JP2019535785A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019535785A5 JP2019535785A5 JP2019528489A JP2019528489A JP2019535785A5 JP 2019535785 A5 JP2019535785 A5 JP 2019535785A5 JP 2019528489 A JP2019528489 A JP 2019528489A JP 2019528489 A JP2019528489 A JP 2019528489A JP 2019535785 A5 JP2019535785 A5 JP 2019535785A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- insulin
- subject
- mace
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 17
- 102000004877 Insulin Human genes 0.000 claims 9
- 108090001061 Insulin Proteins 0.000 claims 9
- 229940125396 insulin Drugs 0.000 claims 9
- 238000011282 treatment Methods 0.000 claims 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims 3
- 208000020832 chronic kidney disease Diseases 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 2
- 206010027525 Microalbuminuria Diseases 0.000 claims 2
- 208000031481 Pathologic Constriction Diseases 0.000 claims 2
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 2
- 210000003423 ankle Anatomy 0.000 claims 2
- 230000036772 blood pressure Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 230000002526 effect on cardiovascular system Effects 0.000 claims 2
- 229960004225 insulin degludec Drugs 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 201000001474 proteinuria Diseases 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 208000037804 stenosis Diseases 0.000 claims 2
- 230000036262 stenosis Effects 0.000 claims 2
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 208000019553 vascular disease Diseases 0.000 claims 2
- 230000002861 ventricular Effects 0.000 claims 2
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 108010057186 Insulin Glargine Proteins 0.000 claims 1
- FYZPCMFQCNBYCY-WIWKJPBBSA-N Insulin degludec Chemical compound CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC1=O)[C@@H](C)O)[C@@H](C)CC FYZPCMFQCNBYCY-WIWKJPBBSA-N 0.000 claims 1
- COCFEDIXXNGUNL-RFKWWTKHSA-N Insulin glargine Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(=O)NCC(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 COCFEDIXXNGUNL-RFKWWTKHSA-N 0.000 claims 1
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 230000008321 arterial blood flow Effects 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000007211 cardiovascular event Effects 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims 1
- 230000008602 contraction Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 229960001089 dobutamine Drugs 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 108010050259 insulin degludec Proteins 0.000 claims 1
- 229960002869 insulin glargine Drugs 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 210000003141 lower extremity Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 238000012633 nuclear imaging Methods 0.000 claims 1
- 239000003538 oral antidiabetic agent Substances 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16200906 | 2016-11-28 | ||
| EP16200906.2 | 2016-11-28 | ||
| EP17174682.9 | 2017-06-07 | ||
| EP17174682 | 2017-06-07 | ||
| PCT/EP2017/080600 WO2018096162A1 (en) | 2016-11-28 | 2017-11-28 | Insulin degludec in cardiovascular conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019535785A JP2019535785A (ja) | 2019-12-12 |
| JP2019535785A5 true JP2019535785A5 (OSRAM) | 2020-12-17 |
| JP7193455B2 JP7193455B2 (ja) | 2022-12-20 |
Family
ID=60937677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019528489A Active JP7193455B2 (ja) | 2016-11-28 | 2017-11-28 | 心血管状態におけるインスリンデグルデク |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11278596B2 (OSRAM) |
| EP (1) | EP3544683A1 (OSRAM) |
| JP (1) | JP7193455B2 (OSRAM) |
| CN (1) | CN110022935A (OSRAM) |
| MA (1) | MA46897A (OSRAM) |
| WO (1) | WO2018096162A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11278596B2 (en) | 2016-11-28 | 2022-03-22 | Novo Nordisk A/S | Insulin degludec in cardiovascular conditions |
| AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| JP7518149B2 (ja) | 2019-07-12 | 2024-07-17 | ノヴォ ノルディスク アー／エス | 高濃度インスリン製剤 |
| CN113773397B (zh) * | 2020-06-10 | 2023-10-20 | 宁波鲲鹏生物科技有限公司 | 一种德谷胰岛素的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ300837B6 (cs) | 1996-08-30 | 2009-08-26 | Novo Nordisk A/S | Deriváty GLP-1(7-37) nebo jeho analogy, farmaceutický prostredek je obsahující a jejich použití |
| GB0309154D0 (en) | 2003-01-14 | 2003-05-28 | Aventis Pharma Inc | Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia |
| JP4463814B2 (ja) | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
| RU2014143271A (ru) | 2012-03-28 | 2016-05-20 | Санофи | Базовая инсулинотерапия |
| JP6755175B2 (ja) | 2013-03-20 | 2020-09-16 | ノヴォ ノルディスク アー／エス | インスリン投薬レジメン |
| JP2016519127A (ja) | 2013-04-30 | 2016-06-30 | ノヴォ ノルディスク アー／エス | 新規投与レジメン |
| US11278596B2 (en) | 2016-11-28 | 2022-03-22 | Novo Nordisk A/S | Insulin degludec in cardiovascular conditions |
| US11673933B2 (en) | 2016-11-28 | 2023-06-13 | Novo Nordisk A/S | Method for using insulin degludec for the improvement of glycemic control and reduction of acute and long-term diabetes complications |
-
2017
- 2017-11-28 US US16/463,598 patent/US11278596B2/en active Active
- 2017-11-28 WO PCT/EP2017/080600 patent/WO2018096162A1/en not_active Ceased
- 2017-11-28 JP JP2019528489A patent/JP7193455B2/ja active Active
- 2017-11-28 EP EP17825753.1A patent/EP3544683A1/en not_active Withdrawn
- 2017-11-28 CN CN201780073496.7A patent/CN110022935A/zh active Pending
- 2017-11-28 MA MA046897A patent/MA46897A/fr unknown
-
2022
- 2022-02-08 US US17/667,223 patent/US12233114B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019535785A5 (OSRAM) | ||
| Filippatos et al. | SGLT2 inhibitors and cardioprotection: a matter of debate and multiple hypotheses | |
| Herman et al. | Insulin therapy increases cardiovascular risk in type 2 diabetes | |
| Friedman et al. | Obesity and pulmonary hypertension: a review of pathophysiologic mechanisms | |
| RU2768283C2 (ru) | Семаглутид при сердечно-сосудистых состояниях | |
| Tsoutsouki et al. | Advances in the management of diabetes: therapies for type 2 diabetes | |
| HRP20220058T1 (hr) | Sastavi i metode za smanjenje velikih neželjenih kardiovaskularnih događaja | |
| JP2016539164A5 (OSRAM) | ||
| Sun et al. | Early assistance with left ventricular assist device limits left ventricular remodeling after acute myocardial infarction in a swine model | |
| AU2024201937A1 (en) | Liraglutide in cardiovascular conditions | |
| JP7193455B2 (ja) | 心血管状態におけるインスリンデグルデク | |
| JP2019535791A5 (OSRAM) | ||
| Li et al. | New insights and advances of sodium-glucose cotransporter 2 inhibitors in heart failure | |
| Lee et al. | Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors | |
| JP2020523408A5 (OSRAM) | ||
| Sedrak et al. | Evolving role of double and triple therapy with GLP-1 receptor agonists in obesity and cardiovascular disease | |
| Kochanowski et al. | Biventricular takotsubo cardiomyopathy in an elderly woman with uncontrolled type 2 diabetes: the biphasic echocardiographic and clinical pattern | |
| Breite et al. | Changing Fields-Diabetes Medications Invading the Cardiovascular Space | |
| Maji et al. | A review on the role of peroxisome prolifertor-activated receptor-γ agonists and hybrids in type 2 diabetes and cardiomyopathy | |
| Khutsoane | Liraglutide, an incretin mimetic: drug trends | |
| Ari et al. | A rare cause of reversible dilated cardiomyopathy: hypocalcemia | |
| Teixeira Filho et al. | Right ventricular aneurysm following right ventricular infarction | |
| Filippas-Ntekouan | Effect of SGLT-2 inhibitors on the serum and urine metabolome in patients with type 2 diabetes mellitus | |
| Sharma | Glucagon-like Peptide-1 Analogs | |
| Muhailan et al. | Thyroid Storm with Resultant Cardiac Arrest. |