JP2020511541A5 - - Google Patents
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- Publication number
- JP2020511541A5 JP2020511541A5 JP2020500785A JP2020500785A JP2020511541A5 JP 2020511541 A5 JP2020511541 A5 JP 2020511541A5 JP 2020500785 A JP2020500785 A JP 2020500785A JP 2020500785 A JP2020500785 A JP 2020500785A JP 2020511541 A5 JP2020511541 A5 JP 2020511541A5
- Authority
- JP
- Japan
- Prior art keywords
- humanized antibody
- antibody
- humanized
- seq
- antibody according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims 3
- 230000001338 necrotic effect Effects 0.000 claims 3
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 2
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 2
- 102000002689 Toll-like receptor Human genes 0.000 claims 2
- 108020000411 Toll-like receptor Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000003460 anti-nuclear Effects 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 210000004322 M2 macrophage Anatomy 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023098123A JP7624478B2 (ja) | 2017-03-20 | 2023-06-14 | 癌治療において壊死を標的とするヒト化抗核抗体 |
| JP2025008079A JP2025066768A (ja) | 2017-03-20 | 2025-01-20 | 癌治療において壊死を標的とするヒト化抗核抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762473554P | 2017-03-20 | 2017-03-20 | |
| US62/473,554 | 2017-03-20 | ||
| PCT/US2018/023123 WO2018175310A1 (en) | 2017-03-20 | 2018-03-19 | Humanized anti-nuclear antibodies for targeting necrosis in cancer therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023098123A Division JP7624478B2 (ja) | 2017-03-20 | 2023-06-14 | 癌治療において壊死を標的とするヒト化抗核抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511541A JP2020511541A (ja) | 2020-04-16 |
| JP2020511541A5 true JP2020511541A5 (enExample) | 2021-04-30 |
| JP7299209B2 JP7299209B2 (ja) | 2023-06-27 |
Family
ID=63584724
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020500785A Active JP7299209B2 (ja) | 2017-03-20 | 2018-03-19 | 癌治療において壊死を標的とするヒト化抗核抗体 |
| JP2023098123A Active JP7624478B2 (ja) | 2017-03-20 | 2023-06-14 | 癌治療において壊死を標的とするヒト化抗核抗体 |
| JP2025008079A Pending JP2025066768A (ja) | 2017-03-20 | 2025-01-20 | 癌治療において壊死を標的とするヒト化抗核抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023098123A Active JP7624478B2 (ja) | 2017-03-20 | 2023-06-14 | 癌治療において壊死を標的とするヒト化抗核抗体 |
| JP2025008079A Pending JP2025066768A (ja) | 2017-03-20 | 2025-01-20 | 癌治療において壊死を標的とするヒト化抗核抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US11384157B2 (enExample) |
| EP (1) | EP3601364A4 (enExample) |
| JP (3) | JP7299209B2 (enExample) |
| KR (2) | KR102698752B1 (enExample) |
| CN (2) | CN115947859A (enExample) |
| AU (2) | AU2018237046B2 (enExample) |
| CA (1) | CA3056703A1 (enExample) |
| WO (1) | WO2018175310A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102698752B1 (ko) * | 2017-03-20 | 2024-08-26 | 캔서 테라퓨틱스 래버러토리즈 인코포레이티드 | 암 치료법에서 괴사를 표적화하기 위한 인간화 항-핵 항체 |
| CN115819604B (zh) * | 2022-09-09 | 2025-04-15 | 季华实验室 | 抗双链dna抗体、核苷酸片段、磁珠及提取外周血游离dna的方法 |
| LU103248B1 (en) | 2024-02-19 | 2025-08-19 | Stratec Se | Container handling device |
| WO2025194038A1 (en) * | 2024-03-15 | 2025-09-18 | Caris Science, Inc. | Antibody compositions and methods for targeting extracellular nucleosome proteins |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074437A2 (en) | 2003-02-14 | 2004-09-02 | University Of Southern California | Compositions and methods for cancer immunotherapy |
| MX2009013328A (es) * | 2007-06-25 | 2010-06-02 | Esbatech An Alcon Biomedical R | Metodos para modificar anticuerpos, y anticuerpos modificados con propiedades funcionales mejoradas. |
| WO2011062997A2 (en) * | 2009-11-17 | 2011-05-26 | Musc Foundation For Research Development | Human monoclonal antibodies to human nucleolin |
| JP6709733B2 (ja) * | 2014-01-13 | 2020-06-17 | バレリオン セラピューティクス， エルエルシー | 内在化部分 |
| US10383945B2 (en) * | 2015-02-18 | 2019-08-20 | The United States of America as Represented by the Department of Verterans Affairs | Methods for DNA-dependent targeting of a cell permeant antibody |
| WO2017011411A1 (en) | 2015-07-10 | 2017-01-19 | Ohio State Innovation Foundation | Methods and compositions relating to anti-nucleolin recombinant immunoagents |
| SG11201903306SA (en) * | 2016-10-21 | 2019-05-30 | Altor Bioscience Corp | Multimeric il-15-based molecules |
| KR102698752B1 (ko) * | 2017-03-20 | 2024-08-26 | 캔서 테라퓨틱스 래버러토리즈 인코포레이티드 | 암 치료법에서 괴사를 표적화하기 위한 인간화 항-핵 항체 |
-
2018
- 2018-03-19 KR KR1020197030327A patent/KR102698752B1/ko active Active
- 2018-03-19 EP EP18770253.5A patent/EP3601364A4/en active Pending
- 2018-03-19 CN CN202310018919.2A patent/CN115947859A/zh active Pending
- 2018-03-19 JP JP2020500785A patent/JP7299209B2/ja active Active
- 2018-03-19 CA CA3056703A patent/CA3056703A1/en active Pending
- 2018-03-19 AU AU2018237046A patent/AU2018237046B2/en active Active
- 2018-03-19 CN CN201880019797.6A patent/CN110461878B/zh active Active
- 2018-03-19 WO PCT/US2018/023123 patent/WO2018175310A1/en not_active Ceased
- 2018-03-19 US US16/496,177 patent/US11384157B2/en active Active
- 2018-03-19 KR KR1020247027978A patent/KR20240148849A/ko active Pending
-
2022
- 2022-06-14 US US17/839,953 patent/US12258421B2/en active Active
-
2023
- 2023-06-14 JP JP2023098123A patent/JP7624478B2/ja active Active
-
2024
- 2024-11-07 AU AU2024259793A patent/AU2024259793A1/en active Pending
-
2025
- 2025-01-20 JP JP2025008079A patent/JP2025066768A/ja active Pending
- 2025-01-21 US US19/032,799 patent/US20250215114A1/en active Pending
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