JP2019514932A5 - - Google Patents
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- JP2019514932A5 JP2019514932A5 JP2018556473A JP2018556473A JP2019514932A5 JP 2019514932 A5 JP2019514932 A5 JP 2019514932A5 JP 2018556473 A JP2018556473 A JP 2018556473A JP 2018556473 A JP2018556473 A JP 2018556473A JP 2019514932 A5 JP2019514932 A5 JP 2019514932A5
- Authority
- JP
- Japan
- Prior art keywords
- api
- protein
- additive
- drying
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008186 active pharmaceutical agent Substances 0.000 claims 34
- 239000000654 additive Substances 0.000 claims 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 21
- 235000018102 proteins Nutrition 0.000 claims 20
- 102000004169 proteins and genes Human genes 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 20
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 18
- 230000000996 additive effect Effects 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 18
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 14
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 10
- 108091006905 Human Serum Albumin Proteins 0.000 claims 10
- 102000008100 Human Serum Albumin Human genes 0.000 claims 10
- 238000009472 formulation Methods 0.000 claims 10
- 239000002904 solvent Substances 0.000 claims 10
- 230000004071 biological effect Effects 0.000 claims 8
- 238000001035 drying Methods 0.000 claims 8
- 150000007524 organic acids Chemical class 0.000 claims 8
- 150000002898 organic sulfur compounds Chemical class 0.000 claims 8
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 7
- 108010010803 Gelatin Proteins 0.000 claims 7
- 229940098773 bovine serum albumin Drugs 0.000 claims 7
- 235000019253 formic acid Nutrition 0.000 claims 7
- 229920000159 gelatin Polymers 0.000 claims 7
- 239000008273 gelatin Substances 0.000 claims 7
- 235000019322 gelatine Nutrition 0.000 claims 7
- 235000011852 gelatine desserts Nutrition 0.000 claims 7
- 239000011877 solvent mixture Substances 0.000 claims 7
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- 102000009027 Albumins Human genes 0.000 claims 6
- 108010088751 Albumins Proteins 0.000 claims 6
- 102000004506 Blood Proteins Human genes 0.000 claims 6
- 108010017384 Blood Proteins Proteins 0.000 claims 6
- 102000008186 Collagen Human genes 0.000 claims 6
- 108010035532 Collagen Proteins 0.000 claims 6
- 102000007544 Whey Proteins Human genes 0.000 claims 6
- 108010046377 Whey Proteins Proteins 0.000 claims 6
- 229920001436 collagen Polymers 0.000 claims 6
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 6
- 235000021119 whey protein Nutrition 0.000 claims 6
- CPEUVMUXAHMANV-UHFFFAOYSA-N flubendazole Chemical compound C1=C2NC(NC(=O)OC)=NC2=CC=C1C(=O)C1=CC=C(F)C=C1 CPEUVMUXAHMANV-UHFFFAOYSA-N 0.000 claims 5
- 229960004500 flubendazole Drugs 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 4
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 4
- 229960000074 biopharmaceutical Drugs 0.000 claims 4
- 229960004125 ketoconazole Drugs 0.000 claims 4
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims 3
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 3
- 244000105624 Arachis hypogaea Species 0.000 claims 3
- 235000007319 Avena orientalis Nutrition 0.000 claims 3
- 244000075850 Avena orientalis Species 0.000 claims 3
- 244000025254 Cannabis sativa Species 0.000 claims 3
- 235000012766 Cannabis sativa ssp. sativa var. sativa Nutrition 0.000 claims 3
- 235000012765 Cannabis sativa ssp. sativa var. spontanea Nutrition 0.000 claims 3
- 102000011632 Caseins Human genes 0.000 claims 3
- 108010076119 Caseins Proteins 0.000 claims 3
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims 3
- 108010014258 Elastin Proteins 0.000 claims 3
- 102000016942 Elastin Human genes 0.000 claims 3
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims 3
- 240000005979 Hordeum vulgare Species 0.000 claims 3
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 3
- 108060003951 Immunoglobulin Proteins 0.000 claims 3
- 108010076876 Keratins Proteins 0.000 claims 3
- 102000011782 Keratins Human genes 0.000 claims 3
- 108090000942 Lactalbumin Proteins 0.000 claims 3
- 102000004407 Lactalbumin Human genes 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 102000014171 Milk Proteins Human genes 0.000 claims 3
- 108010011756 Milk Proteins Proteins 0.000 claims 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 3
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims 3
- 108010058846 Ovalbumin Proteins 0.000 claims 3
- 108010084695 Pea Proteins Proteins 0.000 claims 3
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims 3
- 241000209056 Secale Species 0.000 claims 3
- 235000007238 Secale cereale Nutrition 0.000 claims 3
- 108010073771 Soybean Proteins Proteins 0.000 claims 3
- 241000209140 Triticum Species 0.000 claims 3
- 235000021307 Triticum Nutrition 0.000 claims 3
- 240000008042 Zea mays Species 0.000 claims 3
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 3
- 235000009120 camo Nutrition 0.000 claims 3
- 239000005018 casein Substances 0.000 claims 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 3
- 235000021240 caseins Nutrition 0.000 claims 3
- 235000005607 chanvre indien Nutrition 0.000 claims 3
- 235000005822 corn Nutrition 0.000 claims 3
- 229920002549 elastin Polymers 0.000 claims 3
- 238000004108 freeze drying Methods 0.000 claims 3
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims 3
- 229960002867 griseofulvin Drugs 0.000 claims 3
- 239000011487 hemp Substances 0.000 claims 3
- 229960001680 ibuprofen Drugs 0.000 claims 3
- 102000018358 immunoglobulin Human genes 0.000 claims 3
- 229960000905 indomethacin Drugs 0.000 claims 3
- 229960004130 itraconazole Drugs 0.000 claims 3
- 235000021239 milk protein Nutrition 0.000 claims 3
- 229960002009 naproxen Drugs 0.000 claims 3
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 3
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 3
- 229960001597 nifedipine Drugs 0.000 claims 3
- 229940092253 ovalbumin Drugs 0.000 claims 3
- 235000019702 pea protein Nutrition 0.000 claims 3
- 235000020232 peanut Nutrition 0.000 claims 3
- 229960002036 phenytoin Drugs 0.000 claims 3
- 229940001941 soy protein Drugs 0.000 claims 3
- 238000001694 spray drying Methods 0.000 claims 3
- 229960001722 verapamil Drugs 0.000 claims 3
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims 2
- MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 claims 2
- OIRFJRBSRORBCM-UHFFFAOYSA-N Iopanoic acid Chemical compound CCC(C(O)=O)CC1=C(I)C=C(I)C(N)=C1I OIRFJRBSRORBCM-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 229960004420 aceclofenac Drugs 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 2
- 229960004099 azithromycin Drugs 0.000 claims 2
- 229960000997 bicalutamide Drugs 0.000 claims 2
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 2
- 229960000623 carbamazepine Drugs 0.000 claims 2
- 229960000876 cinnarizine Drugs 0.000 claims 2
- DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 claims 2
- 229960003529 diazepam Drugs 0.000 claims 2
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- OLNTVTPDXPETLC-XPWALMASSA-N ezetimibe Chemical compound N1([C@@H]([C@H](C1=O)CC[C@H](O)C=1C=CC(F)=CC=1)C=1C=CC(O)=CC=1)C1=CC=C(F)C=C1 OLNTVTPDXPETLC-XPWALMASSA-N 0.000 claims 2
- 229960000815 ezetimibe Drugs 0.000 claims 2
- 229960002297 fenofibrate Drugs 0.000 claims 2
- YMTINGFKWWXKFG-UHFFFAOYSA-N fenofibrate Chemical compound C1=CC(OC(C)(C)C(=O)OC(C)C)=CC=C1C(=O)C1=CC=C(Cl)C=C1 YMTINGFKWWXKFG-UHFFFAOYSA-N 0.000 claims 2
- 229960004580 glibenclamide Drugs 0.000 claims 2
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims 2
- 229960002979 iopanoic acid Drugs 0.000 claims 2
- NXFQHRVNIOXGAQ-YCRREMRBSA-N nitrofurantoin Chemical compound O1C([N+](=O)[O-])=CC=C1\C=N\N1C(=O)NC(=O)C1 NXFQHRVNIOXGAQ-YCRREMRBSA-N 0.000 claims 2
- 229960000564 nitrofurantoin Drugs 0.000 claims 2
- 235000005985 organic acids Nutrition 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229960000746 testosterone undecanoate Drugs 0.000 claims 2
- UDSFVOAUHKGBEK-CNQKSJKFSA-N testosterone undecanoate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCCC)[C@@]1(C)CC2 UDSFVOAUHKGBEK-CNQKSJKFSA-N 0.000 claims 2
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 238000007605 air drying Methods 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229960002206 bifonazole Drugs 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- -1 darnavir Chemical compound 0.000 claims 1
- 229960005107 darunavir Drugs 0.000 claims 1
- CJBJHOAVZSMMDJ-HEXNFIEUSA-N darunavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)C1=CC=CC=C1 CJBJHOAVZSMMDJ-HEXNFIEUSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000413 hydrolysate Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000047 product Substances 0.000 claims 1
- 229960000311 ritonavir Drugs 0.000 claims 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 claims 1
- 229960001852 saquinavir Drugs 0.000 claims 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 239000007962 solid dispersion Substances 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 claims 1
- 229960003862 vemurafenib Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2016/5302A BE1023653B1 (nl) | 2016-04-29 | 2016-04-29 | Eiwit gebaseerd excipient voor actieve farmaceutische stoffen |
| BE2016/5302 | 2016-04-29 | ||
| BE2016/5977 | 2016-12-26 | ||
| BE201605977 | 2016-12-26 | ||
| PCT/EP2017/060143 WO2017186889A1 (en) | 2016-04-29 | 2017-04-28 | Protein based excipient for active pharmaceutical ingredients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514932A JP2019514932A (ja) | 2019-06-06 |
| JP2019514932A5 true JP2019514932A5 (cg-RX-API-DMAC7.html) | 2020-04-23 |
| JP7094226B2 JP7094226B2 (ja) | 2022-07-01 |
Family
ID=58699093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018556473A Active JP7094226B2 (ja) | 2016-04-29 | 2017-04-28 | 医薬品有効成分用のタンパク質をベースにした添加物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20190083629A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3448435B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP7094226B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN109152842B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2017256767B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112018072113A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3018812A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2925656T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL262568A (cg-RX-API-DMAC7.html) |
| MX (1) | MX394644B (cg-RX-API-DMAC7.html) |
| PT (1) | PT3448435T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017186889A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201806357B (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20190307886A1 (en) * | 2016-12-23 | 2019-10-10 | University Of Copenhagen | A co-amorphous form of a substance and a protein |
| EP4069200A1 (en) * | 2019-12-04 | 2022-10-12 | Albumedix Ltd | Methods and compositions produced thereby |
| CN111821309B (zh) * | 2020-04-30 | 2021-08-24 | 深圳市新阳唯康科技有限公司 | 一种具有改良溶出速度的达芦那韦组合物 |
| CN111840255B (zh) * | 2020-07-31 | 2022-03-01 | 北京丰帆生物医药科技有限公司 | 一种维拉帕米温敏缓释制剂及其制备方法和应用 |
| CN112176002B (zh) * | 2020-11-10 | 2022-09-02 | 四川大学 | 胶原基酒精发酵促进剂、及其制备方法和应用 |
| CA3221659A1 (en) | 2021-06-10 | 2022-12-15 | Michael MORGEN | Spray drying of api in supersaturated solutions with formic acid |
| CA3238938A1 (en) | 2021-11-24 | 2023-06-01 | Korbinian LOBMANN | Ternary co-amorphous forms of drugs, proteins, and water-soluble polymers |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5993805A (en) * | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| DE4201173C2 (de) | 1992-01-17 | 1998-10-29 | Alfatec Pharma Gmbh | Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung |
| DE4221880A1 (de) | 1992-07-03 | 1994-01-05 | Alfatec Pharma Gmbh | Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen |
| US5916596A (en) * | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| US20070092563A1 (en) * | 1996-10-01 | 2007-04-26 | Abraxis Bioscience, Inc. | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
| JPH11189548A (ja) | 1997-12-25 | 1999-07-13 | Toshio Sato | 無晶性医薬組成物及びその製造方法 |
| EA004785B1 (ru) * | 1999-09-03 | 2004-08-26 | Янссен Фармацевтика Н.В. | Ветеринарная композиция для введения животному не растворимого в воде лекарственного средства через систему распределения воды |
| IL134701A0 (en) | 2000-02-23 | 2001-04-30 | J P M E D Ltd | Homogeneous solid matrix containing vegetable proteins |
| CN1235587C (zh) * | 2002-12-12 | 2006-01-11 | 复旦大学 | 9－硝基喜树碱固体分散体及其制备方法 |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| CA2669815A1 (en) * | 2006-11-28 | 2008-06-05 | Marinus Pharmaceuticals | Nanoparticulate formulations and methods for the making and use thereof |
| WO2009063367A1 (en) * | 2007-11-15 | 2009-05-22 | Pfizer Products Inc. | Dosage forms comprising celecoxib providing both rapid and sustained pain relief |
| WO2011017835A1 (en) * | 2009-08-11 | 2011-02-17 | Nanjing University | Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding |
| EP2470019A4 (en) | 2009-08-25 | 2013-03-13 | Cardiokine Biopharma Llc | COMPOSITIONS FOR THE ADMINISTRATION OF NON-SOLUBLE AGENTS |
| AU2012295397A1 (en) * | 2011-08-16 | 2014-02-20 | Merck Sharp & Dohme Corp. | Use of inorganic matrix and organic polymer combinations for preparing stable amorphous dispersions |
| CN102327230B (zh) * | 2011-09-30 | 2014-05-21 | 中国药科大学 | 一种包裹紫杉烷类药物的蛋白纳米颗粒及其制备方法 |
| ES2989832T3 (es) * | 2014-03-18 | 2024-11-27 | Izun Pharmaceuticals Corp | Composiciones de cannabinoides unidos a proteínas |
| GB201416293D0 (en) | 2014-09-15 | 2014-10-29 | Solvotrin Therapeutics Ltd | Methods and preparations |
-
2017
- 2017-04-28 CA CA3018812A patent/CA3018812A1/en active Pending
- 2017-04-28 ES ES17722708T patent/ES2925656T3/es active Active
- 2017-04-28 CN CN201780026593.0A patent/CN109152842B/zh active Active
- 2017-04-28 BR BR112018072113-1A patent/BR112018072113A2/pt unknown
- 2017-04-28 EP EP17722708.9A patent/EP3448435B1/en active Active
- 2017-04-28 PT PT177227089T patent/PT3448435T/pt unknown
- 2017-04-28 JP JP2018556473A patent/JP7094226B2/ja active Active
- 2017-04-28 EP EP22171783.8A patent/EP4062941A1/en active Pending
- 2017-04-28 MX MX2018013136A patent/MX394644B/es unknown
- 2017-04-28 US US16/086,549 patent/US20190083629A1/en not_active Abandoned
- 2017-04-28 AU AU2017256767A patent/AU2017256767B2/en active Active
- 2017-04-28 WO PCT/EP2017/060143 patent/WO2017186889A1/en not_active Ceased
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2018
- 2018-09-21 ZA ZA2018/06357A patent/ZA201806357B/en unknown
- 2018-10-24 IL IL262568A patent/IL262568A/en unknown
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2021
- 2021-07-30 US US17/390,185 patent/US20220072136A1/en active Pending
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2024
- 2024-10-08 AU AU2024227175A patent/AU2024227175A1/en active Pending
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