JP2019515880A5 - - Google Patents

Download PDF

Info

Publication number
JP2019515880A5
JP2019515880A5 JP2018549266A JP2018549266A JP2019515880A5 JP 2019515880 A5 JP2019515880 A5 JP 2019515880A5 JP 2018549266 A JP2018549266 A JP 2018549266A JP 2018549266 A JP2018549266 A JP 2018549266A JP 2019515880 A5 JP2019515880 A5 JP 2019515880A5
Authority
JP
Japan
Prior art keywords
alkyl
alkynyl
alkenyl
group
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018549266A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019515880A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/022755 external-priority patent/WO2017161144A1/en
Publication of JP2019515880A publication Critical patent/JP2019515880A/ja
Publication of JP2019515880A5 publication Critical patent/JP2019515880A5/ja
Pending legal-status Critical Current

Links

JP2018549266A 2016-03-16 2017-03-16 炭酸無水酵素ｉｘ阻害剤抱合体およびその使用 Pending JP2019515880A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662309271P 2016-03-16 2016-03-16
US62/309,271 2016-03-16
PCT/US2017/022755 WO2017161144A1 (en) 2016-03-16 2017-03-16 Carbonic anhydrase ix inhibitor conjugates and uses thereof

Publications (2)

Publication Number Publication Date
JP2019515880A JP2019515880A (ja) 2019-06-13
JP2019515880A5 true JP2019515880A5 (enExample) 2020-04-23

Family

ID=59852036

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018549266A Pending JP2019515880A (ja) 2016-03-16 2017-03-16 炭酸無水酵素ｉｘ阻害剤抱合体およびその使用

Country Status (5)

Country Link
US (1) US10857234B2 (enExample)
EP (1) EP3429637A4 (enExample)
JP (1) JP2019515880A (enExample)
CA (1) CA3017211A1 (enExample)
WO (1) WO2017161144A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3429575A4 (en) * 2016-03-16 2019-10-23 Purdue Research Foundation AGAINST CARBOANHYDRASE-IX DRUGS AND METHODS
MX2020011991A (es) 2018-05-10 2021-04-12 Univ Louisville Res Found Inc Inhibidores de la oncoproteina ras, metodos de produccion y metodos de uso de los mismos.
KR20240069480A (ko) * 2022-11-11 2024-05-20 울산과학기술원 자가조립 가능한 펩타이드 분자를 포함하는 양친매성 접합체 및 이의 용도
TW202430150A (zh) * 2022-11-17 2024-08-01 德商溫瑟克斯製藥公司 在腫瘤微環境中可裂解之小分子藥物結合物
CN119504733A (zh) * 2023-08-25 2025-02-25 无锡诺宇医药科技有限公司 靶向碳酸酐酶放射性药物
CN121991164A (zh) * 2024-11-08 2026-05-08 无锡诺宇医药科技有限公司 碳酸酐酶ix蛋白靶向的放射性药物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2438008T3 (es) 2002-05-06 2014-01-15 Endocyte, Inc. Agentes de formación de imágenes dirigidos a vitaminas
RU2470668C2 (ru) * 2005-08-19 2012-12-27 Эндосайт, Инк. Конъюгаты лиганда с несколькими лекарственными средствами
US20090043099A1 (en) 2006-03-17 2009-02-12 The Burnham Institute Methods and compositions for derepression of IAP-inhibited caspase
US20100104626A1 (en) * 2007-02-16 2010-04-29 Endocyte, Inc. Methods and compositions for treating and diagnosing kidney disease
BRPI0812970A2 (pt) 2007-06-25 2019-09-24 Endocyte Inc conjugados contendo espaçadores hidrofílicos
DK2187965T3 (da) 2007-08-17 2020-01-20 Purdue Research Foundation Psma-bindingsligand-linker-konjugater og fremgangsmåder til anvendelse
CA2711678A1 (en) 2008-01-09 2009-07-16 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase ix
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
CN101596433B (zh) 2009-07-15 2011-07-06 中国科学院工程热物理研究所 U形返料器的冷却式隔板
FR2951449B1 (fr) 2009-10-15 2011-11-25 Commissariat Energie Atomique Procede de fonctionnalisation de molecules biologiques
EP2519823B1 (en) 2009-12-28 2022-05-18 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Composite probes and use thereof in super resolution methods
EP2533775A1 (en) 2010-02-12 2012-12-19 Universita' Degli Studi di Firenze Carbonic anhydrase inhibitors
JP5544239B2 (ja) 2010-07-29 2014-07-09 富士フイルム株式会社 重合性組成物
EP2707102B1 (en) * 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
DK2766364T3 (da) * 2011-08-17 2024-09-30 Merck & Cie Folatkonjugater af albumin-bindende enheder
US20140249315A1 (en) * 2013-03-01 2014-09-04 Endocyte, Inc. Processes for preparing tubulysins
WO2015113760A1 (en) 2014-01-28 2015-08-06 Tube Pharmaceuticals Gmbh Cytotoxic tubulysin compounds for conjugation
US9771380B2 (en) 2014-06-09 2017-09-26 University Of Oregon Gold nanoparticles and methods of making and using gold nanoparticles
EP3429575A4 (en) * 2016-03-16 2019-10-23 Purdue Research Foundation AGAINST CARBOANHYDRASE-IX DRUGS AND METHODS
CA3019835A1 (en) * 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy

Similar Documents

Publication Publication Date Title
JP2020502130A5 (enExample)
ES2972577T3 (es) Formación de imágenes y terapia dirigidas a la proteína de activación de fibroblastos (FAP)
CN104955485B (zh) 吡咯并苯并二氮杂卓‑抗her2抗体结合物
CN105102003B (zh) 吡咯并苯并二氮杂卓-抗psma抗体结合物
CN105102068B (zh) 吡咯并苯并二氮杂卓-抗体结合物
CN105050661B (zh) 吡咯并苯并二氮杂卓‑抗体结合物
JP2025066807A (ja) 生体直交型組成物
ES2815098T3 (es) Conjugados de ligadores (ADCs) con inhibidores de KSP
CN108093640B (zh) 位点特异性抗体-药物缀合物
RU2018119683A (ru) Сайт-специфические конъюгаты антитела к her2 и лекарственного средства
ES2755101T3 (es) Nuevos compuestos y conjugados de criptoficina, su preparación y su uso terapéutico
CN105102004A (zh) 吡咯并苯并二氮杂卓-抗cd22抗体结合物
RU2003137593A (ru) Соединения на основе пептидов для направленной доставки к рецепторам интегринов
JP2020502131A5 (enExample)
JP7184775B2 (ja) 黄体化ホルモン放出ホルモン受容体（ｌｈｒｈ－ｒ）コンジュゲートおよびその使用
CA2976811A1 (en) Solid dispersions of ospemifene
JP2016528251A5 (enExample)
CN107683146A (zh) 位点特异性抗体‑药物缀合物
CN111225688B (zh) 靶向碳酸酐酶阳性癌症的基于fbsa的治疗和放射性成像缀合物
JP2020534300A5 (enExample)
CN113473975A (zh) 制备官能化环辛烯的工艺
JP2021521172A (ja) 抗腫瘍剤としてのピロロベンゾジアゼピン及びその複合体
JP2019515880A (ja) 炭酸無水酵素ｉｘ阻害剤抱合体およびその使用
JP2019512511A5 (enExample)
JP2026502604A (ja) エリブリン系薬物の複合体