JP2020507338A5 - - Google Patents

Info

Publication number

JP2020507338A5

JP2020507338A5 JP2019559134A JP2019559134A JP2020507338A5 JP 2020507338 A5 JP2020507338 A5 JP 2020507338A5 JP 2019559134 A JP2019559134 A JP 2019559134A JP 2019559134 A JP2019559134 A JP 2019559134A JP 2020507338 A5 JP2020507338 A5 JP 2020507338A5

Authority

JP

Japan

Prior art keywords

seq

functional fragment

amino acid

acid sequence

humanized antibody

Prior art date

2017-01-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000012634 fragment Substances 0.000 claims description 30
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 26
• 206010028980 Neoplasm Diseases 0.000 claims description 6
• 201000011510 cancer Diseases 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims description 4
• 102000002068 Glycopeptides Human genes 0.000 claims description 4
• 108010015899 Glycopeptides Proteins 0.000 claims description 4
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 4
• 102100034256 Mucin-1 Human genes 0.000 claims description 4
• OVRNDRQMDRJTHS-KEWYIRBNSA-N N-acetyl-D-galactosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-KEWYIRBNSA-N 0.000 claims description 4
• MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims description 4
• 239000013604 expression vector Substances 0.000 claims description 3
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 239000003814 drug Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 239000003937 drug carrier Substances 0.000 description 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
• 229940126619 mouse monoclonal antibody Drugs 0.000 description 1