JP2020508691A5 - - Google Patents
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- JP2020508691A5 JP2020508691A5 JP2019548419A JP2019548419A JP2020508691A5 JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5 JP 2019548419 A JP2019548419 A JP 2019548419A JP 2019548419 A JP2019548419 A JP 2019548419A JP 2020508691 A5 JP2020508691 A5 JP 2020508691A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- soluble
- fusion protein
- protein complex
- 15rαsu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108020001507 fusion proteins Proteins 0.000 claims description 75
- 102000037865 fusion proteins Human genes 0.000 claims description 75
- 108090000623 proteins and genes Proteins 0.000 claims description 70
- 102000004169 proteins and genes Human genes 0.000 claims description 70
- 108090000172 Interleukin-15 Proteins 0.000 claims description 44
- 102000003812 Interleukin-15 Human genes 0.000 claims description 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108060003951 Immunoglobulin Proteins 0.000 claims description 14
- 239000012634 fragment Substances 0.000 claims description 14
- 102000018358 immunoglobulin Human genes 0.000 claims description 14
- 201000010099 disease Diseases 0.000 claims description 8
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- 108091007433 antigens Proteins 0.000 claims description 4
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- 102100037850 Interferon gamma Human genes 0.000 description 1
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- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
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- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022194613A JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762467623P | 2017-03-06 | 2017-03-06 | |
| US62/467,623 | 2017-03-06 | ||
| PCT/US2018/021220 WO2018165208A1 (en) | 2017-03-06 | 2018-03-06 | Il-15-based fusions to il-12 and il-18 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Division JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508691A JP2020508691A (ja) | 2020-03-26 |
| JP2020508691A5 true JP2020508691A5 (OSRAM) | 2021-04-15 |
| JP7191030B2 JP7191030B2 (ja) | 2022-12-16 |
Family
ID=63448011
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548419A Active JP7191030B2 (ja) | 2017-03-06 | 2018-03-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022194613A Pending JP2023027174A (ja) | 2017-03-06 | 2022-12-06 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
| JP2024082540A Active JP7720950B2 (ja) | 2017-03-06 | 2024-05-21 | Ｉｌ－１２及びｉｌ－１８へのｉｌ－１５系融合 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US11129883B2 (OSRAM) |
| EP (1) | EP3592778A4 (OSRAM) |
| JP (3) | JP7191030B2 (OSRAM) |
| KR (4) | KR102867975B1 (OSRAM) |
| CN (2) | CN110785435B (OSRAM) |
| AU (1) | AU2018231170B2 (OSRAM) |
| CA (2) | CA3216726C (OSRAM) |
| WO (1) | WO2018165208A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2388266B1 (en) * | 2007-05-11 | 2014-04-23 | Altor BioScience Corporation | Fusion molecules and IL-15 variants |
| CA3216726C (en) | 2017-03-06 | 2025-08-05 | Altor Bioscience Corporation | IL-15-BASED FUSION PROTEINS SPECIFIC TO IL-12 AND IL-18 |
| CN107384859A (zh) * | 2017-09-05 | 2017-11-24 | 四川新生命干细胞科技股份有限公司 | 一种高纯度nk细胞的分离培养方法 |
| CN111315395A (zh) | 2017-09-06 | 2020-06-19 | 耶鲁大学 | 白细胞介素-18变体和使用方法 |
| AU2019226392B2 (en) * | 2018-03-01 | 2025-02-27 | Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañón | Method for obtaining regulatory T cells derived from thymic tissue and use of said cells as cell immunotherapy in immune system disorders |
| WO2020023713A1 (en) * | 2018-07-26 | 2020-01-30 | Nantbio, Inc. | Tri-cytokine txm compositions and methods |
| WO2020047333A1 (en) | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| EP4592314A3 (en) | 2018-08-30 | 2025-11-05 | ImmunityBio, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
| SG11202101779RA (en) * | 2018-08-30 | 2021-03-30 | Hcw Biologics Inc | Multi-chain chimeric polypeptides and uses thereof |
| CN118976120A (zh) * | 2018-09-07 | 2024-11-19 | 南特生物公司 | 刺激hank和nk92mi细胞的靶向il-12治疗和方法 |
| CN114269903B (zh) * | 2019-06-21 | 2025-11-25 | 免疫生物公司 | 多链嵌合多肽和其用途 |
| US20210008107A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | CIML NK cells and Methods Therefor |
| CA3117134A1 (en) * | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | Ciml nk cells and methods therefor |
| WO2021006875A1 (en) | 2019-07-08 | 2021-01-14 | Nantkwest, Inc. | Mononuclear cell derived nk cells |
| US11453862B2 (en) | 2019-07-08 | 2022-09-27 | Immunitybio, Inc. | Mononuclear cell derived NK cells |
| WO2021044439A1 (en) * | 2019-09-08 | 2021-03-11 | Immunoadaptive Cell Therapy Pvt Ltd. | Inducible cytokine signals & methods for immunotherapy |
| RU2753282C2 (ru) * | 2019-09-19 | 2021-08-12 | Закрытое Акционерное Общество "Биокад" | ИММУНОЦИТОКИН, ВКЛЮЧАЮЩИЙ ГЕТЕРОДИМЕРНЫЙ БЕЛКОВЫЙ КОМПЛЕКС НА ОСНОВЕ IL-15/IL-15Rα, И ЕГО ПРИМЕНЕНИЕ |
| AU2020358979A1 (en) * | 2019-10-03 | 2022-04-21 | Xencor, Inc. | Targeted IL-12 heterodimeric Fc-fusion proteins |
| WO2021097227A1 (en) * | 2019-11-14 | 2021-05-20 | Altor Bioscience, Llc | Il-15 fusion protein enhanced adoptive cell therapeutics |
| KR102400884B1 (ko) * | 2019-11-15 | 2022-05-23 | 주식회사 제넥신 | 변형된 인터루킨-7 및 인터루킨-2를 포함하는 융합단백질 및 이의 용도 |
| AU2021220870A1 (en) | 2020-02-11 | 2022-08-04 | Immunitybio, Inc. | Methods of treating age-related and inflammatory diseases |
| KR20220140572A (ko) | 2020-02-11 | 2022-10-18 | 에이치씨더블유 바이올로직스, 인크. | 조절 t 세포를 활성화시키는 방법 |
| AU2021219720B2 (en) | 2020-02-11 | 2025-10-02 | Immunitybio, Inc. | Chromatography resin and uses thereof |
| US12497462B2 (en) | 2020-04-29 | 2025-12-16 | Immunitybio, Inc. | Anti-CD26 proteins and uses thereof |
| US12024545B2 (en) | 2020-06-01 | 2024-07-02 | HCW Biologics, Inc. | Methods of treating aging-related disorders |
| AU2022230374B2 (en) * | 2021-03-03 | 2025-06-19 | Immunitybio, Inc. | Highly potent m-cenk cells and methods |
| CN117479831A (zh) | 2021-06-09 | 2024-01-30 | 南特知识产权控股有限责任公司 | 用于在植物中生产感兴趣的蛋白质的方法和系统 |
| CN114853899B (zh) * | 2021-11-02 | 2024-05-28 | 北京华奥玄德生物医药科技有限公司 | 一种il-12和il-18变体的融合蛋白及其制备方法和用途 |
| EP4572781A2 (en) * | 2022-08-16 | 2025-06-25 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Synergistic interactions for improved cancer treatment |
| CN121152797A (zh) * | 2023-03-31 | 2025-12-16 | 免疫生物公司 | Il-12/il-18超级因子 |
| WO2024259391A2 (en) * | 2023-06-14 | 2024-12-19 | Fuse Biotherapeutics Inc. | Single-and multi-cytokine fusion proteins and uses thereof |
| WO2025068413A1 (en) * | 2023-09-28 | 2025-04-03 | Prokarium Limited | Interleukin 18 variants |
| WO2025184052A1 (en) * | 2024-02-26 | 2025-09-04 | Allegheny Singer Research Institute | Interleukin 2 and interleukin 12 fusion proteins and methods of using |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| AU5098393A (en) | 1992-08-14 | 1994-03-15 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Recombinant toxin with increased half-life |
| US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
| US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
| US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5534592A (en) | 1995-09-22 | 1996-07-09 | The Goodyear Tire & Rubber Company | High performance blend for tire treads |
| AU728657B2 (en) | 1996-03-18 | 2001-01-18 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
| US7445779B2 (en) | 2002-12-31 | 2008-11-04 | Schering Corporation | Methods of modulating IFNy production |
| DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
| CN105021814B (zh) | 2003-11-10 | 2018-02-16 | 阿尔特生物科学公司 | 可溶性tcr分子及其用途 |
| EP2388266B1 (en) * | 2007-05-11 | 2014-04-23 | Altor BioScience Corporation | Fusion molecules and IL-15 variants |
| EP3173484B1 (en) | 2007-05-30 | 2018-09-26 | Postech Academy-Industry- Foundation | Immunoglobulin fusion proteins |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| JP6251570B2 (ja) | 2010-09-21 | 2017-12-20 | アルター・バイオサイエンス・コーポレーション | 多量体ｉｌ−１５可溶性融合分子並びにその製造及び使用方法 |
| US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
| ES2888249T3 (es) * | 2011-10-11 | 2022-01-03 | Univ Zuerich | Medicamento de combinación que comprende IL-12 y un agente para el bloqueo de moléculas inhibidoras de linfocitos T para terapia tumoral |
| EP3673915A1 (en) | 2014-06-30 | 2020-07-01 | Altor BioScience Corporation | Il-15-based molecules and methods of use thereof |
| US20180200366A1 (en) * | 2016-10-21 | 2018-07-19 | Altor Bioscience Corporation | Multimeric il-15-based molecules |
| CA3216726C (en) | 2017-03-06 | 2025-08-05 | Altor Bioscience Corporation | IL-15-BASED FUSION PROTEINS SPECIFIC TO IL-12 AND IL-18 |
| US20190048055A1 (en) | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| US11161890B2 (en) | 2017-08-28 | 2021-11-02 | Altor Bioscience LLC. | IL-15-based fusions to IL-7 and IL-21 |
| EP3773657A4 (en) | 2018-03-26 | 2021-12-08 | Altor Bioscience LLC | ANTI-PDL1, IL-15 AND TGF BETA RECEPTOR COMBINATION MOLECULES |
-
2018
- 2018-03-06 CA CA3216726A patent/CA3216726C/en active Active
- 2018-03-06 JP JP2019548419A patent/JP7191030B2/ja active Active
- 2018-03-06 KR KR1020247039400A patent/KR102867975B1/ko active Active
- 2018-03-06 CN CN201880016721.8A patent/CN110785435B/zh active Active
- 2018-03-06 EP EP18764359.8A patent/EP3592778A4/en active Pending
- 2018-03-06 KR KR1020237042270A patent/KR102739572B1/ko active Active
- 2018-03-06 KR KR1020197029313A patent/KR102625293B1/ko active Active
- 2018-03-06 US US15/913,837 patent/US11129883B2/en active Active
- 2018-03-06 WO PCT/US2018/021220 patent/WO2018165208A1/en not_active Ceased
- 2018-03-06 AU AU2018231170A patent/AU2018231170B2/en active Active
- 2018-03-06 CA CA3055318A patent/CA3055318C/en active Active
- 2018-03-06 CN CN202311813891.8A patent/CN117986384A/zh active Pending
- 2018-03-06 KR KR1020257032318A patent/KR20250150164A/ko active Pending
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2021
- 2021-09-27 US US17/486,683 patent/US11571470B2/en active Active
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2022
- 2022-08-19 US US17/820,980 patent/US11612645B2/en active Active
- 2022-12-06 JP JP2022194613A patent/JP2023027174A/ja active Pending
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2023
- 2023-02-13 US US18/168,428 patent/US11872272B2/en active Active
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2024
- 2024-03-20 US US18/611,464 patent/US20240252609A1/en not_active Abandoned
- 2024-05-21 JP JP2024082540A patent/JP7720950B2/ja active Active
- 2024-09-25 US US18/896,286 patent/US12233116B2/en active Active
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2025
- 2025-01-15 US US19/021,639 patent/US20250152686A1/en active Pending
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