JP2020510452A - トランスフェクションおよび薬剤送達用の新規デバイス - Google Patents

トランスフェクションおよび薬剤送達用の新規デバイス Download PDF

Info

Publication number
JP2020510452A
JP2020510452A JP2019527319A JP2019527319A JP2020510452A JP 2020510452 A JP2020510452 A JP 2020510452A JP 2019527319 A JP2019527319 A JP 2019527319A JP 2019527319 A JP2019527319 A JP 2019527319A JP 2020510452 A JP2020510452 A JP 2020510452A
Authority
JP
Japan
Prior art keywords
ultrasound
transmission device
patient
therapeutic
ultrasonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2019527319A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020510452A5 (enExample
Inventor
ダン ガジット
ダン ガジット
ガディ ペレド
ガディ ペレド
キャサリン ダブリュ． フェラーラ
キャサリン ダブリュ． フェラーラ
ダグラス エヌ． スティーブンス
ダグラス エヌ． スティーブンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of JP2020510452A publication Critical patent/JP2020510452A/ja
Publication of JP2020510452A5 publication Critical patent/JP2020510452A5/ja
Priority to JP2023094688A priority Critical patent/JP7605906B2/ja
Priority to JP2024217256A priority patent/JP2025028152A/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
    • A61B8/085—Clinical applications involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0875—Clinical applications for diagnosis of bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B2017/22005—Effects, e.g. on tissue
    • A61B2017/22007—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing
    • A61B2017/22008—Cavitation or pseudocavitation, i.e. creation of gas bubbles generating a secondary shock wave when collapsing used or promoted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/42—Details of probe positioning or probe attachment to the patient
    • A61B8/4209—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames
    • A61B8/4218—Details of probe positioning or probe attachment to the patient by using holders, e.g. positioning frames characterised by articulated arms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0013—Fracture healing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0091—Beam steering with moving parts, e.g. transducers, lenses, reflectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A61N2007/027—Localised ultrasound hyperthermia with multiple foci created simultaneously
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
    • G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
    • G01S15/899—Combination of imaging systems with ancillary equipment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2019527319A 2016-11-22 2017-11-20 トランスフェクションおよび薬剤送達用の新規デバイス Withdrawn JP2020510452A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023094688A JP7605906B2 (ja) 2016-11-22 2023-06-08 トランスフェクションおよび薬剤送達用の新規デバイス
JP2024217256A JP2025028152A (ja) 2016-11-22 2024-12-12 トランスフェクションおよび薬剤送達用の新規デバイス

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662425546P 2016-11-22 2016-11-22
US62/425,546 2016-11-22
PCT/US2017/062640 WO2018098091A1 (en) 2016-11-22 2017-11-20 A novel transfection and drug delivery device

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023094688A Division JP7605906B2 (ja) 2016-11-22 2023-06-08 トランスフェクションおよび薬剤送達用の新規デバイス

Publications (2)

Publication Number Publication Date
JP2020510452A true JP2020510452A (ja) 2020-04-09
JP2020510452A5 JP2020510452A5 (enExample) 2022-01-06

Family

ID=62196099

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019527319A Withdrawn JP2020510452A (ja) 2016-11-22 2017-11-20 トランスフェクションおよび薬剤送達用の新規デバイス
JP2023094688A Active JP7605906B2 (ja) 2016-11-22 2023-06-08 トランスフェクションおよび薬剤送達用の新規デバイス
JP2024217256A Pending JP2025028152A (ja) 2016-11-22 2024-12-12 トランスフェクションおよび薬剤送達用の新規デバイス

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023094688A Active JP7605906B2 (ja) 2016-11-22 2023-06-08 トランスフェクションおよび薬剤送達用の新規デバイス
JP2024217256A Pending JP2025028152A (ja) 2016-11-22 2024-12-12 トランスフェクションおよび薬剤送達用の新規デバイス

Country Status (5)

Country Link
US (1) US11413477B2 (enExample)
EP (1) EP3544497A4 (enExample)
JP (3) JP2020510452A (enExample)
CN (1) CN109963506B (enExample)
WO (1) WO2018098091A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413477B2 (en) 2016-11-22 2022-08-16 Cedars-Sinai Medical Center Transfection and drug delivery

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200205781A1 (en) * 2018-12-27 2020-07-02 Avent, Inc. Miniscule Transducer for a Medical Article
CN114717267B (zh) * 2022-04-15 2023-10-31 深圳高性能医疗器械国家研究院有限公司 基因转染方法及系统

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000507118A (ja) * 1996-02-15 2000-06-13 バイオセンス・インコーポレイテッド カテーテルに基づく手術
US20030078227A1 (en) * 1998-07-02 2003-04-24 Greenleaf James F. Site-directed transfection with ultrasound and cavitation nuclei
JP2004532205A (ja) * 2001-03-22 2004-10-21 クロモス・モレキユラー・システムズ・インコーポレーテツド 細胞への核酸分子の送達およびその評価方法
WO2006030534A1 (en) * 2004-09-17 2006-03-23 I-Check, Inc. Integrated system for noninvasive focused energy treatment using energy activated drugs
JP2012090857A (ja) * 2010-10-28 2012-05-17 Hitachi Aloka Medical Ltd 脊椎手術支援用超音波プローブ及びその製造方法
JP2012135522A (ja) * 2010-12-27 2012-07-19 Toshiba Corp 超音波装置
JP2013022391A (ja) * 2011-07-25 2013-02-04 Hitachi Medical Corp 超音波治療装置
CN103463742A (zh) * 2013-09-26 2013-12-25 浙江大学 一种抑制关节置换术后假体周围骨溶解的超声仪
JP2014151123A (ja) * 2013-02-13 2014-08-25 Nippon Sigmax Kk 超音波骨折治療装置
US20150165243A1 (en) * 2004-09-24 2015-06-18 Guided Therapy Systems, Llc System and Method for Treating Cartilage and Injuries to Joints and Connective Tissue
WO2016139832A1 (ja) * 2015-03-02 2016-09-09 国立大学法人 東京大学 生体内運動追跡装置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7686763B2 (en) * 1998-09-18 2010-03-30 University Of Washington Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy
EP1170363B1 (en) * 2000-02-02 2007-11-21 Kaneda, Yasufumi Virus envelope vector for gene transfer
US20020068869A1 (en) * 2000-06-27 2002-06-06 Axel Brisken Drug delivery catheter with internal ultrasound receiver
US6613005B1 (en) * 2000-11-28 2003-09-02 Insightec-Txsonics, Ltd. Systems and methods for steering a focused ultrasound array
AU2004235782B2 (en) * 2003-05-02 2009-07-02 Clearflow, Inc. Body-space drainage-tube debris removal
US7604601B2 (en) * 2005-04-26 2009-10-20 Biosense Webster, Inc. Display of catheter tip with beam direction for ultrasound system
CN101028524B (zh) * 2006-03-03 2010-10-20 重庆融海超声医学工程研究中心有限公司 超声微泡靶向定位控释药物/基因装置及靶向转移的方法
US8287471B2 (en) * 2007-02-20 2012-10-16 National Health Research Institutes Medical treatment using an ultrasound phased array
EP2214573B1 (en) * 2007-10-26 2019-07-03 University Of Virginia Patent Foundation System for treatment and imaging using ultrasonic energy and microbubbles
CN101475962B (zh) * 2009-01-07 2011-07-27 上海市第一人民医院 一种介导基因转染的方法
WO2012042423A1 (en) * 2010-09-30 2012-04-05 Koninklijke Philips Electronics N.V. Monitoring and control of microbubble cavitation in therapeutic ultrasound
US9308041B2 (en) * 2010-12-22 2016-04-12 Biosense Webster (Israel) Ltd. Lasso catheter with rotating ultrasound transducer
CN102836505A (zh) * 2011-06-15 2012-12-26 黄品同 一种具有超声聚焦定位功能的聚焦超声空化治疗仪
CN103654842A (zh) * 2012-09-19 2014-03-26 重庆融海超声医学工程研究中心有限公司 超声监控与靶向控释系统
US20140128734A1 (en) * 2012-11-05 2014-05-08 Ekos Corporation Catheter systems and methods
CN203059751U (zh) * 2012-11-30 2013-07-17 深圳先进技术研究院 三排混频线阵超声探头及超声波基因转染系统
KR101533402B1 (ko) * 2014-01-28 2015-07-03 알피니언메디칼시스템 주식회사 고강도 집속 초음파 치료기 및 그 제어방법
CN107660137B (zh) * 2015-04-02 2020-10-09 卡尔迪亚韦弗公司 用于治疗瓣膜病的方法和装置
EP3426157B1 (en) * 2016-03-11 2022-02-16 Sorbonne Universite External ultrasound generating treating device for spinal cord and spinal nerves treatment
US11413477B2 (en) 2016-11-22 2022-08-16 Cedars-Sinai Medical Center Transfection and drug delivery
US11369810B2 (en) * 2016-12-19 2022-06-28 Michalakis Averkiou Method and apparatus for ultrasonic mediation of drug delivery using microbubbles
JP7466575B2 (ja) * 2019-05-31 2024-04-12 サニーブルック リサーチ インスティチュート 経頭蓋超音波治療手順中に頭蓋骨によって引き起こされる熱収差を低減するためのシステム及び方法

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000507118A (ja) * 1996-02-15 2000-06-13 バイオセンス・インコーポレイテッド カテーテルに基づく手術
US20030078227A1 (en) * 1998-07-02 2003-04-24 Greenleaf James F. Site-directed transfection with ultrasound and cavitation nuclei
JP2004532205A (ja) * 2001-03-22 2004-10-21 クロモス・モレキユラー・システムズ・インコーポレーテツド 細胞への核酸分子の送達およびその評価方法
WO2006030534A1 (en) * 2004-09-17 2006-03-23 I-Check, Inc. Integrated system for noninvasive focused energy treatment using energy activated drugs
US20150165243A1 (en) * 2004-09-24 2015-06-18 Guided Therapy Systems, Llc System and Method for Treating Cartilage and Injuries to Joints and Connective Tissue
JP2012090857A (ja) * 2010-10-28 2012-05-17 Hitachi Aloka Medical Ltd 脊椎手術支援用超音波プローブ及びその製造方法
JP2012135522A (ja) * 2010-12-27 2012-07-19 Toshiba Corp 超音波装置
JP2013022391A (ja) * 2011-07-25 2013-02-04 Hitachi Medical Corp 超音波治療装置
JP2014151123A (ja) * 2013-02-13 2014-08-25 Nippon Sigmax Kk 超音波骨折治療装置
CN103463742A (zh) * 2013-09-26 2013-12-25 浙江大学 一种抑制关节置换术后假体周围骨溶解的超声仪
WO2016139832A1 (ja) * 2015-03-02 2016-09-09 国立大学法人 東京大学 生体内運動追跡装置

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413477B2 (en) 2016-11-22 2022-08-16 Cedars-Sinai Medical Center Transfection and drug delivery

Also Published As

Publication number Publication date
CN109963506A (zh) 2019-07-02
JP2023111991A (ja) 2023-08-10
US11413477B2 (en) 2022-08-16
CN109963506B (zh) 2024-05-07
EP3544497A4 (en) 2020-08-05
EP3544497A1 (en) 2019-10-02
JP7605906B2 (ja) 2024-12-24
US20200078607A1 (en) 2020-03-12
JP2025028152A (ja) 2025-02-28
WO2018098091A1 (en) 2018-05-31

Similar Documents

Publication Publication Date Title
JP7605906B2 (ja) トランスフェクションおよび薬剤送達用の新規デバイス
US8715186B2 (en) Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
US11097133B2 (en) Method and system for combined energy therapy profile
Ter Haar HIFU tissue ablation: concept and devices
JP6980696B2 (ja) 超音波撮像及び治療装置
JP2012504011A (ja) 超音波療法治療のためのシステム及び方法
CN101130126A (zh) 一种影像设备引导的高强度聚焦超声治疗系统
JP2001046387A (ja) 超音波治療アプリケータ
Alkins et al. High-intensity focused ultrasound ablation therapy of gliomas
EP2481446B1 (en) System for combined energy therapy profile
EP1813304B1 (en) Apparatus for introducing a drug with ultrasounds
JP2020510452A5 (enExample)
US20100125271A1 (en) System for treating undesired body tissue
JPH11164837A (ja) 超音波治療装置
HK40008492A (en) A novel transfection and drug delivery device
HK40008492B (zh) 一种新型的转染和药物递送装置
KR20190015866A (ko) 고강도 집속 초음파 장치
KR20190009209A (ko) 초음파 치료 카트리지 및 이를 포함하는 치료 장치
TWI651109B (zh) 治療型超音波裝置及其用途
Lai et al. Medical ultrasound application beyond imaging: insights from ultrasound sensing and biological response

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190527

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201022

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20201022

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20210309

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210813

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210823

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211124

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20211124

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220421

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220721

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221021

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230209

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230608

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20230714