JP2020002042A - Oral composition - Google Patents

Abstract

To provide an oral composition which suppresses white turbidity by sufficiently solubilizing an oil-soluble perfume, has excellent storage stability and reduces a foreign taste derived from a surfactant.SOLUTION: There is provided an oral composition which can suppress white turbidity by sufficiently solubilizing an oil-soluble perfume by blending and solubilizing a polyoxyethylene hardened castor oil and a polyoxyethylene polyoxypropylene alkyl ether together with the oil-soluble perfume, can impart excellent storage stability and reduce a foreign taste derived from a surfactant.SELECTED DRAWING: None

Description

  TECHNICAL FIELD The present invention relates to an oral composition in which an oil-soluble flavor is sufficiently solubilized to suppress white turbidity, has excellent storage stability, and has reduced unpleasant taste derived from a surfactant.

  BACKGROUND ART In a liquid oral composition such as a mouth freshener, a mouthwash, and a liquid dentifrice, an oil-soluble fragrance is blended in order to impart a flavor when used and to give a good feeling of use. In the liquid oral composition, it is necessary to increase the amount of the oil-soluble flavor to give a sufficient flavor at the time of use, but the oral composition contains an aqueous base such as water. When the blending amount of the oil-soluble flavor increases, the oil-soluble flavor becomes difficult to be solubilized, and there is a problem that cloudiness occurs.

  Therefore, conventionally, various formulation techniques for solubilizing oil-soluble flavors for stabilization have been studied. For example, Patent Literature 1 discloses an oral composition containing an oil-soluble fragrance, having excellent transparency and excellent stability, comprising (A) 0.01 to 0.5% by mass of myristoyl glutamate, (B) poly (B) Oxyethylene hydrogenated castor oil, at least one or two or more nonionic surfactants selected from glycerin fatty acid esters and sugar fatty acid esters, (C) an oil-soluble flavor, and (D) 90% by weight or more of water, A liquid oral composition having a weight ratio ((B) / (A)) of component (B) to component (A) of 5 to 50 is disclosed.

  On the other hand, in recent years, demands for oral compositions have been diversified, and there is a demand for oral compositions having strong scents and exhibiting good flavor. Increasing the amount of the oil-soluble fragrance enhances the scent, but increasing the amount of the oil-soluble fragrance requires the addition of a surfactant to solubilize the oil-soluble fragrance. However, the surfactant has a peculiar off-taste such as bitterness, and the incorporation of the surfactant results in a reduction in flavor. Therefore, it is required to sufficiently solubilize the oil-soluble flavor with a surfactant, suppress the white turbidity caused by the oil-soluble flavor, and increase the storage stability, while reducing the off-taste derived from the surfactant, At present, such formulation technology has not been established.

JP 2013-181011 A

  An object of the present invention is to provide an oral composition in which an oil-soluble flavor is sufficiently solubilized, cloudiness is suppressed, has excellent storage stability, and has a reduced off-taste derived from a surfactant. To provide.

  The present inventors have conducted intensive studies to solve the above-mentioned problems, and found that in an oral composition, polyoxyethylene hydrogenated castor oil and polyoxyethylene polyoxypropylene alkyl ether were blended and solubilized together with an oil-soluble flavor. As a result, it has been found that the oil-soluble flavor can be sufficiently solubilized, white turbidity can be suppressed, excellent storage stability can be imparted, and the off-taste derived from the surfactant can be reduced. The present invention has been completed by further study based on such knowledge.

That is, the present invention provides the following aspects of the invention.
Item 1. An oral composition comprising (A) an oil-soluble flavor, (B) a polyoxyethylene hydrogenated castor oil, (C) a polyoxyethylene polyoxypropylene alkyl ether, and (D) water.
Item 2. Item wherein the component (C) is contained in an amount of 15 to 150 parts by weight and the total amount of the component (B) and the component (C) is 2 to 3.5% by weight per 100 parts by weight of the component (B). 2. The composition for oral cavity according to 1.
Item 3. Item 3. The oral composition according to Item 1 or 2, further comprising (E) a monohydric lower alcohol.
Item 4. Item 4. The oral composition according to any one of Items 1 to 3, further comprising (F) a polyhydric alcohol.
Item 5. A method for suppressing cloudiness of an oral composition containing a fat-soluble flavor,
A method for suppressing white turbidity, comprising blending (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition.
Item 6. A method for stabilizing an oral composition containing an oil-soluble flavor,
A stabilizing method comprising mixing (A) an oil-soluble fragrance, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition.
Item 7. In an oral composition containing a surfactant, a method for reducing the off-tastes of the surfactant,
A method for reducing an unpleasant taste, comprising blending (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition.

  According to the oral cavity composition of the present invention, the oil-soluble flavor can be sufficiently solubilized, so that cloudiness due to the oil-soluble flavor can be suppressed and a good appearance can be exhibited. In addition, the oral composition of the present invention has excellent storage stability because the solubilized state of the oil-soluble flavor can be stably maintained even when stored. Furthermore, although the oral composition of the present invention contains a surfactant in order to solubilize the oil-soluble flavor, the off-taste derived from the surfactant can be reduced, thereby impairing the flavor of the oil-soluble flavor. Thus, a good feeling of use can be obtained.

1. Oral composition The oral composition of the present invention contains (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water. It is characterized by. In the oral composition of the present invention, (A) an oil-soluble flavor and (D) water, together with (B) polyoxyethylene hydrogenated castor oil and (C) polyoxyethylene polyoxypropylene alkyl ether, oil It has become possible to sufficiently solubilize soluble fragrances to suppress cloudiness, to provide excellent storage stability, and to reduce off-tastes (such as bitterness) derived from surfactants. Hereinafter, the oral composition of the present invention will be described in detail.

[(A) Oil-soluble flavor and content]
The composition for oral cavity of the present invention contains an oil-soluble fragrance (which may be referred to as “(A) component”. The type of the oil-soluble fragrance used in the present invention is applicable to the oral cavity. There is no particular limitation to this limit, and examples thereof include single flavors and essential oils.

  Specific perfumes include, specifically, menthol, carvone, anethole, eugenol, cineol, thymol, geraniol, citronellol, vanillin, methyl salicylate, menthone, isomenthone, limonene, pinene, pregon, menthyl lactate, terpinyl acetate, terpineol, linalool, Benzyl succinate, methyl eugenol, ocimene, methyl acetate, citronenyl acetate, ethyl linalool, varnish and the like. These individual fragrances may be synthesized or may be purified from nature.

  Specific examples of essential oils include mint oils such as spearmint oil, peppermint oil and peppermint oil; citrus oils such as lemon oil, mandarin oil, lime oil, yuzu oil, grapefruit oil, orange oil; sage oil, eucalyptus oil, Clove oil, rosemary oil, thyme oil, nutmeg oil, laurel oil, basil oil, perilla oil, estragon oil, parsley oil, celery oil, coriander oil, fennel oil, cinnamon oil, pepper oil, nutmeg oil, mace oil, clove Herbs and spice oils such as oil, ginger oil, cardamom oil, fennel oil, anise oil, cinnamon oil, winter green oil, clove oil, pimento oil, parsley oil, tea tree oil, tabana oil, star anise oil, etc. Can be

  These fat-soluble flavors may be used alone or in a combination of two or more. Further, as a fat-soluble flavor, two or more single flavors, one or more single flavors and one or more essential oils, or a combination of two or more essential oils, and flavored to give a desired fruit flavor. May be used.

  Among these fat-soluble flavors, preferably, menthol, geraniol, citronellol, limonene, linalool, citrus oil, herb spice oil and the like are exemplified.

  The content of the component (A) in the oral composition of the present invention is not particularly limited, but is, for example, 0.01 to 5.0% by weight, preferably 0.1 to 2.5% by weight, and more preferably 0 to 2.5% by weight. 0.5 to 1.5% by weight.

[(B) Polyoxyethylene hydrogenated castor oil]
The oral composition of the present invention contains polyoxyethylene hydrogenated castor oil (sometimes referred to as “component (B)”) as a surfactant. Polyoxyethylene hydrogenated castor oil is a compound obtained by etherifying hydrogenated castor oil with a polyoxyethylene chain.

  The number of moles of ethylene oxide added to the polyoxyethylene chain in the polyoxyethylene hydrogenated castor oil is not particularly limited, but is, for example, 5 to 100, preferably 10 to 80, and more preferably 20 to 60.

  As polyoxyethylene hydrogenated castor oil, specifically, PEG-5 hydrogenated castor oil, PEG-10 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-40 hydrogenated Castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-70 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-90 hydrogenated castor oil, PEG-100 hydrogenated castor oil And the like.

  These polyoxyethylene hydrogenated castor oils may be used alone or in a combination of two or more.

  Among these polyoxyethylene hydrogenated castor oils, from the viewpoint of further improving the white turbidity suppressing effect, the storage stability, and the effect of reducing the off-taste derived from the surfactant, preferably the number of moles of ethylene oxide added is 20 to Polyoxyethylene hydrogenated castor oil of 60, more preferably PEG-50 hydrogenated castor oil, and PEG-60 hydrogenated castor oil.

  The content of the component (B) in the oral composition of the present invention is not particularly limited, but may be, for example, 0.5 to 5.0% by weight. From the viewpoint of further improving the effect of suppressing cloudiness, storage stability, and the effect of reducing off-taste derived from a surfactant, the content of the component (B) in the oral composition of the present invention is preferably 0.75. 0.0 to 4.0% by weight, more preferably 1.0 to 3.5% by weight.

[(C) polyoxyethylene polyoxypropylene alkyl ether]
The composition for oral cavity of the present invention further contains polyoxyethylene polyoxypropylene alkyl ether (sometimes referred to as “component (C)”) as a surfactant. Polyoxyethylene polyoxypropylene alkyl ether is a compound in which a polyoxyethylene polyoxypropylene chain is ether-bonded to an alkyl group.

  The number of moles of ethylene oxide added to the polyoxyethylene polyoxypropylene chain is not particularly limited, but is, for example, 2 to 100, preferably 10 to 80, and more preferably 12 to 40.

  The number of moles of propylene oxide added to the polyoxyethylene polyoxypropylene chain is not particularly limited, but is, for example, 1 to 40, preferably 1 to 20, and more preferably 1 to 10.

  The number of carbon atoms in the alkyl group constituting the polyoxyethylene polyoxypropylene alkyl ether is not particularly limited, but is, for example, 6 to 24, preferably 8 to 22, and more preferably 12 to 20.

  Specific examples of the polyoxyethylene polyoxypropylene alkyl ether include PPG-4cetes-1, PPG-4cetes-10, PPG-4cetes-20, PPG-8cetes-20, and PPG-6decyltetrade. Ces-12, PPG-6decyltetradeces-20, PPG-6decyltetradeces-30 and the like.

  These polyoxyethylene polyoxypropylene alkyl ethers may be used alone or in a combination of two or more.

  Among these polyoxyethylene polyoxypropylene alkyl ethers, from the viewpoint of further improving the white turbidity suppressing effect, the storage stability, and the effect of reducing the off-taste derived from the surfactant, the number of moles of ethylene oxide added is preferably 12 Polyoxyethylene polyoxypropylene alkyl ether having an addition mole number of propylene oxide of 1 to 10 and an alkyl group of 12 to 20 carbon atoms; more preferably PPG-4 ceteth-20, PPG-6 decyltetra Deces-12, PPG-6decyltetradeces-20, and PPG-6decyltetradeces-30.

  The content of the component (C) in the composition for oral cavity of the present invention is not particularly limited, and examples thereof include 0.1 to 3.0% by weight. From the viewpoint of further improving the effect of suppressing cloudiness, storage stability, and the effect of reducing off-taste derived from a surfactant, the content of the component (C) in the oral composition of the present invention is preferably 0.5%. To 2.0% by weight, more preferably 0.5 to 1.5% by weight.

  Further, in the oral composition of the present invention, the content of the total amount of the components (B) and (C) (the total amount of the components (B) and (C)) is the same as the content of each component described above. There is no particular limitation as long as it is within the appropriate range. For example, the total amount of the component (B) and the component (C) is 1.0 to 5.0% by weight. The total amount of the component (B) and the component (C) is preferably from 1.5 to 4.0, from the viewpoint of further improving the effect of suppressing cloudiness, the storage stability, and the effect of reducing the off-taste attributed to the surfactant. % By weight, and more preferably 2.0 to 3.0% by weight.

  Further, in the oral composition of the present invention, the ratio of the component (B) and the component (C) is not particularly limited as long as it is within the range according to the content of each component described above, for example, ( The component (C) is included in an amount of 15 to 150 parts by weight based on 100 parts by weight of the component (B). From the viewpoint of further improving the clouding suppression effect, storage stability, and the effect of reducing the off-taste derived from the surfactant, the component (C) is preferably 100 to 100 parts by weight of the component (B). Parts by weight, more preferably 25 to 100 parts by weight.

  In the oral composition of the present invention, the ratio of the component (A) to the total amount of the components (B) and (C) may be within the range according to the content of each component described above. Although not particularly limited, for example, the total amount of the components (B) and (C) is 100 to 500 parts by weight based on 100 parts by weight of the component (A). From the viewpoint of further improving the white turbidity suppressing effect, storage stability, and the effect of reducing the off-taste derived from the surfactant, based on 100 parts by weight of the component (A), the total amount of the components (B) and (C) However, preferably 150 to 400 parts by weight, more preferably 200 to 300 parts by weight.

[(D) water]
The oral composition of the present invention contains water (sometimes referred to as “(D) component”) as a base. The content of the component (D) in the composition for oral cavity of the present invention is appropriately set according to the form of the preparation, and is, for example, 30 to 85% by weight, preferably 40 to 75% by weight, and more preferably 50 to 70% by weight.

[(E) monohydric lower alcohol]
The oral composition of the present invention preferably further contains a monohydric lower alcohol (sometimes referred to as “(E) component”). By containing a monohydric lower alcohol, the oil-soluble flavor can be stably solubilized, and the clouding suppression effect and the storage stability can be further improved.

  The monohydric lower alcohol is not particularly limited as long as it can be applied to the oral cavity, and is, for example, a monohydric alcohol having 2 to 5 carbon atoms, preferably ethanol, propanol, isopropanol, butanol, and more preferably ethanol. Is mentioned.

  These monohydric lower alcohols may be used alone or in a combination of two or more.

  When the component (E) is contained in the oral composition of the present invention, the content thereof is not particularly limited, but may be, for example, 5 to 35% by weight, preferably 7.5 to 25% by weight, and more preferably 10 to 25% by weight. １５15% by weight.

  When the oral composition of the present invention contains the component (E), the ratio of the component (E) to the component (A) may be within the range according to the content of each component described above, Although not particularly limited, for example, the component (E) may be 250 to 3500 parts by weight, preferably 250 to 2500 parts by weight, more preferably 500 to 1500 parts by weight, per 100 parts by weight of the component (A).

[(F) Polyhydric alcohol]
The oral composition of the present invention preferably further contains a polyhydric alcohol (sometimes referred to as “(F) component”). By containing the polyhydric alcohol, the oil-soluble flavor can be stably solubilized, and the clouding suppression effect and the storage stability can be further improved.

  The polyhydric alcohol used in the present invention is not particularly limited as long as it can be applied in the oral cavity. Examples thereof include ethylene glycol, 1,3-butylene glycol, propylene glycol, isoprene glycol, diethylene glycol, and diethylene glycol. Propylene glycol, polypropylene glycol, glycerin and the like can be mentioned.

  These polyhydric alcohols may be used alone or in a combination of two or more.

  Among these polyhydric alcohols, glycerin is preferably used from the viewpoint of further improving the clouding suppression effect and the storage stability.

  When the component (F) is contained in the oral composition of the present invention, the content thereof is not particularly limited, but is, for example, 5 to 35% by weight, preferably 7.5 to 35% by weight, and more preferably 10 to 35% by weight. ２５25% by weight.

  When the oral composition of the present invention contains the component (F), the ratio of the component (F) to the component (A) may be within a range according to the content of each component described above, Although not particularly limited, for example, component (F) may be 250 to 3500 parts by weight, preferably 250 to 3500 parts by weight, more preferably 500 to 2500 parts by weight, per 100 parts by weight of component (A).

[(G) Polar oil]
The oral composition of the present invention may contain a polar oil (sometimes referred to as “(G) component”). By including the polar oil, it is possible to further improve the clouding suppression effect, the storage stability, and the effect of reducing the off-taste attributed to the surfactant.

  The polar oil means an oil having an IOB (balance of inorganic / organic properties) in the range of 0.05 to 1.1. The IOB of the polar oil used in the present invention is preferably 0.1 to 0.9, more preferably 0.15 to 0.5, and particularly preferably 0.3 to 0.4.

  Further, the viscosity of the polar oil used in the present invention is not particularly limited, but as the viscosity at 20 ° C., for example, 5 to 600 mPa · s, preferably 40 to 550 mPa · s, more preferably 140 to 510 mPa · s. Is mentioned. In the present specification, the viscosity of the polar oil is measured using a B-type viscometer “TOKI SANGYO VISCOMMETER TVB-10” (manufactured by Toki Sangyo Co., Ltd.) with a rotor: NO. 1 (rotational speed: 12 rpm, time: 30 sec, unit: mPa · s) means a value measured under a temperature condition of 20 ° C.

  The type of polar oil is not particularly limited as long as it can be applied in the oral cavity, and examples thereof include fatty acid esters, higher fatty acids, higher alcohols, and vegetable oils.

  Among the polar oils, fatty acid esters include, for example, esters of fatty acids with monohydric or polyhydric alcohols. Examples of the fatty acid ester include a monoester in which one molecule of a fatty acid is bonded to one molecule of a monohydric or polyhydric alcohol, a diester in which two molecules of a fatty acid are bonded to one molecule of a polyhydric alcohol, and a polyhydric alcohol in which three molecules of a fatty acid are trivalent or more. Triester bonded to one molecule, tetraester bonded to one molecule of polyhydric alcohol having four or more fatty acids, diester bonded to two molecules of dihydric alcohol, one molecule of fatty acid to one molecule of cholesterol And cholesteryl fatty acid bonded to the amino acid.

  In the monoester in which one molecule of the fatty acid is bonded to one molecule of the monohydric or polyhydric alcohol, the number of carbon atoms of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 20. Examples of the number include 2 to 34, preferably 2 to 20. As the monoester, specifically, isopropyl myristate, octyldodecyl myristate, octyldodecyl oleate, dipentaerythritol fatty acid ester, isopropyl adipate, isobutyl adipate, isopropyl sebacate, cetyl ethylhexanoate, ethylhexane Palmityl acid, myristyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, ethyl oleate, batyl stearate, hexyldecyl isostearate, isopropyl linoleate, cetyl octanoate, butyl stearate, ethyl laurate, laurine Hexyl acid, decyl oleate, hexyl decyl dimethyl octoate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, Isocetyl sostearate, fatty acid ester of dipentaerythritol, N-alkyl glycol monoisostearate, alkyl benzoate (C12-15), methyl ester of castor oil fatty acid, oleyl oleate, 2-heptylundecyl palmitate, myristic acid 2-hexyldecyl, 2-hexyldecyl palmitate and the like can be mentioned.

  In a diester in which two molecules of fatty acid are bonded to one molecule of polyhydric alcohol, the number of carbon atoms of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 18, and the number of carbon atoms of the constituent polyhydric alcohol is, for example, 2 to 2. 34, preferably 2 to 6. Specific examples of the diester include propylene glycol dicaprylate, neopentyl glycol dioctoate, neopentyl glycol diethylhexanoate, glycol diethylhexanoate, neopentyl glycol dicaprate, glycerin diheptylundecanoate, glycerin di (caprylate / (Capric acid) butylene glycol and the like.

  In a triester in which three molecules of a fatty acid are bonded to one molecule of a trihydric or higher polyhydric alcohol, the number of carbon atoms of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 18, and the number of carbon atoms of the constituent polyhydric alcohol is Is, for example, 2 to 34, preferably 3 to 6. Specific examples of the triester include triethylhexanoin (glyceryl triethylhexanoate), diglyceryl triisostearate, glyceryl tri (caprylate / caprate), glyceryl triisopalmitate, glyceryl triisooctanoate, and triethylhexane. Trimethylolpropane acid, trimethylolpropane triisostearate, trimethylolpropane triisostearate, glyceryl triisostearate, glyceryl trimmyristate, glyceride tri-2-heptylundecanoate, and the like.

  In the tetraester in which four molecules of the fatty acid are bonded to one molecule of the polyhydric alcohol having a valency of 4 or more, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 10, and the carbon number of the constituent 1 polyhydric alcohol. Examples thereof include 2 to 34, preferably 4 to 8. Specific examples of the tetraester include pentaerythrityl tetraethylhexanoate and pentaerythrityl tetraoctanoate.

  In a diester in which two molecules of a monohydric alcohol are bonded to one molecule of a dicarboxylic acid, the carbon number of the constituent fatty acid is, for example, 4 to 30, preferably 4 to 12, and the carbon number of the constituent monohydric or polyhydric alcohol is For example, 2 to 34, preferably 2 to 20. Specific examples of the diester include diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, diisostearyl malate, diethylhexyl naphthalene dicarboxylate, di-2-hexyldecyl adipate, and di2-adipate. Heptylundecyl, di-2-ethylhexyl succinate and the like.

  In fatty acid cholesteryl, the number of carbon atoms of the constituent fatty acid is, for example, 4 to 30, preferably 6 to 20. Specific examples of the fatty acid cholesteryl include lanolin fatty acid cholesteryl, cholesteryl hydroxystearate, and macadamia nut fatty acid cholesteryl.

  These fatty acid esters may be used alone or in a combination of two or more.

  Among the polar oils, higher fatty acids include, for example, fatty acids having 8 to 30 carbon atoms, preferably 10 to 20 carbon atoms. Specifically, lauric acid, myristic acid, palmitic acid, sebacic acid, oleic acid, stearin Acids, linoleic acid and the like. These fatty acids may be used alone or in combination of two or more.

  Among the polar oils, examples of the higher alcohol include alcohols having 12 to 22 carbon atoms, specifically, lauryl alcohol, myristyl alcohol, palmityl alcohol, cetanol, oleyl alcohol, stearyl alcohol, isoaryl alcohol, and the like. Examples include stearyl alcohol, cetostearyl alcohol, and behenyl alcohol. These higher alcohols may be used alone or in a combination of two or more.

  Of the polar oils, vegetable oil refers to oils and fats extracted from lipids contained in plants, which are liquid at normal temperature, mainly containing triglycerides in which fatty acids and glycerin are ester-bonded, and are used as fat-soluble flavors. Essential oils (ie, volatile components distilled from plants that exhibit aroma). As vegetable oils, for example, sunflower seed oil, jojoba seed oil, olive oil, coconut oil, palm oil, palm kernel oil, safflower oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil , Hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, corn oil, rapeseed oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, jojoba oil and the like. Can be These vegetable oils may be used alone or in a combination of two or more.

  These polar oils may be used alone or in combination of two or more.

  Among these polar oils, preferably, a fatty acid ester; more preferably, a tetraester in which four molecules of a fatty acid are bonded to one molecule of a polyhydric alcohol having a valency of 4 or more; particularly preferably, pentaerythyl tetraethylhexanoate.

  When the oral composition of the present invention contains the component (G), the content thereof is not particularly limited, but is, for example, 0.01 to 1.5% by weight, preferably 0.1 to 0.5% by weight. %, More preferably 0.1 to 0.3% by weight.

  When the oral composition of the present invention contains the component (G), the ratio of the component (G) to the component (A) may be within the range according to the content of each component described above, Although not particularly limited, for example, based on 100 parts by weight of the component (A), the component (G) is 0.2 to 15,000 parts by weight, preferably 4 to 500 parts by weight, more preferably 10 to 300 parts by weight. Can be

[Other components]
The oral composition of the present invention contains, in addition to the components described above, components commonly used in the art, depending on the form of the oral composition, as long as the effects of the present invention are not impaired. Is also good. Such components include, for example, preservatives, bactericides, antimicrobial agents, anti-inflammatory agents, abrasives, glucosyltransferase (GTase) inhibitors, plaque inhibitors, hyperesthesia inhibitors, tartar preventives, tooth strengthening / reinforcing Calcifying agents, local anesthetics, blood circulation enhancers, surfactants other than the components (B) and (C), thickeners, wetting agents, sweeteners, pigments, deodorants, pH adjusters, and the like. .

  As preservatives, bactericides, antibacterial agents, for example, hinokitiol, benzoic acids, salicylic acids, sorbic acids, parabens, chlorhexidine chloride, chlorhexidine gluconate, isopropylmethylphenol, triclosan, lysozyme chloride, chlorhexidine hydrochloride, potassium iodide, etc. Is mentioned.

  Anti-inflammatory agents, for example, dipotassium glycyrrhizinate, glycyrrhetinic acid, methyl glycyrrhizinate, stearyl glycyrrhizinate, pyridoxine glycyrrhetinate, stearyl glycyrrhetinate, glyceryl glyceryl, glycyrrhetinic acid monoglucuronide, allantoin, tranexamic acid, epsilon aminocaproic acid, azulene , Sodium chloride, vitamins and the like.

  Examples of the abrasive include silicic anhydride, hydrated silicic acid, aluminum oxide, aluminum hydroxide, calcium hydrogen phosphate, calcium phosphate, calcium pyrophosphate, calcium carbonate, crystalline cellulose, polyethylene powder, charcoal particles, and the like.

  Examples of the GTase inhibitor include, for example, extracts of plants of the genus Oenothera genus, extracts of grape vines, dextranase, mutanase, tustein, tannins, ellagic acid, polyphenol, oolong tea extract, green tea extract, Assemblies, syrups, fennel, peony, gentian, senso, dragon bile, oren.

  Examples of the plaque inhibitor include zinc citrate and gluconic acid.

  Examples of the hypersensitivity inhibitor include potassium nitrate and strontium chloride.

  Examples of the tartar preventive include polyphosphates, zeolite, ethanehydroxydiphosphonate and the like.

  Examples of the tooth strengthening / remineralizing agent include fluorine, sodium fluoride, sodium fluorophosphate, stannous fluoride and the like.

  Examples of the local anesthetic include procaine, tetracaine, bupivacaine, mepipacaine, chloroprocaine, proparacaine, meprilcaine or a salt thereof, orthocaine, oxesazein, oxypolyentoxydecane, funnel extract, percaminpase, tesit desitin and the like.

  Examples of the blood circulation promoting agent include nonyl acid varnishylamide, nicotinic acid benzyl ester, capsaicin, and pepper extract.

  Surfactants (other than the components (B) and (C)) include glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene. Nonionic surfactants such as sorbitol fatty acid ester, polyoxyethylene alkyl ether, lecithin derivative; sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfate, sodium myristyl sulfate, sodium N-lauroyl sarcosinate, N-myristril sarcosine acid Sodium, sodium dodecylbenzene sulfonate, hydrogenated coconut fatty acid sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, α-olefin Anionic surfactants such as sodium sulfonate, sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurine; lauryl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, benzethonium chloride, benzalkonium chloride, stearyl dimethyl chloride Cationic surfactants such as benzyl ammonium; coconut oil fatty acid amidopropyl betaine, lauryl dimethylamino acetate betaine, lauryl dimethylamine oxide, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine, N-lauryl diaminoethyl Amphoteric surfactants such as glycine, N-myristyldiaminoethylglycine, N-alkyl-1-hydroxyethylimidazoline betaine sodium and lecithin; It is.

  Examples of the thickener include polysaccharides such as pullulan, pullulan derivatives and starch; hydroxypropylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, hydroxyethylmethylcellulose, carboxymethylcellulose, carboxymethylcellulose salts (carboxymethylcellulose sodium, carboxymethylcellulose potassium, etc.) , Methylcellulose, ethylcellulose, polyacrylic acid, polyacrylate (sodium polyacrylate, acrylic acid / octyl acrylate copolymer), and methacrylic acid copolymer (methacrylic acid and n-butyl acrylate) Cellulosics such as polymers, polymers of methacrylic acid and methyl methacrylate, and polymers of methacrylic acid and ethyl acrylate) Synthetic polymer such as carboxyvinyl polymer, polyethylene glycol, polyvinyl alcohol and polyvinylpyrrolidone; lectin, alginic acid, alginates (sodium alginate, potassium alginate, magnesium alginate, propylene glycol alginate, triethanolamine alginate, alginic acid) Natural polymer materials such as triisopropanolamine, ammonium alginate, butylamine alginate, diamylamine alginate), sodium chondroitin sulfate, agar, chitosan, carrageenan; amino acid polymer materials such as collagen and gelatin; gum arabic, gum karaya, gum tragacanth; Xanthan gum, locust bean gum, guar gum, tamarind gum, gellan gum, etc. System polymer material, and the like.

  Examples of the humectant include xylitol, maltitol, lactol, erythritol and the like.

  Examples of the sweetener include saccharin sodium, stevioside, stevia extract, aspartame, xylitol, syrup, honey, sorbitol, maltitol, mannitol, erythritol, sugars (lactose, sucrose, fructose, glucose, etc.).

  Examples of the dye include a natural dye, a synthetic dye, and a mixture thereof.

  Examples of the deodorant include zinc chloride, sodium copper chlorophyllin, green coffee bean extract, burdock powder, green tea, roasted rice bran extract and the like.

  Examples of the pH adjuster include acetic acid, hydrochloric acid, sulfuric acid, nitric acid, citric acid, malic acid, lactic acid, phosphoric acid, benzoic acid, sodium hydroxide, potassium hydroxide, sodium acetate, sodium carbonate, sodium citrate, and citric acid Examples thereof include sodium hydrogen, sodium lactate, calcium lactate, sodium phosphate, sodium hydrogen phosphate, and sodium benzoate.

  When these components are contained in the oral composition of the present invention, the contents thereof may be appropriately set within a range usually used in the technical field.

[Dosage form / formulation form]
The dosage form of the oral composition of the present invention is not particularly limited as long as it can be applied to the oral cavity, and examples thereof include a liquid or semi-solid (gel, paste) form.

  The formulation of the oral composition of the present invention is not particularly limited as long as it can be applied to the oral cavity and stay in the oral cavity for a certain period of time, but, for example, liquid dentifrice, liquid dentifrice, toothpaste, Mouthwashes (liquid dentifrices and mouthwashes may be generally referred to as mouth rinse, mouthwash, dental rinse, etc.), oral fresheners (mouth spray, etc.), oral hygiene agents such as oral ointments Is mentioned. Of these, liquid dentifrices, mouthwashes and the like are preferred, and mouth rinses and mouth sprays are more preferred.

[Production method]
The composition for oral cavity of the present invention can be produced according to a known method for preparing a solubilized preparation. For example, as a method for producing the oral composition of the present invention, the component (B) and the component (C) are mixed, and after the component (A) is added and mixed, the component (D) is added. What is necessary is just to mix.

2. Cloudiness suppression method, stabilization method, off-flavor reduction method The cloudiness suppression method of the present invention is a method for suppressing cloudiness of an oral composition containing a fat-soluble flavor, and the oral composition, (A) oil-soluble flavor , (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water. According to the white turbidity suppressing method of the present invention, the oil-soluble fragrance is sufficiently solubilized, and it becomes possible to suppress white turbidity of the oral composition.

  Further, the stabilizing method of the present invention is a method for stabilizing an oral composition containing an oil-soluble flavor, wherein the oral composition contains (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, It is characterized by blending (C) polyoxyethylene polyoxypropylene alkyl ether and (D) water. According to the stabilization method of the present invention, the oil-soluble flavor is solubilized stably, and it becomes possible to impart storage stability to the oral composition.

  Further, the method for reducing the off-flavor of the present invention is a method for reducing the off-flavor of a surfactant in an oral composition containing a surfactant, wherein the oral composition has (A) an oil-soluble flavor, (B) It is characterized by blending polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water. By the method for reducing off-flavors of the present invention, off-flavors (bitterness, etc.) of surfactants can be reduced, and the feeling of use of the oral composition can be improved.

  In the white turbidity suppressing method, the stabilizing method, and the off-taste reducing method of the present invention, the types and contents of the components (A) to (D), other components and contents, and the dosage form and formulation of the oral composition Are as described in the section of “1. Oral composition”.

  Hereinafter, the present invention will be described more specifically with reference to Examples, but the present invention is not limited thereto.

  The pentaerythyl tetraethylhexanoate used in the following Examples, Comparative Examples, and Formulation Examples has an IOB value of 0.35 and a viscosity at 20 ° C. of 140 mPa · s.

Test example 1
Mouthwashes having the compositions shown in Tables 1 to 3 were prepared. Specifically, first, ethanol and a surfactant (polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene sorbitan fatty acid ester, polyglycerin fatty acid ester) are mixed, and the resulting mixture is mixed with an oil-soluble flavor. After adding and mixing the polar oil, water, glycerin and sodium saccharin were added and mixed to prepare a mouthwash.

The appearance, storage stability, and taste of each of the obtained mouthwashes were evaluated by the following methods.
<Appearance>
The appearance of the mouthwash immediately after preparation was observed and evaluated according to the following criteria.
-Appearance criteria- : Completely transparent.
+: There is slight cloudiness.
++: Cloudy and translucent.
+++: There is cloudiness, but there is slight transparency.
++++: completely dark and cloudy, and lacks transparency.

<Storage stability>
50 ml of each mouthwash immediately after preparation was placed in a 110 ml transparent glass container (screw tube No. 8, manufactured by Maruem Co., Ltd.) and stored at 25 ° C. for 14 days under light-shielded conditions. The appearance of the mouthwash after storage was visually observed and evaluated according to the following criteria.
-: Completely transparent.
+: There is slight cloudiness.
++: Cloudy and translucent.
+++: There is cloudiness, but there is slight transparency.
++++: completely dark and cloudy, and lacks transparency.
<Taste>
Each mouthwash immediately after preparation is filled in a spray container, and sprayed (about 1.0 ml) into the mouth of five panelists (previously brushed for 3 minutes without dentifrice) three times (approximately 1.0 ml). According to the standard, the taste was scored using the off-taste (bitterness) derived from the surfactant as an index.
5: No bitterness is felt.
4: Slightly bitter, but not bothersome 3: Slightly bitter, but not bothersome
2: Slight bitterness is felt but hardly disturbing 1: Bitterness is felt and disturbing.
0: Very strong bitterness is felt and unpleasant.

Furthermore, the scores determined by each panel were averaged, and the evaluation results were compiled according to the following classification criteria.
<Scoring criteria>
◎: Average of scores is 3 or more ○: Average of scores is 2 or more and less than 3 points Δ: Average of scores is 1 or more and less than 2 points ×: Average of scores is less than 1 point

  Tables 1 to 3 show the obtained results. As a result, when polyoxyethylene hydrogenated castor oil and polyoxyethylene polyoxypropylene alkyl ether are contained together with the oil-soluble fragrance (Examples 1 to 8), cloudiness is suppressed, the appearance is good, the storage stability and the presentation are good. The taste (bitterness suppression) was also excellent. On the other hand, when one of the polyoxyethylene hydrogenated castor oil and the polyoxyethylene polyoxypropylene alkyl ether is lacking (Comparative Examples 1 to 8), although the taste (bitterness suppression) is excellent, the appearance and storage stability are good. I couldn't satisfy the sex. Furthermore, when a polyoxyethylene sorbitan fatty acid ester or a polyglycerin fatty acid ester is used as a surfactant (Comparative Examples 9 and 10), and when a polyoxyethylene polyoxypropylene alkyl ether and a polyglycerin fatty acid ester are used in combination (Comparative Examples) Even in Example 11), all of the appearance, storage stability and taste (bitterness suppression) could not be satisfied.

Formulation Example A mouthwash having the composition shown in Table 3 was prepared in the same manner as in Test Example 1. In each of the obtained mouthwashes, cloudiness was suppressed, the appearance was good, and the storage stability and the taste (suppression of bitterness) were all excellent.

Claims (7)

  An oral composition comprising (A) an oil-soluble flavor, (B) a polyoxyethylene hydrogenated castor oil, (C) a polyoxyethylene polyoxypropylene alkyl ether, and (D) water.   The component (C) is contained in an amount of 15 to 150 parts by weight per 100 parts by weight of the component (B), and the total amount of the components (B) and (C) is 2 to 3.5% by weight. Item 7. The oral composition according to Item 1.   The oral composition according to claim 1 or 2, further comprising (E) a monohydric lower alcohol.   The oral composition according to any one of claims 1 to 3, further comprising (F) a polyhydric alcohol. A method for suppressing cloudiness of an oral composition containing a fat-soluble flavor,
A method for suppressing white turbidity, comprising blending (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition. A method for stabilizing an oral composition containing an oil-soluble flavor,
A stabilizing method comprising mixing (A) an oil-soluble flavor, (B) a polyoxyethylene hydrogenated castor oil, (C) a polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition. In an oral composition containing a surfactant, a method for reducing the off-tastes of the surfactant,
A method for reducing off-flavors, comprising blending (A) an oil-soluble flavor, (B) polyoxyethylene hydrogenated castor oil, (C) polyoxyethylene polyoxypropylene alkyl ether, and (D) water with an oral composition.