JP2020097554A - External composition for skin containing seamless capsule - Google Patents

Abstract

To provide a novel external composition for skin.SOLUTION: An external composition for skin contains a seamless capsule, wherein, the seamless capsule contains, in its internal phase and/or outer phase, oligopeptide or a derivative thereof, N-hydroxy succinimide and chrysin.SELECTED DRAWING: None

Description

The present invention relates to an external composition for skin and the like containing a seamless capsule.

The external composition for skin containing the seamless capsule is usually applied to the skin and used by hand. For example, its use is spreading in the field of cosmetics.

International Publication No. 2018/043661 Japanese Patent No. 3756042

An object of the present invention is to provide a novel composition for external use on skin.

The present invention includes the subject matter described in the following sections, for example.
Item 1.
An external skin composition containing a seamless capsule, wherein the internal capsule and/or the external phase of the seamless capsule contains an oligopeptide or a derivative thereof, N-hydroxysuccinimide and chrysin.
Item 2.
Item 2. The external composition for skin according to Item 1, further comprising an acetyl tetrapeptide in the inner phase and/or the outer phase of the seamless capsule.
Item 3.
Item 3. The external composition for skin according to Item 1 or 2, wherein the total content of the oligopeptide or its derivative, N-hydroxysuccinimide, and chrysin is 0.002% by weight or more.
Item 4.
Item 4. The external composition for skin according to any one of Items 1 to 3, for eliminating dark circles under the eyes.

There is provided a novel composition for external use on the skin, which comprises a seamless capsule. Further, preferably, irritation upon application to the skin is suppressed.

The present invention includes an external composition for skin containing a seamless capsule. Hereinafter, the external composition for skin may be referred to as "the external composition for skin of the present invention".

The external composition for skin of the present invention contains a solvent and a seamless capsule. The seamless capsule is a kind of soft capsule, and is a capsule in which the contents are enclosed by a seamless film. Examples of the solvent include water, ethanol, propanediol, propylene glycol, butylene glycol, glycerin and the like, and these components can be used alone or in combination of two or more. In addition, the solvent may contain various components described below, and may be the same as the content liquid of the seamless capsule.

The external composition for skin of the present invention preferably contains an oligopeptide or a derivative thereof, N-hydroxysuccinimide or chrysin. Examples of oligopeptides include dipeptides, tripeptides, tetrapeptides, pentapeptides, hexapeptides, and the like, and the amino acids constituting the oligopeptide may be L-form or D-form. The derivative of an oligopeptide means an oligopeptide in which the N-terminal and C-terminal of the oligopeptide are modified, and among them, a fatty acid derivative of an oligopeptide in which a fatty acid is bound to the oligopeptide is preferable. Examples of the fatty acid include lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid. Among them, lauric acid, myristic acid, and palmitic acid are preferable, and palmitic acid is particularly preferable. Examples of fatty acid derivatives of oligopeptides include palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tripeptide-8, palmitoyl tripeptide-38, palmitoyl tetrapeptide-7, palmitoyl pentapeptide-4, palmitoyl hexapeptide-19. , Palmitoyl hexapeptide-12 and the like, and among them, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 are preferable. The oligopeptide or its derivative may be a natural product or a synthetic product, and is not particularly limited, such as a product extracted from a natural product or a commercially available product. The oligopeptides or derivatives thereof can be used alone or in combination of two or more. In addition, the oligopeptide may be used alone, the oligopeptide derivative may be used alone, or the oligopeptide and its derivative may be used in combination.

The total content of the oligopeptide or its derivative, N-hydroxysuccinimide and chrysin in the external composition for skin of the present invention is 0.002% by weight or more based on the total weight of the external composition for skin. The content is preferably 0.003% by weight or more, more preferably 0.004% by weight or more. The content of the oligopeptide or its derivative in the external composition for skin of the present invention is preferably 0.0001% by weight or more, and 0.0002% by weight or more, based on the total weight of the external composition for skin. Is more preferable, and 0.0003% by weight or more is further preferable. The content of N-hydroxysuccinimide in the external composition for skin of the present invention is preferably 0.0001% by weight or more and 0.001% by weight or more based on the total weight of the external composition for skin. It is more preferably 0.002% by weight or more, still more preferably 0.003% by weight or more, and particularly preferably 0.004% by weight or more. The content of chrysin in the external composition for skin of the present invention is preferably 0.0001% by weight or more, and more preferably 0.0002% by weight or more, based on the total weight of the external composition for skin. In the external composition for skin of the present invention, the content weight ratio of oligopeptide or its derivative and chrysin is preferably 0.5 to 10 parts by weight of oligopeptide or its derivative with respect to 1 part by weight of chrysin. The upper or lower limit of the range may be, for example, 1, 2, 3, 4, 5, 6, 7, 8, 9 parts by weight. In the external composition for skin of the present invention, the content weight ratio of N-hydroxysuccinimide and chrysin is preferably 0.5 to 50 parts by weight of N-hydroxysuccinimide with respect to 1 part by weight of chrysin. .. The upper or lower limit of the range may be, for example, 1, 5, 10, 15, 20, 25, 30, 35, 40, 45 parts by weight.

In the present invention, the inner phase of the seamless capsule means the inner side of the film of the seamless capsule, and the outer phase of the seamless capsule means the solvent containing the seamless capsule. The inclusion in the outer phase of the seamless capsule may mean that the component is attached to the film surface of the seamless capsule, or may be contained in the solvent containing the seamless capsule.

In the external composition for skin of the present invention, the oligopeptide or its derivative, N-hydroxysuccinimide and chrysin may be contained in the inner phase of the seamless capsule, or may be contained in the outer phase of the seamless capsule. , May be contained in the inner phase and the outer phase of the seamless capsule. Further, at least one of the oligopeptide or its derivative, N-hydroxysuccinimide and chrysin may be contained in the inner phase of the seamless capsule, or two or all of them may be contained in the inner phase of the seamless capsule. May be. Further, at least one of the oligopeptide or its derivative, N-hydroxysuccinimide and chrysin may be contained in the outer phase of the seamless capsule, or two or all of them may be contained in the outer phase of the seamless capsule. Good.

The external composition for skin of the present invention preferably further contains an acetyl tetrapeptide. Examples of the acetyltetrapeptide include acetyltetrapeptide-2, acetyltetrapeptide-5, acetyltetrapeptide-9, acetyltetrapeptide-11, acetyltetrapeptide-15, acetyltetrapeptide-22 and the like, and among them, acetyltetrapeptide. -5 is preferable. In the external composition for skin of the present invention, acetyltetrapeptide may be contained in the inner phase of the seamless capsule, may be contained in the outer phase of the seamless capsule, and may be contained in the inner phase and the outer phase of the seamless capsule. May be

The film of the seamless capsule used in the external composition for skin of the present invention contains a thickener. Examples of the thickener include agar, carrageenan, gelatin, alginic acid or a salt thereof, pullulan, glucomannan, gum arabic, gellan gum, hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinyl alcohol, carboxymethylcellulose, pectin, xanthan gum, starch and the like. It is preferable that it contains at least agar and carrageenan.

The seamless capsule film used in the external composition for skin of the present invention may contain, in addition to the above-mentioned compounds, components that can be usually used in the capsule film, as long as the effects of the present invention are not impaired. For example, a plasticizer, a preservative, a pH adjuster, a coloring agent and the like can be mentioned.

As the plasticizer, glycerin, polyethylene glycol, propylene glycol, polypropylene glycol, butylene glycol, glucose, fructose, galactose, sucrose, maltose, trehalose, raffinose, pullulan, gum arabic, arabinogalactan, cellulose, sorbitol, maltitol, lactitol. , Palatinit, xylitol, mannitol, galactitol and the like.

One particularly preferred embodiment of the present invention is butylene glycol, glycerin, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, chrysin, N-hydroxysuccinimide, acetyl tetrapeptide-in the inner and/or outer phase of the seamless capsule. A composition for external use for skin, comprising 5 and propanediol, and agar and carrageenan in the film of a seamless capsule. The butylene glycol content is 11-18% by weight, the glycerin content is 6-10% by weight, and the palmitoyl tetrapeptide-7 content is 0.00005, relative to the total weight of the external composition for skin. Is 0.0002% by weight, the content of palmitoyl tripeptide-1 is 0.0001 to 0.0004% by weight, and the content of N-hydroxysuccinimide is 0.002 to 0.008% by weight. The content of chrysin is 0.0001 to 0.0004% by weight, the content of acetyltetrapeptide-5 is 0.00002 to 0.0001% by weight, and the content of propanediol is 0.02 to 0.02% by weight. It is preferable that the content is 0.05% by weight, the content of agar is 0.6 to 1.0% by weight, and the content of carrageenan is 0.2 to 0.4% by weight.

The external composition for skin of the present invention can be obtained by blending a seamless capsule with a solvent or the like. The seamless capsule used in the present invention can be manufactured by a conventional method. For example, a spherical seamless capsule can be manufactured by vibrating and cutting a two-layered liquid flow composed of a coating liquid on the outer side and a content liquid on the inner side while vibrating at a constant interval.

When the oligopeptide or its derivative, N-hydroxysuccinimide or chrysin is contained in the internal phase of the seamless capsule, the external composition for skin of the present invention can be prepared by blending these components in the content liquid of the seamless capsule. The thing can be manufactured. When contained in the outer phase of the seamless capsule, the external composition for skin of the present invention can be produced by blending these components in a solvent containing the seamless capsule. When contained in the internal phase and the external phase of the seamless capsule, in the content liquid of the seamless capsule and in the solvent containing the seamless capsule, by mixing these components, to produce the external composition for skin of the present invention. You can

The external composition for skin of the present invention can preferably eliminate dark circles under the eyes. Without wishing to be bound by theory, as a factor having such an effect, the oligopeptides and derivatives thereof used in the external composition for skin of the present invention give firmness to the skin around the eyes and raise the tone. N-hydroxysuccinimide and chrysin, which have an action and are used in the external composition for skin of the present invention, have an action of removing pigmenting substances from blood such as biliverdin, bilirubin and iron, which cause darkening under the eyes. I think it is because I have it. In one embodiment, the external composition for skin of the present invention can preferably suppress sagging under the eyes. Although not wishing to be bound by theory, as a factor having such an effect, the acetyltetrapeptide used in the external composition for skin of the present invention is one of the causes of the sagging of the lower part of the eye. It is believed that this is because it has the effect of preventing the accumulation of water.

In addition to the above-mentioned compounds, the external composition for skin of the present invention may contain components that can be usually used in the external composition for skin, as long as the effects of the present invention are not impaired. For example, surfactants and polymer compounds, oils and fats, alcohols, moisturizers, ultraviolet absorbers, chelating agents, amino acids, sugars, vitamins, solvents, pH regulators, antioxidants, antioxidant aids, preservatives. Agents, fragrances, other active ingredients, etc. may be mentioned. These components may be contained in the inner phase of the seamless capsule, may be contained in the outer phase of the seamless capsule, or may be contained in the inner phase and the outer phase of the seamless capsule.

Examples of the surfactant include anionic surfactant; cationic surfactant; amphoteric surfactant such as imidazoline-based amphoteric surfactant and betaine-based surfactant; sorbitan-based surfactant, glycerin fatty acid ester, polyglycerin fatty acid Ester, propylene glycol fatty acid ester, alkyl glycoside, Tween-based surfactant, polyoxyethylene glycerin fatty acid ester, polyoxyethylene polyglycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene hydrogenated castor oil derivative, sucrose fatty acid Examples thereof include nonionic surfactants such as esters, polyoxyethylene alkyl ethers, pluronic type surfactants, and alkanolamides. These may be used alone or in combination of two or more.

Examples of the polymer compound include polyethylene glycol having an average molecular weight of about several hundred to 20,000; cellulosic polymer; alginic acid polymer; starch polymer; acrylic polymer; vinyl polymer and other non-natural polymer Polymers, plant-based polymers such as carrageenan, pectin, agar, starch, gum arabic, guar gum, arge colloid, collagen and its derivatives, animal-based polymers such as casein and gelatin, microbial polymers such as xanthan gum and gellan gum Examples include natural polymers such as. These may be used alone or in combination of two or more.

Examples of fats and oils are vegetable oils; animal oils; hydrocarbon oils such as liquid paraffin, squalane, and petrolatum; chain polysiloxanes, cyclic polysiloxanes, methyltrimethicone, silicone resins, modified polysiloxanes, and other silicones; lauric acid, stearin. Higher fatty acids such as acids and oleic acid; waxes such as beeswax, lanolin and derivatives thereof; monoalkyl fatty acid esters; polyhydric alcohol fatty acid esters; hydrogenated oils and the like. These may be used alone or in combination of two or more.

Examples of alcohols include lower alcohols such as ethyl alcohol and butyl alcohol; higher alcohols such as lauryl alcohol, stearyl alcohol, behenyl alcohol and batyl alcohol; polyhydric alcohols such as ethylene glycol, propylene glycol and glycerin; dipropylene glycol and di alcohol. Examples thereof include polyhydric alcohol polymers such as glycerin and polyglycerin; sugar alcohols such as sorbitol, maltitol, mannitol and erythritol; and other alcohols such as lanolin alcohol, cholesterol and phytosterol. These may be used alone or in combination of two or more.

Examples of the humectant include low molecular weight polyhydric alcohols such as polyethylene glycol, propylene glycol and glycerin, chondroitin sulfate, sodium hyaluronate, sodium lactate, pyrrolidone carboxylate, collagens and plant extracts. These may be used alone or in combination of two or more.

The external composition for skin of the present invention can be used, for example, as an external preparation for skin (medicine, quasi drug) or cosmetic according to a conventional method. The external skin preparation can be used in a dosage form suitable for application to the skin, for example, gel, cream, ointment, liniment, lotion, emulsion, suspension, aerosol, plaster and the like. Preferred are gels, creams, lotions and emulsions. In addition, cosmetics include lotions, emulsions, creams, beauty essences, packs, makeup base lotions, makeup base creams, skin cosmetics such as sunscreen, cleansing lotions, cleansing creams, cleansing foams, facial cleansers, body shampoos. It can be used as a skin cleansing agent. Preference is given to lotions, emulsions, creams and beauty essences.

The term "comprising" includes "consisting essentially of" and "consisting of." in the present specification also includes "consisting essentially of" and "consisting of". Further, the invention includes all combinations of the constituent elements described in this specification.

The contents of the present invention will be specifically described with reference to the following examples. However, the present invention is not limited to these. Further, "%" means "% by weight" unless otherwise specified. Further, the compounding amount value of each component shown in each table also shows "wt%" unless otherwise specified.

Production Example A composition for external use for skin was prepared according to the formulation shown in Table 1. Part I of Table 1 corresponds to the content liquid of the seamless capsule and the solvent to which the seamless capsule is added. The components shown in part I of Table 1 were mixed and an appropriate amount of water was added to adjust the viscosity. A seamless capsule was prepared according to a conventional method using a seamless capsule film (including agar and carrageenan as a thickener) obtained from Fuji Capsule Co., Ltd. The prepared seamless capsule was added to the solvent shown in Part I of Table 1 to obtain an external composition for skin.

When the obtained composition for external use was applied to the skin and blended by hand, the seamless capsules were crushed, and no residue was left on the capsule film, resulting in a smooth feel.

Test Example The external composition for skin prepared in the Production Example was subjected to a patch test on 20 subjects. A patch tape for skin test filled with about 0.03 ml of the prepared composition for external skin application was applied to the back, and after 24 hours, the patch tape for skin test was peeled off. 60 minutes after the peeling, and 24 hours after the peeling, the doctor made a judgment. The judgment criteria are shown in Table 2.

As a result of the patch test, all 20 subjects showed negative results after 60 minutes and 24 hours after peeling, and the external composition for skin of the present invention suppressed irritation to the skin and was safe. I found it expensive.

Claims (3)

An external skin composition containing a seamless capsule, wherein the internal capsule and/or the external phase of the seamless capsule contains an oligopeptide or a derivative thereof, N-hydroxysuccinimide and chrysin. The external composition for skin according to claim 1, further comprising an acetyl tetrapeptide in the inner phase and/or the outer phase of the seamless capsule. The external composition for skin according to claim 1 or 2 for eliminating dark circles under the eyes.