JP2020143083A5 - - Google Patents
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- JP2020143083A5 JP2020143083A5 JP2020080644A JP2020080644A JP2020143083A5 JP 2020143083 A5 JP2020143083 A5 JP 2020143083A5 JP 2020080644 A JP2020080644 A JP 2020080644A JP 2020080644 A JP2020080644 A JP 2020080644A JP 2020143083 A5 JP2020143083 A5 JP 2020143083A5
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- 239000000090 biomarker Substances 0.000 claims 35
- 150000001875 compounds Chemical class 0.000 claims 35
- 238000000034 method Methods 0.000 claims 35
- 239000008194 pharmaceutical composition Substances 0.000 claims 24
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 22
- 150000003839 salts Chemical group 0.000 claims 5
- 239000007787 solid Chemical group 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- IXZOHGPZAQLIBH-NRFANRHFSA-N (3s)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione Chemical compound O=C1N([C@@H]2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 IXZOHGPZAQLIBH-NRFANRHFSA-N 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000003719 b-lymphocyte Anatomy 0.000 claims 4
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000005259 peripheral blood Anatomy 0.000 claims 4
- 239000011886 peripheral blood Substances 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- VVHQVXXPZDALDV-BOXHHOBZSA-N (3s)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1h-isoindol-2-yl]piperidine-2,6-dione;hydrochloride Chemical compound Cl.O=C1N([C@@H]2C(NC(=O)CC2)=O)CC2=C1C=CC=C2OCC(C=C1)=CC=C1CN1CCOCC1 VVHQVXXPZDALDV-BOXHHOBZSA-N 0.000 claims 3
- 101000599042 Homo sapiens Zinc finger protein Aiolos Proteins 0.000 claims 3
- 102100037798 Zinc finger protein Aiolos Human genes 0.000 claims 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims 2
- 102000015367 CRBN Human genes 0.000 claims 2
- 102100037799 DNA-binding protein Ikaros Human genes 0.000 claims 2
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims 2
- 101000599038 Homo sapiens DNA-binding protein Ikaros Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 101000941994 Homo sapiens Protein cereblon Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 239000002299 complementary DNA Substances 0.000 claims 2
- 230000002354 daily effect Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 208000035824 paresthesia Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- 208000004998 Abdominal Pain Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006820 Arthralgia Diseases 0.000 claims 1
- 206010008479 Chest Pain Diseases 0.000 claims 1
- 241000448747 Clasis Species 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010013082 Discomfort Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000004044 Hypesthesia Diseases 0.000 claims 1
- 108010013958 Ikaros Transcription Factor Proteins 0.000 claims 1
- 102000017182 Ikaros Transcription Factor Human genes 0.000 claims 1
- 206010023232 Joint swelling Diseases 0.000 claims 1
- 206010031009 Oral pain Diseases 0.000 claims 1
- 206010034719 Personality change Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 claims 1
- 206010042674 Swelling Diseases 0.000 claims 1
- 206010047571 Visual impairment Diseases 0.000 claims 1
- 230000005856 abnormality Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 230000009266 disease activity Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 230000003203 everyday effect Effects 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 208000034783 hypoesthesia Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 230000033764 rhythmic process Effects 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 208000029257 vision disease Diseases 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
- IXZOHGPZAQLIBH-UHFFFAOYSA-N O=C(c1cccc(OCc2ccc(CN3CCOCC3)cc2)c1C1)N1C(CCC(N1)=O)C1=O Chemical compound O=C(c1cccc(OCc2ccc(CN3CCOCC3)cc2)c1C1)N1C(CCC(N1)=O)C1=O IXZOHGPZAQLIBH-UHFFFAOYSA-N 0.000 description 1
- XMDMKYZTWXTUTD-UHFFFAOYSA-N OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O Chemical compound OC(c1c(C2)c(OCc3ccc(CN4CCOCC4)cc3)ccc1)N2C(CCC(N1)=O)C1=O XMDMKYZTWXTUTD-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021213603A JP2022058443A (ja) | 2014-05-19 | 2021-12-28 | 全身性エリテマトーデスの治療のための３－（４－（（４－（モルホリノメチル－ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462000428P | 2014-05-19 | 2014-05-19 | |
| US62/000,428 | 2014-05-19 | ||
| US201462053626P | 2014-09-22 | 2014-09-22 | |
| US62/053,626 | 2014-09-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568653A Division JP2017522270A (ja) | 2014-05-19 | 2015-05-18 | 全身性エリテマトーデスの治療のための３−（４−（（４−（モルホリノメチル−ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオン |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213603A Division JP2022058443A (ja) | 2014-05-19 | 2021-12-28 | 全身性エリテマトーデスの治療のための３－（４－（（４－（モルホリノメチル－ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020143083A JP2020143083A (ja) | 2020-09-10 |
| JP2020143083A5 true JP2020143083A5 (enExample) | 2020-12-10 |
Family
ID=53268937
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568653A Pending JP2017522270A (ja) | 2014-05-19 | 2015-05-18 | 全身性エリテマトーデスの治療のための３−（４−（（４−（モルホリノメチル−ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオン |
| JP2020080644A Pending JP2020143083A (ja) | 2014-05-19 | 2020-04-30 | 全身性エリテマトーデスの治療のための３−（４−（（４−（モルホリノメチル−ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオン |
| JP2021213603A Pending JP2022058443A (ja) | 2014-05-19 | 2021-12-28 | 全身性エリテマトーデスの治療のための３－（４－（（４－（モルホリノメチル－ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016568653A Pending JP2017522270A (ja) | 2014-05-19 | 2015-05-18 | 全身性エリテマトーデスの治療のための３−（４−（（４−（モルホリノメチル−ベンジル）オキシ）−１−オキソイソインドリン−２−イル）ピペリジン−２，６−ジオン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021213603A Pending JP2022058443A (ja) | 2014-05-19 | 2021-12-28 | 全身性エリテマトーデスの治療のための３－（４－（（４－（モルホリノメチル－ベンジル）オキシ）－１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US10245266B2 (enExample) |
| EP (1) | EP3145513B1 (enExample) |
| JP (3) | JP2017522270A (enExample) |
| ES (1) | ES2969532T3 (enExample) |
| TW (2) | TWI794885B (enExample) |
| WO (1) | WO2015179276A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2536706T3 (pl) | 2010-02-11 | 2017-10-31 | Celgene Corp | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| PT2882441T (pt) | 2012-08-09 | 2020-06-29 | Celgene Corp | Tratamento de doenças associadas à imunidade e inflamatórias |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| US9695145B2 (en) | 2013-01-22 | 2017-07-04 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4- morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| ES2969532T3 (es) * | 2014-05-19 | 2024-05-21 | Celgene Corp | 3-(4-((4-(Morfolinometil-bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona para el tratamiento de lupus eritematoso sistémico |
| WO2018010142A1 (en) * | 2016-07-14 | 2018-01-18 | Shanghai Meton Pharmaceutical Co., Ltd | Iso-citrate dehydrogenase (idh) inhibitor |
| US11529339B2 (en) | 2018-10-01 | 2022-12-20 | Celgene Corporation | Combination therapy for the treatment of cancer |
| CN116234553A (zh) * | 2020-10-02 | 2023-06-06 | 新基公司 | 治疗系统性红斑狼疮的方法和作为对疗法临床敏感性的预测指标的生物标志物的用途 |
| WO2024064646A1 (en) | 2022-09-20 | 2024-03-28 | Celgene Corporation | Salts and solid forms of (s)- or racemic 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and methods of using the same |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| ES2243052T3 (es) | 1998-03-16 | 2005-11-16 | Celgene Corporation | Derivados de la 2- (2,6-dioxopiperidin-3-il) isoindolina, su preparacion y su empleo como inhibidores de las citocinas inflamatorias. |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| GB0120441D0 (en) | 2001-08-22 | 2001-10-17 | Novartis Forschungsstiftung | Model of autoimmune disease and methods for identifying anti autoimmune disease disorders |
| US7173032B2 (en) | 2001-09-21 | 2007-02-06 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| WO2007133725A1 (en) | 2006-05-12 | 2007-11-22 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| US20080045485A1 (en) | 2006-08-17 | 2008-02-21 | Peter Muir | Methods of diagnosing synovial disease in a mammal by detecting bacterial DNA in synovial tissues from dogs with inflammatory knee arthritis and degenerative anterior cruciate ligament rupture |
| CN101562977A (zh) | 2006-12-15 | 2009-10-21 | 艾博特公司 | 新的二唑化合物 |
| KR101791757B1 (ko) | 2007-03-20 | 2017-10-30 | 셀진 코포레이션 | 4'-ｏ-치환된 아이소인돌린 유도체 및 이를 포함하는 조성물 및 이의 사용 방법 |
| US20100075333A1 (en) | 2007-03-30 | 2010-03-25 | Alain Moreau | Method of determining the risk of scoliosis |
| JP5442185B2 (ja) | 2007-04-24 | 2014-03-12 | 日本メナード化粧品株式会社 | 感作性物質評価方法 |
| EP2269072B1 (en) | 2008-03-31 | 2017-08-23 | Boston Medical Center Corporation | Predictive marker for topoisomerase i inhibitors |
| CN102144163A (zh) | 2008-04-10 | 2011-08-03 | 麻省理工学院 | 关于鉴定和使用靶向癌症干细胞的试剂的方法 |
| NZ592801A (en) | 2008-12-05 | 2013-08-30 | Abbvie Inc | Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
| CA2758523C (en) | 2009-04-18 | 2019-03-12 | Genentech, Inc. | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
| PL2536706T3 (pl) | 2010-02-11 | 2017-10-31 | Celgene Corp | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| KR20130056855A (ko) | 2010-03-01 | 2013-05-30 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 치료진단용 생물학적 지표들 |
| EP2544687A1 (en) * | 2010-03-12 | 2013-01-16 | Celgene Corporation | Methods for the treatment of non-hodgkin's lymphomas using lenalidomide, and gene and protein biomarkers as a predictor |
| US20140148350A1 (en) | 2010-08-18 | 2014-05-29 | David Spetzler | Circulating biomarkers for disease |
| JP2014507160A (ja) | 2011-02-22 | 2014-03-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス エス．アー．エール．エル． | 循環バイオマーカー |
| AU2013271378A1 (en) * | 2012-06-07 | 2014-12-18 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the inhibition of Pin1 |
| CA3136093C (en) | 2012-06-29 | 2025-07-08 | Celgene Corporation | METHODS FOR DETERMINING THE EFFICACY OF A DRUG USING PROTEINS ASSOCIATED WITH CEREBLON |
| PT2880447T (pt) * | 2012-07-31 | 2019-08-02 | Novartis Ag | Marcadores associados à sensibilidade a inibidores de minuto duplo humano 2 (mdm2) |
| US20140343058A1 (en) | 2012-08-09 | 2014-11-20 | Celgene Corporation | Treatment of systemic lupus erythematosus |
| US20150038511A1 (en) | 2012-08-09 | 2015-02-05 | Celgene Corporation | Treatment of immune-related and inflammatory diseases |
| PT2882441T (pt) | 2012-08-09 | 2020-06-29 | Celgene Corp | Tratamento de doenças associadas à imunidade e inflamatórias |
| UA117141C2 (uk) | 2013-10-08 | 2018-06-25 | Селджин Корпорейшн | Склади (s)-3-(4-((4-(морфолінометил)бензил)оксі)-1-оксоізоіндолін-2-іл)піперидин-2,6-діону |
| ES2969532T3 (es) * | 2014-05-19 | 2024-05-21 | Celgene Corp | 3-(4-((4-(Morfolinometil-bencil)oxi)-1-oxoisoindolin-2-il)piperidin-2,6-diona para el tratamiento de lupus eritematoso sistémico |
-
2015
- 2015-05-18 ES ES15725213T patent/ES2969532T3/es active Active
- 2015-05-18 TW TW110125851A patent/TWI794885B/zh active
- 2015-05-18 TW TW104115791A patent/TWI745271B/zh active
- 2015-05-18 US US15/312,450 patent/US10245266B2/en active Active
- 2015-05-18 JP JP2016568653A patent/JP2017522270A/ja active Pending
- 2015-05-18 EP EP15725213.1A patent/EP3145513B1/en active Active
- 2015-05-18 WO PCT/US2015/031345 patent/WO2015179276A1/en not_active Ceased
-
2019
- 2019-03-01 US US16/290,493 patent/US10596179B2/en active Active
-
2020
- 2020-02-25 US US16/801,000 patent/US10980812B2/en active Active
- 2020-04-30 JP JP2020080644A patent/JP2020143083A/ja active Pending
-
2021
- 2021-03-29 US US17/216,106 patent/US11660302B2/en active Active
- 2021-12-28 JP JP2021213603A patent/JP2022058443A/ja active Pending
-
2023
- 2023-05-03 US US18/142,973 patent/US20240041894A1/en not_active Abandoned
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