JP2019520412A5 - - Google Patents
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- Publication number
- JP2019520412A5 JP2019520412A5 JP2019500778A JP2019500778A JP2019520412A5 JP 2019520412 A5 JP2019520412 A5 JP 2019520412A5 JP 2019500778 A JP2019500778 A JP 2019500778A JP 2019500778 A JP2019500778 A JP 2019500778A JP 2019520412 A5 JP2019520412 A5 JP 2019520412A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- imidazo
- phenyl
- amine
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC*(*(C)CC)C(C=C[C@@](C)(C=C(C)C(NC1=NC=*CC)=NC1=C)[Rh])=C Chemical compound CCC*(*(C)CC)C(C=C[C@@](C)(C=C(C)C(NC1=NC=*CC)=NC1=C)[Rh])=C 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16178928 | 2016-07-11 | ||
| EP16178928.4 | 2016-07-11 | ||
| PCT/EP2017/067262 WO2018011138A1 (en) | 2016-07-11 | 2017-07-10 | 2-phenylimidazo[4,5-b]pyridin-7-amine derivates useful as inhibitors of mammalian tyrosine kinase ror1 activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019520412A JP2019520412A (ja) | 2019-07-18 |
| JP2019520412A5 true JP2019520412A5 (https=) | 2020-07-27 |
| JP6891262B2 JP6891262B2 (ja) | 2021-06-18 |
Family
ID=56409027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019500778A Expired - Fee Related JP6891262B2 (ja) | 2016-07-11 | 2017-07-10 | 哺乳動物のチロシンキナーゼｒｏｒ１活性の阻害剤として有用な２−フェニルイミダゾ［４，５−ｂ］ピリジン−７−アミン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11008318B2 (https=) |
| EP (1) | EP3481824B1 (https=) |
| JP (1) | JP6891262B2 (https=) |
| KR (1) | KR102466810B1 (https=) |
| CN (1) | CN109563092B (https=) |
| ES (1) | ES2899113T3 (https=) |
| WO (1) | WO2018011138A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710835D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Antibodies |
| GB201710836D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | ROR1 Car T-Cells |
| GB201710838D0 (en) | 2017-07-05 | 2017-08-16 | Ucl Business Plc | Bispecific antibodies |
| BR112020017159A2 (pt) * | 2018-02-23 | 2020-12-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Inibidores de glutaminil ciclases bacterianas para uso no tratamento de doenças periodontais e relacionadas |
| CN112574176B (zh) * | 2019-09-27 | 2024-03-15 | 隆泰申医药科技(南京)有限公司 | 一种杂芳基类化合物及其应用 |
| JP7700218B2 (ja) * | 2020-09-17 | 2025-06-30 | 浙江海正薬業股▲ふん▼有限公司 | ピペラジン誘導体、その製造方法、およびその使用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1460067A4 (en) | 2001-11-26 | 2005-12-07 | Takeda Pharmaceutical | BICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE |
| SE0202464D0 (sv) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Use of compounds |
| SE0202462D0 (sv) * | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel use |
| CN101830899A (zh) | 2004-12-23 | 2010-09-15 | 霍夫曼-拉罗奇有限公司 | 杂环氨基甲酸酯衍生物,它们的制备及作为药剂的应用 |
| JP2008525355A (ja) | 2004-12-23 | 2008-07-17 | エフ．ホフマン−ラ ロシュ アーゲー | ベンズアミド誘導体、これらの製造及び医薬剤としての使用。 |
| AU2006209117B2 (en) | 2005-01-28 | 2009-12-10 | Daewoong Pharmaceutical Co., Ltd. | Novel benzoimidazole derivatives and pharmaceutical composition comprising the same |
| EP1891069A1 (en) | 2005-05-24 | 2008-02-27 | AstraZeneca AB | 2-phenyl substituted imidazol [4,5b]pyridine/ pyrazine and purine derivatives as glucokinase modulators |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| US8088761B2 (en) | 2005-12-22 | 2012-01-03 | Cancer Research Technology Limited | Enzyme inhibitors |
| WO2007083978A1 (en) | 2006-01-23 | 2007-07-26 | Crystalgenomics, Inc. | Imidazopyridine derivatives inhibiting protein kinase activity, method for the preparation thereof and pharmaceutical composition containing same |
| WO2008121064A1 (en) | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | New imidazo[4,5-b]pyridine-6-halo-7-aryl/heteroaryl compounds 705 |
| WO2008121063A1 (en) | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | New imidazo[ 4,5-b]pyridine-7-carboxamides 704 |
| WO2009001021A1 (en) | 2007-06-26 | 2008-12-31 | Chroma Therapeutics Ltd. | Imidazopyridine derivatives useful as enzyme inhibitors for the treatment of cell proliferative and autoimmune diseases |
| CA2716947A1 (en) | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
| US20120295915A1 (en) | 2009-11-24 | 2012-11-22 | Chaudhari Amita M | Azabenzimidazoles as fatty acid synthase inhibitors |
| US9150647B2 (en) | 2009-12-18 | 2015-10-06 | Kancera Ab | Biological inhibitors of ROR1 capable of inducing cell death |
| KR20130076046A (ko) * | 2011-12-28 | 2013-07-08 | 한미약품 주식회사 | 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체 |
| ES2567552T3 (es) * | 2012-01-30 | 2016-04-25 | Cephalon, Inc. | Imidazo [4,5-b] derivados de piridina como los moduladores ALK y JAK para el tratamiento de trastornos proliferativos |
| JP6218848B2 (ja) * | 2012-11-20 | 2017-10-25 | プロキナーゼ ゲゼルシャフト ミット ベシュレンクテル ハフツング | プロテインキナーゼ阻害剤としてのチオエーテル誘導体 |
| CN107567445B (zh) * | 2015-02-02 | 2021-06-29 | 坎塞拉有限公司 | 可用作哺乳动物酪氨酸激酶ror1活性抑制剂的2-苯基-3h-咪唑并[4,5-b]吡啶衍生物 |
-
2017
- 2017-07-10 EP EP17735582.3A patent/EP3481824B1/en not_active Not-in-force
- 2017-07-10 KR KR1020197003657A patent/KR102466810B1/ko active Active
- 2017-07-10 ES ES17735582T patent/ES2899113T3/es active Active
- 2017-07-10 US US16/314,708 patent/US11008318B2/en not_active Expired - Fee Related
- 2017-07-10 CN CN201780043024.7A patent/CN109563092B/zh not_active Expired - Fee Related
- 2017-07-10 JP JP2019500778A patent/JP6891262B2/ja not_active Expired - Fee Related
- 2017-07-10 WO PCT/EP2017/067262 patent/WO2018011138A1/en not_active Ceased
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