JP2020505352A - インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 - Google Patents

インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 Download PDF

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JP2020505352A
JP2020505352A JP2019538525A JP2019538525A JP2020505352A JP 2020505352 A JP2020505352 A JP 2020505352A JP 2019538525 A JP2019538525 A JP 2019538525A JP 2019538525 A JP2019538525 A JP 2019538525A JP 2020505352 A JP2020505352 A JP 2020505352A
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alpha
phe
lys
peptide
asn
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JP2020505352A5 (enExample
Inventor
アショク バンダーリー，
アショク バンダーリー，
グレゴリー ボーン，
グレゴリー ボーン，
Original Assignee
プロタゴニスト セラピューティクス， インコーポレイテッド
プロタゴニスト セラピューティクス， インコーポレイテッド
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Publication of JP2020505352A publication Critical patent/JP2020505352A/ja
Publication of JP2020505352A5 publication Critical patent/JP2020505352A5/ja
Priority to JP2022193564A priority Critical patent/JP7819087B2/ja
Priority to JP2025088409A priority patent/JP2025162551A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2019538525A 2017-01-18 2018-01-18 インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用 Withdrawn JP2020505352A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022193564A JP7819087B2 (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762447778P 2017-01-18 2017-01-18
US62/447,778 2017-01-18
PCT/US2018/014257 WO2018136646A1 (en) 2017-01-18 2018-01-18 Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases

Related Child Applications (1)

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JP2022193564A Division JP7819087B2 (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Publications (2)

Publication Number Publication Date
JP2020505352A true JP2020505352A (ja) 2020-02-20
JP2020505352A5 JP2020505352A5 (enExample) 2021-02-25

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JP2019538525A Withdrawn JP2020505352A (ja) 2017-01-18 2018-01-18 インターロイキン−２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2022193564A Active JP7819087B2 (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A Pending JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

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JP2022193564A Active JP7819087B2 (ja) 2017-01-18 2022-12-02 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用
JP2025088409A Pending JP2025162551A (ja) 2017-01-18 2025-05-28 インターロイキン－２３受容体のペプチド阻害剤および炎症性疾患を治療するためのそれらの使用

Country Status (7)

Country Link
US (2) US20200207822A1 (enExample)
EP (2) EP3570864B1 (enExample)
JP (3) JP2020505352A (enExample)
AU (1) AU2018210174B2 (enExample)
CA (1) CA3049889A1 (enExample)
ES (1) ES3065770T3 (enExample)
WO (1) WO2018136646A1 (enExample)

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SG10201810154WA (en) 2014-07-17 2018-12-28 Protagonist Therapeutics Inc Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
WO2016054445A1 (en) 2014-10-01 2016-04-07 Protagonist Therapeutics, Inc. Novel cyclic monomer and dimer peptides having integrin antagonist activity
JP2017535527A (ja) 2014-10-01 2017-11-30 プロタゴニスト セラピューティクス， インコーポレイテッド 新規のα４β７ペプチド単量体及び二量体拮抗薬
US10787490B2 (en) 2015-07-15 2020-09-29 Protaganist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
CA3009834A1 (en) 2015-12-30 2017-07-06 Protagonist Therapeutics, Inc. Analogues of hepcidin mimetics with improved in vivo half lives
SI3464336T1 (sl) 2016-06-01 2022-06-30 Athira Pharma, Inc. Spojine
WO2018022937A1 (en) 2016-07-27 2018-02-01 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
WO2019157268A1 (en) 2018-02-08 2019-08-15 Protagonist Therapeutics, Inc. Conjugated hepcidin mimetics
CA3104418A1 (en) 2018-07-12 2020-01-16 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
AU2020311395A1 (en) * 2019-07-10 2022-02-03 Protagonist Therapeutics, Inc. Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases
SMT202500254T1 (it) * 2020-01-15 2025-09-12 Janssen Biotech Inc Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie
MX2022008740A (es) * 2020-01-15 2022-09-23 Janssen Biotech Inc Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias.
AU2021383828A1 (en) 2020-11-20 2023-07-06 Janssen Pharmaceutica Nv Compositions of peptide inhibitors of interleukin-23 receptor
KR20240034224A (ko) 2021-07-14 2024-03-13 얀센 바이오테크 인코포레이티드 인터류킨-23 수용체의 지질화된 펩티드 억제제
CA3226539A1 (en) * 2021-07-14 2023-01-19 Janssen Biotech, Inc. Peptide inhibitors of interleukin-23 receptor
AU2022402440A1 (en) 2021-12-01 2024-05-30 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2024003313A1 (en) 2022-06-30 2024-01-04 Sanofi New peptides as selective il-23 receptor antagonists
WO2024015958A1 (en) * 2022-07-14 2024-01-18 Janssen Pharmaceutica Nv Cyclic peptide inhibitors of il-23
CN120529897A (zh) * 2023-01-16 2025-08-22 詹森药业有限公司 白介素-23受体的脂化肽抑制剂的制剂
EP4471048A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
EP4471049A1 (en) 2023-06-01 2024-12-04 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
CN121909205A (zh) 2023-09-08 2026-04-21 赛诺菲 作为选择性il-23受体抑制剂的新型肽
CN121794283A (zh) 2023-09-08 2026-04-03 赛诺菲 作为选择性il-23受体抑制剂的新型肽
AU2025218720A1 (en) 2024-02-06 2026-05-21 Paragon Therapeutics, Inc. Il-23 antibody compositions and methods of use
WO2025171006A1 (en) 2024-02-06 2025-08-14 Paragon Therapeutics, Inc. Il-23 binding protein compositions and methods of use
WO2026013260A1 (en) 2024-07-12 2026-01-15 Zealand Pharma A/S Peptide inhibitors of interleukin-23 receptor
WO2026026815A1 (zh) * 2024-07-30 2026-02-05 西藏海思科制药有限公司 白介素-23受体的肽抑制剂及其用途
WO2026057052A1 (zh) * 2024-09-14 2026-03-19 深圳信立泰药业股份有限公司 一种il-23受体抑制剂及其制备方法和用途

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Also Published As

Publication number Publication date
EP3570864C0 (en) 2026-02-18
EP3570864A4 (en) 2020-12-30
EP3570864B1 (en) 2026-02-18
JP2023014346A (ja) 2023-01-26
EP3570864A1 (en) 2019-11-27
ES3065770T3 (en) 2026-05-07
WO2018136646A1 (en) 2018-07-26
US20240132558A1 (en) 2024-04-25
AU2018210174A1 (en) 2019-07-25
JP2025162551A (ja) 2025-10-27
EP4755908A2 (en) 2026-06-10
US20200207822A1 (en) 2020-07-02
JP7819087B2 (ja) 2026-02-24
CA3049889A1 (en) 2018-07-26
AU2018210174B2 (en) 2022-04-07

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