JP2020156320A - 幹細胞の増殖促進剤 - Google Patents
幹細胞の増殖促進剤 Download PDFInfo
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- JP2020156320A JP2020156320A JP2019056191A JP2019056191A JP2020156320A JP 2020156320 A JP2020156320 A JP 2020156320A JP 2019056191 A JP2019056191 A JP 2019056191A JP 2019056191 A JP2019056191 A JP 2019056191A JP 2020156320 A JP2020156320 A JP 2020156320A
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Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
(1)日本型イネと印度型イネの交雑種もしくはその後代の種子、又は該種子の抽出物を有効成分として含有する、幹細胞増殖促進剤。
(2)前記日本型イネが、「コシヒカリ」、「恵糯」、「コシヒカリ」の変異体、「恵糯」の変異体、「コシヒカリ」の子孫系統、及び「恵糯」の子孫系統から選択されるイネである、(1)に記載の幹細胞増殖促進剤。
(3)前記印度型イネが、「IR−8」、「IR−64」、「タカナリ」、「IR−8」の変異体、「IR−64」の変異体、「タカナリ」の変異体、「IR−8」の子孫系統、「IR−64」の子孫系統、及び「タカナリ」の子孫系統から選択されるイネである、(1)に記載の幹細胞増殖促進剤。
(4)幹細胞を、(1)〜(3)のいずれかに記載の幹細胞増殖促進剤を含有する培地で培養する工程を含む、幹細胞の増殖促進方法。
(5)幹細胞を、(1)〜(3)のいずれかに記載の幹細胞増殖促進剤を含有する培地で培養する工程を含む、幹細胞の製造方法。
(6)(1)〜(3)のいずれかに記載の幹細胞増殖促進剤を含む、幹細胞増殖用組成物。
本発明に係る幹細胞の増殖促進剤は、日本型イネと印度型イネの交雑種もしくはその後代の種子、又は該種子の抽出物を有効成分として含有する。
(1)日本型イネと印度型イネの交雑種の作出
以下に、日本型イネと印度型イネの交雑種の作出例を示す。
(作出例1)
特許文献(特開2012−210206)に記載の方法に準拠して、日本型イネ品種「コシヒカリ」の子孫系統(準同質遺伝子系統)を雌親、国際稲研究所(IRRI)で育成された印度型イネ品種「IR−64」を花粉親として交雑した雑種F1の自殖F2世代から数世代にわたって選抜を繰り返すことで、極短稈で小粒の種子を有することを特徴とする粳性系統のイネを育成した。その選抜系統の1つを「14SP−004」と命名した。
日本型イネ品種「恵糯」を雌親、日本型イネと印度型イネの交雑品種「ST−1」(日本育種学会、第133回春季大会にて報告された品種)を花粉親として交雑した雑種F1の自殖F2世代から数世代にわたって選抜を繰り返すことで短稈穂数型を示すことを特徴とする粳性の固定系統を育成した。その選抜固定系統の1つを「MEN−006−001」と命名した。
日本型イネ品種「恵糯」を雌親、日本型イネと印度型イネの交雑品種「ST−1」(日本育種学会、第133回春季大会にて報告された品種)を花粉親として交雑した雑種F1の自殖F2世代から数世代にわたって選抜を繰り返すことで長稈穂重型を示すことを特徴とする糯性の固定系統を育成した。その選抜固定系統の1つを「MEN−006−009」と命名した。
(1)で作出したイネ系統、比較として「コシヒカリ」、「タカナリ」、「山田錦」を抽出材料として用い、以下の方法でそれらの溶媒抽出物を製造した。
コメ乾燥物10gに精製水200mLを加え、95〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥して熱水抽出物を得た。
コメ乾燥物10gに50%エタノール200mLを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固して、50%エタノール抽出物を得た。
コメ乾燥物10gにエタノール200mLを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固して、エタノール抽出物を得た。
コメ乾燥物10gにヘキサン200mLを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固して、ヘキサン抽出物を得た。
ヒト幹細胞培養液(TOYOBO社製)を用いて培養したヒト成体幹細胞(脂肪組織由来;DSファーマバイオメディカル社製)を、6cmディッシュに3×105個播種し、各抽出物を最終濃度が100μg/mL、200μg/mL、300μg/mLになるように添加し、3日間培養を続けた。3日間の培養後、細胞をPBS(−)にて3回洗浄した後、ラバーポリスマンにて集め、それぞれの細胞数をカウントした。
Claims (6)
- 日本型イネと印度型イネの交雑種もしくはその後代の種子、又は該種子の抽出物を有効成分として含有する、幹細胞増殖促進剤。
- 前記日本型イネが、「コシヒカリ」、「恵糯」、「コシヒカリ」の変異体、「恵糯」
の変異体、「コシヒカリ」の子孫系統、及び「恵糯」の子孫系統から選択されるイネである、請求項1に記載の幹細胞増殖促進剤。 - 前記印度型イネが、「IR−8」、「IR−64」、「タカナリ」、「IR−8」の変異体、「IR−64」の変異体、「タカナリ」の変異体、「IR−8」の子孫系統、「IR−64」の子孫系統、及び「タカナリ」の子孫系統から選択されるイネである、請求項1に記載の幹細胞増殖促進剤。
- 幹細胞を、請求項1〜3のいずれか1項に記載の幹細胞増殖促進剤を含有する培地で培養する工程を含む、幹細胞の増殖促進方法。
- 幹細胞を、請求項1〜3のいずれか1項に記載の幹細胞増殖促進剤を含有する培地で培養する工程を含む、幹細胞の製造方法。
- 請求項1〜3のいずれか1項に記載の幹細胞増殖促進剤を含む、幹細胞増殖用組成物。
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