims 1 to 9 or claim 12, which is used for the treatment of burns.   The composition according to any one of claims 1 to 9 or claim 13, which is used for treating sunburn.   The composition according to any one of claims 1 to 9 or claim 14, which is used for treating tinea pedis.   The composition according to any one of claims 1 to 9 or claim 15, which is used for treating blisters.   The composition according to any one of claims 1 to 9 or claim 18, which is used for treating insect bites.   The composition according to any one of claims 1 to 9 or claim 19, which is used for the treatment of inflammatory diaper dermatitis.   The composition according to any one of claims 1 to 9 or claim 20 for use in the treatment of contact dermatitis associated with incontinence. A method of making a composition for topical application, the method comprising:
Exetam Albense, Rumex Crispas, Arctium Rappa, Trifolium platense, Keridonium majus, Tuya Occidentalis, Ultica Dioica, Symfitum officinale, Mahonia aquifolium, Echinacea purpurea, Stellaria media, Gallium Providing a plant extract derived from at least 6 plants selected from the group consisting of: Aloe vera, Matricaria lectita, Hypericum perforatum, Calendula officinalis, and Panax ginseng,
A colloidal suspension of elemental silver suspended in a base, wherein the content of the elemental silver in the colloidal suspension is 1 × 10 ⁻⁵ % to 1 × 10 ⁵ by weight of the base. ^-2 %, providing a colloidal suspension of elemental silver, and
Mixing the plant extract with a colloidal suspension of elemental silver to provide a composition for topical application;
Including the method.   36. The method of claim 35, wherein the base is water.   The plant extract and the colloidal suspension of elemental silver are mixed at a weight-volume ratio of the plant extract and the colloidal suspension of elemental silver of 1:20 to 1: 4. The method described.   A dressing containing the composition according to any one of claims 1 to 34.   A porous sheet impregnated with the composition according to any one of claims 1 to 34. A method of treating an affected area of skin disease, comprising:
Providing a composition according to any of claims 1 to 34,
Topically applying the composition to the affected area of the skin disease,
Including the method. A non-therapeutic beauty method,
Providing a composition according to any of claims 1 to 34,
Selecting a body part to which the composition is applied;
Topically applying the composition to the selected site;
Including beauty methods.