JP2020503252A5 - - Google Patents
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- Publication number
- JP2020503252A5 JP2020503252A5 JP2019521034A JP2019521034A JP2020503252A5 JP 2020503252 A5 JP2020503252 A5 JP 2020503252A5 JP 2019521034 A JP2019521034 A JP 2019521034A JP 2019521034 A JP2019521034 A JP 2019521034A JP 2020503252 A5 JP2020503252 A5 JP 2020503252A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- clec
- composition according
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 20
- 101710160443 C-type lectin domain family 1 member A Proteins 0.000 claims description 19
- 102100032557 C-type lectin domain family 1 member A Human genes 0.000 claims description 19
- 239000005557 antagonist Substances 0.000 claims description 16
- 230000005867 T cell response Effects 0.000 claims description 8
- 230000004071 biological effect Effects 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 101000942282 Homo sapiens C-type lectin domain family 1 member A Proteins 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 239000002246 antineoplastic agent Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 229940127089 cytotoxic agent Drugs 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 102000015636 Oligopeptides Human genes 0.000 claims 2
- 108010038807 Oligopeptides Proteins 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 229930193936 anticarin Natural products 0.000 claims 2
- 229940041181 antineoplastic drug Drugs 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 230000022131 cell cycle Effects 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000002955 immunomodulating agent Substances 0.000 claims 2
- 238000011275 oncology therapy Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 206010061692 Benign muscle neoplasm Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010005949 Bone cancer Diseases 0.000 claims 1
- 208000018084 Bone neoplasm Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 208000005024 Castleman disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 208000007766 Kaposi sarcoma Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 201000004458 Myoma Diseases 0.000 claims 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 claims 1
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000010505 Nose Neoplasms Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000002471 Penile Neoplasms Diseases 0.000 claims 1
- 206010034299 Penile cancer Diseases 0.000 claims 1
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 1
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000000728 Thymus Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000000053 blastoma Diseases 0.000 claims 1
- 201000000220 brain stem cancer Diseases 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 201000008184 embryoma Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000006866 hypopharynx cancer Diseases 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000037830 nasal cancer Diseases 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 201000002511 pituitary cancer Diseases 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 208000037968 sinus cancer Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 201000009377 thymus cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 206010046885 vaginal cancer Diseases 0.000 claims 1
- 208000013139 vaginal neoplasm Diseases 0.000 claims 1
- 201000005102 vulva cancer Diseases 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022025697A JP7404418B6 (ja) | 2016-10-21 | 2022-02-22 | Ｔ細胞応答を促進するための方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306381.1 | 2016-10-21 | ||
| EP16306381 | 2016-10-21 | ||
| EP17305988.2 | 2017-07-24 | ||
| EP17305988 | 2017-07-24 | ||
| PCT/EP2017/076911 WO2018073440A1 (en) | 2016-10-21 | 2017-10-20 | Methods for promoting t cells response |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022025697A Division JP7404418B6 (ja) | 2016-10-21 | 2022-02-22 | Ｔ細胞応答を促進するための方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020503252A JP2020503252A (ja) | 2020-01-30 |
| JP2020503252A5 true JP2020503252A5 (cg-RX-API-DMAC7.html) | 2020-12-03 |
| JP7032396B2 JP7032396B2 (ja) | 2022-03-08 |
| JP7032396B6 JP7032396B6 (ja) | 2022-03-22 |
Family
ID=60293924
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521034A Active JP7032396B6 (ja) | 2016-10-21 | 2017-10-20 | Ｔ細胞応答を促進するための方法 |
| JP2022025697A Active JP7404418B6 (ja) | 2016-10-21 | 2022-02-22 | Ｔ細胞応答を促進するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022025697A Active JP7404418B6 (ja) | 2016-10-21 | 2022-02-22 | Ｔ細胞応答を促進するための方法 |
Country Status (21)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3529262T1 (sl) * | 2016-10-21 | 2021-12-31 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Postopki za spodbujanje odgovora T-celic |
| US11975029B2 (en) | 2017-02-28 | 2024-05-07 | Vor Biopharma Inc. | Compositions and methods for inhibition of lineage specific proteins |
| CN113423725A (zh) | 2018-08-28 | 2021-09-21 | Vor生物制药股份有限公司 | 遗传工程化造血干细胞及其用途 |
| EP4069372A1 (en) * | 2019-12-05 | 2022-10-12 | Ose Immunotherapeutics | Anti-clec-1a antibodies and antigen-binding fragment thereof |
| CN113156140A (zh) * | 2021-03-05 | 2021-07-23 | 青岛大学附属医院 | C型凝集素样受体-1作为真菌性角膜炎的治疗标志物的应用 |
| CA3220346A1 (en) * | 2021-06-08 | 2022-12-15 | Sabrina PENGAM | Humanized anti-clec-1a antibodies and antigen-binding fragments thereof and mimetics thereof |
| US20250026839A1 (en) | 2021-11-09 | 2025-01-23 | Ose Immunotherapeutics | Identification of CLEC-1 Ligand and Uses Thereof |
| JP2025525884A (ja) | 2022-08-01 | 2025-08-07 | オーエスイー・イミュノセラピューティクス | ヘテロ二量体Ｆｃ－ＣＬＥＣ－１融合分子及びその使用 |
| WO2025032213A1 (en) | 2023-08-10 | 2025-02-13 | Ose Immunotherapeutics | Identification of hla-dra as a ligand of clec-1 and uses thereof |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| ATE427968T1 (de) | 1992-08-21 | 2009-04-15 | Univ Bruxelles | Immunoglobuline ohne leichtkette |
| US5618829A (en) | 1993-01-28 | 1997-04-08 | Mitsubishi Chemical Corporation | Tyrosine kinase inhibitors and benzoylacrylamide derivatives |
| WO1995002420A2 (en) | 1993-07-15 | 1995-01-26 | Cancer Research Campaign Technology Ltd. | Prodrugs of protein tyrosine kinase inhibitors |
| EP0690452A3 (en) | 1994-06-28 | 1999-01-07 | Advanced Micro Devices, Inc. | Electrically erasable memory and method of erasure |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US5639757A (en) | 1995-05-23 | 1997-06-17 | Pfizer Inc. | 4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors |
| ATE213730T1 (de) | 1996-04-12 | 2002-03-15 | Warner Lambert Co | Umkehrbare inhibitoren von tyrosin kinasen |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| US6100254A (en) | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
| US6740665B1 (en) | 1999-02-10 | 2004-05-25 | Ramachandran Murali | Tyrosine kinase inhibitors and methods of using the same |
| US6245759B1 (en) | 1999-03-11 | 2001-06-12 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2001000213A1 (en) | 1999-06-30 | 2001-01-04 | Merck & Co., Inc. | Src kinase inhibitor compounds |
| US6329380B1 (en) | 1999-06-30 | 2001-12-11 | Merck & Co., Inc. | SRC kinase inhibitor compounds |
| US6316444B1 (en) | 1999-06-30 | 2001-11-13 | Merck & Co., Inc. | SRC kinase inhibitor compounds |
| PL355639A1 (en) | 1999-09-10 | 2004-05-04 | Merck & Co, Inc. | Tyrosine kinase inhibitors |
| US6794393B1 (en) | 1999-10-19 | 2004-09-21 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| JP3822494B2 (ja) | 1999-10-19 | 2006-09-20 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
| WO2001028993A2 (en) | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Tyrosine kinase inhibitors |
| CN1454215B (zh) * | 1999-11-15 | 2013-01-02 | 米勒腾尼生物技术有限公司 | 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞 |
| US6313138B1 (en) | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6420382B2 (en) | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| DE60208792T2 (de) | 2001-06-22 | 2006-08-31 | Merck & Co., Inc. | Tyrosin-kinase inhibitoren |
| WO2003011836A1 (en) | 2001-08-01 | 2003-02-13 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6927293B2 (en) | 2001-08-30 | 2005-08-09 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US8246959B1 (en) * | 2003-08-01 | 2012-08-21 | University Of Washington | Dendritic cell-associated lectin-like molecules, compositions and methods of use |
| US7908091B2 (en) | 2006-03-17 | 2011-03-15 | Prometheus Laboratories Inc. | Methods of predicting and monitoring tyrosine kinase inhibitor therapy |
| AU2008218184B2 (en) * | 2007-02-02 | 2013-01-10 | Baylor Research Institute | Activation of human antigen-presenting cells through CLEC-6 |
| JP5641508B2 (ja) * | 2010-02-23 | 2014-12-17 | 国立大学法人 東京大学 | 樹状細胞免疫受容体刺激剤 |
| EP3171882A1 (en) * | 2014-07-21 | 2017-05-31 | Novartis AG | Treatment of cancer using a cll-1 chimeric antigen receptor |
| SI3529262T1 (sl) | 2016-10-21 | 2021-12-31 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Postopki za spodbujanje odgovora T-celic |
-
2017
- 2017-10-20 SI SI201730876T patent/SI3529262T1/sl unknown
- 2017-10-20 LT LTEPPCT/EP2017/076911T patent/LT3529262T/lt unknown
- 2017-10-20 SM SM20210555T patent/SMT202100555T1/it unknown
- 2017-10-20 DK DK17797066.2T patent/DK3529262T3/da active
- 2017-10-20 US US16/343,757 patent/US11365257B2/en active Active
- 2017-10-20 AU AU2017345286A patent/AU2017345286B2/en active Active
- 2017-10-20 WO PCT/EP2017/076911 patent/WO2018073440A1/en not_active Ceased
- 2017-10-20 HU HUE17797066A patent/HUE056016T2/hu unknown
- 2017-10-20 KR KR1020197014209A patent/KR102646708B1/ko active Active
- 2017-10-20 JP JP2019521034A patent/JP7032396B6/ja active Active
- 2017-10-20 HR HRP20211544TT patent/HRP20211544T1/hr unknown
- 2017-10-20 PL PL17797066T patent/PL3529262T3/pl unknown
- 2017-10-20 MA MA46570A patent/MA46570B1/fr unknown
- 2017-10-20 ES ES17797066T patent/ES2883678T3/es active Active
- 2017-10-20 ES ES21178847T patent/ES2978486T3/es active Active
- 2017-10-20 EP EP17797066.2A patent/EP3529262B1/en active Active
- 2017-10-20 RS RS20211221A patent/RS62463B1/sr unknown
- 2017-10-20 IL IL266111A patent/IL266111B/en unknown
- 2017-10-20 MD MDE20190953T patent/MD3529262T2/ro unknown
- 2017-10-20 EP EP21178847.6A patent/EP3950709B1/en active Active
- 2017-10-20 CA CA3039348A patent/CA3039348C/en active Active
- 2017-10-20 CN CN201780065072.6A patent/CN110291102A/zh active Pending
-
2021
- 2021-09-24 CY CY20211100839T patent/CY1124584T1/el unknown
-
2022
- 2022-02-22 JP JP2022025697A patent/JP7404418B6/ja active Active
- 2022-05-10 US US17/740,849 patent/US12091464B2/en active Active
-
2024
- 2024-08-21 US US18/811,491 patent/US20240400695A1/en active Pending
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