JP2019511536A5 - - Google Patents
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- Publication number
- JP2019511536A5 JP2019511536A5 JP2018553923A JP2018553923A JP2019511536A5 JP 2019511536 A5 JP2019511536 A5 JP 2019511536A5 JP 2018553923 A JP2018553923 A JP 2018553923A JP 2018553923 A JP2018553923 A JP 2018553923A JP 2019511536 A5 JP2019511536 A5 JP 2019511536A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- subject
- epidural space
- hypertension
- thoracic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims 41
- 210000000115 thoracic cavity Anatomy 0.000 claims 18
- 206010020772 Hypertension Diseases 0.000 claims 13
- 230000002526 effect on cardiovascular system Effects 0.000 claims 13
- 102000003566 TRPV1 Human genes 0.000 claims 12
- 239000004480 active ingredient Substances 0.000 claims 10
- 229940044601 receptor agonist Drugs 0.000 claims 7
- 239000000018 receptor agonist Substances 0.000 claims 7
- IKYCZSUNGFRBJS-UHFFFAOYSA-N Euphorbia factor RL9 = U(1) = Resiniferatoxin Natural products COC1=CC(O)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 IKYCZSUNGFRBJS-UHFFFAOYSA-N 0.000 claims 6
- DSDNAKHZNJAGHN-UHFFFAOYSA-N resinferatoxin Natural products C1=C(O)C(OC)=CC(CC(=O)OCC=2CC3(O)C(=O)C(C)=CC3C34C(C)CC5(OC(O4)(CC=4C=CC=CC=4)OC5C3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-UHFFFAOYSA-N 0.000 claims 6
- DSDNAKHZNJAGHN-MXTYGGKSSA-N resiniferatoxin Chemical compound C1=C(O)C(OC)=CC(CC(=O)OCC=2C[C@]3(O)C(=O)C(C)=C[C@H]3[C@@]34[C@H](C)C[C@@]5(O[C@@](O4)(CC=4C=CC=CC=4)O[C@@H]5[C@@H]3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-MXTYGGKSSA-N 0.000 claims 6
- 229940073454 resiniferatoxin Drugs 0.000 claims 6
- 206010065918 Prehypertension Diseases 0.000 claims 4
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 3
- 229960002428 fentanyl Drugs 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 102000003840 Opioid Receptors Human genes 0.000 claims 2
- 108090000137 Opioid Receptors Proteins 0.000 claims 2
- 229940121954 Opioid receptor agonist Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000004165 myocardium Anatomy 0.000 claims 2
- 239000003402 opiate agonist Substances 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 230000037390 scarring Effects 0.000 claims 2
- 241000406668 Loxodonta cyclotis Species 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000035487 diastolic blood pressure Effects 0.000 claims 1
- 230000003205 diastolic effect Effects 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000035488 systolic blood pressure Effects 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021170184A JP7341203B2 (ja) | 2016-04-13 | 2021-10-18 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
| JP2023138999A JP2023155365A (ja) | 2016-04-13 | 2023-08-29 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662322079P | 2016-04-13 | 2016-04-13 | |
| US62/322,079 | 2016-04-13 | ||
| PCT/US2017/027480 WO2017180907A1 (en) | 2016-04-13 | 2017-04-13 | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021170184A Division JP7341203B2 (ja) | 2016-04-13 | 2021-10-18 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019511536A JP2019511536A (ja) | 2019-04-25 |
| JP2019511536A5 true JP2019511536A5 (https=) | 2020-05-14 |
| JP6980694B2 JP6980694B2 (ja) | 2021-12-15 |
Family
ID=60039929
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553923A Active JP6980694B2 (ja) | 2016-04-13 | 2017-04-13 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
| JP2021170184A Active JP7341203B2 (ja) | 2016-04-13 | 2021-10-18 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
| JP2023138999A Pending JP2023155365A (ja) | 2016-04-13 | 2023-08-29 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021170184A Active JP7341203B2 (ja) | 2016-04-13 | 2021-10-18 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
| JP2023138999A Pending JP2023155365A (ja) | 2016-04-13 | 2023-08-29 | 投与のための方法およびレシニフェラトキシンで心血管疾患を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20170296506A1 (https=) |
| EP (1) | EP3442523A4 (https=) |
| JP (3) | JP6980694B2 (https=) |
| KR (2) | KR102395342B1 (https=) |
| CN (2) | CN120114438A (https=) |
| AU (1) | AU2017248665B2 (https=) |
| CA (1) | CA3020815A1 (https=) |
| IL (2) | IL298314B2 (https=) |
| WO (1) | WO2017180907A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210108979A (ko) | 2018-12-21 | 2021-09-03 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 부적응 통증을 치료하기 위한 레시니페라톡신의 신경 주위 투여 |
| JP7530365B2 (ja) | 2019-01-22 | 2024-08-07 | ソレント・セラピューティクス・インコーポレイテッド | レシニフェラトキシンを投与することによって変形性関節症疼痛を処置するための方法 |
| IL300072A (en) * | 2020-08-11 | 2023-03-01 | Sorrento Therapeutics Inc | Treatment of pneumonia by nerve ablation |
| CA3219312A1 (en) * | 2021-05-18 | 2022-11-24 | Alexis Nahama | Presurgical perineural administration of resiniferatoxin for reduction of post-operative pain |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0211230D0 (en) * | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| CA2607219A1 (en) * | 2005-05-18 | 2007-02-15 | Neuraxon, Inc. | Substituted benzimidazole compounds with dual nos inhibitory activity and mu opioid agonist activity |
| ES2535233T3 (es) * | 2006-01-25 | 2015-05-06 | Insys Therapeutics, Inc. | Pulverización de fentanilo sublingual |
| US20100158973A1 (en) * | 2006-03-13 | 2010-06-24 | Hadasit Medical Research Services & Development Llimited | Therapeutic uses of cannabidiol compounds |
| CN101522181A (zh) * | 2006-10-04 | 2009-09-02 | 纽若科伊公司 | 诱导低体温药物在治疗局部缺血的应用 |
| CN101951937A (zh) * | 2007-12-21 | 2011-01-19 | 赫尔辛医疗股份公司 | 使用伊帕瑞林刺激胃肠系统动力的方法 |
| AU2011311765B2 (en) * | 2010-10-06 | 2015-07-16 | Celltrend Gmbh | A new method for diagnosing hypertension as well as cardiomyopathies |
| NO3046901T3 (https=) * | 2013-09-17 | 2018-03-17 | ||
| US9956166B2 (en) | 2013-09-18 | 2018-05-01 | Sorrento Therapeutics, Inc. | Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin |
-
2017
- 2017-04-13 IL IL298314A patent/IL298314B2/en unknown
- 2017-04-13 US US15/487,263 patent/US20170296506A1/en not_active Abandoned
- 2017-04-13 KR KR1020187032832A patent/KR102395342B1/ko active Active
- 2017-04-13 AU AU2017248665A patent/AU2017248665B2/en active Active
- 2017-04-13 CN CN202411012641.9A patent/CN120114438A/zh active Pending
- 2017-04-13 EP EP17783159.1A patent/EP3442523A4/en active Pending
- 2017-04-13 WO PCT/US2017/027480 patent/WO2017180907A1/en not_active Ceased
- 2017-04-13 CA CA3020815A patent/CA3020815A1/en active Pending
- 2017-04-13 JP JP2018553923A patent/JP6980694B2/ja active Active
- 2017-04-13 CN CN201780036933.8A patent/CN109562096A/zh active Pending
- 2017-04-13 KR KR1020227014423A patent/KR102508022B1/ko active Active
- 2017-04-13 IL IL262328A patent/IL262328B2/en unknown
-
2021
- 2021-07-14 US US17/375,796 patent/US20220000837A1/en not_active Abandoned
- 2021-10-18 JP JP2021170184A patent/JP7341203B2/ja active Active
-
2023
- 2023-08-29 JP JP2023138999A patent/JP2023155365A/ja active Pending
-
2024
- 2024-03-29 US US18/622,241 patent/US20250082605A1/en active Pending
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