JP2019523226A5 - - Google Patents
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- JP2019523226A5 JP2019523226A5 JP2018564844A JP2018564844A JP2019523226A5 JP 2019523226 A5 JP2019523226 A5 JP 2019523226A5 JP 2018564844 A JP2018564844 A JP 2018564844A JP 2018564844 A JP2018564844 A JP 2018564844A JP 2019523226 A5 JP2019523226 A5 JP 2019523226A5
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- 239000000203 mixture Substances 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 18
- 239000007908 nanoemulsion Substances 0.000 claims 17
- 206010028980 Neoplasm Diseases 0.000 claims 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 13
- 239000003921 oil Substances 0.000 claims 11
- 235000019198 oils Nutrition 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 11
- 201000011510 cancer Diseases 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 8
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 8
- 238000012377 drug delivery Methods 0.000 claims 7
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 5
- 230000036457 multidrug resistance Effects 0.000 claims 5
- 239000000194 fatty acid Substances 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- -1 LNA ester Chemical class 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 3
- 229960001573 cabazitaxel Drugs 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 229960004488 linolenic acid Drugs 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
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- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000034994 death Effects 0.000 claims 2
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- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 1
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- 101000999998 Homo sapiens Aggrecan core protein Proteins 0.000 claims 1
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- 101000860860 Homo sapiens COUP transcription factor 2 Proteins 0.000 claims 1
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- 101000985653 Homo sapiens Homeobox protein MSX-1 Proteins 0.000 claims 1
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- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 1
- 101000688216 Homo sapiens Intestinal-type alkaline phosphatase Proteins 0.000 claims 1
- 101000977765 Homo sapiens Iroquois-class homeodomain protein IRX-4 Proteins 0.000 claims 1
- 101000614439 Homo sapiens Keratin, type I cytoskeletal 15 Proteins 0.000 claims 1
- 101001139146 Homo sapiens Krueppel-like factor 2 Proteins 0.000 claims 1
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- 101000946863 Homo sapiens T-cell surface glycoprotein CD3 delta chain Proteins 0.000 claims 1
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- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 1
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
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- 235000004347 Perilla Nutrition 0.000 claims 1
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- 101100215777 Schizosaccharomyces pombe (strain 972 / ATCC 24843) ain1 gene Proteins 0.000 claims 1
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- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 1
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- MIKGZEBOVNKYMG-DTLBNKEJSA-N dha-docetaxel Chemical compound C1([C@H](NC(=O)OC(C)(C)C)[C@@H](OC(=O)CC/C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)C(=O)O[C@@H]2C(=C3[C@@H](O)C(=O)[C@]4(C)[C@@H](O)CC5OC[C@]5(C4[C@H](OC(=O)C=4C=CC=CC=4)[C@](C3(C)C)(O)C2)OC(C)=O)C)=CC=CC=C1 MIKGZEBOVNKYMG-DTLBNKEJSA-N 0.000 claims 1
- LRCZQSDQZJBHAF-PUBGEWHCSA-N dha-paclitaxel Chemical compound N([C@H]([C@@H](OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC)C(=O)O[C@@H]1C(=C2[C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]3[C@H](OC(=O)C=3C=CC=CC=3)[C@](C2(C)C)(O)C1)OC(C)=O)C)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 LRCZQSDQZJBHAF-PUBGEWHCSA-N 0.000 claims 1
- CLBIEZBAENPDFY-HNXGFDTJSA-N dinophysistoxin 1 Chemical compound C([C@H](O1)[C@H](C)/C=C/[C@H]2CC[C@@]3(CC[C@H]4O[C@@H](C([C@@H](O)[C@@H]4O3)=C)[C@@H](O)C[C@H](C)[C@@H]3[C@@H](CC[C@@]4(O3)[C@@H](CCCO4)C)C)O2)C(C)=C[C@]21O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O CLBIEZBAENPDFY-HNXGFDTJSA-N 0.000 claims 1
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 1
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 1
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- 239000008157 edible vegetable oil Substances 0.000 claims 1
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346755P | 2016-06-07 | 2016-06-07 | |
| US62/346,755 | 2016-06-07 | ||
| PCT/US2017/036330 WO2017214260A1 (en) | 2016-06-07 | 2017-06-07 | Nanoemulsion compositions of taxoid drugs, and methods for the use thereof to target cancer cells and cancer stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019523226A JP2019523226A (ja) | 2019-08-22 |
| JP2019523226A5 true JP2019523226A5 (enExample) | 2020-07-27 |
| JP7518604B2 JP7518604B2 (ja) | 2024-07-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018564844A Active JP7518604B2 (ja) | 2016-06-07 | 2017-06-07 | タキソイド薬物のナノエマルション組成物、並びに標的癌細胞及び癌幹細胞に対するその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10206875B2 (enExample) |
| EP (1) | EP3463299A4 (enExample) |
| JP (1) | JP7518604B2 (enExample) |
| CN (2) | CN116019768A (enExample) |
| AU (1) | AU2017277497B2 (enExample) |
| CA (1) | CA3026412A1 (enExample) |
| IL (1) | IL263504A (enExample) |
| MX (1) | MX2018015112A (enExample) |
| WO (1) | WO2017214260A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7518604B2 (ja) * | 2016-06-07 | 2024-07-18 | タルガジェニックス，インコーポレイテッド | タキソイド薬物のナノエマルション組成物、並びに標的癌細胞及び癌幹細胞に対するその使用方法 |
| CA3121615A1 (en) * | 2017-12-20 | 2019-06-27 | Targagenix, Inc. | Combination taxoid nanoemulsion with immunotherapy in cancer |
| JP7610208B2 (ja) * | 2019-03-22 | 2025-01-08 | インテグレイテッド ナノセラピューティクス インコーポレイテッド | 足場部分から調製した脂質結合体 |
| CN114599394A (zh) * | 2019-10-25 | 2022-06-07 | 安进公司 | 用于在低蛋白浓度下使蛋白损失最小化的组合物和方法 |
| CA3157484A1 (en) * | 2019-11-05 | 2021-05-14 | Ulagaraj Selvaraj | Nanoparticles comprising prodrugs stabilized by albumin for treatment of cancer and other diseases |
| CN111004195B (zh) * | 2019-12-03 | 2022-01-28 | 沈阳药科大学 | 卡巴他赛弱碱性衍生物及其制剂 |
| CN114317398B (zh) * | 2020-09-27 | 2024-03-01 | 中国科学院分子细胞科学卓越创新中心 | Gli1和EpCAM基因共同标记的肝祖细胞群及其应用 |
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| US6426367B1 (en) * | 1999-09-09 | 2002-07-30 | Efa Sciences Llc | Methods for selectively occluding blood supplies to neoplasias |
| CA2544128A1 (en) * | 2003-10-30 | 2005-05-12 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| US8557861B2 (en) * | 2004-09-28 | 2013-10-15 | Mast Therapeutics, Inc. | Low oil emulsion compositions for delivering taxoids and other insoluble drugs |
| US20070148194A1 (en) * | 2005-11-29 | 2007-06-28 | Amiji Mansoor M | Novel nanoemulsion formulations |
| EP2317978A2 (en) * | 2008-07-23 | 2011-05-11 | Bharat Serums And Vaccines Ltd. | Stable injectable oil-in-water docetaxel nanoemulsion |
| US20100021471A1 (en) * | 2008-07-25 | 2010-01-28 | Brookhaven Science Associates, Llc | Carbon nanotube-based drug delivery systems and methods of making same |
| US20140105829A1 (en) * | 2012-10-15 | 2014-04-17 | Nemucore Medical Innovations, Inc. | Therapeutic nanoemulsion formulation for the targeted delivery of docetaxel and methods of making and using the same |
| US11197828B2 (en) * | 2014-06-19 | 2021-12-14 | Solural Pharma ApS | Solid oral dosage form of lipophilic compounds |
| JP6634034B2 (ja) * | 2014-06-25 | 2020-01-22 | シネルジア・バイオ・サイエンシーズ・プライベイト・リミテッドＳｙｎｅｒｇｉａ Ｂｉｏ Ｓｃｉｅｎｃｅｓ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 医薬水中油型ナノエマルジョン |
| JP7518604B2 (ja) * | 2016-06-07 | 2024-07-18 | タルガジェニックス，インコーポレイテッド | タキソイド薬物のナノエマルション組成物、並びに標的癌細胞及び癌幹細胞に対するその使用方法 |
| CA3121615A1 (en) * | 2017-12-20 | 2019-06-27 | Targagenix, Inc. | Combination taxoid nanoemulsion with immunotherapy in cancer |
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2017
- 2017-06-07 JP JP2018564844A patent/JP7518604B2/ja active Active
- 2017-06-07 AU AU2017277497A patent/AU2017277497B2/en active Active
- 2017-06-07 CN CN202310169465.9A patent/CN116019768A/zh active Pending
- 2017-06-07 EP EP17810927.8A patent/EP3463299A4/en active Pending
- 2017-06-07 US US15/616,103 patent/US10206875B2/en not_active Ceased
- 2017-06-07 WO PCT/US2017/036330 patent/WO2017214260A1/en not_active Ceased
- 2017-06-07 MX MX2018015112A patent/MX2018015112A/es unknown
- 2017-06-07 CN CN201780047015.5A patent/CN109562065A/zh active Pending
- 2017-06-07 CA CA3026412A patent/CA3026412A1/en active Pending
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2018
- 2018-12-04 IL IL263504A patent/IL263504A/en unknown
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2021
- 2021-02-19 US US17/179,720 patent/USRE50096E1/en active Active
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2024
- 2024-07-16 US US18/774,363 patent/US20250009658A1/en active Pending
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