JP2019532012A5 - - Google Patents
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- JP2019532012A5 JP2019532012A5 JP2018567646A JP2018567646A JP2019532012A5 JP 2019532012 A5 JP2019532012 A5 JP 2019532012A5 JP 2018567646 A JP2018567646 A JP 2018567646A JP 2018567646 A JP2018567646 A JP 2018567646A JP 2019532012 A5 JP2019532012 A5 JP 2019532012A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- click
- pair
- biological sample
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022084324A JP2022126650A (ja) | 2016-06-28 | 2022-05-24 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2024114392A JP7737517B2 (ja) | 2016-06-28 | 2024-07-18 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2025142894A JP2026000932A (ja) | 2016-06-28 | 2025-08-29 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662355390P | 2016-06-28 | 2016-06-28 | |
| US62/355,390 | 2016-06-28 | ||
| PCT/EP2017/065796 WO2018002016A1 (en) | 2016-06-28 | 2017-06-27 | Application of click chemistry for signal amplification in ihc and ish assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022084324A Division JP2022126650A (ja) | 2016-06-28 | 2022-05-24 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532012A JP2019532012A (ja) | 2019-11-07 |
| JP2019532012A5 true JP2019532012A5 (https=) | 2020-07-30 |
| JP7128121B2 JP7128121B2 (ja) | 2022-08-30 |
Family
ID=59350876
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567646A Active JP7128121B2 (ja) | 2016-06-28 | 2017-06-27 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2022084324A Withdrawn JP2022126650A (ja) | 2016-06-28 | 2022-05-24 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2024114392A Active JP7737517B2 (ja) | 2016-06-28 | 2024-07-18 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2025142894A Pending JP2026000932A (ja) | 2016-06-28 | 2025-08-29 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022084324A Withdrawn JP2022126650A (ja) | 2016-06-28 | 2022-05-24 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2024114392A Active JP7737517B2 (ja) | 2016-06-28 | 2024-07-18 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| JP2025142894A Pending JP2026000932A (ja) | 2016-06-28 | 2025-08-29 | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US11249085B2 (https=) |
| EP (2) | EP4631529A3 (https=) |
| JP (4) | JP7128121B2 (https=) |
| CN (2) | CN121021395A (https=) |
| WO (1) | WO2018002016A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2940439C (en) * | 2014-02-24 | 2024-03-19 | Ventana Medical Systems, Inc. | Quinone methide analog signal amplification |
| WO2018002015A1 (en) * | 2016-06-28 | 2018-01-04 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
| JP7128121B2 (ja) * | 2016-06-28 | 2022-08-30 | ヴェンタナ メディカル システムズ， インク． | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
| US11492610B2 (en) | 2018-03-08 | 2022-11-08 | California Institute Of Technology | Sample multiplexing for single-cell RNA sequencing |
| JP7455816B2 (ja) | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| ES3011267T3 (en) * | 2019-06-07 | 2025-04-07 | Univ Princeton | Proximity-based labeling systems and applications thereof |
| CN112305227A (zh) * | 2019-07-31 | 2021-02-02 | 深圳市帝迈生物技术有限公司 | 自交联蛋白、配体组合物、制备方法、试剂盒及系统 |
| EP4073064A4 (en) * | 2019-12-11 | 2024-01-24 | The General Hospital Corporation | METHOD FOR IMAGING CELLS |
| US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
| CN112113820A (zh) * | 2020-05-28 | 2020-12-22 | 王剑 | 一种细胞病理学样本的染色制片方法 |
| CA3189327A1 (en) | 2020-08-19 | 2022-02-24 | Vijaya Raghavan PATTABIRAMAN | Modified il-18 polypeptides and uses thereof |
| WO2022043491A2 (en) * | 2020-08-28 | 2022-03-03 | Ventana Medical Systems, Inc. | Conjugates including a detectable moiety |
| WO2022066512A1 (en) | 2020-09-22 | 2022-03-31 | Ventana Medical Systems, Inc. | Prediction of response to epidermal growth factor receptor-directed therapies using epiregulin and amphiregulin |
| WO2022092301A1 (ja) * | 2020-10-30 | 2022-05-05 | 株式会社ナード研究所 | シクロオクチン誘導体またはその塩、これを用いた標的分子の濃縮方法および検出方法、ならびに濃縮または検出用キット |
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| WO2022156920A1 (en) | 2021-01-25 | 2022-07-28 | Ventana Medical Systems, Inc. | Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties |
| JP2024516380A (ja) * | 2021-04-18 | 2024-04-15 | ヴェンタナ メディカル システムズ， インク． | 形態学的マーカー染色 |
| EP4337092A1 (en) | 2021-05-13 | 2024-03-20 | Ventana Medical Systems, Inc. | Real-time prediction of tissue fixation time |
| AU2022306974A1 (en) | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases |
| US20230201365A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Modified cd20 antibodies and uses thereof |
| WO2023281480A1 (en) | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics Ag | Conjugates of checkpoint inhibitors with il-2, and uses thereof |
| US20230201364A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Antibody conjugates and manufacture thereof |
| EP4366781A1 (en) | 2021-07-09 | 2024-05-15 | Bright Peak Therapeutics AG | Checkpoint inhibitors conjugated to il-2, and uses thereof |
| CN113567677B (zh) * | 2021-07-23 | 2024-04-12 | 湖北百奥斯生物科技有限公司 | 一种免疫荧光信号放大技术标记方法 |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| CN113564229B (zh) * | 2021-07-28 | 2022-04-01 | 中国人民解放军陆军军医大学 | 基于点击化学连接和发夹堆叠组装检测microRNA的试剂和方法 |
| WO2023058624A1 (ja) * | 2021-10-08 | 2023-04-13 | コニカミノルタ株式会社 | 染色方法、評価方法および標本 |
| CA3244053A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | MODIFIED IL-18 POLYPEPTIDES |
| AU2023226005A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Activatable il-18 polypeptides |
| AU2023226512A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Immune antigen specific il-18 immunocytokines and uses thereof |
| WO2023161857A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | Bifunctional cytokine compositions |
| WO2024002924A2 (en) * | 2022-06-28 | 2024-01-04 | F. Hoffmann-La Roche Ag | Fluorescent dyes with large stokes shift |
| WO2024064338A1 (en) | 2022-09-22 | 2024-03-28 | Agilent Technologies, Inc. | Anti-human icos antibodies for use in immunohistochemistry (ihc) protocols and for diagnosing cancer |
| WO2024137817A1 (en) | 2022-12-23 | 2024-06-27 | Ventana Medical Systems, Inc. | Materials and methods for evaluation of antigen presentation machinery components and uses thereof |
| US20240424127A1 (en) | 2023-01-11 | 2024-12-26 | Bright Peak Therapeutics Ag | Il-7 polypeptides, immunocytokines comprising same, and uses thereof |
| US20240417436A1 (en) | 2023-01-11 | 2024-12-19 | Bright Peak Therapeutics Ag | Conditionally activated immunocytokines and methods of use |
| WO2024215528A1 (en) | 2023-04-13 | 2024-10-17 | Ventana Medical Systems, Inc. | Proliferation assay for fixed solid tumors |
| WO2024263272A2 (en) * | 2023-06-20 | 2024-12-26 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods and systems for sensitive and multiplexed analysis of biological samples using cleavable fluorphores and 'click' chemistry |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
| WO2025041102A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Targeted immune activation with il-18 immunocytokines |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| US20250186594A1 (en) | 2023-08-23 | 2025-06-12 | Bright Peak Therapeutics Ag | Il-18 polypeptides modified with polymers |
| US20250213705A1 (en) | 2023-08-23 | 2025-07-03 | Bright Peak Therapeutics Ag | Psma targeting ligands and methods of use |
| WO2025137443A1 (en) | 2023-12-22 | 2025-06-26 | Rayzebio, Inc. | Radiopharmaceutical compositions targeting somatostatin receptors and uses thereof |
| US20250222146A1 (en) | 2023-12-22 | 2025-07-10 | Rayzebio, Inc. | Radiopharmaceuticals Targeting Somatostatin Receptor 2 and Uses Thereof |
| WO2025193604A1 (en) | 2024-03-11 | 2025-09-18 | Ventana Medical Systems, Inc. | Non-enzymatic dissociation of ffpe tissue and generation of single cells with intact cell surface markers |
| WO2026069134A1 (en) | 2024-09-26 | 2026-04-02 | Bright Peak Therapeutics Ag | Human therapy with il-18 immunocytokines |
| WO2026083295A1 (en) | 2024-10-16 | 2026-04-23 | Bright Peak Therapeutics Ag | Trispecific compositions comprising il-2, vegf binding domains, and pd-1 binding domains |
| WO2026083296A1 (en) | 2024-10-16 | 2026-04-23 | Bright Peak Therapeutics Ag | Trispecific compositions comprising il-18, vegf binding domains, and pd-1 binding domains |
Family Cites Families (41)
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|---|---|---|---|---|
| US5196306A (en) | 1989-03-29 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| JP3847559B2 (ja) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 独立スライド加熱器を有する自動化分子病理学装置 |
| EP1084269B1 (en) * | 1998-06-04 | 2007-04-25 | PerkinElmer LAS, Inc. | Novel peroxidase substrates and their use in catalyzed reporter deposition |
| CA2342767C (en) | 1998-09-03 | 2009-11-03 | Trellis Bioinformatics, Inc. | Multihued labels |
| EP1415156B1 (en) | 2001-07-10 | 2009-09-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detecting the activation state of multiple proteins in single cells |
| US6855503B2 (en) * | 2002-12-20 | 2005-02-15 | Amersham Biosciences Corp | Heterocyclic FRETdye cassettes for labeling biological molecules and their use in DNA sequencing |
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| CN105142672B (zh) * | 2012-10-23 | 2019-04-05 | 西纳福克斯股份有限公司 | 经修饰的抗体、抗体-缀合物及其制备方法 |
| US10610608B2 (en) * | 2013-08-01 | 2020-04-07 | Rochester Institute Of Technology | Modular imaging agents containing amino acids and peptides |
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| US10758895B2 (en) | 2014-09-30 | 2020-09-01 | University of Pittsburgh—of the Commonwealth System of Higher Education | Cu(I)-catalyzed azide-alkyne cycloadditions (CuAAC) ligands and methods for carrying out Cu(I)-catalyzed azide-alkyne cycloaddition reactions |
| US10335495B2 (en) | 2014-12-04 | 2019-07-02 | Celgene Corporation | Biomolecule conjugates |
| WO2018002015A1 (en) * | 2016-06-28 | 2018-01-04 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
| JP7128121B2 (ja) | 2016-06-28 | 2022-08-30 | ヴェンタナ メディカル システムズ， インク． | Ｉｈｃ及びｉｓｈアッセイにおけるシグナル増幅のためのクリックケミストリーの応用 |
-
2017
- 2017-06-27 JP JP2018567646A patent/JP7128121B2/ja active Active
- 2017-06-27 WO PCT/EP2017/065796 patent/WO2018002016A1/en not_active Ceased
- 2017-06-27 EP EP25197430.9A patent/EP4631529A3/en active Pending
- 2017-06-27 CN CN202511190807.0A patent/CN121021395A/zh active Pending
- 2017-06-27 CN CN201780052986.9A patent/CN109641922B/zh active Active
- 2017-06-27 EP EP17739893.0A patent/EP3475291B1/en active Active
-
2018
- 2018-12-19 US US16/226,489 patent/US11249085B2/en active Active
-
2020
- 2020-10-27 US US17/081,493 patent/US12372531B2/en active Active
-
2022
- 2022-01-28 US US17/586,980 patent/US12517132B2/en active Active
- 2022-01-28 US US17/586,996 patent/US11860167B2/en active Active
- 2022-05-24 JP JP2022084324A patent/JP2022126650A/ja not_active Withdrawn
-
2024
- 2024-07-18 JP JP2024114392A patent/JP7737517B2/ja active Active
-
2025
- 2025-05-12 US US19/204,731 patent/US20250271441A1/en active Pending
- 2025-08-29 JP JP2025142894A patent/JP2026000932A/ja active Pending
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