JP2020511414A5 - - Google Patents
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- Publication number
- JP2020511414A5 JP2020511414A5 JP2019531960A JP2019531960A JP2020511414A5 JP 2020511414 A5 JP2020511414 A5 JP 2020511414A5 JP 2019531960 A JP2019531960 A JP 2019531960A JP 2019531960 A JP2019531960 A JP 2019531960A JP 2020511414 A5 JP2020511414 A5 JP 2020511414A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- binding fragment
- cancer
- fibrosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1621446.2 | 2016-12-16 | ||
| GBGB1621446.2A GB201621446D0 (en) | 2016-12-16 | 2016-12-16 | IL-11 antibodies |
| GB1709535.7 | 2017-06-15 | ||
| GBGB1709535.7A GB201709535D0 (en) | 2017-06-15 | 2017-06-15 | IL-11 Antibodies |
| PCT/EP2017/083051 WO2018109174A2 (en) | 2016-12-16 | 2017-12-15 | Il-11 antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511414A JP2020511414A (ja) | 2020-04-16 |
| JP2020511414A5 true JP2020511414A5 (https=) | 2021-01-28 |
| JP7181870B2 JP7181870B2 (ja) | 2022-12-01 |
Family
ID=60915498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531960A Active JP7181870B2 (ja) | 2016-12-16 | 2017-12-15 | Ｉｌ－１１抗体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20180186871A1 (https=) |
| EP (1) | EP3555131B1 (https=) |
| JP (1) | JP7181870B2 (https=) |
| KR (1) | KR20190096390A (https=) |
| CN (1) | CN110382531B (https=) |
| AU (1) | AU2017378111A1 (https=) |
| BR (1) | BR112019012342A2 (https=) |
| CA (1) | CA3045871A1 (https=) |
| MX (1) | MX2019007020A (https=) |
| TW (1) | TW201829460A (https=) |
| WO (1) | WO2018109174A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201522186D0 (en) | 2015-12-16 | 2016-01-27 | Singapore Health Services Pte Ltd And Nat University Of Singapore The | Treatment of fibrosis |
| AU2017378111A1 (en) | 2016-12-16 | 2019-06-13 | National University Of Singapore | IL-11 antibodies |
| GB201621439D0 (en) | 2016-12-16 | 2017-02-01 | Singapore Health Services Pte Ltd And Nat Univ Of Singapore | IL-11Ra Antibodies |
| GB201716733D0 (en) * | 2017-10-12 | 2017-11-29 | Nat Univ Singapore | Treatment of SMC mediated disease |
| GB201809699D0 (en) | 2018-06-13 | 2018-08-01 | Singapore Health Serv Pte Ltd | IL-11 antibodies |
| CN109503712B (zh) * | 2018-12-12 | 2021-06-01 | 广州市第八人民医院 | 一种单克隆抗体ZKns2E11及其应用 |
| TWI858005B (zh) | 2019-01-21 | 2024-10-11 | 新加坡商新加坡保健服務私人有限公司 | 肝毒性之治療 |
| GB201902419D0 (en) | 2019-02-22 | 2019-04-10 | Singapore Health Serv Pte Ltd | Treatment of kidney injury |
| CN114364693A (zh) | 2019-05-03 | 2022-04-15 | 新加坡保健服务私人有限公司 | 代谢性疾病的治疗和预防 |
| GB201906291D0 (en) | 2019-05-03 | 2019-06-19 | Singapore Health Serv Pte Ltd | Treatment and prevention of metabolic diseases |
| GB202009292D0 (en) * | 2020-06-18 | 2020-08-05 | Singapore Health Serv Pte Ltd | Treatment and prevention of disease caused by type IV collagen dysfunction |
| WO2022033538A1 (zh) * | 2020-08-13 | 2022-02-17 | 广东东阳光药业有限公司 | Il-11的抗体及其应用 |
| GB202017244D0 (en) * | 2020-10-30 | 2020-12-16 | Nat Univ Singapore | Methods to extend health-span and treat age-related diseases |
| CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
| MX2023009946A (es) | 2021-02-26 | 2023-09-04 | Bayer Ag | Inhibidores de il-11 o il-11ra para uso en el tratamiento de sangrado uterino anormal. |
| US20250282861A1 (en) * | 2021-04-12 | 2025-09-11 | Syddansk Universitet | Mfap4 and treatment of fibrosis |
| US20250092126A1 (en) | 2021-07-26 | 2025-03-20 | Boehringer Ingelheim International Gmbh | Treatment and prevention of alcoholic liver disease |
| JP2024532709A (ja) * | 2021-08-12 | 2024-09-10 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Ｉｌ－１１ヒト化抗体及びその用途 |
| KR20240067079A (ko) | 2021-08-30 | 2024-05-16 | 라센 테라퓨틱스 1, 인코포레이티드 | 항-IL-11Rα 항체 |
| US20250082608A1 (en) | 2021-12-16 | 2025-03-13 | Singapore Health Services Pte Ltd. | Treatment and prevention of glomerular disease |
| CN114384245B (zh) * | 2022-03-24 | 2022-06-24 | 江苏美克医学技术有限公司 | 新型冠状病毒s-rbd蛋白和n蛋白双表位识别的联检试剂盒及其应用 |
| WO2024158700A2 (en) * | 2023-01-23 | 2024-08-02 | The Regents Of The University Of California | Methods and compositions for treating ewing sarcoma |
| WO2024226646A2 (en) * | 2023-04-25 | 2024-10-31 | Memorial Sloan-Kettering Cancer Center | Dlk1 -targeting antibodies and uses thereof |
| EP4702047A1 (en) | 2023-04-25 | 2026-03-04 | VVB Bio Pte. Ltd. | Anti il-11 antibody |
| CN120518761B (zh) * | 2023-06-05 | 2025-12-26 | 北京东方百泰生物科技股份有限公司 | 一种结合il-11的抗体、其抗原结合片段及应用 |
| KR20260047586A (ko) * | 2023-07-24 | 2026-04-08 | 벤더르빌트 유니버시티 | 인플루엔자 b 바이러스에 대한 광범위 반응성 항체 |
| CN117085137A (zh) * | 2023-10-10 | 2023-11-21 | 上海交通大学医学院附属第九人民医院 | Il-11抑制剂及其在抗瘢痕治疗中的应用 |
| WO2025108343A1 (zh) * | 2023-11-22 | 2025-05-30 | 上海华奥泰生物药业股份有限公司 | 靶向il-11的抗原结合蛋白 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2275268T3 (es) | 1994-12-22 | 2007-06-01 | Genetics Institute, Llc | Uso de un receptor de la interleuquina 11 humana. |
| US6540993B1 (en) | 1995-06-27 | 2003-04-01 | Wyeth | Method of treating inflammatory bowel disease using a topical formulation of IL-11 |
| US6126933A (en) | 1995-06-27 | 2000-10-03 | Genetics Institute | Methods of treating inflammatory bowel diseases by administering IL-11 |
| US5679339A (en) | 1995-06-27 | 1997-10-21 | Keith; James | Method of using IL-11 for treating spondyloarthropies |
| GB9702944D0 (en) | 1997-02-13 | 1997-04-02 | Univ Manchester | Reducing fibrosis |
| GB9721961D0 (en) | 1997-10-16 | 1997-12-17 | Glaxo Group Ltd | Novel molecules |
| CA2237915A1 (en) | 1998-05-19 | 1999-11-19 | Stephen Shaughnessy | Osteoporosis treatment |
| US6953777B2 (en) | 1999-03-11 | 2005-10-11 | Genetics Indtitute LLC | Use of interleukin-11 to prevent immune-mediated cytotoxicity |
| AU5756100A (en) | 1999-06-21 | 2001-01-09 | Genetics Institute Inc. | Treatment of fibrosis by antagonism of il-13 and il-13 receptor chains |
| GB0021668D0 (en) | 2000-09-04 | 2000-10-18 | Smithkline Beecham Plc | New use |
| BR0314356A (pt) | 2002-09-16 | 2005-07-19 | Wyeth Corp | Formulações de liberação retardada para administração oral de um agente terapêutico polipetìdeo e métodos utilizando as mesmas |
| EP1709074A4 (en) | 2003-12-16 | 2008-06-11 | Commw Scient Ind Res Org | CYTOKIN BINDING DOMAINS |
| WO2005070446A1 (en) | 2004-01-15 | 2005-08-04 | Scios Inc. | Method for treating cardiac remodeling following myocardial injury |
| US20080300147A1 (en) | 2004-03-26 | 2008-12-04 | Nasser Chegini | Detection and Treatment of Fibrotic Disorders |
| EP1598364A1 (en) * | 2004-05-21 | 2005-11-23 | AGIRx Limited | Chimerical soluble hyper IL-11 receptor and use thereof |
| ATE399868T1 (de) | 2004-08-27 | 2008-07-15 | Conaris Res Inst Ag | Optimierte nukleotidsequenzen die für sgp130 kodieren |
| BRPI0619476A2 (pt) | 2005-12-05 | 2011-10-04 | Wyeth Corp | composições de interleucina-11 e métodos de uso |
| US8361966B2 (en) | 2006-10-27 | 2013-01-29 | Osaka University | Use of interleukin-11 as therapeutic agent for heart disease |
| US8182814B2 (en) | 2007-10-26 | 2012-05-22 | Csl Limited | Methods of treating inflammatory airway conditions by inhibition of IL-11 activity |
| JP5330398B2 (ja) | 2007-10-26 | 2013-10-30 | シーエスエル、リミテッド | サイトカインムテイン |
| US8518888B2 (en) | 2008-10-14 | 2013-08-27 | Csl Limited | Method of treatment of gastrointestinal-type cancer with antagonistic antibodies to IL-11R |
| KR101133769B1 (ko) | 2011-04-18 | 2012-04-09 | 한국생명공학연구원 | 신규한 옥사졸리딘계 및 인돌계 화합물, 이의 제조방법 및 이를 포함하는 약학 조성물 |
| CN104995211B (zh) | 2013-02-07 | 2019-09-13 | Csl有限公司 | Il-11r结合蛋白及其应用 |
| CN105497893B (zh) | 2015-12-10 | 2019-02-01 | 黑龙江省科学院高技术研究院 | IL-11单克隆抗体在抑制PI3K/Akt信号通路中的应用 |
| GB201522186D0 (en) | 2015-12-16 | 2016-01-27 | Singapore Health Services Pte Ltd And Nat University Of Singapore The | Treatment of fibrosis |
| RU2016125115A (ru) | 2016-06-23 | 2017-12-28 | Федеральное государственное бюджетное учреждение науки Институт биологического приборостроения с опытным производством Российской Академии наук (ИБП РАН) | Терапевтическое антитело, специфичное к интерлейкину-11, ингибирующее сигналирование через его рецептор, и способ его использования для лечения пациентов |
| AU2017378111A1 (en) | 2016-12-16 | 2019-06-13 | National University Of Singapore | IL-11 antibodies |
| GB201621439D0 (en) | 2016-12-16 | 2017-02-01 | Singapore Health Services Pte Ltd And Nat Univ Of Singapore | IL-11Ra Antibodies |
| RU2016151730A (ru) | 2016-12-28 | 2018-06-29 | Федеральное государственное бюджетное учреждение науки Институт биологического приборостроения с опытным производством Российской Академии наук (ИБП РАН) | Антитела для лабораторной диагностики концентрации интерлейкина-11 |
| GB201809699D0 (en) | 2018-06-13 | 2018-08-01 | Singapore Health Serv Pte Ltd | IL-11 antibodies |
| GB201809700D0 (en) | 2018-06-13 | 2018-08-01 | Singapore Health Serv Pte Ltd | IL-11 antibodies |
| WO2022033538A1 (zh) * | 2020-08-13 | 2022-02-17 | 广东东阳光药业有限公司 | Il-11的抗体及其应用 |
| CN113980129B (zh) * | 2021-01-15 | 2023-07-28 | 东大生物技术(苏州)有限公司 | 一组il-11单克隆抗体及其医药用途 |
-
2017
- 2017-12-15 AU AU2017378111A patent/AU2017378111A1/en not_active Abandoned
- 2017-12-15 KR KR1020197020575A patent/KR20190096390A/ko not_active Ceased
- 2017-12-15 WO PCT/EP2017/083051 patent/WO2018109174A2/en not_active Ceased
- 2017-12-15 US US15/843,173 patent/US20180186871A1/en not_active Abandoned
- 2017-12-15 CA CA3045871A patent/CA3045871A1/en not_active Abandoned
- 2017-12-15 MX MX2019007020A patent/MX2019007020A/es unknown
- 2017-12-15 BR BR112019012342A patent/BR112019012342A2/pt not_active Application Discontinuation
- 2017-12-15 EP EP17823089.2A patent/EP3555131B1/en active Active
- 2017-12-15 CN CN201780078160.XA patent/CN110382531B/zh active Active
- 2017-12-15 TW TW106144224A patent/TW201829460A/zh unknown
- 2017-12-15 JP JP2019531960A patent/JP7181870B2/ja active Active
-
2019
- 2019-12-23 US US16/726,173 patent/US11078268B2/en active Active
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