JP2019535822A5 - - Google Patents

Info

Publication number

JP2019535822A5

JP2019535822A5 JP2019547064A JP2019547064A JP2019535822A5 JP 2019535822 A5 JP2019535822 A5 JP 2019535822A5 JP 2019547064 A JP2019547064 A JP 2019547064A JP 2019547064 A JP2019547064 A JP 2019547064A JP 2019535822 A5 JP2019535822 A5 JP 2019535822A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

liver

reducing

fat

Prior art date

2017-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 18
• 210000004185 liver Anatomy 0.000 claims 5
• 102000023984 PPAR alpha Human genes 0.000 claims 3
• 238000009825 accumulation Methods 0.000 claims 3
• 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 3
• 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 3
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
• 102100027943 Carnitine O-palmitoyltransferase 1, liver isoform Human genes 0.000 claims 2
• 101000859570 Homo sapiens Carnitine O-palmitoyltransferase 1, liver isoform Proteins 0.000 claims 2
• 108010016731 PPAR gamma Proteins 0.000 claims 2
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
• 230000007850 degeneration Effects 0.000 claims 2
• 102000004311 liver X receptors Human genes 0.000 claims 2
• 108090000865 liver X receptors Proteins 0.000 claims 2
• 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 2
• ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 2
• 229960003073 pirfenidone Drugs 0.000 claims 2
• 239000007939 sustained release tablet Substances 0.000 claims 2
• 208000007082 Alcoholic Fatty Liver Diseases 0.000 claims 1
• 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
• 102100033601 Collagen alpha-1(I) chain Human genes 0.000 claims 1
• 102000004127 Cytokines Human genes 0.000 claims 1
• 108090000695 Cytokines Proteins 0.000 claims 1
• 101000909313 Homo sapiens Carnitine O-palmitoyltransferase 2, mitochondrial Proteins 0.000 claims 1
• 101000989606 Homo sapiens Cholinephosphotransferase 1 Proteins 0.000 claims 1
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
• -1 IL-1β Proteins 0.000 claims 1
• 206010061218 Inflammation Diseases 0.000 claims 1
• 102100022338 Integrin alpha-M Human genes 0.000 claims 1
• 102100037850 Interferon gamma Human genes 0.000 claims 1
• 108010074328 Interferon-gamma Proteins 0.000 claims 1
• 102000003814 Interleukin-10 Human genes 0.000 claims 1
• 108090000174 Interleukin-10 Proteins 0.000 claims 1
• 102000013691 Interleukin-17 Human genes 0.000 claims 1
• 108050003558 Interleukin-17 Proteins 0.000 claims 1
• 102000004889 Interleukin-6 Human genes 0.000 claims 1
• 108090001005 Interleukin-6 Proteins 0.000 claims 1
• 101710091439 Major capsid protein 1 Proteins 0.000 claims 1
• 108010028924 PPAR alpha Proteins 0.000 claims 1
• 102000000536 PPAR gamma Human genes 0.000 claims 1
• 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 claims 1
• 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 claims 1
• 102100026839 Sterol regulatory element-binding protein 1 Human genes 0.000 claims 1
• 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 1
• 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 1
• 208000026594 alcoholic fatty liver disease Diseases 0.000 claims 1
• 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 claims 1
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
• 208000019425 cirrhosis of liver Diseases 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 230000004936 stimulating effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1