JP2021517906A5 - - Google Patents
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- Publication number
- JP2021517906A5 JP2021517906A5 JP2020557314A JP2020557314A JP2021517906A5 JP 2021517906 A5 JP2021517906 A5 JP 2021517906A5 JP 2020557314 A JP2020557314 A JP 2020557314A JP 2020557314 A JP2020557314 A JP 2020557314A JP 2021517906 A5 JP2021517906 A5 JP 2021517906A5
- Authority
- JP
- Japan
- Prior art keywords
- sbt
- oil
- pharmaceutical composition
- composition according
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 239000003921 oil Substances 0.000 claims 12
- 235000019198 oils Nutrition 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 7
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000008157 edible vegetable oil Substances 0.000 claims 6
- 239000007908 nanoemulsion Substances 0.000 claims 5
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 4
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 4
- BMQGVNUXMIRLCK-OAGWZNDDSA-N cabazitaxel Chemical compound O([C@H]1[C@@H]2[C@]3(OC(C)=O)CO[C@@H]3C[C@@H]([C@]2(C(=O)[C@H](OC)C2=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=3C=CC=CC=3)C[C@]1(O)C2(C)C)C)OC)C(=O)C1=CC=CC=C1 BMQGVNUXMIRLCK-OAGWZNDDSA-N 0.000 claims 4
- 229960001573 cabazitaxel Drugs 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 4
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 4
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 4
- 229960004488 linolenic acid Drugs 0.000 claims 4
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 4
- 239000006014 omega-3 oil Substances 0.000 claims 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 4
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 2
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical compound C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims 2
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 102000008096 B7-H1 Antigen Human genes 0.000 claims 2
- 241000167854 Bourreria succulenta Species 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 102000016680 Dioxygenases Human genes 0.000 claims 2
- 108010028143 Dioxygenases Proteins 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 235000004347 Perilla Nutrition 0.000 claims 2
- 244000124853 Perilla frutescens Species 0.000 claims 2
- 235000019496 Pine nut oil Nutrition 0.000 claims 2
- 244000292604 Salvia columbariae Species 0.000 claims 2
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 claims 2
- 235000001498 Salvia hispanica Nutrition 0.000 claims 2
- 229960000548 alemtuzumab Drugs 0.000 claims 2
- 229940094199 black currant oil Drugs 0.000 claims 2
- 235000021324 borage oil Nutrition 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 235000019693 cherries Nutrition 0.000 claims 2
- 235000014167 chia Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 2
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 2
- -1 dosetaxel Chemical compound 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- 235000021323 fish oil Nutrition 0.000 claims 2
- 239000010460 hemp oil Substances 0.000 claims 2
- 230000001965 increasing effect Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 2
- 235000021388 linseed oil Nutrition 0.000 claims 2
- 239000000944 linseed oil Substances 0.000 claims 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229960002450 ofatumumab Drugs 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 239000010490 pine nut oil Substances 0.000 claims 2
- 229960004641 rituximab Drugs 0.000 claims 2
- 229940032094 squalane Drugs 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 239000010497 wheat germ oil Substances 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000032612 Glial tumor Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000008595 infiltration Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023202505A JP2024023463A (ja) | 2017-12-20 | 2023-11-30 | がんにおける免疫療法との併用タキソイドナノエマルジョン |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762608015P | 2017-12-20 | 2017-12-20 | |
| US62/608,015 | 2017-12-20 | ||
| PCT/US2018/066465 WO2019126302A2 (en) | 2017-12-20 | 2018-12-19 | Combination taxoid nanoemulsion with immunotherapy in cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023202505A Division JP2024023463A (ja) | 2017-12-20 | 2023-11-30 | がんにおける免疫療法との併用タキソイドナノエマルジョン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021517906A JP2021517906A (ja) | 2021-07-29 |
| JP2021517906A5 true JP2021517906A5 (enExample) | 2022-01-11 |
| JP7450888B2 JP7450888B2 (ja) | 2024-03-18 |
Family
ID=66815378
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020557314A Active JP7450888B2 (ja) | 2017-12-20 | 2018-12-19 | がんにおける免疫療法との併用タキソイドナノエマルジョン |
| JP2023202505A Abandoned JP2024023463A (ja) | 2017-12-20 | 2023-11-30 | がんにおける免疫療法との併用タキソイドナノエマルジョン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023202505A Abandoned JP2024023463A (ja) | 2017-12-20 | 2023-11-30 | がんにおける免疫療法との併用タキソイドナノエマルジョン |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11497713B2 (enExample) |
| EP (1) | EP3752130A4 (enExample) |
| JP (2) | JP7450888B2 (enExample) |
| CN (1) | CN112996501A (enExample) |
| CA (1) | CA3121615A1 (enExample) |
| WO (1) | WO2019126302A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116019768A (zh) * | 2016-06-07 | 2023-04-28 | 塔佳吉尼克斯公司 | 靶向癌细胞和癌干细胞的紫杉烷类药物的纳米乳剂组合物及其使用方法 |
| JP7450888B2 (ja) * | 2017-12-20 | 2024-03-18 | タルガジェニックス，インコーポレイテッド | がんにおける免疫療法との併用タキソイドナノエマルジョン |
| CN116173094A (zh) * | 2023-03-15 | 2023-05-30 | 中南大学湘雅二医院 | 一种杜仲籽油在制备抗癌药物中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5919815A (en) * | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
| CA2544128A1 (en) * | 2003-10-30 | 2005-05-12 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| US20070148194A1 (en) * | 2005-11-29 | 2007-06-28 | Amiji Mansoor M | Novel nanoemulsion formulations |
| SMT201800366T1 (it) * | 2012-04-04 | 2018-09-13 | Halozyme Inc | Combinazione terapia con ialuronidasi e taxano mirato al tumore |
| JP2017513931A (ja) * | 2014-04-03 | 2017-06-01 | インビクタス オンコロジー ピーヴィティー．リミテッド | 超分子コンビナトリアル治療薬 |
| CN116019768A (zh) * | 2016-06-07 | 2023-04-28 | 塔佳吉尼克斯公司 | 靶向癌细胞和癌干细胞的紫杉烷类药物的纳米乳剂组合物及其使用方法 |
| JP7450888B2 (ja) * | 2017-12-20 | 2024-03-18 | タルガジェニックス，インコーポレイテッド | がんにおける免疫療法との併用タキソイドナノエマルジョン |
-
2018
- 2018-12-19 JP JP2020557314A patent/JP7450888B2/ja active Active
- 2018-12-19 EP EP18891027.7A patent/EP3752130A4/en active Pending
- 2018-12-19 WO PCT/US2018/066465 patent/WO2019126302A2/en not_active Ceased
- 2018-12-19 CN CN201880092498.5A patent/CN112996501A/zh active Pending
- 2018-12-19 US US16/225,629 patent/US11497713B2/en active Active
- 2018-12-19 CA CA3121615A patent/CA3121615A1/en active Pending
-
2022
- 2022-11-14 US US17/986,430 patent/US12186428B2/en active Active
-
2023
- 2023-11-30 JP JP2023202505A patent/JP2024023463A/ja not_active Abandoned
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