JP2019516352A - Ｆｌｔ３に対するキメラ受容体及びその使用方法 - Google Patents

Ｆｌｔ３に対するキメラ受容体及びその使用方法 Download PDF

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JP2019516352A
JP2019516352A JP2018551409A JP2018551409A JP2019516352A JP 2019516352 A JP2019516352 A JP 2019516352A JP 2018551409 A JP2018551409 A JP 2018551409A JP 2018551409 A JP2018551409 A JP 2018551409A JP 2019516352 A JP2019516352 A JP 2019516352A
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cell
clone
seq
amino acid
receptor
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JP2019516352A5 (show.php
Inventor
バッカー，アリス
ウー，ローレン
アルベドソン，タラ
ウィルツィウス，ジェッド・ジェイ
ロドリゲス，ルーベン・アルバレス
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Kite Pharma Inc
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Kite Pharma Inc
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Publication of JP2019516352A publication Critical patent/JP2019516352A/ja
Publication of JP2019516352A5 publication Critical patent/JP2019516352A5/ja
Priority to JP2022035975A priority Critical patent/JP7561155B2/ja
Priority to JP2024070373A priority patent/JP2024105337A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005—Vertebrate antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70517—CD8
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0636—T lymphocytes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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JP2018551409A 2016-04-01 2017-03-31 Ｆｌｔ３に対するキメラ受容体及びその使用方法 Pending JP2019516352A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022035975A JP7561155B2 (ja) 2016-04-01 2022-03-09 Ｆｌｔ３に対するキメラ受容体及びその使用方法
JP2024070373A JP2024105337A (ja) 2016-04-01 2024-04-24 Ｆｌｔ３に対するキメラ受容体及びその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662317219P 2016-04-01 2016-04-01
US62/317,219 2016-04-01
PCT/US2017/025613 WO2017173410A1 (en) 2016-04-01 2017-03-31 Chimeric receptors to flt3 and methods of use thereof

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JP2019516352A true JP2019516352A (ja) 2019-06-20
JP2019516352A5 JP2019516352A5 (show.php) 2020-05-07

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JP2018551409A Pending JP2019516352A (ja) 2016-04-01 2017-03-31 Ｆｌｔ３に対するキメラ受容体及びその使用方法
JP2022035975A Active JP7561155B2 (ja) 2016-04-01 2022-03-09 Ｆｌｔ３に対するキメラ受容体及びその使用方法
JP2024070373A Pending JP2024105337A (ja) 2016-04-01 2024-04-24 Ｆｌｔ３に対するキメラ受容体及びその使用方法

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JP2022035975A Active JP7561155B2 (ja) 2016-04-01 2022-03-09 Ｆｌｔ３に対するキメラ受容体及びその使用方法
JP2024070373A Pending JP2024105337A (ja) 2016-04-01 2024-04-24 Ｆｌｔ３に対するキメラ受容体及びその使用方法

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US (2) US20190183931A1 (show.php)
EP (1) EP3436479A1 (show.php)
JP (3) JP2019516352A (show.php)
KR (2) KR102389096B1 (show.php)
CN (1) CN109641956A (show.php)
AR (2) AR109626A1 (show.php)
AU (3) AU2017240801A1 (show.php)
BR (1) BR112018070187A8 (show.php)
CA (1) CA3019655A1 (show.php)
CL (1) CL2018002792A1 (show.php)
CO (1) CO2018011804A2 (show.php)
CR (2) CR20180518A (show.php)
EA (1) EA201892193A1 (show.php)
IL (2) IL296966A (show.php)
MA (1) MA44507A (show.php)
MX (1) MX2023013729A (show.php)
MY (2) MY201207A (show.php)
NZ (1) NZ746925A (show.php)
PE (2) PE20241061A1 (show.php)
PH (1) PH12018502118B1 (show.php)
SA (1) SA518400154B1 (show.php)
SG (2) SG10201911963VA (show.php)
TN (1) TN2018000337A1 (show.php)
TW (2) TW202313669A (show.php)
UA (1) UA128326C2 (show.php)
WO (1) WO2017173410A1 (show.php)

Cited By (1)

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JP2024508223A (ja) * 2021-01-28 2024-02-26 アロジーン セラピューティクス，インコーポレイテッド 免疫細胞を形質導入する方法

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CN119899277A (zh) 2017-06-02 2025-04-29 辉瑞公司 靶向flt3的嵌合抗原受体
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