JP2019513359A5 - - Google Patents

Info

Publication number

JP2019513359A5

JP2019513359A5 JP2018550449A JP2018550449A JP2019513359A5 JP 2019513359 A5 JP2019513359 A5 JP 2019513359A5 JP 2018550449 A JP2018550449 A JP 2018550449A JP 2018550449 A JP2018550449 A JP 2018550449A JP 2019513359 A5 JP2019513359 A5 JP 2019513359A5

Authority

JP

Japan

Prior art keywords

colloidal suspension

nanocapsules

suspension according

eox

active ingredient

Prior art date

2017-03-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 239000002088 nanocapsule Substances 0.000 claims description 20
• 239000000725 suspension Substances 0.000 claims description 18
• 239000002563 ionic surfactant Substances 0.000 claims description 11
• 239000004480 active ingredient Substances 0.000 claims description 8
• 239000002736 nonionic surfactant Substances 0.000 claims description 7
• 238000000034 method Methods 0.000 claims description 6
• 229920000642 polymer Polymers 0.000 claims description 4
• 238000001035 drying Methods 0.000 claims description 2
• -1 polyoxyethylene Polymers 0.000 claims 5
• 229920001400 block copolymer Polymers 0.000 claims 3
• 229920001577 copolymer Polymers 0.000 claims 3
• 235000014113 dietary fatty acids Nutrition 0.000 claims 3
• 239000000194 fatty acid Substances 0.000 claims 3
• 229930195729 fatty acid Natural products 0.000 claims 3
• 229920001477 hydrophilic polymer Polymers 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 229930006000 Sucrose Natural products 0.000 claims 2
• 125000000129 anionic group Chemical group 0.000 claims 2
• 125000002091 cationic group Chemical group 0.000 claims 2
• 239000008101 lactose Substances 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000003921 oil Substances 0.000 claims 2
• 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims 2
• 239000005720 sucrose Substances 0.000 claims 2
• 239000000341 volatile oil Substances 0.000 claims 2
• JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical group CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 claims 1
• JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 1
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 240000002234 Allium sativum Species 0.000 claims 1
• 235000017519 Artemisia princeps Nutrition 0.000 claims 1
• 244000065027 Artemisia princeps Species 0.000 claims 1
• 244000056139 Brassica cretica Species 0.000 claims 1
• 235000003351 Brassica cretica Nutrition 0.000 claims 1
• 235000003343 Brassica rupestris Nutrition 0.000 claims 1
• 240000001548 Camellia japonica Species 0.000 claims 1
• LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 244000223760 Cinnamomum zeylanicum Species 0.000 claims 1
• 241000555825 Clupeidae Species 0.000 claims 1
• 235000007129 Cuminum cyminum Nutrition 0.000 claims 1
• 244000304337 Cuminum cyminum Species 0.000 claims 1
• 244000163122 Curcuma domestica Species 0.000 claims 1
• 235000003392 Curcuma domestica Nutrition 0.000 claims 1
• 244000133098 Echinacea angustifolia Species 0.000 claims 1
• 235000013628 Lantana involucrata Nutrition 0.000 claims 1
• 235000006679 Mentha X verticillata Nutrition 0.000 claims 1
• 235000002899 Mentha suaveolens Nutrition 0.000 claims 1
• 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 1
• 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 claims 1
• 240000007673 Origanum vulgare Species 0.000 claims 1
• 235000021314 Palmitic acid Nutrition 0.000 claims 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
• 244000178231 Rosmarinus officinalis Species 0.000 claims 1
• 229920002472 Starch Polymers 0.000 claims 1
• 235000021355 Stearic acid Nutrition 0.000 claims 1
• 244000223014 Syzygium aromaticum Species 0.000 claims 1
• 235000016639 Syzygium aromaticum Nutrition 0.000 claims 1
• 240000002657 Thymus vulgaris Species 0.000 claims 1
• 235000007303 Thymus vulgaris Nutrition 0.000 claims 1
• 241000219094 Vitaceae Species 0.000 claims 1
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
• 229930003316 Vitamin D Natural products 0.000 claims 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 1
• 229930003427 Vitamin E Natural products 0.000 claims 1
• 229930003448 Vitamin K Natural products 0.000 claims 1
• 244000273928 Zingiber officinale Species 0.000 claims 1
• 235000006886 Zingiber officinale Nutrition 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
• 235000021028 berry Nutrition 0.000 claims 1
• QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims 1
• 239000005018 casein Substances 0.000 claims 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
• 235000021240 caseins Nutrition 0.000 claims 1
• 239000001913 cellulose Substances 0.000 claims 1
• 229920002678 cellulose Polymers 0.000 claims 1
• 235000010980 cellulose Nutrition 0.000 claims 1
• 235000017803 cinnamon Nutrition 0.000 claims 1
• 235000020971 citrus fruits Nutrition 0.000 claims 1
• 235000018597 common camellia Nutrition 0.000 claims 1
• 235000003373 curcuma longa Nutrition 0.000 claims 1
• 235000014134 echinacea Nutrition 0.000 claims 1
• 239000003925 fat Substances 0.000 claims 1
• 150000004665 fatty acids Chemical class 0.000 claims 1
• 239000010419 fine particle Substances 0.000 claims 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
• 235000004611 garlic Nutrition 0.000 claims 1
• 235000008397 ginger Nutrition 0.000 claims 1
• 235000021021 grapes Nutrition 0.000 claims 1
• 239000002207 metabolite Substances 0.000 claims 1
• 239000011859 microparticle Substances 0.000 claims 1
• 235000010460 mustard Nutrition 0.000 claims 1
• WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
• IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
• SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
• 229920001451 polypropylene glycol Polymers 0.000 claims 1
• 229920000053 polysorbate 80 Polymers 0.000 claims 1
• 235000019512 sardine Nutrition 0.000 claims 1
• 229940083466 soybean lecithin Drugs 0.000 claims 1
• 239000008107 starch Substances 0.000 claims 1
• 235000019698 starch Nutrition 0.000 claims 1
• 239000008117 stearic acid Substances 0.000 claims 1
• 239000001585 thymus vulgaris Substances 0.000 claims 1
• 235000013976 turmeric Nutrition 0.000 claims 1
• 235000019155 vitamin A Nutrition 0.000 claims 1
• 239000011719 vitamin A Substances 0.000 claims 1
• 235000019166 vitamin D Nutrition 0.000 claims 1
• 239000011710 vitamin D Substances 0.000 claims 1
• 150000003710 vitamin D derivatives Chemical class 0.000 claims 1
• 235000019165 vitamin E Nutrition 0.000 claims 1
• 229940046009 vitamin E Drugs 0.000 claims 1
• 239000011709 vitamin E Substances 0.000 claims 1
• 235000019168 vitamin K Nutrition 0.000 claims 1
• 239000011712 vitamin K Substances 0.000 claims 1
• 150000003721 vitamin K derivatives Chemical class 0.000 claims 1
• 229940045997 vitamin a Drugs 0.000 claims 1
• 229940046008 vitamin d Drugs 0.000 claims 1
• 150000003722 vitamin derivatives Chemical class 0.000 claims 1
• 229940046010 vitamin k Drugs 0.000 claims 1
• 239000008267 milk Substances 0.000 description 10
• 210000004080 milk Anatomy 0.000 description 7
• 235000013336 milk Nutrition 0.000 description 7
• 239000012071 phase Substances 0.000 description 5
• 238000004519 manufacturing process Methods 0.000 description 3
• 238000003756 stirring Methods 0.000 description 3
• 239000008346 aqueous phase Substances 0.000 description 2
• 238000000265 homogenisation Methods 0.000 description 2
• 238000002360 preparation method Methods 0.000 description 2
• 230000015572 biosynthetic process Effects 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• 239000000693 micelle Substances 0.000 description 1
• 229920001983 poloxamer Polymers 0.000 description 1