JP2020512358A - 健康を増進するための方法および組成物 - Google Patents
健康を増進するための方法および組成物 Download PDFInfo
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- JP2020512358A JP2020512358A JP2019553179A JP2019553179A JP2020512358A JP 2020512358 A JP2020512358 A JP 2020512358A JP 2019553179 A JP2019553179 A JP 2019553179A JP 2019553179 A JP2019553179 A JP 2019553179A JP 2020512358 A JP2020512358 A JP 2020512358A
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- acid
- cannabinoid
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- decarboxylated
- carboxylated
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Abstract
Description
本出願は、2017年3月30日に出願された米国仮特許出願番号第62/479,091号、2017年5月15日に出願された米国仮特許出願番号第62/506,475号、および2018年2月20日に出願された米国仮特許出願番号第62/632,965号に基づく優先権を主張しており、これら仮特許出願の各々は、参考として本明細書中に全体が援用される。
テルペノイドは、栄養サプリメントまたは栄養補助食品として摂取されると、対象に有益な効果を与えうる化合物である。テルペノイドは、対象の健康、身体的ウェルビーイング、および/または感情的ウェルビーイングに有益となりうる。
一態様では、本開示は、(i)カルボキシル化カンナビノイドと脱カルボキシル化カンナビノイドの混合物と、(ii)1種または複数のテルペノイドとを含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.5より大きく、テルペノイド分解化合物を実質的に含まない、単位用量を提供する。一部の実施形態では、単位用量は、少なくとも5mgの脱カルボキシル化カンナビノイドを含む。一部の実施形態では、脱カルボキシル化カンナビノイドは、Δ9テトラヒドロカンナビノールを含む。
本明細書において言及するすべての刊行物、特許、および特許出願は、個々の各刊行物、特許、または特許出願について参照により引用されることが詳細かつ個別に示されたかの如く、参照により本明細書に援用される。
本発明の種々の実施形態を本明細書において示し、説明してきたが、そのような実施形態が例として提供されるにすぎないことは当業者には言うまでもない。本発明から逸脱することなく、数多くの変形形態、変更形態、および代用形態を当業者が発想する場合もある。本明細書に記載する本発明の実施形態の種々の代替形態を用いてもよいことを理解すべきである。
組成物
投薬形態
方法
適応症
キット
コンピューター制御システム
慢性痛を有する対象のための組成物による疼痛緩和処置
慢性痛を患っている対象(たとえば、患者)に、処置を行う医師または他の疼痛管理専門家による、自身の疼痛レベルの査定および評価を受けてもらう。次いで、このような対象に、カンナビノイドと1種または複数のテルペノイドとを含む10mg/日の組成物を処方する。次いで、2週間後に対象を再び評価して、症状が改善したかを判定する。評価の後、疼痛のレベルの変化に応じて、投与量を増やす、減らす、または同じままとする。慢性痛の症状の安定した解消に影響を及ぼすのに必要なだけ、処置を継続する。
アルツハイマー病と診断されている対象の処置
臨床的にアルツハイマー病と診断されている対象を、記憶喪失や錯乱などの一般的な症状について評価する。
組成物の単位用量の合成
産業研究室にある反応槽を氷浴に浸す。反応槽に、100グラムのカンナビス植物、1mLの酢酸、および5Lの水を投入する。氷浴を取り外し、反応液が室温に達したら、反応液を撹拌する。
キットを使用しての組成物の単位用量の使用者合成
キットを使用者に販売する。キットは、カルボキシル化カンナビノイドの脱カルボキシル化カンナビノイドへの変換が使用者によって実施できるように、必要なすべての出発材料を含む。キットは、2グラムのカンナビス植物と、1グラムのクエン酸と、ボウルと、酸を利用する変換の実施についての説明書とを含む。
Claims (51)
- (i)カルボキシル化カンナビノイドと脱カルボキシル化カンナビノイドの混合物と、
(ii)1種または複数のテルペノイドと
を含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.5より大きく、
テルペノイド分解化合物を実質的に含まない
単位用量。 - 少なくとも5mgの脱カルボキシル化カンナビノイドを含む、請求項1に記載の単位用量。
- 前記脱カルボキシル化カンナビノイドがΔ9テトラヒドロカンナビノールを含む、請求項1に記載の単位用量。
- 前記1種または複数のテルペノイドが、ミルセン、リモネン、リナロオール、trans−オシメン、ベータ−ピネン、アルファ−ピネン、ベータ−カリオフィレン、デルタ−3−カレン、trans−ガンマ−ビサボレン、trans−アルファ−ファルネセン、ベータ−フェンコール、アルファ−フムレン、およびグアジョールからなる群から選択される、請求項1に記載の単位用量。
- 前記1種または複数のテルペノイド分解化合物が、ゲラニオール、イソ酪酸ゲラニル、p−シメネン、p−シメン、p−メンタ−1,5,8−トリエン、カルボン、3−メチル−6−(1−メチルエチリデン)−2−シクロヘキセン−1−オン、3−メチル−6−(1−メチルエテニル)−2−シクロヘキセン−1−オン、オイカルボン、チモール、p−メンタ−1(7),8−ジエン−2−オール、ペリリルアルコール、カンフェン、ベータ−ミルセン、アルファ−フェランドレン、アルファ−テルピネン、ガンマ−テルピネン、テルピノレン、4−ヒドロキシ−2−メチル−2−シクロヘキセノン、p−シメネン、o−シメン、3−カレン−2−オン、3−カレン−5−オン、3−カレンオキシド、3−カレン−2,5−ジオン、trans−2−ヒドロキシ−3−カレン−5−オン、チモール、カルバクロール、1,4−シネオール、オイカリプトール、3−(1−メチルエチル)−6−オキソ−2−ヘプテナール、および3,7−ジメチル6−オキソ−2−オクテナールからなる群から選択される、請求項1に記載の単位用量。
- 極微量の酸をさらに含む、請求項1に記載の単位用量。
- 薬学的に許容される賦形剤をさらに含む、請求項1に記載の単位用量。
- 前記薬学的に許容される賦形剤が、結合剤、充填剤、可塑剤、滑沢剤、消泡剤、緩衝剤、ポリマー、酸化防止剤、保存剤、キレート剤、香味剤、着色剤、着香剤、懸濁化剤、およびこれらの組合せからなる群から選択される、請求項7に記載の単位用量。
- 経口、局所、吸入、静脈内、または筋肉内投与用に製剤化されている、請求項1に記載の単位用量。
- 固体形態である、請求項1に記載の単位用量。
- 液体形態である、請求項1に記載の単位用量。
- 錠剤、チュアブル錠剤、カプセル剤、カプレット剤、丸剤、顆粒、エマルション、ゲル、噴霧剤、カプセルに入った複数のビーズ、粉末、懸濁液、液体、半液体、半固体、溶液、シロップ、またはスラリーである。請求項1に記載の単位用量。
- 密閉容器に入れて温度約25℃かつ相対湿度レベル約50%で6か月間経過後、前記カンナビノイドの少なくとも80%を保持する、請求項1に記載の単位用量。
- チューブ、広口瓶、箱、バイアル、袋、トレー、ドラム、ボトル、注射器、および缶からなる群から選択される容器に包装されている、請求項1に記載の単位用量。
- 請求項1に記載の単位用量と、前記のカルボキシル化カンナビノイドと脱カルボキシル化カンナビノイドの混合物および1種または複数のテルペノイドをそれを必要とする対象に補給することについての説明書とを含むキット。
- Δ9テトラヒドロカンナビノールを調製するためのキットであって、
(i)少なくとも50%のテトラヒドロカンナビノール酸を前記Δ9テトラヒドロカンナビノールに変換するのに有効な量で存在する酸と、
(ii)前記酸と前記テトラヒドロカンナビノール酸とを含む反応混合物を保持するように構成された反応槽と、
(iii)前記酸を利用して前記変換を行うことについての説明書と
を含むキット。 - テトラヒドロカンナビノール酸をさらに含む、請求項16に記載のキット。
- 前記酸が弱酸である、請求項16に記載のキット。
- 前記酸が約3〜約7のpKaを有する、請求項16に記載のキット。
- 前記酸が、乳酸、クエン酸、リンゴ酸、酢酸、安息香酸、アスコルビン酸、酒石酸、およびシュウ酸からなる群から選択される、請求項16に記載のキット。
- 1種または複数のカンナビノイドおよび1種または複数のテルペノイドを、それを必要とする対象に補給する方法であって、前記対象に、
i. カルボキシル化カンナビノイドと脱カルボキシル化カンナビノイドの混合物と、
ii. 1種または複数のテルペノイドと
を含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.5より大きく、
テルペノイド分解化合物を実質的に含まない
単位用量を投与することを含む方法。 - 前記対象が、疼痛、ストレス、悪心、嘔吐、不眠、不安、および食欲減退からなる群から選択される症状をわずらう、請求項21に記載の方法。
- 前記単位用量が、経口、局所、吸入、静脈内、または筋肉内投与される、請求項21に記載の方法。
- 前記単位用量が、少なくとも1日1回投与される、請求項21に記載の方法。
- 前記対象への前記単位用量の投与に続いて、前記対象の健康状態または体調をモニターすることをさらに含む、請求項21に記載の方法。
- 脱カルボキシル化カンナビノイドを生成する方法であって、
(i)カンナビス植物またはその部分を、前記カンナビス植物中に存在するカルボキシル化カンナビノイドを脱カルボキシル化カンナビノイドに変換するのに有効な条件下で酸と接触させて、反応混合物を形成することと、
(ii)前記脱カルボキシル化カンナビノイドから前記カンナビス植物またはその部分を分離し、それによって、前記脱カルボキシル化カンナビノイドを生成することと
を含む方法。 - 前記脱カルボキシル化カンナビノイドがΔ9テトラヒドロカンナビノールを含む、請求項26に記載の方法。
- (ii)の前記反応混合物における脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.1より大きい、請求項26に記載の方法。
- 前記条件が300℃未満の温度である、請求項26に記載の方法。
- 前記カルボキシル化カンナビノイドの前記脱カルボキシル化カンナビノイドへの前記変換の間、外部加熱が適用されない、請求項28に記載の方法。
- 前記酸が弱酸である、請求項26に記載の方法。
- 前記接触が、ブレンド、混合、撹拌、またはこれらの組合せを含む、請求項26に記載の方法。
- 前記分離が、濾過、抽出、遠心分離、可溶化、濃縮、洗浄、電気分解、吸着、精製、クロマトグラフィー、分別、結晶化、およびこれらの組合せからなる群から選択される、請求項26に記載の方法。
- (i)カルボキシル化カンナビノイドおよび脱カルボキシル化カンナビノイドと、
(ii)1種または複数のテルペノイドと、
(iii)酸と
を含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.1より大きく、
前記酸は、カルボキシル化カンナビノイドの少なくとも一部分を脱カルボキシル化カンナビノイドに変換することにおいて有効な量で存在する
混合物。 - 前記カルボキシル化カンナビノイドがテトラヒドロカンナビノール酸を含む、請求項34に記載の混合物。
- 少なくとも0.05molの前記脱カルボキシル化カンナビノイドを含む、請求項33に記載の混合物。
- 前記脱カルボキシル化カンナビノイドがΔ9テトラヒドロカンナビノールを含む、請求項33に記載の混合物。
- Δ9テトラヒドロカンナビノールのテトラヒドロカンナビノール酸に対するwt/wt比が約0.1より大きい、請求項37に記載の混合物。
- テルペノイド分解化合物を実質的に含まない、請求項33に記載の混合物。
- 前記酸が有機酸である、請求項33に記載の混合物。
- 脱カルボキシル化カンナビノイド製剤を生成する方法であって、
(a)混合物を含む反応槽を提供することであって、前記混合物は、
i. カルボキシル化カンナビノイドおよび脱カルボキシル化カンナビノイドと、
ii. 1種または複数のテルペノイドと、
iii. 酸と
を含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.1より大きく、
前記酸は、カルボキシル化カンナビノイドの少なくとも一部分を脱カルボキシル化カンナビノイドに変換することにおいて有効な量で存在することと、
(b)前記混合物を混合することであって、前記脱カルボキシル化カンナビノイド製剤を得ることと
を含む方法。 - 前記脱カルボキシル化カンナビノイド製剤が、少なくとも5mgの脱カルボキシル化カンナビノイドを含む、請求項41に記載の方法。
- 前記脱カルボキシル化カンナビノイド製剤がΔ9テトラヒドロカンナビノールを含む、請求項41に記載の方法。
- 前記1種または複数のテルペノイドが、ミルセン、リモネン、リナロオール、trans−オシメン、ベータ−ピネン、アルファ−ピネン、ベータ−カリオフィレン、デルタ−3−カレン、trans−ガンマ−ビサボレン、trans−アルファ−ファルネセン、ベータ−フェンコール、アルファ−フムレン、およびグアジョールからなる群から選択される、請求項41に記載の方法。
- 前記酸が弱酸である、請求項41に記載の方法。
- 前記酸が約3〜約7のpKaを有する、請求項41に記載の方法。
- 前記酸が、乳酸、クエン酸、リンゴ酸、酢酸、安息香酸、アスコルビン酸、酒石酸、およびシュウ酸からなる群から選択される、請求項41に記載の方法。
- (i)カルボキシル化カンナビノイドと脱カルボキシル化カンナビノイドの混合物と、
(ii)1種または複数のテルペノイドと
を含み、脱カルボキシル化カンナビノイドのカルボキシル化カンナビノイドに対するwt/wt比が0.5より大きく、
テルペノイド分解化合物を実質的に含まず、
酸を実質的に含まない
単位用量。 - 前記酸が弱酸である、請求項48に記載の単位用量。
- 前記酸が約3〜約7のpKaを有する、請求項48に記載の単位用量。
- 前記酸が、乳酸、クエン酸、リンゴ酸、酢酸、安息香酸、アスコルビン酸、酒石酸、およびシュウ酸からなる群から選択される、請求項48に記載の単位用量。
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US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
WO2019191830A1 (en) * | 2018-04-04 | 2019-10-10 | Vincenzo Maida | Topical cannabinoid formulations and instillates, kits, and methods for treating integumentary wounds, and uses thereof |
EP3793542A4 (en) * | 2018-05-14 | 2022-03-30 | Buzzelet Development And Technologies Ltd | TERPENE-ENRICHED CANNABINOID COMPOSITIONS AND THEIR USES IN THE TREATMENT OF INFECTIOUS DISEASES |
EP3864000A4 (en) | 2018-10-10 | 2022-08-10 | Treehouse Biosciences, Inc. | CANNABIGEROL SYNTHESIS |
WO2020084450A1 (en) * | 2018-10-23 | 2020-04-30 | Radient Technologies Innovations Inc. | Method of automating cannabis decarboxylation and extraction by recursive decarboxylation, sampling, and extraction steps |
WO2020084425A1 (en) * | 2018-10-24 | 2020-04-30 | Radient Technologies Innovations Inc. | Side effect and symptom relief |
US10959961B2 (en) * | 2018-12-14 | 2021-03-30 | Natural Extraction Systems, LLC | Methods of administering anionic cannabinoid molecules dissolved in water |
US10609944B1 (en) | 2018-12-14 | 2020-04-07 | Natural Extraction Systems, LLC | Compositions comprising 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-3-hydroxy-5-pentylphenolate and 2-[(1R,6R)-6-isopropenyl-3-methylcyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol |
JP2022529781A (ja) | 2019-04-17 | 2022-06-24 | コンパス パスファインダー リミテッド | サイロシビンによるうつ病及び他の様々な障害の治療 |
US11622956B1 (en) | 2019-06-26 | 2023-04-11 | RCR BioPharma | Compound and method for treating diseases and disorders |
WO2021016710A1 (en) * | 2019-07-30 | 2021-02-04 | Tassili Life Sciences, Corp. | Controlled release formulations of multiple active pharmaceutical agents, and psilocybe-derived agents in combination with cannabis-derived agents and methods for their use |
US10780075B1 (en) * | 2019-07-31 | 2020-09-22 | Etain IP, LLC | Water soluble cannabis composition |
US11793753B2 (en) | 2019-09-12 | 2023-10-24 | Nulixir Inc. | Methods and systems for forming layered solid particles |
US20220362319A1 (en) * | 2021-05-12 | 2022-11-17 | PPM Labs LLC | Cannabinoid Concentration Process |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016064987A1 (en) * | 2014-10-21 | 2016-04-28 | United Cannabis Corp. | Cannabis extracts and methods of preparing and using same |
WO2018023163A1 (en) * | 2016-08-03 | 2018-02-08 | Zelda Therapeutics Operations Pty Ltd | Cannabis composition |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2400320B (en) | 2001-05-04 | 2005-06-08 | Gw Pharma Ltd | Cannabinoid-rich extracts |
WO2014159688A1 (en) * | 2013-03-14 | 2014-10-02 | Sc Laboratories, Inc. | Bioactive concentrates and uses thereof |
WO2015068052A2 (en) * | 2013-10-31 | 2015-05-14 | Full Spectrum Laboratories, Ltd. | Terpene and cannabinoid formulations |
US10406186B2 (en) * | 2015-01-31 | 2019-09-10 | Constance Therapeutics, Inc. | Cannabis oil extracts and compositions |
BR112017018316A2 (pt) * | 2015-02-27 | 2018-04-17 | Ebbu Llc | composições compreendendo combinações de canabinoides purificados, com pelo menos um flavonoide, terpeno ou mineral |
US9747740B2 (en) * | 2015-03-02 | 2017-08-29 | Ford Global Technologies, Llc | Simultaneous button press secure keypad code entry |
CA3022553C (en) | 2016-05-06 | 2023-02-21 | Zeyead GHARIB | The manufacturing methods, compositions, and medical applications of orally administered cannabis pharmaceuticals |
US20180344786A1 (en) * | 2017-06-06 | 2018-12-06 | NC3 Systems | System and method enhanced cannabiniod effect delivery |
AU2018338611A1 (en) * | 2017-09-28 | 2020-02-27 | Canopy Growth Corporation | Edible cannabinoid compositions |
-
2018
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016064987A1 (en) * | 2014-10-21 | 2016-04-28 | United Cannabis Corp. | Cannabis extracts and methods of preparing and using same |
WO2018023163A1 (en) * | 2016-08-03 | 2018-02-08 | Zelda Therapeutics Operations Pty Ltd | Cannabis composition |
Non-Patent Citations (3)
Title |
---|
"マリファナと他のドラッグとのコンビネーション", TOPHOBBY マリファナの栽培 [オンライン], JPN6021051659, 1 January 2016 (2016-01-01), ISSN: 0004875985 * |
CURRENT DRUG ABUSE REVIEWS, vol. 4, JPN6021051657, 2011, pages 81 - 86, ISSN: 0004875987 * |
J NEURAL TRANSM, vol. 114, JPN6021051658, 2007, pages 959 - 968, ISSN: 0004875986 * |
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AU2018243694A1 (en) | 2019-10-17 |
BR112019020554A2 (pt) | 2020-04-28 |
MX2022004262A (es) | 2022-05-06 |
CN110709069A (zh) | 2020-01-17 |
WO2018183115A1 (en) | 2018-10-04 |
EP3600271A4 (en) | 2020-12-16 |
EP3600271A1 (en) | 2020-02-05 |
CA3057994A1 (en) | 2018-10-04 |
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