JP2020505352A - インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 - Google Patents

インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 Download PDF

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JP2020505352A
JP2020505352A JP2019538525A JP2019538525A JP2020505352A JP 2020505352 A JP2020505352 A JP 2020505352A JP 2019538525 A JP2019538525 A JP 2019538525A JP 2019538525 A JP2019538525 A JP 2019538525A JP 2020505352 A JP2020505352 A JP 2020505352A
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alpha
phe
lys
peptide
asn
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JP2020505352A5 (enExample
Inventor
アショク バンダーリー，
アショク バンダーリー，
グレゴリー ボーン，
グレゴリー ボーン，
Original Assignee
プロタゴニスト セラピューティクス， インコーポレイテッド
プロタゴニスト セラピューティクス， インコーポレイテッド
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Publication of JP2020505352A5 publication Critical patent/JP2020505352A5/ja
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Priority to JP2025088409A priority patent/JP2025162551A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019538525A 2017-01-18 2018-01-18 インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 Withdrawn JP2020505352A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022193564A JP2023014346A (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762447778P 2017-01-18 2017-01-18
US62/447,778 2017-01-18
PCT/US2018/014257 WO2018136646A1 (en) 2017-01-18 2018-01-18 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases

Related Child Applications (1)

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JP2022193564A Division JP2023014346A (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Publications (2)

Publication Number Publication Date
JP2020505352A true JP2020505352A (ja) 2020-02-20
JP2020505352A5 JP2020505352A5 (enExample) 2021-02-25

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Family Applications (3)

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JP2019538525A Withdrawn JP2020505352A (ja) 2017-01-18 2018-01-18 インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2022193564A Pending JP2023014346A (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A Pending JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Family Applications After (2)

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JP2022193564A Pending JP2023014346A (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A Pending JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Country Status (6)

Country Link
US (2) US20200207822A1 (enExample)
EP (1) EP3570864A4 (enExample)
JP (3) JP2020505352A (enExample)
AU (1) AU2018210174B2 (enExample)
CA (1) CA3049889A1 (enExample)
WO (1) WO2018136646A1 (enExample)

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PT2968443T (pt) 2013-03-15 2021-12-28 Protagonist Therapeutics Inc Análogos de hepcidina e seus usos
SG10201810321PA (en) 2014-05-16 2018-12-28 Protagonist Therapeutics Inc α4β7 INTEGRIN THIOETHER PEPTIDE ANTAGONISTS
ES2977537T3 (es) 2014-07-17 2024-08-26 Protagonist Therapeutics Inc Inhibidores peptídicos orales del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias intestinales
US10301371B2 (en) 2014-10-01 2019-05-28 Protagonist Therapeutics, Inc. Cyclic monomer and dimer peptides having integrin antagonist activity
SG11201702553RA (en) 2014-10-01 2017-04-27 Protagonist Therapeutics Inc NOVEL α4β7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
WO2017117411A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
AU2017273857B2 (en) 2016-06-01 2021-08-19 Athira Pharma, Inc. Compounds
EP4092038A1 (en) 2017-09-11 2022-11-23 Protagonist Therapeutics, Inc. Opioid agonist peptides and uses thereof
EP4501952A3 (en) 2018-02-08 2025-04-16 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
EP3997105A4 (en) * 2019-07-10 2023-09-13 Protagonist Therapeutics, Inc. PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES
TW202116793A (zh) * 2019-07-10 2021-05-01 美商領導醫療有限公司 介白素-23受體之肽抑制劑及其於治療發炎疾病的用途
CN115279782A (zh) 2020-01-15 2022-11-01 詹森生物科技公司 白介素-23受体的肽抑制剂及其用于治疗炎性疾病的用途
IL294680A (en) * 2020-01-15 2022-09-01 Janssen Biotech Inc Peptide inhibitors of the interleukin-23 receptor and their use for the treatment of inflammatory diseases
IL302996B2 (en) 2020-11-20 2025-04-01 Janssen Pharmaceutica Nv Compositions of interleukin-23 receptor peptide inhibitors
EP4370531A4 (en) * 2021-07-14 2025-09-03 Janssen Biotech Inc PEPTIDE INHIBITORS OF THE INTERLEUKIN-23 RECEPTOR
AU2022311814A1 (en) 2021-07-14 2024-02-29 Janssen Biotech, Inc. Lipidated peptide inhibitors of interleukin-23 receptor
CA3240982A1 (en) 2021-12-01 2023-06-08 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
JP2025521647A (ja) 2022-06-30 2025-07-10 サノフイ 選択的ｉｌ－２３受容体アンタゴニストとしての新規ペプチド
JP2025523026A (ja) * 2022-07-14 2025-07-17 ヤンセン ファーマシューティカ エヌ．ベー． Ｉｌ－２３の環状ペプチド阻害剤
KR20250135270A (ko) * 2023-01-16 2025-09-12 얀센 파마슈티카 엔브이 인터류킨-23 수용체의 지질화된 펩티드 억제제의 제형
EP4471048A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
EP4471049A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2025051912A1 (en) 2023-09-08 2025-03-13 Sanofi New peptides as selective il-23 receptor inhibitors
WO2025051920A1 (en) 2023-09-08 2025-03-13 Sanofi New peptides as selective il-23 receptor inhibitors

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WO2016011208A1 (en) * 2014-07-17 2016-01-21 Protagonist Therapeutics, Inc. Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases

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US20030166138A1 (en) * 2002-02-21 2003-09-04 Todd Kinsella Cyclic peptides and analogs useful to treat allergies
EA017849B1 (ru) 2007-02-15 2013-03-29 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Соагонисты глюкагоновых/glp-1-рецепторов
CA2707840A1 (en) 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
US8946150B2 (en) 2011-06-14 2015-02-03 Medical Diagnostic Laboratories, LLC. Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
US9605027B2 (en) * 2011-06-14 2017-03-28 Medical Diagnostic Laboratories, Llc Polypeptides that bound to IL-23 receptor and inhibit binding of IL-23 and cell signaling thereof
CN108348580B (zh) * 2015-07-15 2022-05-10 领导医疗有限公司 白细胞介素-23受体的肽抑制剂以及其治疗炎症性疾病的用途
WO2018089693A2 (en) * 2016-11-09 2018-05-17 Protagonist Therapeutics, Inc. Methods for determining and monitoring gastrointestinal inflammation

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WO2016011208A1 (en) * 2014-07-17 2016-01-21 Protagonist Therapeutics, Inc. Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases

Also Published As

Publication number Publication date
EP3570864A1 (en) 2019-11-27
US20240132558A1 (en) 2024-04-25
WO2018136646A1 (en) 2018-07-26
US20200207822A1 (en) 2020-07-02
CA3049889A1 (en) 2018-07-26
AU2018210174A1 (en) 2019-07-25
EP3570864A4 (en) 2020-12-30
JP2025162551A (ja) 2025-10-27
AU2018210174B2 (en) 2022-04-07
JP2023014346A (ja) 2023-01-26

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