JP2020508310A5 - - Google Patents
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- JP2020508310A5 JP2020508310A5 JP2019544894A JP2019544894A JP2020508310A5 JP 2020508310 A5 JP2020508310 A5 JP 2020508310A5 JP 2019544894 A JP2019544894 A JP 2019544894A JP 2019544894 A JP2019544894 A JP 2019544894A JP 2020508310 A5 JP2020508310 A5 JP 2020508310A5
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- Prior art keywords
- pharmaceutical composition
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- compound
- cancer
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 45
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 238000012377 drug delivery Methods 0.000 claims 28
- 239000003981 vehicle Substances 0.000 claims 28
- 206010003402 Arthropod sting Diseases 0.000 claims 12
- 208000003014 Bites and Stings Diseases 0.000 claims 12
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
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- 201000011510 cancer Diseases 0.000 claims 8
- 230000008685 targeting Effects 0.000 claims 8
- 150000002148 esters Chemical class 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 230000001404 mediated effect Effects 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
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- 102000002227 Interferon Type I Human genes 0.000 claims 3
- 108010014726 Interferon Type I Proteins 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
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- 208000015181 infectious disease Diseases 0.000 claims 3
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- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
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- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 2
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- 206010051066 Gastrointestinal stromal tumour Diseases 0.000 claims 1
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- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
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- 102000004338 Transferrin Human genes 0.000 claims 1
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- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
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- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 150000001615 biotins Chemical class 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 201000010897 colon adenocarcinoma Diseases 0.000 claims 1
- 230000007123 defense Effects 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 201000006974 gastroesophageal cancer Diseases 0.000 claims 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 1
- 230000035876 healing Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000037452 priming Effects 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 230000014567 type I interferon production Effects 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 230000002485 urinary effect Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 0 *CCC1C(CC(*)N2)=C2N=C*1 Chemical compound *CCC1C(CC(*)N2)=C2N=C*1 0.000 description 4
- YSTLWRLEDVOAMH-YUMQZZPRSA-N CC[C@@H]([C@H]1OC2(CC2)CC1)O[O]=S Chemical compound CC[C@@H]([C@H]1OC2(CC2)CC1)O[O]=S YSTLWRLEDVOAMH-YUMQZZPRSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022187897A JP2023022165A (ja) | 2017-02-21 | 2022-11-25 | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762461642P | 2017-02-21 | 2017-02-21 | |
| US62/461,642 | 2017-02-21 | ||
| PCT/US2018/019015 WO2018156625A1 (en) | 2017-02-21 | 2018-02-21 | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187897A Division JP2023022165A (ja) | 2017-02-21 | 2022-11-25 | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508310A JP2020508310A (ja) | 2020-03-19 |
| JP2020508310A5 true JP2020508310A5 (cg-RX-API-DMAC7.html) | 2021-04-08 |
| JP7591348B2 JP7591348B2 (ja) | 2024-11-28 |
Family
ID=63253365
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019544894A Active JP7591348B2 (ja) | 2017-02-21 | 2018-02-21 | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
| JP2022187897A Withdrawn JP2023022165A (ja) | 2017-02-21 | 2022-11-25 | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022187897A Withdrawn JP2023022165A (ja) | 2017-02-21 | 2022-11-25 | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US10933078B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3585379A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7591348B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3053568A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018156625A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109475570B (zh) | 2016-03-18 | 2022-04-01 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| AU2017293781B2 (en) | 2016-07-06 | 2022-12-22 | Invox Pharma Limited | Compounds, compositions, and methods for the treatment of disease |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| JP7591348B2 (ja) | 2017-02-21 | 2024-11-28 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
| JP7270608B2 (ja) | 2017-08-31 | 2023-05-10 | エフ－スター・セラピューティクス・インコーポレイテッド | 化合物、組成物、及び疾患の治療方法 |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11584774B2 (en) | 2017-09-11 | 2023-02-21 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2019084060A1 (en) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
| PH12020550585A1 (en) | 2017-11-10 | 2021-04-19 | Takeda Pharmaceuticals Co | Sting modulator compounds, and methods of making and using |
| US11685761B2 (en) | 2017-12-20 | 2023-06-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| EP3820477A4 (en) | 2018-07-10 | 2022-07-13 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES |
| US20200113912A1 (en) | 2018-09-12 | 2020-04-16 | Silverback Therapeutics, Inc. | Methods and Compositions for the Treatment of Disease with Immune Stimulatory Conjugates |
| US11161864B2 (en) | 2018-10-29 | 2021-11-02 | Venenum Biodesign, LLC | Sting agonists |
| US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
| CA3137119A1 (en) * | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| AU2020358726A1 (en) | 2019-10-01 | 2022-04-07 | Silverback Therapeutics, Inc. | Combination therapy with immune stimulatory conjugates |
| JP7735291B2 (ja) | 2020-02-21 | 2025-09-08 | エーアールエス ファーマシューティカルズ、インコーポレイテッド | ネクチン－４抗体コンジュゲートおよびその使用 |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| AU2021300362A1 (en) | 2020-07-01 | 2023-02-23 | ARS Pharmaceuticals, Inc. | Anti-ASGR1 antibody conjugates and uses thereof |
| WO2022083584A1 (zh) * | 2020-10-20 | 2022-04-28 | 泰励生物科技（上海）有限公司 | 多功能环二核苷酸及其用途 |
| AU2021374958A1 (en) | 2020-11-09 | 2023-06-22 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
| WO2023020993A1 (en) * | 2021-08-16 | 2023-02-23 | Glaxosmithkline Biologicals Sa | Novel methods |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6257607B2 (ja) | 2012-06-08 | 2018-01-10 | アデュロ バイオテック，インコーポレイテッド | 癌免疫療法のための組成物および方法 |
| EP2931738B1 (en) | 2012-12-13 | 2019-02-06 | Aduro Biotech, Inc. | Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use |
| CA2908154C (en) * | 2013-04-29 | 2023-11-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| CN105188373B (zh) | 2013-05-18 | 2017-09-22 | 艾杜罗生物科技公司 | 抑制“干扰素基因刺激蛋白”依赖性信号传导的组合物和方法 |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| CU24377B1 (es) | 2013-05-18 | 2018-12-05 | Aduro Biotech Inc | Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting |
| SG11201609021QA (en) | 2014-06-04 | 2016-11-29 | Glaxosmithkline Ip Dev Ltd | Cyclic di-nucleotides as modulators of sting |
| DK3233882T3 (da) * | 2014-12-16 | 2020-01-27 | Kayla Therapeutics | Fluorinerede cykliske dinukleotider til cytokininduktion |
| WO2016096577A1 (en) | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| GB201501462D0 (en) * | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| EA035817B1 (ru) | 2015-03-10 | 2020-08-14 | Адуро Байотек, Инк. | Композиции и способы для активации сигналинга, зависимого от "гена стимулятора интерферона" |
| JP6596146B2 (ja) | 2015-08-13 | 2019-10-23 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド化合物 |
| CN108430503A (zh) | 2015-10-28 | 2018-08-21 | 艾杜罗生物科技公司 | 用于激活“干扰素基因刺激物”依赖性信号传导的组合物和方法 |
| CR20180286A (es) * | 2015-12-03 | 2018-07-16 | Glaxosmithkline Ip Dev Ltd | Dinucleotidos de purina cíclicos como moduladores de sting |
| WO2017106740A1 (en) | 2015-12-16 | 2017-06-22 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"-dependent interferon production |
| CN109475570B (zh) | 2016-03-18 | 2022-04-01 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| WO2018118665A1 (en) * | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| WO2018119117A1 (en) | 2016-12-22 | 2018-06-28 | The Regents Of The University Of California | Methods of producing cyclic dinucleotides |
| JP7591348B2 (ja) * | 2017-02-21 | 2024-11-28 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | インターフェロン遺伝子刺激因子依存性シグナル伝達のアゴニストとしての環状ジヌクレオチド |
| WO2018198084A1 (en) | 2017-04-27 | 2018-11-01 | Lupin Limited | Cyclic di-nucleotide compounds with tricyclic nucleobases |
| US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
| EP3692048A4 (en) | 2017-08-30 | 2021-10-20 | Beijing Xuanyi Pharmasciences Co., Ltd. | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
| JP7270608B2 (ja) | 2017-08-31 | 2023-05-10 | エフ－スター・セラピューティクス・インコーポレイテッド | 化合物、組成物、及び疾患の治療方法 |
-
2018
- 2018-02-21 JP JP2019544894A patent/JP7591348B2/ja active Active
- 2018-02-21 US US16/484,179 patent/US10933078B2/en active Active
- 2018-02-21 CA CA3053568A patent/CA3053568A1/en active Pending
- 2018-02-21 WO PCT/US2018/019015 patent/WO2018156625A1/en not_active Ceased
- 2018-02-21 EP EP18757865.3A patent/EP3585379A4/en active Pending
-
2020
- 2020-10-07 US US17/065,304 patent/US11400108B2/en active Active
-
2022
- 2022-06-27 US US17/809,190 patent/US12036231B2/en active Active
- 2022-11-25 JP JP2022187897A patent/JP2023022165A/ja not_active Withdrawn
-
2024
- 2024-06-05 US US18/734,176 patent/US20250041324A1/en active Pending