JP2019524098A - 非分裂細胞のゲノム編集のための方法と組成物 - Google Patents
非分裂細胞のゲノム編集のための方法と組成物 Download PDFInfo
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- JP2019524098A JP2019524098A JP2019501985A JP2019501985A JP2019524098A JP 2019524098 A JP2019524098 A JP 2019524098A JP 2019501985 A JP2019501985 A JP 2019501985A JP 2019501985 A JP2019501985 A JP 2019501985A JP 2019524098 A JP2019524098 A JP 2019524098A
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- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C07K2319/00—Fusion polypeptide
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
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- Cell Biology (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022159696A JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662363164P | 2016-07-15 | 2016-07-15 | |
| US62/363,164 | 2016-07-15 | ||
| PCT/US2017/042151 WO2018013932A1 (en) | 2016-07-15 | 2017-07-14 | Methods and compositions for genome editing in non-dividing cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159696A Division JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019524098A true JP2019524098A (ja) | 2019-09-05 |
| JP2019524098A5 JP2019524098A5 (cg-RX-API-DMAC7.html) | 2020-08-20 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019501985A Pending JP2019524098A (ja) | 2016-07-15 | 2017-07-14 | 非分裂細胞のゲノム編集のための方法と組成物 |
| JP2022159696A Active JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A Pending JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022159696A Active JP7493563B2 (ja) | 2016-07-15 | 2022-10-03 | 分裂細胞または非分裂細胞のゲノム編集のための方法と組成物 |
| JP2024082104A Pending JP2024119833A (ja) | 2016-07-15 | 2024-05-20 | 非分裂細胞のゲノム編集のための方法と組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US11674158B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP4321623A3 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2019524098A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2017295898B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3030587A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2018013932A1 (cg-RX-API-DMAC7.html) |
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| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9840699B2 (en) | 2013-12-12 | 2017-12-12 | President And Fellows Of Harvard College | Methods for nucleic acid editing |
| EP3204496A1 (en) | 2014-10-10 | 2017-08-16 | Editas Medicine, Inc. | Compositions and methods for promoting homology directed repair |
| WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| CA2999500A1 (en) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
| SG10202104041PA (en) | 2015-10-23 | 2021-06-29 | Harvard College | Nucleobase editors and uses thereof |
| EP3384055B1 (en) | 2015-11-30 | 2025-07-16 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| EP3433363A1 (en) | 2016-03-25 | 2019-01-30 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
| US20190127713A1 (en) | 2016-04-13 | 2019-05-02 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| WO2017180694A1 (en) | 2016-04-13 | 2017-10-19 | Editas Medicine, Inc. | Cas9 fusion molecules gene editing systems, and methods of use thereof |
| CA3030587A1 (en) | 2016-07-15 | 2018-01-18 | Salk Institute For Biological Studies | Methods and compositions for genome editing in non-dividing cells |
| US12214056B2 (en) | 2016-07-19 | 2025-02-04 | Duke University | Therapeutic applications of CPF1-based genome editing |
| KR102827276B1 (ko) | 2016-08-03 | 2025-07-01 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
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| US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| GB2575930A (en) | 2017-03-23 | 2020-01-29 | Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11866726B2 (en) | 2017-07-14 | 2024-01-09 | Editas Medicine, Inc. | Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites |
| US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
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| WO2019051237A1 (en) * | 2017-09-08 | 2019-03-14 | Life Technologies Corporation | ENHANCED RECOMBINANT RECOMBINATION METHODS AND COMPOSITIONS THEREOF |
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| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
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| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2019239361A1 (en) * | 2018-06-14 | 2019-12-19 | Novartis Ag | Method for sequence insertion using crispr |
| CN113301924A (zh) | 2018-08-18 | 2021-08-24 | 哈佛学院校长同事会 | 原位基因编辑 |
| JP2021533803A (ja) * | 2018-08-24 | 2021-12-09 | ロックアネイビオ, インコーポレイテッド | Fasl免疫モジュレート遺伝子治療組成物および使用方法 |
| WO2020051360A1 (en) * | 2018-09-05 | 2020-03-12 | The Broad Institute, Inc. | Base editing for treating hutchinson-gilford progeria syndrome |
| US12285495B2 (en) | 2018-10-15 | 2025-04-29 | Fondazione Telethon Ets | Genome editing methods and constructs |
| WO2020082046A2 (en) | 2018-10-18 | 2020-04-23 | Intellia Therapeutics, Inc. | Compositions and methods for expressing factor ix |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| JP2022513407A (ja) * | 2018-10-30 | 2022-02-07 | クリスパー・セラピューティクス・アクチェンゲゼルシャフト | Nhejを介したゲノム編集のための組成物および方法 |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
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| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| JP2022529424A (ja) * | 2019-04-14 | 2022-06-22 | デューク ユニバーシティ | ジストロフィン機能を修復するためのCRISPR/Casをベースにしたゲノム編集組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
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| CN112741906B (zh) * | 2019-10-31 | 2022-07-05 | 华东师范大学 | 一种用于治疗b型血友病的产品 |
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| EP3485023A1 (en) | 2019-05-22 |
| US20190225991A1 (en) | 2019-07-25 |
| EP3485023C0 (en) | 2023-11-15 |
| JP7493563B2 (ja) | 2024-05-31 |
| JP2023092453A (ja) | 2023-07-03 |
| WO2018013932A1 (en) | 2018-01-18 |
| US20230399663A1 (en) | 2023-12-14 |
| AU2017295898B2 (en) | 2023-08-17 |
| EP4321623A3 (en) | 2024-05-15 |
| AU2017295898A1 (en) | 2019-02-21 |
| EP3485023B1 (en) | 2023-11-15 |
| EP4321623A2 (en) | 2024-02-14 |
| CA3030587A1 (en) | 2018-01-18 |
| JP2024119833A (ja) | 2024-09-03 |
| US20240409961A1 (en) | 2024-12-12 |
| US11959094B2 (en) | 2024-04-16 |
| US11674158B2 (en) | 2023-06-13 |
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