JP2019514343A5 - - Google Patents
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- JP2019514343A5 JP2019514343A5 JP2018542268A JP2018542268A JP2019514343A5 JP 2019514343 A5 JP2019514343 A5 JP 2019514343A5 JP 2018542268 A JP2018542268 A JP 2018542268A JP 2018542268 A JP2018542268 A JP 2018542268A JP 2019514343 A5 JP2019514343 A5 JP 2019514343A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- seq
- polypeptide
- fragment
- staphylococcal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 206010041925 Staphylococcal infections Diseases 0.000 claims description 24
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- 150000001413 amino acids Chemical class 0.000 claims description 13
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- 235000001014 amino acid Nutrition 0.000 description 3
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- 102000004169 proteins and genes Human genes 0.000 description 3
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
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- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 238000000159 protein binding assay Methods 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 101000746783 Homo sapiens Cytochrome b-c1 complex subunit 6, mitochondrial Proteins 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 102000048638 human UQCRH Human genes 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662294413P | 2016-02-12 | 2016-02-12 | |
| US62/294,413 | 2016-02-12 | ||
| PCT/IB2017/050763 WO2017137954A2 (en) | 2016-02-12 | 2017-02-10 | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019514343A JP2019514343A (ja) | 2019-06-06 |
| JP2019514343A5 true JP2019514343A5 (enExample) | 2020-03-26 |
| JP7117244B2 JP7117244B2 (ja) | 2022-08-12 |
Family
ID=59563610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018542268A Active JP7117244B2 (ja) | 2016-02-12 | 2017-02-10 | 黄色ブドウ球菌疾患の間にコアグラーゼ活性を中和する抗体に関連した組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11214600B2 (enExample) |
| EP (1) | EP3416979A4 (enExample) |
| JP (1) | JP7117244B2 (enExample) |
| AU (1) | AU2017218768B2 (enExample) |
| WO (1) | WO2017137954A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9181329B2 (en) * | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| EP2844275B1 (en) * | 2012-04-26 | 2020-05-13 | University of Chicago | Staphylococcal coagulase antigens and methods of their use |
| CN114062665B (zh) * | 2020-08-05 | 2023-04-28 | 菲鹏生物股份有限公司 | 示踪粒子标记目标分子及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610293B1 (en) | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
| CA2341177A1 (en) | 1998-08-31 | 2000-03-09 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
| DK1121135T3 (da) | 1998-09-14 | 2009-03-23 | Nabi Biopharmaceuticals | Præparater af beta-glucaner og specifikke immunglobuliner |
| ES2730275T3 (es) * | 2004-09-22 | 2019-11-11 | Glaxosmithkline Biologicals Sa | Composición inmunógena para uso en vacunación contra estafilococos |
| AR060188A1 (es) * | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Procedimiento de conjugacion |
| KR101541383B1 (ko) * | 2006-03-30 | 2015-08-03 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| SMT202000246T1 (it) | 2009-04-03 | 2020-07-08 | Univ Chicago | Composizioni e metodi relativi a varianti della proteina a (spa) |
| CA2758490C (en) * | 2009-04-14 | 2023-05-02 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| BR112013000097B1 (pt) | 2010-07-02 | 2022-02-01 | The University Of Chicago | Polipeptídeo imunogênico isolado, composição imunogênica e seu uso |
| US9085631B2 (en) * | 2011-04-08 | 2015-07-21 | Nov Vac APS | Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus |
| EP2844275B1 (en) * | 2012-04-26 | 2020-05-13 | University of Chicago | Staphylococcal coagulase antigens and methods of their use |
| AU2013252888B2 (en) * | 2012-04-26 | 2018-06-14 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease |
| WO2015057893A2 (en) | 2013-10-15 | 2015-04-23 | The Texas A&M University System | Compositions and the use of a fibrinogn binding motif presence in efb and coa for vaccine against staphylococcus aureus and drug delivery |
| US9353189B2 (en) * | 2014-01-24 | 2016-05-31 | William R Church | Antibody specific to Staphylococcus aureus, therapeutic method and detection method using same |
-
2017
- 2017-02-10 US US16/077,213 patent/US11214600B2/en active Active
- 2017-02-10 AU AU2017218768A patent/AU2017218768B2/en not_active Ceased
- 2017-02-10 WO PCT/IB2017/050763 patent/WO2017137954A2/en not_active Ceased
- 2017-02-10 JP JP2018542268A patent/JP7117244B2/ja active Active
- 2017-02-10 EP EP17749960.5A patent/EP3416979A4/en not_active Withdrawn
-
2021
- 2021-12-21 US US17/645,344 patent/US20220227819A1/en not_active Abandoned
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