JP2019530558A5 - - Google Patents
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- Publication number
- JP2019530558A5 JP2019530558A5 JP2019540509A JP2019540509A JP2019530558A5 JP 2019530558 A5 JP2019530558 A5 JP 2019530558A5 JP 2019540509 A JP2019540509 A JP 2019540509A JP 2019540509 A JP2019540509 A JP 2019540509A JP 2019530558 A5 JP2019530558 A5 JP 2019530558A5
- Authority
- JP
- Japan
- Prior art keywords
- aerosol
- concentrator
- linear single
- slit
- cylindrical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000443 aerosol Substances 0.000 description 123
- 239000007789 gas Substances 0.000 description 17
- 239000002245 particle Substances 0.000 description 17
- 239000000843 powder Substances 0.000 description 11
- 238000001704 evaporation Methods 0.000 description 10
- 230000008020 evaporation Effects 0.000 description 10
- 239000008263 liquid aerosol Substances 0.000 description 8
- GWUAFYNDGVNXRS-UHFFFAOYSA-N helium;molecular oxygen Chemical compound [He].O=O GWUAFYNDGVNXRS-UHFFFAOYSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000000926 separation method Methods 0.000 description 5
- 230000001133 acceleration Effects 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 description 2
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000012387 aerosolization Methods 0.000 description 2
- 208000028659 discharge Diseases 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 238000001856 aerosol method Methods 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000005980 lung dysfunction Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2016/056477 WO2018071008A1 (en) | 2016-10-11 | 2016-10-11 | Apparatus and method for generating and concentrating fine particle aerosols |
| US15/291,020 US10207062B2 (en) | 2016-10-11 | 2016-10-11 | Apparatus and method for generating and concentrating fine particle aerosols |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530558A JP2019530558A (ja) | 2019-10-24 |
| JP2019530558A5 true JP2019530558A5 (https=) | 2021-05-13 |
| JP6948725B2 JP6948725B2 (ja) | 2021-10-13 |
Family
ID=66634182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540509A Active JP6948725B2 (ja) | 2016-10-11 | 2016-10-11 | 微粒子エアロゾルの生成及び濃縮のための器具及び方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10207062B2 (https=) |
| EP (1) | EP3525852B1 (https=) |
| JP (1) | JP6948725B2 (https=) |
| CN (1) | CN109843362B (https=) |
| AU (1) | AU2016425989A1 (https=) |
| CA (1) | CA3039180A1 (https=) |
| WO (1) | WO2018071008A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112666049B (zh) * | 2020-11-24 | 2024-03-01 | 中国辐射防护研究院 | 一种模拟后处理着火事故气溶胶多隔间输运的平台及方法 |
| NL2027229B1 (en) * | 2020-12-24 | 2022-07-20 | Medspray B V | Device and method to aerosolize nanoparticle formulations |
| US20240399079A1 (en) * | 2023-06-05 | 2024-12-05 | Kaer Biotherapeutics Corporation | In-line pressure balanced aerosol concentrator |
| WO2025019302A1 (en) * | 2023-07-14 | 2025-01-23 | The Trustees Of Princeton University | Micron and submicron diameter spray droplet generation |
| CN118750709B (zh) * | 2024-09-09 | 2024-11-05 | 苏州嘉树医疗科技有限公司 | 喷头及雾化器 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767524A (en) * | 1987-08-05 | 1988-08-30 | Lovelace Medical Foundation | Virtual impactor |
| US4852561A (en) * | 1988-07-27 | 1989-08-01 | Sperry C R | Inhalation device |
| US5425802A (en) * | 1993-05-05 | 1995-06-20 | The United States Of American As Represented By The Administrator Of Environmental Protection Agency | Virtual impactor for removing particles from an airstream and method for using same |
| US5522380A (en) * | 1995-01-18 | 1996-06-04 | Dwork; Paul | Metered dose medication adaptor with improved incentive spirometer |
| US6234167B1 (en) | 1998-10-14 | 2001-05-22 | Chrysalis Technologies, Incorporated | Aerosol generator and methods of making and using an aerosol generator |
| US6491233B2 (en) | 2000-12-22 | 2002-12-10 | Chrysalis Technologies Incorporated | Vapor driven aerosol generator and method of use thereof |
| US6779520B2 (en) | 2001-10-30 | 2004-08-24 | Iep Pharmaceutical Devices Inc. | Breath actuated dry powder inhaler |
| EP1503744A1 (en) * | 2002-05-13 | 2005-02-09 | Alexza Molecular Delivery Corporation | Delivery of drug amines through an inhalation route |
| US6799571B1 (en) * | 2002-06-19 | 2004-10-05 | Molecular Rotation, Llc | Medicinal powder delivery system |
| EP1556171B1 (en) * | 2002-09-06 | 2010-12-15 | Philip Morris USA Inc. | Aerosol generating devices and methods for generating aerosols having controlled particle sizes |
| DE10244795A1 (de) | 2002-09-26 | 2004-04-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
| WO2006026237A1 (en) * | 2004-05-20 | 2006-03-09 | Discovery Laboratories, Inc. | Methods, systems and devices for noninvasive pulmonary delivery |
| US7802569B2 (en) * | 2005-12-22 | 2010-09-28 | Kaer Biotherapeutics Corporation | Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery |
| US8375987B2 (en) | 2005-12-22 | 2013-02-19 | Donovan B. Yeates | Concentrator for increasing the particle concentration in an aerosol flow |
| US8616532B2 (en) | 2005-12-22 | 2013-12-31 | Donovan B. Yeates | Flow conditioner for a compact, low flow resistance aerosol generator |
| US8596268B2 (en) | 2005-12-22 | 2013-12-03 | Donovan B. Yeates | Method of operating a compact, low flow resistance aerosol generator |
| US7614280B1 (en) * | 2006-03-06 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Army | Quantitative fit test system and method for assessing respirator biological fit factors |
| CA2698137A1 (en) * | 2006-08-30 | 2008-03-06 | Kurve Technology, Inc. | Aerosol generating and delivery device |
| US20080078385A1 (en) * | 2006-09-29 | 2008-04-03 | Yang Xiao | System and method for delivery of medication via inhalation |
| US8251055B2 (en) * | 2006-10-02 | 2012-08-28 | Philip Morris Usa Inc. | Continuous high pressure delivery system |
| US7875095B2 (en) * | 2008-05-22 | 2011-01-25 | Enertechnix, Inc | Skimmer for concentrating an aerosol |
| CN201255705Y (zh) * | 2008-07-25 | 2009-06-10 | 北京汇丰隆生物科技发展有限公司 | 一种大流量气溶胶采样装置 |
| US20100191177A1 (en) * | 2009-01-23 | 2010-07-29 | Iscience Interventional Corporation | Device for aspirating fluids |
| EP2319334A1 (en) * | 2009-10-27 | 2011-05-11 | Philip Morris Products S.A. | A smoking system having a liquid storage portion |
| RU2561570C2 (ru) * | 2010-09-06 | 2015-08-27 | Кьези Фармасьютичи С.П.А. | Исполнительный механизм дозирующего ингалятора и дозирующий ингалятор |
| CN103209728B (zh) * | 2010-09-24 | 2015-10-14 | 多诺万·B.·耶茨 | 紧凑、低流阻的气溶胶发生器及其操作方法 |
| US10463815B2 (en) * | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
| CN104368250B (zh) * | 2013-08-13 | 2017-12-22 | 北京慧荣和科技有限公司 | 气体或气溶胶混合或稀释装置 |
| CN105833398B (zh) * | 2016-06-12 | 2022-02-25 | 江苏鱼跃医疗设备股份有限公司 | 一种具有导流装置的高效雾化杯 |
-
2016
- 2016-10-11 EP EP16918871.1A patent/EP3525852B1/en active Active
- 2016-10-11 CN CN201680090018.2A patent/CN109843362B/zh active Active
- 2016-10-11 US US15/291,020 patent/US10207062B2/en active Active
- 2016-10-11 CA CA3039180A patent/CA3039180A1/en active Pending
- 2016-10-11 WO PCT/US2016/056477 patent/WO2018071008A1/en not_active Ceased
- 2016-10-11 AU AU2016425989A patent/AU2016425989A1/en not_active Abandoned
- 2016-10-11 JP JP2019540509A patent/JP6948725B2/ja active Active
-
2019
- 2019-01-30 US US16/262,704 patent/US20190160232A1/en not_active Abandoned
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