JP2019522037A5 - - Google Patents

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JP2019522037A5
JP2019522037A5 JP2019504916A JP2019504916A JP2019522037A5 JP 2019522037 A5 JP2019522037 A5 JP 2019522037A5 JP 2019504916 A JP2019504916 A JP 2019504916A JP 2019504916 A JP2019504916 A JP 2019504916A JP 2019522037 A5 JP2019522037 A5 JP 2019522037A5
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JP2019504916A
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Japanese (ja)
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JP6885629B2 (ja
JP2019522037A (ja
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Priority claimed from PCT/US2017/043979 external-priority patent/WO2018022771A1/en
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Priority to JP2021078313A priority Critical patent/JP7208659B2/ja
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JP2019504916A 2016-07-29 2017-07-26 インドリノン化合物の使用 Active JP6885629B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021078313A JP7208659B2 (ja) 2016-07-29 2021-05-06 インドリノン化合物の使用

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201662368707P 2016-07-29 2016-07-29
US62/368,707 2016-07-29
US201662417572P 2016-11-04 2016-11-04
US62/417,572 2016-11-04
US201662422504P 2016-11-15 2016-11-15
US62/422,504 2016-11-15
US201662426107P 2016-11-23 2016-11-23
US62/426,107 2016-11-23
US201762503238P 2017-05-08 2017-05-08
US62/503,238 2017-05-08
US201762534067P 2017-07-18 2017-07-18
US62/534,067 2017-07-18
PCT/US2017/043979 WO2018022771A1 (en) 2016-07-29 2017-07-26 Uses of indolinone compounds

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2020204766A Division JP7182304B2 (ja) 2016-07-29 2020-12-10 インドリノン化合物の使用
JP2021078313A Division JP7208659B2 (ja) 2016-07-29 2021-05-06 インドリノン化合物の使用

Publications (3)

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JP2019522037A JP2019522037A (ja) 2019-08-08
JP2019522037A5 true JP2019522037A5 (cg-RX-API-DMAC7.html) 2019-10-17
JP6885629B2 JP6885629B2 (ja) 2021-06-16

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JP2019504916A Active JP6885629B2 (ja) 2016-07-29 2017-07-26 インドリノン化合物の使用
JP2020204766A Active JP7182304B2 (ja) 2016-07-29 2020-12-10 インドリノン化合物の使用
JP2021078313A Active JP7208659B2 (ja) 2016-07-29 2021-05-06 インドリノン化合物の使用

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JP2020204766A Active JP7182304B2 (ja) 2016-07-29 2020-12-10 インドリノン化合物の使用
JP2021078313A Active JP7208659B2 (ja) 2016-07-29 2021-05-06 インドリノン化合物の使用

Country Status (11)

Country Link
US (4) US10159660B2 (cg-RX-API-DMAC7.html)
EP (1) EP3490553B1 (cg-RX-API-DMAC7.html)
JP (3) JP6885629B2 (cg-RX-API-DMAC7.html)
KR (2) KR102282794B1 (cg-RX-API-DMAC7.html)
CN (2) CN114569606B (cg-RX-API-DMAC7.html)
CA (1) CA3029851A1 (cg-RX-API-DMAC7.html)
MX (1) MX395539B (cg-RX-API-DMAC7.html)
PH (1) PH12019500070A1 (cg-RX-API-DMAC7.html)
SG (1) SG11201811661TA (cg-RX-API-DMAC7.html)
TW (2) TWI857351B (cg-RX-API-DMAC7.html)
WO (1) WO2018022771A1 (cg-RX-API-DMAC7.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX388564B (es) * 2014-10-09 2025-03-20 Oncternal Therapeutics Inc Compuestos de indolinona y usos de los mismos.
WO2017172368A1 (en) 2016-03-31 2017-10-05 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CN114569606B (zh) * 2016-07-29 2024-04-19 英克特诺治疗公司 吲哚啉酮化合物的用途
CN110818611B (zh) * 2018-08-13 2023-01-24 中国科学院上海药物研究所 一类吲哚酮类化合物、其制备方法、药物组合物和用途
WO2020113216A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
US20240299558A1 (en) * 2021-06-18 2024-09-12 University Of Maryland, Baltimore Proteolysis targeting chimeras and polypharmacological agents targeting bcl-2, and methods of use thereof
TW202320802A (zh) * 2021-07-16 2023-06-01 美商塞萊托藥品股份有限公司 Ｂｃｌ抑制劑之脂質體調配物
WO2025235561A1 (en) * 2024-05-08 2025-11-13 Enspire Group LLC Venetoclax oral drugs and uses thereof

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3483704D1 (de) 1983-07-22 1991-01-17 Du Pont Phenylchinolinsaeure und derivate als antitumormittel.
EP1135123B1 (en) 1998-12-04 2004-12-29 Neurosearch A/S Use of isatin derivatives as ion channel activating agents
UA75054C2 (uk) 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
WO2001064681A2 (en) 2000-02-28 2001-09-07 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
CN1155572C (zh) 2001-01-19 2004-06-30 中国人民解放军军事医学科学院毒物药物研究所 吲哚类衍生物及其抗肿瘤用途
US20030157486A1 (en) 2001-06-21 2003-08-21 Graff Jonathan M. Methods to identify signal sequences
EP3034510A1 (en) 2004-04-30 2016-06-22 Alnylam Pharmaceuticals Inc. Oligonucleotides comprising a c5-modified pyrimidine
AR056317A1 (es) 2005-04-20 2007-10-03 Xenon Pharmaceuticals Inc Compuestos de oxindol y composicion farmaceutica
US20090217390A1 (en) 2005-04-29 2009-08-27 Fernando Lecanda Cordero Non-human animal sarcoma model
WO2008046083A2 (en) 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of oxindole compounds as therapeutic agents
US8232310B2 (en) 2006-12-29 2012-07-31 Georgetown University Targeting of EWS-FLI1 as anti-tumor therapy
CA2953987A1 (en) 2006-12-29 2008-07-10 Georgetown University Targeting of ews-fli1 as anti-tumor therapy
PL2154966T3 (pl) 2007-04-20 2014-03-31 Univ New York State Res Found Benzoimidazole i ich kompozycje farmaceutyczne
US8377992B2 (en) 2007-10-22 2013-02-19 The Wistar Institute TRBD-binding effectors and methods for using the same to modulate telomerase activity
US20110218155A1 (en) 2008-10-10 2011-09-08 Dana-Farber Cancer Institute, Inc. Chemical modulators of pro-apoptotic bax and bcl-2 polypeptides
MX368109B (es) 2008-10-21 2019-09-18 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
US8710068B2 (en) 2009-01-19 2014-04-29 The Trustees Of The University Of Pennsylvania Method of treating cancer using a survivin inhibitor
AR078161A1 (es) * 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
WO2012078519A2 (en) 2010-12-06 2012-06-14 Numerate, Inc. 3-acylidene-2-oxoindole derivatives for inhibition of transglutaminase 2
CN102516152B (zh) 2011-12-12 2014-12-10 华东师范大学 一种α-二氟羰基取代的手性叔醇类化合物及其合成方法和应用
US20130259927A1 (en) 2012-04-02 2013-10-03 Gradalis, Inc. Ewing's Sarcoma Bifunctional shRNA Design
NZ723971A (en) 2012-04-12 2018-01-26 Univ Georgetown Methods and compositions for treating ewings sarcoma family of tumors
WO2014015153A2 (en) * 2012-07-20 2014-01-23 Star Biotechnology, Llc Compositions and methods for treating ewing's sarcoma and other disorders related to ews-fli1
EP2968536B1 (en) 2013-03-13 2023-06-28 The United States of America, as represented by The Secretary, Department of Health and Human Services Methods for modulating chemotherapeutic cytotoxicity
MX369503B (es) 2013-04-08 2019-11-11 Pharmacyclics Llc Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas.
WO2014173241A1 (en) * 2013-04-26 2014-10-30 Beigene, Ltd. Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones
KR101500363B1 (ko) * 2013-07-01 2015-03-16 현대자동차 주식회사 하이브리드 자동차의 동력전달장치
WO2015018521A1 (en) * 2013-08-06 2015-02-12 Oncoethix Sa Method of treating diffuse large b-cell lymphoma (dlbcl) using a bet-bromodomain inhibitor
CN103435606A (zh) 2013-08-22 2013-12-11 中国药科大学 CDK2与GSK3β双重抑制剂及用途
WO2015061229A1 (en) 2013-10-24 2015-04-30 Georgetown University Methods and compositions for treating cancer
MX2016005283A (es) * 2013-10-25 2017-02-20 Pharmacyclics Llc Tratamiento que utiliza inhibidores de tirosina quinasa de bruton e inmunoterapia.
WO2015078929A1 (en) * 2013-11-27 2015-06-04 Oncoethix Sa Method of treating leukemia using pharmaceutical formulation containing thienotriazolodiazepine compounds
CN105793251B (zh) * 2013-12-05 2018-10-12 豪夫迈·罗氏有限公司 具有亲电子官能性的杂芳基吡啶酮和氮杂-吡啶酮化合物
JP2017514806A (ja) 2014-04-16 2017-06-08 シグナル ファーマシューティカルズ，エルエルシー Ｔｏｒキナーゼ阻害剤組み合わせ療法を使用して癌を治療する方法
WO2015187848A1 (en) * 2014-06-04 2015-12-10 Sampath Deepa Hdac inhibitor and btk inhibitor combinations
US20160022684A1 (en) * 2014-07-25 2016-01-28 Pharmacyclics Llc Bet inhibitor and bruton's tyrosine kinase inhibitor combinations
US20170281642A1 (en) * 2014-08-28 2017-10-05 Oncoethix Gmbh Methods of treating acute myeloid leukemia or acute lymphoid leukemia using pharmaceutical compositions containing thienotriazolodiazepine compounds
MX388564B (es) 2014-10-09 2025-03-20 Oncternal Therapeutics Inc Compuestos de indolinona y usos de los mismos.
WO2017172368A1 (en) 2016-03-31 2017-10-05 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
CN114569606B (zh) * 2016-07-29 2024-04-19 英克特诺治疗公司 吲哚啉酮化合物的用途
US20190255127A1 (en) 2018-02-21 2019-08-22 Batu Biologics, Inc. Augmentation of Oncolytic Viral Efficacy through Immunological Targeting Tumor Endothelial Cells

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