JP2019524755A5 - - Google Patents
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- Publication number
- JP2019524755A5 JP2019524755A5 JP2019503457A JP2019503457A JP2019524755A5 JP 2019524755 A5 JP2019524755 A5 JP 2019524755A5 JP 2019503457 A JP2019503457 A JP 2019503457A JP 2019503457 A JP2019503457 A JP 2019503457A JP 2019524755 A5 JP2019524755 A5 JP 2019524755A5
- Authority
- JP
- Japan
- Prior art keywords
- foam
- emulsion
- weight
- foam according
- polar liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006260 foam Substances 0.000 claims 33
- 239000007788 liquid Substances 0.000 claims 11
- 239000000839 emulsion Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 235000018185 Betula X alpestris Nutrition 0.000 claims 7
- 235000018212 Betula X uliginosa Nutrition 0.000 claims 7
- 239000007787 solid Substances 0.000 claims 6
- 206010052428 Wound Diseases 0.000 claims 5
- 208000027418 Wounds and injury Diseases 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000002245 particle Substances 0.000 claims 4
- 239000003380 propellant Substances 0.000 claims 4
- 206010014989 Epidermolysis bullosa Diseases 0.000 claims 3
- 206010042033 Stevens-Johnson syndrome Diseases 0.000 claims 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 3
- 150000003648 triterpenes Chemical class 0.000 claims 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 claims 2
- JYDNKGUBLIKNAM-UHFFFAOYSA-N Oxyallobutulin Natural products C1CC(=O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C(=C)C)C5C4CCC3C21C JYDNKGUBLIKNAM-UHFFFAOYSA-N 0.000 claims 2
- 201000011152 Pemphigus Diseases 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- 206010040844 Skin exfoliation Diseases 0.000 claims 2
- 235000019486 Sunflower oil Nutrition 0.000 claims 2
- 206010044223 Toxic epidermal necrolysis Diseases 0.000 claims 2
- 231100000087 Toxic epidermal necrolysis Toxicity 0.000 claims 2
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 claims 2
- MVIRREHRVZLANQ-UHFFFAOYSA-N betulin Natural products CC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5C(CCC5(CO)CCC34C)C(=C)C)C1(C)C MVIRREHRVZLANQ-UHFFFAOYSA-N 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims 2
- 201000001976 pemphigus vulgaris Diseases 0.000 claims 2
- 150000002978 peroxides Chemical class 0.000 claims 2
- 239000002600 sunflower oil Substances 0.000 claims 2
- 239000007762 w/o emulsion Substances 0.000 claims 2
- QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 claims 1
- CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 claims 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 claims 1
- 206010062542 Arterial insufficiency Diseases 0.000 claims 1
- DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 claims 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 claims 1
- 208000014692 Lyell syndrome Diseases 0.000 claims 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 claims 1
- PSZDOEIIIJFCFE-UHFFFAOYSA-N Oleanolic alcohol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(CO)CCC(C)(C)CC5C4=CCC3C21C PSZDOEIIIJFCFE-UHFFFAOYSA-N 0.000 claims 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 208000037014 Rare skin disease Diseases 0.000 claims 1
- 231100000168 Stevens-Johnson syndrome Toxicity 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 208000000558 Varicose Ulcer Diseases 0.000 claims 1
- QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 claims 1
- 239000001273 butane Substances 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 claims 1
- PSZDOEIIIJFCFE-OSQDELBUSA-N erythrodiol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C PSZDOEIIIJFCFE-OSQDELBUSA-N 0.000 claims 1
- HTZRWCSRPTWJCT-UHFFFAOYSA-N erythrodiol Natural products CC1(C)CCC2(CO)CCC3C(CCC4C3(C)CCC5C(C)(C)C(O)CCC45C)C2C1 HTZRWCSRPTWJCT-UHFFFAOYSA-N 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 239000001282 iso-butane Substances 0.000 claims 1
- 238000000608 laser ablation Methods 0.000 claims 1
- PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 claims 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 1
- 230000001338 necrotic effect Effects 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 claims 1
- 239000001272 nitrous oxide Substances 0.000 claims 1
- 229940100243 oleanolic acid Drugs 0.000 claims 1
- 239000012188 paraffin wax Substances 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 229940048845 polyglyceryl-3 diisostearate Drugs 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 claims 1
- 208000006934 radiodermatitis Diseases 0.000 claims 1
- 206010040882 skin lesion Diseases 0.000 claims 1
- 231100000444 skin lesion Toxicity 0.000 claims 1
- -1 sorbitan fatty acid ester Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662363634P | 2016-07-18 | 2016-07-18 | |
| US62/363,634 | 2016-07-18 | ||
| PCT/US2017/042610 WO2018017576A1 (en) | 2016-07-18 | 2017-07-18 | Betulin-containing water-in-oil foams and compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524755A JP2019524755A (ja) | 2019-09-05 |
| JP2019524755A5 true JP2019524755A5 (enExample) | 2020-08-27 |
Family
ID=60995998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019503457A Pending JP2019524755A (ja) | 2016-07-18 | 2017-07-18 | ベツリン含有油中水型泡沫及びその組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20190183797A1 (enExample) |
| EP (1) | EP3484434A4 (enExample) |
| JP (1) | JP2019524755A (enExample) |
| CN (1) | CN110035735A (enExample) |
| WO (1) | WO2018017576A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107019660B (zh) | 2017-04-27 | 2018-05-11 | 养生堂（上海）化妆品研发有限公司 | 保湿化妆品组合物 |
| WO2019134982A1 (en) | 2018-01-04 | 2019-07-11 | Amryt Research Limited | Betulin-containing birch bark extracts and their formulation |
| EP3583954A1 (en) | 2018-06-19 | 2019-12-25 | neubourg skin care GmbH | Nanodispersions of birch bark extract, electrospun fibers containing such nanodispersions and their use for the treatment of wounds |
| CN109512780A (zh) * | 2019-01-09 | 2019-03-26 | 河南省医药科学研究院 | 一种凝胶药膏及其制备方法和应用 |
| CN109777814B (zh) * | 2019-02-21 | 2022-04-08 | 南京农业大学 | 神经酰胺合成酶基因在调控灵芝三萜生物合成中的应用 |
| EP3969003A4 (en) * | 2019-05-15 | 2023-02-08 | Ichilov Tech Ltd. | METHOD AND COMPOSITION FOR THE TREATMENT OF SKIN DISEASES ASSOCIATED WITH ACCELERATED CORNEODESMOSOME DEGRADATION OR WEAK CELL ADHESION |
| DE102020006675A1 (de) * | 2020-10-30 | 2022-05-05 | Prof4Skin Gmbh | Verfahren zur Herstellung von Wundauflagen aus phopholipidhaltigen Nanodipersionen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU47604A1 (enExample) * | 1964-12-17 | 1966-06-17 | ||
| DE50102055D1 (de) * | 2000-03-28 | 2004-05-27 | Birken Gmbh | Emulsion enthaltend einen triterpen-haltigen pflanzenextrakt, verfahren zur herstellung der emulsion sowie zur gewinnung des pflanzenextraktes |
| DE10108387A1 (de) * | 2001-02-21 | 2002-08-29 | Basf Ag | Kosmetisches oder pharmazeutisches Mittel |
| DE102004030044A1 (de) * | 2004-06-22 | 2006-01-12 | Birken Gmbh | Triterpenhaltiger Oleogelbildner, triterpenhaltiges Oleogel und Verfahren zur Herstellung eines triterpenhaltigen Oleogels |
| DE102009047092A1 (de) * | 2009-11-24 | 2011-05-26 | Birken Gmbh | Verwendung eines triterpenhaltigen Oleogels zur Wundheilung |
| EP2363108B1 (de) * | 2010-03-02 | 2017-08-30 | Neubourg Skin Care GmbH & Co. KG | Schaumformulierungen enthaltend mindestens ein Triterpenoid |
-
2017
- 2017-07-18 CN CN201780056023.6A patent/CN110035735A/zh active Pending
- 2017-07-18 WO PCT/US2017/042610 patent/WO2018017576A1/en not_active Ceased
- 2017-07-18 JP JP2019503457A patent/JP2019524755A/ja active Pending
- 2017-07-18 EP EP17831691.5A patent/EP3484434A4/en not_active Withdrawn
- 2017-07-18 US US16/318,805 patent/US20190183797A1/en not_active Abandoned
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