JP2019512495A - 急性骨髄性白血病の治療のための併用療法 - Google Patents

急性骨髄性白血病の治療のための併用療法 Download PDF

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JP2019512495A
JP2019512495A JP2018548236A JP2018548236A JP2019512495A JP 2019512495 A JP2019512495 A JP 2019512495A JP 2018548236 A JP2018548236 A JP 2018548236A JP 2018548236 A JP2018548236 A JP 2018548236A JP 2019512495 A JP2019512495 A JP 2019512495A
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salt
amino
acute myeloid
myeloid leukemia
methylpiperazin
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Japanese (ja)
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JP2019512495A5 (enExample
Inventor
エルクット バーチェジ
エルクット バーチェジ
陽子 山木
陽子 山木
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Astellas Pharma Inc
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Astellas Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018548236A 2016-03-29 2017-03-27 急性骨髄性白血病の治療のための併用療法 Pending JP2019512495A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662314700P 2016-03-29 2016-03-29
US62/314700 2016-03-29
US201662368343P 2016-07-29 2016-07-29
US62/368343 2016-07-29
PCT/JP2017/012293 WO2017170348A1 (en) 2016-03-29 2017-03-27 Combination therapy for the treatment of acute myeloid leukemia

Publications (2)

Publication Number Publication Date
JP2019512495A true JP2019512495A (ja) 2019-05-16
JP2019512495A5 JP2019512495A5 (enExample) 2020-04-09

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JP2018548236A Pending JP2019512495A (ja) 2016-03-29 2017-03-27 急性骨髄性白血病の治療のための併用療法

Country Status (10)

Country Link
US (2) US20190117649A1 (enExample)
EP (1) EP3436014A4 (enExample)
JP (1) JP2019512495A (enExample)
KR (1) KR20180124055A (enExample)
CN (1) CN108883109A (enExample)
BR (1) BR112018069111A2 (enExample)
CA (1) CA3018155A1 (enExample)
MX (1) MX2018011975A (enExample)
RU (1) RU2018134167A (enExample)
WO (1) WO2017170348A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3824906A1 (en) 2016-12-21 2021-05-26 Amgen Inc. Anti-tnf alpha antibody formulations
KR101954370B1 (ko) 2018-07-25 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
CA3130244A1 (en) * 2019-02-22 2020-08-27 Hanmi Pharm. Co., Ltd. Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia
PE20212153A1 (es) * 2019-02-22 2021-11-09 Hanmi Pharm Ind Co Ltd Composicion farmaceutica que comprende un inhibidor de flt3 y un agente hipometilante para tratar la leucemia mieloide aguda
KR20200102948A (ko) 2019-02-22 2020-09-01 한미약품 주식회사 Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
MY204603A (en) * 2019-04-03 2024-09-05 Astellas Pharma Inc Pharmaceutical composition
KR20210002015A (ko) 2019-06-27 2021-01-06 한미약품 주식회사 Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물
AU2020367035A1 (en) * 2019-10-14 2022-05-12 Astrazeneca Ab Combination therapy for treating a hematological malignancy
CN114828842A (zh) * 2019-10-21 2022-07-29 理森制药股份公司 用于治疗急性髓系白血病的包含dhodh抑制剂的组合物
US11945785B2 (en) 2021-12-30 2024-04-02 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of FLT3
KR102559124B1 (ko) 2022-08-25 2023-07-26 주식회사 엔젠바이오 Flt3 유전자 증폭용 조성물 및 이의 용도

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 128, no. 22, JPN6020049994, 2 December 2016 (2016-12-02), pages 2830, ISSN: 0004417084 *
EXPERT REVIEW OF HEMATOLOGY, vol. 9, no. 5, JPN6020049991, 17 March 2016 (2016-03-17), pages 433 - 445, ISSN: 0004563950 *
LEUKEMIA, vol. 30, JPN6020049993, 15 January 2016 (2016-01-15), pages 1025 - 1032, ISSN: 0004563951 *

Also Published As

Publication number Publication date
BR112018069111A2 (pt) 2019-03-19
CA3018155A1 (en) 2017-10-05
MX2018011975A (es) 2019-01-15
KR20180124055A (ko) 2018-11-20
WO2017170348A1 (en) 2017-10-05
US20200360372A1 (en) 2020-11-19
EP3436014A4 (en) 2019-11-27
EP3436014A1 (en) 2019-02-06
US20190117649A1 (en) 2019-04-25
RU2018134167A (ru) 2020-04-29
CN108883109A (zh) 2018-11-23
RU2018134167A3 (enExample) 2020-06-30

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