JP2020502071A - ニコチンアミドとアミノ酸とを含むグルタチオン前駆体を含むパーソナルケア組成物 - Google Patents
ニコチンアミドとアミノ酸とを含むグルタチオン前駆体を含むパーソナルケア組成物 Download PDFInfo
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- JP2020502071A JP2020502071A JP2019528650A JP2019528650A JP2020502071A JP 2020502071 A JP2020502071 A JP 2020502071A JP 2019528650 A JP2019528650 A JP 2019528650A JP 2019528650 A JP2019528650 A JP 2019528650A JP 2020502071 A JP2020502071 A JP 2020502071A
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- 239000005017 polysaccharide Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
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- 238000011002 quantification Methods 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 1
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- 230000001953 sensory effect Effects 0.000 description 1
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- 230000036548 skin texture Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- HVFAVOFILADWEZ-UHFFFAOYSA-M sodium;2-[2-(dodecanoylamino)ethyl-(2-hydroxyethyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCCN(CCO)CC([O-])=O HVFAVOFILADWEZ-UHFFFAOYSA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
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- 241000894007 species Species 0.000 description 1
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- 235000020238 sunflower seed Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
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- 239000011715 vitamin B12 Substances 0.000 description 1
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- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
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Abstract
Description
a.重量で、組成物の
i.約0.001%〜約2%のシスチンと、
ii.約0.01〜約10%のグルタメート源と、
iii.約0.01〜約10%のグリシンと、
iv.約0.01〜約5%のニコチンアミドと
を含むグルタチオン前駆体と、
b.化粧品として許容される担体と
を含み、
c.組成物のpHは約3.5〜約8.5の範囲内である。
本発明によるGSH前駆体は、アミノ酸(グルタメート及びシスチン、任意選択的にはグリシン)及び4−置換resonicotinamidercinolを含む。一実施形態において、GSH前駆体中のアミノ酸は、シスチン及びグルタメート源である。一実施形態において、GSH前駆体中のアミノ酸は、シスチン及びグルタメート源及びグリシンである。
(式中、Rは−CONH2である。)
本発明において使用されるニコチンアミド化合物は、塩、複合体、水和物及び溶媒和物を生成することができる。適した塩は、フッ化物、塩化物、臭化物、ヨウ化物、酢酸塩、アスコルビン酸塩、安息香酸塩、炭酸塩、クエン酸塩、カルバミン酸塩、ギ酸塩、グルコン酸塩、乳酸塩、脂肪酸カルボン酸塩、脂肪酸ジカルボン酸塩、シュウ酸塩、臭化メチル、硫酸メチル、硝酸塩、リン酸塩、二リン酸塩、コハク酸塩、硫酸塩又はトリフルオロ酢酸塩から選択される。
一実施形態において、シスチンは、0.001〜2%、或いは0.005〜1%、又は0.008〜0.5%、或いは0.008〜0.4%の量で含まれている。一実施形態において、グルタメート源(好ましくはピログルタメート)は、0.01〜10%、或いは0.01〜5%、又は0.05〜1%、或いは0.05〜0.5%の量で含まれている。一実施形態において、グリシン源は、0.01〜10%、或いは0.01〜5%、又は0.05〜1%、或いは0.05〜0.5%の量で含まれている。一実施形態において、ニコチンアミドは、0.05%〜10%、或いは0.1〜8%、又は0.2〜5%の量で含まれている。
本発明の組成物は、化粧品として許容される担体も含む。担体の量は、1〜99.9%、好ましくは70〜95%、最適には80〜90%の範囲であり得る。有用な担体には、水、軟化剤、脂肪酸、脂肪族アルコール、増粘剤及びそれらの組合せがある。担体は、水性、無水又はエマルションであってもよい。好ましくは、組成物は水性であり、特に油中水型若しくは水中油型の水と油のエマルション又は水中油中水型若しくは油中水中油型の複数のエマルションである。存在するとき、水は、5〜95重量%、好ましくは約20〜約70重量%、最適には35〜60重量%の範囲の量であり得る。
a)10個〜24個の炭素原子を有する飽和脂肪酸のアルキルエステル。その例には、ネオペンタン酸ベヘニル、イソノニルイソナノノエート、ミリスチン酸イソプロピル及びステアリン酸オクチルが含まれる。
一実施形態において、パーソナルケア組成物のpHは3.5〜8.5の間である。いくつかの実施形態において、パーソナルケア組成物のpHはpH3.5〜pH8の間である。いくつかの実施形態において、パーソナルケア組成物のpHはpH5〜pH7.8の間である。いくつかの実施形態において、パーソナルケア組成物のpHは5〜7.5の間である。
いくつかの実施形態において、パーソナルケア組成物、特に本発明のリーブオン皮膚化粧品組成物は日焼け止めを含む。これらは、典型的には、有機性日焼け止めと無機性日焼け止めとの組合せである。UV−A及びUV−B放射日焼け止めの両方を含むことが特に重要である。
例示の落屑促進剤にはモノカルボン酸が含まれる。モノカルボン酸は、最大16個の炭素鎖長を伴う置換又は非置換であってもよい。いくつかの実施形態において、カルボン酸は、アルファ−ヒドロキシカルボン酸、ベータ−ヒドロキシカルボン酸又はポリヒドロキシカルボン酸である。「酸」という用語は、遊離酸だけでなく、その塩及びC1−C30アルキル又はアリールエステル、並びに環状又は直鎖状のラクトン構造を形成するために水を除去して生成されたラクトンも含むことを意図する。代表的な酸には、グリコール酸、乳酸、リンゴ酸及び酒石酸が含まれる。いくつかの実施形態において、塩は乳酸アンモニウムである。いくつかの実施形態において、ベータ−ヒドロキシカルボン酸はサリチル酸である。いくつかの実施形態において、フェノール酸には、フェルラ酸、サリチル酸、コウジ酸及びそれらの塩が含まれる。
本発明の組成物は、好ましくは、非固体である。本発明の組成物は、好ましくは、リーブオン組成物である。本発明の組成物は、好ましくは、塗布されて皮膚上に残るリーブオン組成物である。これらのリーブオン組成物は、皮膚に塗布され、続いて、生成物の塗布後又は塗布時のいずれかに洗浄、すすぎ、拭き取りなどのいずれかにより除去される組成物とは区別されるべきである。リンスオフ組成物のために通常使用される界面活性剤は、使用中にすすぎが容易なフォーム/泡を生成する能力をリンスオフ組成物に与える物理化学特性を有し、アニオン性、カチオン性、両性及び非イオン性の混合物からなり得る。一方で、リーブオン組成物中で使用される界面活性剤は、そのような特性を有する必要はない。むしろ、リーブオン組成物は、すすぎ落とされるものではないため、非刺激性である必要があり、したがって、リーブオン組成物中の界面活性剤の全濃度及びアニオン性界面活性剤の全濃度を最小限にする必要がある。本発明の組成物中の界面活性剤の全濃度は、好ましくは、1%〜10%以下、より好ましくは8%未満、最も好ましくは高々5%、最適には高々3%である。
いくつかの実施形態において、本発明によるスキンケア組成物は、
a.保存料と、増粘ポリマーと、任意選択的にはグリセリンと、水とを含むすべての水溶性原料を混合する工程と、
b.混合物を70〜90℃の温度まで加熱する工程と、
c.すべての油溶性原料と、式(1)の化合物とを70〜90℃の温度まで混合する工程と、
d.水溶性原料の加熱混合物に混合油溶性原料を加え、撹拌により混合し、混合物を70〜90℃の温度に保つ工程と、
e.混合しながら混合物を室温まで冷却する工程と
により調製することができる。
a.高pH(9〜14又は9〜12)水性溶液中で所望の濃度のシスチンを可溶化する工程
b.乳化剤を使用してこの溶液を含む油中のマクロエマルションを調製する工程、次いで、
c.混合しながら酸性水性溶液を加え、局所用組成物に必要な中性の範囲内のpHを有するエマルションを得る工程、最後に、
d.例えば、BEE International(米国マサチューセッツ州)のNano DeBeeホモジナイザー又はSonic Corporation(米国コネティカット州)製造のSonolatorホモジナイザーなどのホモジナイザーによりエマルションに高剪断を加え、又はエマルションを均質化し、又はソノレーションステップを実施して、90%を超える液滴が100nm〜20ミクロンのサイズ範囲内の直径を有する均質な中性のpH範囲の最終エマルションを生成する工程。
いくつかの実施形態において、スキンケア組成物は、ヒトの皮膚に局所塗布される。いくつかの実施形態において、スキンケア組成物は、皮膚のコンディショニング、皮膚の平滑化、皺のある皮膚又は老化した皮膚の減少、皮膚の炎症の軽減、乾燥の軽減、年齢によるしみの減少、日焼けの軽減及び皮膚の美白からなる群から選択される少なくとも1つの利益を提供する。
実験方法
以下のアミノ酸(ピログルタミン酸及びグリシン)の粉末をSigmaから購入し、粉末を水(pH7)中で再構成することにより各アミノ酸の個々の原液を調製した。すべてのアミノ酸がL立体異性体であった。シスチンは中性溶液に難溶性であるため、シスチン(Sigma)原液を0.5M水酸化ナトリウム(pH12)中で生成した。ピログルタミン酸ナトリウム(ピロリドンカルボン酸ナトリウム(NaPCA)としても既知)は、味の素から50%水溶液として供給された。シスチンエステル、L−シスチンジtert−ブチル二塩酸塩(DTBC)及びL−シスチンジエチル二塩酸塩(DEC)をBachemから購入し、L−シスチンジメチルエステル二塩酸塩(CDME)をSigmaから購入した。これ以降GAPと記載する混合物を生成するために、適切な体積の3つのアミノ酸(グルタメート源(すなわち、NaPCA)、シスチン及びグリシン)を、グルタメート源、シスチン及びグリシンが重量比0.5:1:1になるようにハンクス平衡塩類溶液(Sigma)に合わせた。各アッセイにおいて使用した特定の濃度は以下で言及する。
老化したヒトケラチノサイト(Cascade Biologics、現在、ThermoFisher Scientific(マサチューセッツ州ウォルサム))を、5% CO2を含む37℃の雰囲気の加湿インキュベーター内において、60uM塩化カルシウムと1%ヒトケラチノサイト増殖サプリメント(いずれの培地成分もThermoFisher Scientific製)とを含むEpiLife(登録商標)培地内で維持した。培地を2〜3日毎にリフレッシュした。続いて、細胞を90%コンフルエントでトリプシン処理し、白色壁及び透明底の96ウェルプレートに1×104細胞/ウェルの密度で播種した。播種から1日後又は2日後、細胞培養液をハンクス平衡塩類溶液(HBSS)で置換し、GAP(又は0.12〜0.240mM水酸化ナトリウムビヒクル対照、pH7.5)又は上述の別の試験試薬で、単独又は組合せで、或いはL−シスチンエステル単独でケラチノサイトを1〜2時間前処理した。このアッセイにおいて使用されたGAP混合物を構成するすべてのアミノ酸の濃度をデータ表に示し、以下の略語リストに詳しく記載した。
ヒトケラチノサイト(Promocell(ハイデルベルク、ドイツ))を、5% CO2を含む37℃の雰囲気の加湿インキュベーター内において、60uM塩化カルシウムと1%ヒトケラチノサイト増殖サプリメント(HKGS)とを含むEpiLife(登録商標)ケラチノサイト培地内で維持した。培地を1日おきにリフレッシュした。続いて、細胞を90%コンフルエントでトリプシン処理し、黒色壁及び透明底の96ウェルプレートに1〜2×104細胞/ウェルの密度で播種した。播種後2日目、メナジオン(10〜25uM)、GAP(典型的には、49uMピログルタミン酸、60uMシスチン、194uMグリシン)、GAPビヒクル(0.2mM NaOH、pH7.5)、上述の別の試験試薬、GAPと別の試験試薬との組合せ、若しくはL−シスチンエステル単独を含む、又は含まないハンクス平衡塩類溶液(HBSS)で細胞培養液を置換し、さらに18時間インキュベートした。ROSの検出のために、CellROX green(Life Tech、Thermo Fisher Scientific(米国、ロックフォード))試薬を最終濃度15〜25uMまで各ウェルに加え、加湿インキュベーター内において37℃でさらに2〜4時間インキュベートした。Tecanマイクロプレートリーダー(励起/発光=490/525)を使用してROSの蛍光を検出した。100%に設定したビヒクル対照処理に基づく規格化により、相対的なROS生成を計算した。示されている場合、測定された相対蛍光単位を以下の式に使用して、メナジオン単独処理との比較としてパーセント保護を計算した:
ヒトケラチノサイト(Promocell(ハイデルベルク、ドイツ))を、60uM塩化カルシウムと1%ヒトケラチノサイト増殖サプリメント(HKGS)とを含むEpiLife(登録商標)ケラチノサイト培地内で維持した。培地を1日おきにリフレッシュした。続いて、細胞を90%コンフルエントでトリプシン処理し、96ウェルの透明な組織培養プレートに2x104細胞/ウェルの密度で播種した。播種後2日目、細胞培養液を、ROSアッセイセクションで上述した処理剤で置換した。18時間後、Cell Culture Kit−8(CCK−8)試薬(Dojindo(日本、熊本))をHBSSに1:10で希釈し、加湿インキュベーター内において、細胞と共に37℃で4時間インキュベートした。Tecan Safire2プレートリーダーを使用して、450nmの光吸収を測定した。100%に設定したビヒクル対照処理に基づく規格化により、相対生存率を計算した。
mM=ミリモル
uM=マイクロモル
uL=マイクロリットル
GAP=グルタメートとシスチンとグリシンの混合物
GAP 5=4uMピログルタミン酸ナトリウム、5uMシスチン、16uMグリシン
GAP 10=8uMピログルタミン酸ナトリウム、10uMシスチン、32uMグリシン
GAP 20=16uMピログルタミン酸ナトリウム、20uMシスチン、64uMグリシン
DEC=L−シスチンジエチル二塩酸塩
CDME=L−シスチンジメチルエステル二塩酸塩
DTBC=L−シスチンジtert−ブチル二塩酸塩
[実施例1]
実施例1では、細胞内GSH産生の増強又は活性酸素種の減少のためのGSH構成要素を構成するアミノ酸と組み合わせた(本発明の範囲内の)ニコチンアミド又は本発明の範囲外の化合物の様々な組合せ−構造類似体(ピコリンアミド)又はニコチンアミドの誘導体(ニコチンアミドリボシド又はN−メチルニコチンアミド)のいずれか−を評価した。得られた結果を表1A及び表1Bにまとめた。表1C〜表1Hでは、様々なシスチンエステルの効力も試験した。
Claims (12)
- a.重量で、組成物の
i.約0.001%〜約2%のシスチンと、
ii.約0.01〜約10%のグルタメート源と、
iii.約0.01〜約10%のグリシンと、
iv.約0.01〜約5%のニコチンアミドと
を含むグルタチオン前駆体と、
b.化粧品として許容される担体と
を含み、
c.pHが約3.5〜約8.5の範囲内である、局所用パーソナルケア組成物。 - ニコチンアミドリボシドをさらに含む、請求項1に記載の組成物。
- 前記グルタメート源が、グルタミン、グルタミン酸、ピログルタミン酸及びそれらの混合物からなる群から選択される、請求項1又は2に記載の組成物。
- 前記グルタメート源が、ピログルタミン酸又はその塩である、請求項3に記載の組成物。
- 水性相中にシスチンを含む油中水型エマルションの形態であり、
水滴の90%が、100nm〜20ミクロンのサイズ範囲内の直径を有する、請求項1から4のいずれか一項に記載の組成物。 - 0〜高々0.1%のセレン源を含む請求項1から5のいずれか一項に記載の組成物。
- リーブオン非固体皮膚化粧品組成物である、請求項1から6のいずれか一項に記載の組成物。
- バニシングクリームである、請求項1から7のいずれか一項に記載の組成物。
- 4−アルキルレゾルシノールをさらに含む、請求項1から8のいずれか一項に記載の組成物。
- 12−ヒドロキシステアリン酸をさらに含む、請求項1から9のいずれか一項に記載の組成物。
- 請求項1から10のいずれか一項に記載の組成物を皮膚に塗布する工程を含む、皮膚の外観を改善する方法。
- 請求項1から10のいずれか一項に記載の組成物を皮膚に塗布する工程を含む、均一な皮膚の色を得、且つ色素沈着、年齢によるしみ及び変色を軽減する方法。
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CA3046138A1 (en) | 2018-06-28 |
US20200016059A1 (en) | 2020-01-16 |
EP3558256A1 (en) | 2019-10-30 |
WO2018113637A1 (en) | 2018-06-28 |
EP3558256A4 (en) | 2019-12-11 |
EP3558256B1 (en) | 2023-03-29 |
ZA201903209B (en) | 2020-09-30 |
CN110121332B (zh) | 2022-11-08 |
JP7084567B2 (ja) | 2022-06-15 |
CN110121332A (zh) | 2019-08-13 |
CN115444780A (zh) | 2022-12-09 |
PH12019501107A1 (en) | 2020-01-20 |
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