JP2019535723A5 - - Google Patents
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- Publication number
- JP2019535723A5 JP2019535723A5 JP2019526262A JP2019526262A JP2019535723A5 JP 2019535723 A5 JP2019535723 A5 JP 2019535723A5 JP 2019526262 A JP2019526262 A JP 2019526262A JP 2019526262 A JP2019526262 A JP 2019526262A JP 2019535723 A5 JP2019535723 A5 JP 2019535723A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- pharmaceutically acceptable
- tautomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims 62
- 229910052799 carbon Inorganic materials 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 37
- 125000000623 heterocyclic group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 239000011780 sodium chloride Substances 0.000 claims 12
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 11
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 1
- 200000000018 inflammatory disease Diseases 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662423409P | 2016-11-17 | 2016-11-17 | |
US62/423,409 | 2016-11-17 | ||
PCT/US2017/061895 WO2018093968A1 (en) | 2016-11-17 | 2017-11-16 | Imidazopyridazine modulators of il-12, il-23 and/or ifn-alpha |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019535723A JP2019535723A (ja) | 2019-12-12 |
JP2019535723A5 true JP2019535723A5 (US20080131398A1-20080605-C00009.png) | 2020-11-26 |
JP7012082B2 JP7012082B2 (ja) | 2022-01-27 |
Family
ID=60655055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019526262A Active JP7012082B2 (ja) | 2016-11-17 | 2017-11-16 | Il-12、il-23および/またはifn-アルファのイミダゾピリダジン調節剤 |
Country Status (7)
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201940483A (zh) | 2018-03-12 | 2019-10-16 | 美商艾伯維有限公司 | 酪胺酸激酶2介導的傳訊之抑制劑 |
EP3849981B1 (en) | 2018-09-10 | 2023-02-01 | Eli Lilly and Company | Pyrazolo[1,5-a]pyrimidine-3-carboxamide derivatives useful in the treatment of psoriasis and systemic lupus erythematosus |
JP2022518505A (ja) * | 2019-01-23 | 2022-03-15 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
JP2022537877A (ja) | 2019-04-30 | 2022-08-31 | セルジーン コーポレイション | アプレミラストおよびtyk2阻害剤を含む併用療法 |
AR121251A1 (es) | 2020-02-12 | 2022-05-04 | Lilly Co Eli | Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida |
EP3944859A1 (en) | 2020-07-30 | 2022-02-02 | Assistance Publique Hôpitaux de Paris | Method for treating immune toxicities induced by immune checkpoint inhibitors |
IL312330A (en) | 2021-10-25 | 2024-06-01 | Kymera Therapeutics Inc | TYK2 joints and their uses |
WO2023198199A1 (zh) * | 2022-04-15 | 2023-10-19 | 先声再明医药有限公司 | 膜缔合酪氨酸和苏氨酸激酶抑制剂 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
US7176214B2 (en) | 2003-05-21 | 2007-02-13 | Bristol-Myers Squibb Company | Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same |
US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
US8389527B2 (en) * | 2008-02-06 | 2013-03-05 | Bristol-Myers Squibb Company | Substituted imidazopyridazines useful as kinase inhibitors |
TWI491610B (zh) | 2008-10-09 | 2015-07-11 | 必治妥美雅史谷比公司 | 作為激酶抑制劑之咪唑并嗒腈 |
PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
AR094537A1 (es) * | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
JP6458038B2 (ja) * | 2013-12-10 | 2019-01-23 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用なイミダゾピリダジン化合物 |
JP6843135B2 (ja) | 2015-11-18 | 2021-03-17 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | IL−12、IL−23および/またはIFNα応答のモジュレーターとして有用なイミダゾピリダジン化合物 |
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2017
- 2017-11-16 US US16/461,479 patent/US11299494B2/en active Active
- 2017-11-16 JP JP2019526262A patent/JP7012082B2/ja active Active
- 2017-11-16 KR KR1020197016792A patent/KR102611856B1/ko active IP Right Grant
- 2017-11-16 CN CN201780083328.6A patent/CN110191887B/zh active Active
- 2017-11-16 EP EP17812112.5A patent/EP3541817B1/en active Active
- 2017-11-16 WO PCT/US2017/061895 patent/WO2018093968A1/en unknown
- 2017-11-16 ES ES17812112T patent/ES2849974T3/es active Active