JP2020111529A - Scalp and hair cosmetic for prevention and/or improvement of dandruff and/or itching of scalp - Google Patents

Abstract

To provide a scalp and hair cosmetic for preventing and/or improving dandruff and/or itching of the scalp which contains three components of piroctone olamine, aluminum potassium sulfate and zinc sulfate.SOLUTION: The combined use of piroctone olamine, aluminum potassium sulfate and zinc sulfate exhibits excellent antimicrobial activity against Malassezia resident in the scalp. In addition, a scalp and hair cosmetic containing three components of piroctone olamine, aluminum potassium sulfate and zinc sulfate exhibits an excellent effect of preventing and/or improving dandruff and/or itching of the scalp and also has excellent safety and stability. Consequently, a scalp and hair cosmetic containing three components of piroctone olamine, aluminum potassium sulfate and zinc sulfate is effective for prevention and/or improvement of dandruff and/or itching of the scalp.SELECTED DRAWING: Figure 1

Description

The present invention relates to a scalp hair cosmetic composition which is excellent in the preventive and/or improving effect on scalp dandruff and/or itching.

Dandruff is the exfoliation of the horny piece of the scalp, which also occurs in the normal scalp. Furthermore, when this symptom becomes excessive, it may cause skin trouble called dandruff.

Malassezia is known as one of the causes of dandruff and itching in the scalp. When the sebum on the scalp becomes excessive, the skin resident bacteria, Malassezia, overgrow, causing dandruff and itching. Therefore, a scalp hair cosmetic composition containing an antibacterial agent or a bactericidal agent against Malassezia has been proposed for the purpose of suppressing dandruff and itching of the scalp.

For example, in Patent Document 1, (A) maltooligosaccharide and (B) piroctone olamine, zinc pyrithione, miconazole nitrate and at least one antibacterial agent selected from sulfur are contained, and (A) maltooligosaccharide and ( B) By setting the mass ratio (A/B) of the content of the antibacterial agent to 0.01 to 100, redness and dandruff of the scalp can be dramatically improved, and itching of the scalp can be further improved and itching of the scalp can be achieved. A scalp hair cosmetic composition whose improving effect is sustainable for a long time is disclosed. Patent Document 2 contains one or more kinds selected from (A) eucalyptus extract, (B) polyhydric alcohol, (C) (c1) antibacterial agent and (c2) cooling agent, and has an effect of reducing dandruff and itching and Disclosed is a scalp hair cosmetic composition which is excellent in refreshing feeling and refreshing feeling and is excellent in stability of the preparation over time.

JP, 2011-148777, A JP 2005-206538 A

However, the effects of these scalp hair cosmetics on dandruff and/or itch are not always sufficient, and the development of highly effective new ingredients has been desired.

As a result of earnest research aimed at solving the above-mentioned problems, the present inventors have found that the combined use of three components of piroctone olamine, potassium aluminum sulfate, and zinc sulfate has excellent antibacterial properties against Malassezia that is resident in the scalp. I found that. Furthermore, it was found that a scalp hair cosmetic containing three components of piroctone olamine, potassium aluminum sulfate and zinc sulfate has a preventive and/or improving effect on scalp dandruff and/or itch, and completed the present invention. Came to do.

The piroctone olamine in the present invention is a 1-hydroxy-2-pyridone compound. A growth inhibitory effect against Malassezia is known. It has been used as a raw material for cosmetics and its safety has been confirmed. As piroctone olamine, those commercially available for pharmaceuticals and cosmetics can be used.

Aluminum potassium sulfate in the present invention is a component of alum spring and is represented by AlK(SO ₄ ) ₂ . Also called potassium alum, or potassium alum. The manufacturing method is not particularly limited.

Zinc sulfate in the present invention is a component of a sulfate spring and is represented by ZnSO ₄ . The manufacturing method is not particularly limited.

The content of piroctone olamine in the scalp hair cosmetic composition in the present invention is preferably 0.001 to 1% by weight. If it is less than 0.001% by weight, it is difficult to obtain a sufficient effect, and if it exceeds 1% by weight, the enhancement of the effect is small and it is uneconomical.

The content of potassium aluminum sulfate in the present invention in the scalp hair cosmetic composition is preferably 0.0001 to 1% by weight, more preferably 0.001 to 0.009% by weight. If it is less than 0.0001% by weight, it is difficult to obtain a sufficient effect, and if it exceeds 1% by weight, the enhancement of the effect is small and it is uneconomical.

The content of zinc sulfate in the scalp hair cosmetic composition in the present invention is preferably 0.0001 to 1% by weight, more preferably 0.001 to 0.009% by weight. If it is less than 0.0001% by weight, it is difficult to obtain a sufficient effect, and if it exceeds 1% by weight, the enhancement of the effect is small and it is uneconomical.

The scalp hair cosmetic composition of the present invention, within the range that does not impair the effect, oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, which are components used in ordinary scalp hair cosmetics, It may also contain components such as surfactants, metal soaps, preservatives, fragrances, humectants, powders, ultraviolet absorbers, thickeners, pigments, antioxidants, whitening agents and chelating agents.

In the present invention, piroctone olamine, potassium aluminum sulfate, and zinc sulfate can be used in any of cosmetics, quasi drugs, and pharmaceuticals, and examples of the dosage form thereof include lotion, cream, emulsion, Examples thereof include gel agents, aerosol agents, essences, cleaning agents, ointments and the like.

The combination of three components of piroctone olamine, potassium aluminum sulfate, and zinc sulfate showed excellent antibacterial properties against Malassezia which is resident in the scalp. In addition, the scalp hair cosmetic containing three components of piroctone olamine, potassium aluminum sulfate and zinc sulfate showed an excellent preventive and/or improving effect on scalp dandruff and itching.

It is an antibacterial effect against Malassezia which is resident in the scalp, in the lotions of Formulation Example 1 and Comparative Example.

Next, in order to explain the present invention in detail, formulation examples and experimental examples of the present invention will be given as examples, but the present invention is not limited thereto. The parts of the content shown in the examples are parts by weight.

Prescription example 1 Lotion [prescription] Content 1. Piroctone olamine 0.05 part 2. Aluminum potassium sulfate 0.002
3. Zinc sulfate 0.001
4.1,3-butylene glycol 1.0
5.1-Menthol 0.1
6. Ethanol 40.0
7. Purified water 58.847
[Manufacturing Method] Components 1 to 7 are uniformly mixed to obtain a product.

Comparative Example Comparative Examples 1 to 5 were prepared by containing 0 to 2 components 1 to 3 in Preparation Example 1 and replacing the rest with purified water.
Comparative Example 1: Contains no components 1 to 3 Comparative Example 2: contains only piroctone olamine (component 1) Comparative Example 3: contains only piroctone olamine (component 1) and potassium aluminum sulfate (component 2) Comparative Example 4: Containing only piroctone olamine (Component 1) and zinc sulfate (Component 3) Comparative Example 5: Containing only potassium aluminum sulfate (Component 2) and zinc sulfate (Component 3)

Prescription example 2 Lotion [Prescription] Content 1. Piroctone olamine 0.05 part 2. Aluminum potassium sulfate 0.005
3. Zinc sulfate 0.005
4. Sodium hydrogen carbonate 0.2
5.1,3-butylene glycol 8.0
6. Glycerin 2.0
7. Xanthan gum 0.02
8. Citric acid 0.01
9. Sodium citrate 0.1
10. Ethanol 5.0
11. Methyl paraoxybenzoate 0.1
12. Polyoxyethylene hydrogenated castor oil (40EO) 0.1
13. Perfume 0.1
14. Purified water 84.31
[Production method] Components 1 to 9 and 14 and components 10 to 13 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Prescription example 3 Cream [prescription] Content 1. Piroctone olamine 0.04 part 2. Aluminum potassium sulfate 0.006
3. Zinc sulfate 0.004
4. Squalane 5.5
5. Olive oil 3.0
6. Stearic acid 2.0
7. Beeswax 2.0
8. Octyldodecyl myristate 3.5
9. Polyoxyethylene cetyl ether (20EO) 3.0
10. Behenyl alcohol 1.5
11. Glycerin monostearate 2.5
12. Perfume 0.1
13.1,3-Butylene glycol 8.5
14. Ethyl paraoxybenzoate 0.05
15. Methyl paraoxybenzoate 0.2
16. Purified water 68.10
[Manufacturing Method] Components 4 to 11 are heated and dissolved and mixed, and maintained at 70°C to form an oil phase. Components 1 to 3 and 13 to 16 are dissolved by heating and mixed, and the mixture is kept at 75°C to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, the mixture is cooled with stirring, component 12 is added at 45°C, and further cooled to 30°C to obtain a product.

Prescription example 4 Emulsion [prescription] Content 1. Piroctone olamine 0.05 part 2. Aluminum potassium sulfate 0.005
3. Zinc sulfate 0.003
4. Squalane 5.0
5. Olive oil 5.0
6. Jojoba oil 5.0
7. Cetanol 1.5
8. Glycerin monostearate 2.0
9. Polyoxyethylene cetyl ether (20EO) 3.0
10. Polyoxyethylene sorbitan monooleate 2.0
(20EO)
11. Perfume 0.1
12. Propylene glycol 1.0
13. Glycerin 2.0
14. Methyl paraoxybenzoate 0.2
15. Purified water 73.142
[Manufacturing Method] Components 4 to 10 are heated and dissolved, mixed, and maintained at 70°C to form an oil phase. Components 1 to 3 and 12 to 15 are dissolved by heating and mixed, and the mixture is kept at 75°C to form an aqueous phase. The water phase is added to the oil phase to emulsify, and the mixture is cooled with stirring, component 11 is added at 45°C, and further cooled to 30°C to obtain a product.

Prescription example 5 Gel formulation [prescription] Content 1. Piroctone olamine 0.03 part 2. Aluminum potassium sulfate 0.008
3. Zinc sulfate 0.002
4. Ethanol 5.0
5. Methyl paraoxybenzoate 0.1
6. Polyoxyethylene hydrogenated castor oil (60EO) 0.1
7. Perfume 0.1
8.1,3-butylene glycol 5.0
9. Glycerin 5.0
10. Xanthan gum 0.1
11. Carboxy vinyl polymer 0.2
12. Potassium hydroxide 0.2
13. Purified water 84.16
[Manufacturing Method] Components 4 to 7 and components 1 to 3 and 8 to 13 are uniformly dissolved, and both are mixed to obtain a product.

Next, in order to explain the effect of the present invention in detail, an experimental example will be given.

Experiment 1 Antibacterial test against Malassezia In accordance with the standard plate dilution method of the Japanese Society of Chemotherapy, the minimum inhibitory concentration (MIC, piractone olamine, potassium aluminum sulfate, and zinc sulfate of Malasezia (Malasezzia gloosa NBRC 101597) was used. μg/mL) was measured. That is, the growth properties of Malassezia were examined using a medium to which each component was added so as to be 1 to 1000 μg/mL (common ratio 2). As a medium, Leeming & Notman agar medium (J Clin Microbiol, Vol. 25, PP. 2017-2019, 1987) was used and cultured at 32.5°C for 12 days.

Table 1 shows the minimum inhibitory concentrations of piroctone olamine, potassium aluminum sulfate, and zinc sulfate against Malassezia.

Table 2 shows the minimum inhibitory concentration of piroctone olamine against Malassezia when aluminum potassium sulfate and/or zinc sulfate was used in combination.

From the results in Table 2, it was revealed that the combined use of potassium aluminum sulfate and zinc sulfate markedly improved the antibacterial activity of piroctone olamine against Malassezia.

Experimental Example 2 Examination of Antibacterial Effect Against Malassezia Permanently on the Scalp Using the lotion of Prescription Example 1 and Comparative Example, a one-month use test on the scalp of 86 people with dandruff and/or itchiness on the scalp I went. Before and after use, a 2 cm ² area of the crown was wiped off using a cotton swab containing a 2% polysorbate 80 aqueous solution, and the number of Malassezia bacteria was measured. The number of Malassezia bacteria was measured by DNA quantitative analysis using real-time PCR according to the literature (J Dermatol 43,906-911,2016).

FIG. 1 shows the antibacterial effect against Malassezia that is resident on the scalp in the lotions of Prescription Example 1 and Comparative Example.

From the results of FIG. 1, as compared with Comparative Examples 1 to 5 containing 0 to 2 piroctone olamine, potassium aluminum sulfate and/or zinc sulfate, Formulation Example 1 in which 3 components were used in combination always gave scalp. It was revealed that the antibacterial effect against existing Malassezia is high.

Experimental Example 3 Effect of improving dandruff and itching of scalp Using the lotion of Prescription Example 1 and Comparative Example, a one-month use test for the scalp was conducted on 86 people with dandruff and/or itching on the scalp. .. After use, a questionnaire survey was conducted to investigate the effect of preventing and/or improving dandruff and itching.

The results are shown in Table 3.

From the results in Table 3, as compared to Comparative Examples 1 to 5 containing 0 to 2 piroctone olamine, potassium aluminum sulfate and/or zinc sulfate, Formulation Example 1 in which three components were used in combination had an excellent scalp. It was clarified that the effect of improving dandruff and/or itch was shown. There was no skin trouble during the test period, and there was no problem in safety.

As a result of the same usage test as the external preparations for skin obtained in Formulation Examples 2 to 5, all showed sufficient effect of improving dandruff and/or itch on the scalp. There was no skin trouble during the test period, and there was no problem in safety.

The scalp hair cosmetic composition of the present invention containing piroctone olamine, potassium aluminum sulfate, and zinc sulfate can be used for preventing and/or improving scalp dandruff and/or itching.

Claims (4)

A scalp hair cosmetic composition for preventing and/or improving dandruff and/or itchiness of the scalp, which contains piroctone olamine, potassium aluminum sulfate, and zinc sulfate. The scalp hair cosmetic composition according to claim 1, which has an antibacterial effect against Malassezia. The content of potassium aluminum sulfate is 0.0001 to 1% by weight based on the total amount of scalp hair cosmetics, and the content of zinc sulfate is 0.0001 to less than 1% by weight based on the total amount of scalp hair cosmetics. The scalp hair cosmetic composition according to claim 2. The content of potassium aluminum sulfate is 0.0001 to 0.009% by weight based on the total amount of scalp hair cosmetics, and the content of zinc sulfate is 0.0001 to less than 0.009% by weight based on the total amount of scalp hair cosmetics. The scalp hair cosmetic composition according to claim 2, wherein