JP2019521659A5 - - Google Patents

Download PDF

Info

Publication number
JP2019521659A5
JP2019521659A5 JP2018561967A JP2018561967A JP2019521659A5 JP 2019521659 A5 JP2019521659 A5 JP 2019521659A5 JP 2018561967 A JP2018561967 A JP 2018561967A JP 2018561967 A JP2018561967 A JP 2018561967A JP 2019521659 A5 JP2019521659 A5 JP 2019521659A5
Authority
JP
Japan
Prior art keywords
genome editing
editing complex
complex according
peptide
item
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018561967A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019521659A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/034862 external-priority patent/WO2017205846A1/en
Publication of JP2019521659A publication Critical patent/JP2019521659A/ja
Publication of JP2019521659A5 publication Critical patent/JP2019521659A5/ja
Priority to JP2021184056A priority Critical patent/JP7379447B2/ja
Priority to JP2023169638A priority patent/JP2023165986A/ja
Priority to JP2025079827A priority patent/JP2025118829A/ja
Pending legal-status Critical Current

Links

JP2018561967A 2016-05-27 2017-05-26 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子 Pending JP2019521659A (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021184056A JP7379447B2 (ja) 2016-05-27 2021-11-11 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2023169638A JP2023165986A (ja) 2016-05-27 2023-09-29 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2025079827A JP2025118829A (ja) 2016-05-27 2025-05-12 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662342823P 2016-05-27 2016-05-27
US62/342,823 2016-05-27
US201662394140P 2016-09-13 2016-09-13
US62/394,140 2016-09-13
US201762477357P 2017-03-27 2017-03-27
US62/477,357 2017-03-27
PCT/US2017/034862 WO2017205846A1 (en) 2016-05-27 2017-05-26 Peptides and nanoparticles for intracellular delivery of genome-editing molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021184056A Division JP7379447B2 (ja) 2016-05-27 2021-11-11 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子

Publications (2)

Publication Number Publication Date
JP2019521659A JP2019521659A (ja) 2019-08-08
JP2019521659A5 true JP2019521659A5 (https=) 2020-07-02

Family

ID=59239942

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2018561967A Pending JP2019521659A (ja) 2016-05-27 2017-05-26 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2021184056A Active JP7379447B2 (ja) 2016-05-27 2021-11-11 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2023169638A Withdrawn JP2023165986A (ja) 2016-05-27 2023-09-29 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2025079827A Pending JP2025118829A (ja) 2016-05-27 2025-05-12 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021184056A Active JP7379447B2 (ja) 2016-05-27 2021-11-11 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2023169638A Withdrawn JP2023165986A (ja) 2016-05-27 2023-09-29 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子
JP2025079827A Pending JP2025118829A (ja) 2016-05-27 2025-05-12 ゲノム編集分子の細胞内送達のためのペプチドおよびナノ粒子

Country Status (9)

Country Link
EP (2) EP3464323B1 (https=)
JP (4) JP2019521659A (https=)
CN (2) CN109689677B (https=)
AU (2) AU2017268842B2 (https=)
CA (1) CA3025523A1 (https=)
ES (1) ES2901215T3 (https=)
MX (2) MX388294B (https=)
WO (1) WO2017205846A1 (https=)
ZA (1) ZA201807869B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3665285A4 (en) * 2017-08-10 2021-08-11 Aadigen, LLC PEPTIDES AND NANOPARTICLES FOR INTRACELLULAR VIRUS ADMINISTRATION
US20200323964A1 (en) * 2017-10-16 2020-10-15 Aadigen, Llc Peptides and nanoparticles for intracellular delivery of mrna
FR3081169B1 (fr) * 2018-05-15 2020-06-19 Messenger Biopharma Substitution de la coiffe des arn messagers par deux sequences d'arn introduites a leur extremite 5'
WO2019237387A1 (zh) * 2018-06-16 2019-12-19 深圳市博奥康生物科技有限公司 用于敲除人ACT35基因的gRNA序列及其应用
WO2019237384A1 (zh) * 2018-06-16 2019-12-19 深圳市博奥康生物科技有限公司 用于敲除人CDw137基因的gRNA序列及其应用
CN111363013B (zh) * 2018-12-25 2021-11-19 深圳先进技术研究院 多组分纳米颗粒簇的构建方法
WO2020142676A1 (en) * 2019-01-04 2020-07-09 The University Of Chicago Systems and methods for modulating rna
GB201902648D0 (en) 2019-02-27 2019-04-10 Cyca Oncosolutions Ltd Cell membrane penetrating conjugates
MX2021012740A (es) 2019-04-17 2022-01-24 Aadigen Llc Péptidos y nanopartículas para entrega intracelular de moléculas.
CN109880891B (zh) * 2019-04-22 2021-07-30 上海交通大学 基于核酸酶偶联pcr原理富集低丰度dna突变的检测技术体系及应用
WO2020225309A1 (en) * 2019-05-07 2020-11-12 Ecole Polytechnique Federale De Lausanne (Epfl) Fmrp and cancer treatment
CN110638789A (zh) * 2019-10-31 2020-01-03 南开大学 一种可实现肿瘤靶向递送核糖核蛋白复合物的纳米粒子的制备方法和应用
CA3181170A1 (en) * 2020-04-24 2021-10-28 Aadigen, Llc Compositions for treating cancer with kras mutations and uses thereof
CN116724059A (zh) * 2020-07-24 2023-09-08 阿迪根有限公司 用于治疗病毒感染的组合物和方法
KR102500873B1 (ko) * 2021-02-03 2023-02-17 한국과학기술연구원 자연살해세포 특이적 CRISPR/Cas 시스템을 위한 융합 단백질 및 이의 용도
EP4377472A2 (en) * 2021-07-26 2024-06-05 Imperial College Innovations Limited Nanozyme-catalysed detection of nucleic acids
WO2025059215A1 (en) 2023-09-12 2025-03-20 Aadigen, Llc Methods and compositions for treating or preventing cancer
WO2025090926A1 (en) * 2023-10-26 2025-05-01 The Penn State Research Foundation Ultrasound-sensitive peptide particles with surface-bound gene editing tools for spatially resolved molecule delivery
CN119119204B (zh) * 2024-11-11 2025-03-18 南昌大学 温敏特异性多肽和基于温差特异性无损分离外泌体的方法

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
WO1994010958A1 (en) 1992-11-13 1994-05-26 Mitchell Winalee G Absorbent including super absorbent and capacity monitor
CA2222550A1 (en) 1995-06-07 1996-12-19 Baylor College Of Medicine Nucleic acid transporters for delivery of nucleic acids into a cell
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
JP2002524081A (ja) 1998-09-04 2002-08-06 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 前立腺−特異的膜抗原に特異的な融合受容体およびその使用
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
CA2394850C (en) 1999-12-06 2012-02-07 Sangamo Biosciences, Inc. Methods of using randomized libraries of zinc finger proteins for the identification of gene function
KR20020086508A (ko) 2000-02-08 2002-11-18 상가모 바이오사이언스 인코포레이티드 약물 발견용 세포
US20020131960A1 (en) 2000-06-02 2002-09-19 Michel Sadelain Artificial antigen presenting cells and methods of use thereof
AU2001297703B2 (en) 2000-11-07 2006-10-19 City Of Hope CD19-specific redirected immune cells
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US20050267061A1 (en) 2004-04-08 2005-12-01 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathic and neurodegenerative conditions
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP2008506359A (ja) 2004-04-08 2008-03-06 サンガモ バイオサイエンシズ インコーポレイテッド ジンクフィンガータンパク質による神経因性疼痛の処置
US7514530B2 (en) 2004-04-26 2009-04-07 Centre National De La Recherche Scientifique Peptide carrier for delivering siRNA into mammalian cells
US7579318B2 (en) 2005-12-06 2009-08-25 Centre De La Recherche De La Scientifique Cell penetrating peptides for intracellular delivery of molecules
CA2682527C (en) 2007-03-30 2017-07-11 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
DE102008036364A1 (de) 2008-08-05 2010-02-18 Khs Ag Verfahren zum Herstellen von Behälterzellen
EP2281579A1 (en) 2009-08-05 2011-02-09 BioNTech AG Vaccine composition comprising 5'-Cap modified RNA
US8889394B2 (en) 2009-09-07 2014-11-18 Empire Technology Development Llc Multiple domain proteins
JP6208580B2 (ja) 2010-05-17 2017-10-04 サンガモ セラピューティクス, インコーポレイテッド 新規のdna結合タンパク質及びその使用
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
CN110200997A (zh) 2011-03-23 2019-09-06 弗雷德哈钦森癌症研究中心 用于细胞免疫治疗的方法和组合物
WO2012137036A1 (en) 2011-04-04 2012-10-11 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
KR102134932B1 (ko) 2011-11-11 2020-07-17 프레드 헛친슨 켄서 리서치 센터 암을 위한 사이클린 a1―표적화된 t―세포 면역요법
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
SG10201609210SA (en) 2012-05-03 2016-12-29 Hutchinson Fred Cancer Res Enhanced affinity t cell receptors and methods for making the same
EP3241902B1 (en) * 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
CA2881981A1 (en) 2012-08-20 2014-02-27 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
AU2013327136A1 (en) 2012-10-02 2015-04-16 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy
WO2014053882A1 (en) 2012-10-04 2014-04-10 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
WO2014053881A1 (en) * 2012-10-04 2014-04-10 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
WO2014053880A1 (en) 2012-10-04 2014-04-10 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
WO2014053879A1 (en) 2012-10-04 2014-04-10 Centre National De La Recherche Scientifique Cell penetrating peptides for intracellular delivery of molecules
EP4357457B1 (en) * 2012-10-23 2024-10-16 Toolgen Incorporated Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof
CA3109801C (en) 2013-08-22 2024-01-09 Andrew Cigan Plant genome modification using guide rna/cas endonuclease systems and methods of use
US9526784B2 (en) * 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
CA2933134A1 (en) * 2013-12-13 2015-06-18 Cellectis Cas9 nuclease platform for microalgae genome engineering
CN107406838A (zh) * 2014-11-06 2017-11-28 纳幕尔杜邦公司 Rna引导的内切核酸酶向细胞中的肽介导的递送
EP3237436B1 (en) * 2014-12-24 2019-05-01 Aadigen, Llc Peptides and nanoparticles for intracellular delivery of molecules

Similar Documents

Publication Publication Date Title
JP2019521659A5 (https=)
ES2743188T3 (es) Péptidos y nanopartículas para el suministro intracelular de moléculas
US20200095605A1 (en) Compositions and methods for nucleic acid and/or protein payload delivery
US10377998B2 (en) CRISPR-CAS systems and methods for altering expression of gene products, structural information and inducible modular CAS enzymes
US20230323401A1 (en) Methods and compositions for genome editing
JP7471289B2 (ja) 抗liv1免疫細胞癌療法
Lin et al. Chemical evolution of amphiphilic xenopeptides for potentiated Cas9 ribonucleoprotein delivery
JP2026005238A (ja) Kras突然変異を有するがんを処置するための組成物およびその使用
US20250101425A1 (en) Nanoparticles functionalized with gene editing tools and related methods
JP2024122981A (ja) ゲノム編集方法及び組成物
WO2020223705A2 (en) Methods and compositions for diagnostically-responsive ligand-targeted delivery of therapeutic agents
JP2026500040A (ja) 複合体及びその使用
JP2025518552A (ja) 細胞を操作するための組成物及び方法
US12584145B2 (en) Conjugate systems and methods of use thereof
WO2025261493A1 (zh) 通过表观编辑靶向调节pcsk9的方法及其用途
JP2023538138A (ja) ナノ粒子種基材のための組成物及び方法
JP2023031025A (ja) 小胞分泌制御剤および小胞取り込み制御剤