JP2020500546A - アルロース転換反応物の精製方法 - Google Patents
アルロース転換反応物の精製方法 Download PDFInfo
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- JP2020500546A JP2020500546A JP2019531130A JP2019531130A JP2020500546A JP 2020500546 A JP2020500546 A JP 2020500546A JP 2019531130 A JP2019531130 A JP 2019531130A JP 2019531130 A JP2019531130 A JP 2019531130A JP 2020500546 A JP2020500546 A JP 2020500546A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterized by the components to be separated
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D25/00—Filters formed by clamping together several filtering elements or parts of such elements
- B01D25/12—Filter presses, i.e. of the plate or plate and frame type
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D37/00—Processes of filtration
- B01D37/02—Precoating the filter medium; Addition of filter aids to the liquid being filtered
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
- B01J20/20—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbon; comprising carbon obtained by carbonising processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28016—Particle form
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
- B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
- B01D2215/023—Simulated moving beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
- B01J20/28004—Sorbent size or size distribution, e.g. particle size
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
フラスコ内にアルロース反応液(T%=78.6)50重量%濃度/1Lを準備し、固形分基準で粉末状活性炭0.5重量%を混合した後、75℃で1時間、200rpmにて撹拌した。使用した粉末状活性炭を表1に示す。試料1〜4の活性炭の購入先は、Norit activated carbonであった。その後、パーライトろ過によって活性炭を除去し、脱色および微細物質の除去程度を把握するため、活性炭処理糖液のT%と濁度(720nm吸光度)を測定した。その結果を表3に示した。
フラスコ内にアルロース反応液(T%=78.6)50重量%濃度/1Lを準備し、固形分基準で粒子状活性炭0.5重量%を混合した後、75℃で1時間、200rpmにて撹拌した。使用した粒子状活性炭を表2に示す。試料5〜6の活性炭の購入先はNorit activated carbonであった。その後、パーライトろ過により活性炭を除去し、脱色および微細物質の除去程度を把握するため、活性炭処理糖液のT%と濁度(720nm吸光度)を測定した。その結果を表3に示した。
フラスコ内にアルロース反応液(T%=70.4)50重量%濃度/1Lを準備し、固形分500g基準で粉末状活性炭0.5重量%を混合した後、75℃で1時間、200rpmにて撹拌した。粉末状活性炭は実施例1で使用したものと同じであり、前記表1に示した。その後、パーライトろ過により活性炭を除去し、脱色および微細物質の除去程度を把握するため、活性炭処理糖液のT%と濁度(720nm吸光度)を測定した。その結果を表4に示した。
フラスコ内にアルロース反応液(T%=70.4)50重量%濃度/1Lを準備し、固形分500g基準で粒子状活性炭0.5重量%を混合した後、75℃で1時間、200rpmにて撹拌した。粉末状活性炭は比較例1で使用したものと同じであり、前記表2に示した。その後、パーライトろ過により活性炭を除去し、脱色および微細物質の除去程度を把握するため、活性炭処理糖液のT%と濁度(720nm吸光度)を測定した。その結果を表4に示した。
実施例1と2、比較例1と2の方法で活性炭処理したアルロース反応液の脱色水準を確認するため、UV分光光度計(UV Spectrophotometer)を使用して420nmでのT%を測定した。測定サンプルの濃度は30bxであり、1cm石英セルを使用して分析した。T%は入射光に対する透過光の比率であり、吸光度とは逆に、透過する光が増加する程、値が増加するため、この値が高い程、色が浅くて透明であることを意味する。
前記表4に示す試料5の粒状炭122g(250ml)をカラムに充填し、アルロース反応液(T%=70.4)を50重量%濃度で流した。この時、カラムの温度は75℃であり、速度はSV 1(250ml/60min=4.17ml/min)で流し、カラムにかかる圧力は0.04Mpaであった。
Claims (14)
- アルロース転換反応物と粉末活性炭を混合し、
前記混合液に固液分離工程を行って不純物と活性炭を除去し、濾液を得る工程を含むアルロース転換反応物の精製方法。 - 前記精製方法は、活性炭処理工程を行った後、イオン交換樹脂が充填されたカラムを用いたイオン精製工程をさらに行う請求項1に記載の方法。
- 前記粉末活性炭の平均粒径が10〜250マイクロメートルである請求項1に記載の方法。
- 前記粉末活性炭の混合量は、アルロース転換反応液の全固形分含量100重量%を基準にして0.05〜10重量%である請求項1に記載の方法。
- 前記アルロース転換反応液の全固形分含量は0.5〜80重量%である請求項1に記載の精製方法。
- 前記混合液の温度は30〜90℃である請求項1に記載の方法。
- 前記固液分離工程は、ろ過または遠心分離方法で行われる請求項1に記載の方法。
- 前記ろ過は、フィルタープレスを含むろ過システムに前記混合物を通液して行われる請求項7に記載の方法。
- 前記ろ過システムは、さらにろ過補助剤を含む請求項8に記載の方法。
- 前記ろ過補助剤は、珪藻土、パーライト、セルロース、およびイオン交換樹脂よりなる群から選択された1種以上である請求項9に記載の方法。
- 前記アルロース転換反応物と粉末活性炭を混合する工程は、撹拌して行う請求項1に記載の方法。
- 前記撹拌は、撹拌速度5〜500rpmで行われる請求項11に記載の方法。
- 前記活性炭と反応液との接触時間は0.5〜5時間である請求項1に記載の方法。
- 請求項1〜13のいずれかに記載の方法によってアルロース転換反応物の不純物を除去して精製する工程、
擬似移動層(SMB)クロマトグラフィー分離工程を行ってアルロース分画と果糖ラフィネートを得るアルロース分離工程、および
前記アルロース分画を濃縮または結晶化する工程
を含むアルロースの製造方法。
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KR1020160180086A KR101988441B1 (ko) | 2016-12-27 | 2016-12-27 | 알룰로스의 정제 방법 |
KR10-2016-0180086 | 2016-12-27 | ||
PCT/KR2017/013370 WO2018124487A2 (ko) | 2016-12-27 | 2017-11-22 | 알룰로스 전환 반응물의 정제 방법 |
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JP2020500546A true JP2020500546A (ja) | 2020-01-16 |
JP6936320B2 JP6936320B2 (ja) | 2021-09-15 |
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US (1) | US11084840B2 (ja) |
EP (1) | EP3564250B1 (ja) |
JP (1) | JP6936320B2 (ja) |
KR (1) | KR101988441B1 (ja) |
CN (1) | CN110049991B (ja) |
HU (1) | HUE057330T2 (ja) |
PL (1) | PL3564250T3 (ja) |
TW (1) | TWI674268B (ja) |
WO (1) | WO2018124487A2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2020207952A1 (en) * | 2019-04-10 | 2020-10-15 | Lonza Solutions Ag | Method for preparation of decolorized acetoacetylated glycerol with activated carbon |
EP3865496A1 (de) | 2020-02-12 | 2021-08-18 | Savanna Ingredients GmbH | Verfahren zur herstellung farbloser kohlenhydrate |
WO2022239028A1 (en) * | 2021-05-08 | 2022-11-17 | Petiva Private Limited | A method and system for purifying d-allulose, fructose, and/or glucose |
Citations (4)
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JP2008278794A (ja) * | 2007-05-10 | 2008-11-20 | Mitsubishi Rayon Co Ltd | 生細胞を含有しないタンパク質含有溶液の製造方法 |
CN104447888A (zh) * | 2014-12-04 | 2015-03-25 | 山东福田药业有限公司 | 一种阿洛酮糖的制备方法及其应用 |
KR20160046143A (ko) * | 2014-10-20 | 2016-04-28 | 씨제이제일제당 (주) | D-사이코스 결정을 제조하는 방법 |
JP2016523526A (ja) * | 2013-06-05 | 2016-08-12 | シージェイ チェイルジェダン コーポレーションCj Cheiljedang Corporation | タガトースの製造方法 |
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JPS5239901B2 (ja) | 1973-02-12 | 1977-10-07 | ||
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KR20140054997A (ko) | 2012-10-30 | 2014-05-09 | 현대모비스 주식회사 | 차량용 수납박스의 잠금장치 |
KR20140080282A (ko) | 2012-12-20 | 2014-06-30 | 주식회사 삼양제넥스 | D-사이코스 3-에피머화 효소를 이용한 과당으로부터 사이코스의 제조방법 |
KR101318422B1 (ko) | 2013-04-09 | 2013-10-15 | 주식회사 삼양제넥스 | D-사이코스 에피머화 효소, 및 이를 이용하는 사이코스 생산방법 |
KR101375862B1 (ko) * | 2014-01-17 | 2014-03-17 | 한국과학기술연구원 | 제습장치를 구비한 식기세척기 |
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2016
- 2016-12-27 KR KR1020160180086A patent/KR101988441B1/ko active IP Right Grant
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2017
- 2017-11-22 PL PL17887806T patent/PL3564250T3/pl unknown
- 2017-11-22 EP EP17887806.2A patent/EP3564250B1/en active Active
- 2017-11-22 CN CN201780076528.9A patent/CN110049991B/zh active Active
- 2017-11-22 WO PCT/KR2017/013370 patent/WO2018124487A2/ko unknown
- 2017-11-22 US US16/461,815 patent/US11084840B2/en active Active
- 2017-11-22 JP JP2019531130A patent/JP6936320B2/ja active Active
- 2017-11-22 HU HUE17887806A patent/HUE057330T2/hu unknown
- 2017-11-29 TW TW106141520A patent/TWI674268B/zh active
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JP2008278794A (ja) * | 2007-05-10 | 2008-11-20 | Mitsubishi Rayon Co Ltd | 生細胞を含有しないタンパク質含有溶液の製造方法 |
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Publication number | Publication date |
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JP6936320B2 (ja) | 2021-09-15 |
US11084840B2 (en) | 2021-08-10 |
TWI674268B (zh) | 2019-10-11 |
CN110049991B (zh) | 2022-10-04 |
US20190315791A1 (en) | 2019-10-17 |
EP3564250B1 (en) | 2021-10-20 |
EP3564250A2 (en) | 2019-11-06 |
HUE057330T2 (hu) | 2022-05-28 |
WO2018124487A2 (ko) | 2018-07-05 |
KR20180076028A (ko) | 2018-07-05 |
TW201827451A (zh) | 2018-08-01 |
CN110049991A (zh) | 2019-07-23 |
EP3564250A4 (en) | 2020-09-02 |
WO2018124487A3 (ko) | 2018-08-16 |
KR101988441B1 (ko) | 2019-06-12 |
PL3564250T3 (pl) | 2022-02-14 |
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